S100P dissociates myosin IIA filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration

scientific article

S100P dissociates myosin IIA filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M112.349787
P932PMC publication ID3346139
P698PubMed publication ID22399300

P50authorDavid G. FernigQ37379493
Stephane R. GrossQ39187616
P2093author name stringGuozheng Wang
Min Du
Philip S Rudland
Roger Barraclough
Thamir M Ismail
P2860cites workHeterodimeric interaction and interfaces of S100A1 and S100PQ24294738
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturationQ24297812
Mts1 regulates the assembly of nonmuscle myosin-IIAQ24300636
S100P promotes pancreatic cancer growth, survival, and invasionQ24312176
Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexesQ24647211
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4Q25938983
Membrane structure and fusion-triggering conformational change of the fusion domain from influenza hemagglutininQ27633701
Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopyQ27639801
The crystal structure at 2A resolution of the Ca2+ -binding protein S100PQ27640260
Site-directed mutagenesis by overlap extension using the polymerase chain reactionQ27860503
Interaction in vivo and in vitro of the metastasis-inducing S100 protein, S100A4 (p9Ka) with S100A1Q28141200
Intracellular and extracellular roles of S100 proteinsQ28184555
S100P stimulates cell proliferation and survival via receptor for activated glycation end products (RAGE)Q28184570
Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca(2+)-binding S100 proteinsQ28213405
Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka)Q28214677
IQGAP1: a key regulator of adhesion and migrationQ28250427
Nonmuscle myosin II-B is required for normal development of the mouse heartQ28253497
Effect of Mts1 on the structure and activity of nonmuscle myosin IIQ28257003
Non-muscle myosin II takes centre stage in cell adhesion and migrationQ28262326
Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in miceQ28511656
Nonmuscle myosin IIb is involved in the guidance of fibroblast migrationQ28513074
The C-terminal region of S100A4 is important for its metastasis-inducing propertiesQ28575571
Myosin II activity regulates vinculin recruitment to focal adhesions through FAK-mediated paxillin phosphorylationQ28586815
Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B-depleted miceQ28591891
Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II familyQ28592899
Non-muscle myosins 2A and 2B drive changes in cell morphology that occur as myoblasts align and fuseQ28595022
Rho and Rac take center stageQ28645748
In vivo protein transduction: delivery of a biologically active protein into the mouseQ29615482
Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient miceQ29617498
Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migrationQ30175391
Nanosecond fluorescence resonance energy transfer-fluorescence lifetime imaging microscopy to localize the protein interactions in a single living cellQ30308768
S100A4 regulates macrophage chemotaxisQ30495765
Fluorescence lifetime imaging microscopy: spatial resolution of biochemical processes in the cellQ30656466
Self-association of calcium-binding protein S100A4 and metastasisQ33569866
Conservation of heterochromatin protein 1 functionQ33975076
Mechanism of the Ca²+-dependent interaction between S100A4 and tail fragments of nonmuscle myosin heavy chain IIA.Q34512645
Molecular characterization of the effects of Y-27632.Q34569957
S100 proteins: structure, functions and pathologyQ34625714
Molecular Mechanisms of Tumor Invasion and Metastasis: An Integrated ViewQ35577251
Effect of cromolyn on S100P interactions with RAGE and pancreatic cancer growth and invasion in mouse modelsQ35702968
Inactivation of the E-cadherin-mediated cell adhesion system in human cancersQ35753235
Myosin-IIA heavy-chain phosphorylation regulates the motility of MDA-MB-231 carcinoma cellsQ35942363
The metastasis associated protein S100A4: role in tumour progression and metastasisQ36131038
S100A4 regulates cell motility and invasion in an in vitro model for breast cancer metastasisQ36673631
A review of the S100 proteins in cancerQ36848759
