Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway

scholarly article by Zhenlong Ran et al published 12 December 2018 in Molecular Medicine Reports

Curcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3892/MMR.2018.9749
P932PMC publication ID6323224
P698PubMed publication ID30569107

P2093author name stringYueling Zhang
Jingxue Ma
Xiaoying Wen
Zhenlong Ran
P2860cites workCost-effectiveness of Different Diabetic Retinopathy Screening ModalitiesQ28078692
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Anti-carcinogenic action of curcumin by activation of antioxidant defence system and inhibition of NF-κB signalling in lymphoma-bearing mice.Q53283288
Fas-mediated apoptosis in human lens epithelial cells of cataracts associated with diabetic retinopathyQ73175739
Diabetic retinopathy: new ways to prevent blindnessQ80917409
Curcumin attenuates inflammatory responses by suppressing TLR4-mediated NF-κB signaling pathway in lipopolysaccharide-induced mastitis in miceQ87255583
Andrographolide Ameliorates Atherosclerosis by Suppressing Pro-Inflammation and ROS Generation-Mediated Foam Cell FormationQ89285662
Inhibition of Endoplasmic Reticulum Stress Apoptosis by Estrogen Protects Human Umbilical Vein Endothelial Cells Through the PI3 Kinase-Akt Signaling Pathway.Q32177552
Biomarkers in Diabetic RetinopathyQ33583030
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Curcumin protects retinal cells from light-and oxidant stress-induced cell deathQ33608143
Emerging roles of mitochondria ROS in atherosclerotic lesions: causation or association?Q34239967
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Meriva®, a lecithinized curcumin delivery system, in diabetic microangiopathy and retinopathyQ34513505
The role of SLIT-ROBO signaling in proliferative diabetic retinopathy and retinal pigment epithelial cellsQ35047336
Inhibition of protein kinase C delta attenuates allergic airway inflammation through suppression of PI3K/Akt/mTOR/HIF-1 alpha/VEGF pathwayQ35060705
Reversal of the Caspase-Dependent Apoptotic Cytotoxicity Pathway by Taurine from Lycium barbarum (Goji Berry) in Human Retinal Pigment Epithelial Cells: Potential Benefit in Diabetic RetinopathyQ35903992
A polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation.Q35939307
Ginsenoside Rg1 protects mouse podocytes from aldosterone-induced injury in vitroQ36745190
Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferationQ37130129
Curcumin targeted signaling pathways: basis for anti-photoaging and anti-carcinogenic therapyQ37771391
Inflammation in diabetic retinopathyQ37884176
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Diabetic retinopathy--biomolecules and multiple pathophysiology.Q38275754
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Homocysteine mediates transcriptional changes of the inflammatory pathway signature genes in human retinal pigment epithelial cells.Q38702193
The influence of substrate modulus on retinal pigment epithelial cellsQ38724013
PI3k/Akt signalling pathway plays a crucial role in the anti-inflammatory effects of curcumin in LPS-activated microgliaQ38769452
Prevalence of diabetic retinopathy at first presentation to the retinal screening service in the greater Wellington region of New Zealand 2006-2015, and implications for models of retinal screeningQ38957399
High-glucose-induced CARM1 expression regulates apoptosis of human retinal pigment epithelial cells via histone 3 arginine 17 dimethylation: role in diabetic retinopathyQ38970629
Activation of the TXNIP/NLRP3 inflammasome pathway contributes to inflammation in diabetic retinopathy: a novel inhibitory effect of minocyclineQ39245422
Oxidative stress and diabetic retinopathy: development and treatmentQ39269643
Diabetic retinopathy and inflammation: novel therapeutic targets.Q41012046
Role of inflammation in the pathogenesis of diabetic retinopathyQ41012127
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Imaging in Diabetic RetinopathyQ43154637
A central role for inflammation in the pathogenesis of diabetic retinopathyQ44961996
Curcumin and anthocyanin inhibit pepsin-mediated cell damage and carcinogenic changes in airway epithelial cellsQ45423705
A role for systemic inflammation in diabetic retinopathy.Q46024744
A novel antioxidant 3,7-dihydroxy-isoflav-3-ene (DHIF) inhibits neointimal hyperplasia after vessel injury attenuating reactive oxygen species and nuclear factor-kappaB signalingQ46310607
Anti-oxidant activities of curcumin and related enonesQ46465133
Effects of curcumin on angiotensin-converting enzyme gene expression, oxidative stress and anti-oxidant status in thioacetamide-induced hepatotoxicity.Q46849696
Cooperation of Rel family members in regulating Aβ1-40-mediated pro-inflammatory cytokine secretion by retinal pigment epithelial cellsQ47340755
The anti-inflammatory activity of curcumin is mediated by its oxidative metabolitesQ47447627
Therapeutic revolution in the management of diabetic retinopathyQ47599396
Gambogic acid suppresses inflammation in rheumatoid arthritis rats via PI3K/Akt/mTOR signaling pathwayQ47811326
Proinflammatory cytokine interferon-γ increases the expression of BANCR, a long non-coding RNA, in retinal pigment epithelial cellsQ50062682
P4510describes a project that usesImageJQ1659584
P407language of work or nameEnglishQ1860
P921main subjectglucoseQ37525
curcuminQ312266
molecular medicineQ3523816
P577publication date2018-12-12
P1433published inMolecular Medicine ReportsQ26842180
P1476titleCurcumin inhibits high glucose‑induced inflammatory injury in human retinal pigment epithelial cells through the ROS‑PI3K/AKT/mTOR signaling pathway

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cites work (P2860)
Q91640915Adjuvant Therapies in Diabetic Retinopathy as an Early Approach to Delay Its Progression: The Importance of Oxidative Stress and Inflammation
Q99608901Exploring the Mechanism of Action Compound-Xueshuantong Capsule in Diabetic Retinopathy Treatment Based on Network Pharmacology
Q92142552Ginkgo biloba extract protects diabetic rats against cerebral ischemia‑reperfusion injury by suppressing oxidative stress and upregulating the expression of glutamate transporter 1
Q64997207Nutraceuticals for the Treatment of Diabetic Retinopathy.
Q92086083OMICs approaches-assisted identification of macrophages-derived MIP-1γ as the therapeutic target of botanical products TNTL in diabetic retinopathy

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