Myosin IIC: a third molecular motor driving neuronal dynamicsQ36854943
Cell-matrix adhesionQ36902965
Multiple regulatory steps control mammalian nonmuscle myosin II assembly in live cellsQ37035180
RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteins.Q37106500
Pak protein kinases and their role in cancerQ37376062
Inhibition of focal adhesion kinase (FAK) signaling in focal adhesions decreases cell motility and proliferationQ37381921
Phospholipid binding, phosphorylation by protein kinase C, and filament assembly of the COOH terminal heavy chain fragments of nonmuscle myosin II isoforms MIIA and MIIB.Q38288084
Optical biosensor techniques to analyze protein-polysaccharide interactions.Q38299074
TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells.Q39914433
The basic C-terminal amino acids of calcium-binding protein S100A4 promote metastasisQ39941168
The role of S100P in the invasion of pancreatic cancer cells is mediated through cytoskeletal changes and regulation of cathepsin D.Q40079528
RAGE activation by S100P in colon cancer stimulates growth, migration, and cell signaling pathwaysQ40116296
Rho kinase differentially regulates phosphorylation of nonmuscle myosin II isoforms A and B during cell rounding and migrationQ40223694
Induction of metastasis by S100P in a rat mammary model and its association with poor survival of breast cancer patientsQ40327503
Transducible TAT-HA fusogenic peptide enhances escape of TAT-fusion proteins after lipid raft macropinocytosis.Q40591045
Contractility modulates cell adhesion strengthening through focal adhesion kinase and assembly of vinculin-containing focal adhesions.Q40676349
Non-muscle myosin heavy chain as a possible target for protein encoded by metastasis-related mts-1 geneQ41449150
Induction of the metastatic phenotype by transfection of a benign rat mammary epithelial cell line with the gene for p9Ka, a rat calcium-binding protein, but not with the oncogene EJ-ras-1.Q41562528
Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primatesQ42437364
A rapid in vitro assay for quantitating the invasive potential of tumor cellsQ42807739
Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cellsQ42910952
Rho-mediated assembly of stress fibers is differentially regulated in corneal fibroblasts and myofibroblastsQ44987223
Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy.Q45004417
Focal adhesion kinase suppresses Rho activity to promote focal adhesion turnoverQ46171629
The S100A4 Metastasis Factor Regulates Cellular Motility via a Direct Interaction with Myosin-IIAQ56531468
Simultaneous detection of multiple green fluorescent proteins in live cells by fluorescence lifetime imaging microscopyQ56990643
Metastasis-associated Mts1 (S100A4) Protein Modulates Protein Kinase C Phosphorylation of the Heavy Chain of Nonmuscle MyosinQ58001353
Myosin IIA regulates cell motility and actomyosin–microtubule crosstalkQ58022519
Cell Adhesion AssaysQ58057776
Mutually antagonistic actions of S100A4 and S100A1 on normal and metastatic phenotypesQ58377503
Metastasis-associated protein Mts1 (S100A4) inhibits CK2-mediated phosphorylation and self-assembly of the heavy chain of nonmuscle myosinQ63362549
Interactions in vitro of p9Ka, the rat S-100-related, metastasis-inducing, calcium-binding proteinQ72068667
Interaction of metastasis associated Mts1 protein with nonmuscle myosinQ72194492
Prognostic significance of the metastasis-inducing protein S100A4 (p9Ka) in human breast cancerQ73629119
Protein S100 as prognostic marker for gastrointestinal stromal tumors: a clinicopathological risk factor analysisQ80573453
Roles of IQGAP1 in cell polarization and migrationQ81628837
Regulation of myosin-IIA assembly and Mts1 binding by heavy chain phosphorylationQ81705155
P433issue19
P407language of work or nameEnglishQ1860
P921main subjectcell adhesionQ187640
cell migrationQ189092
P304page(s)15330-15344
P577publication date2012-03-06
P1433published inJournal of Biological ChemistryQ867727
P1476titleS100P dissociates myosin IIA filaments and focal adhesion sites to reduce cell adhesion and enhance cell migration
P478volume287

Reverse relations

cites work (P2860)
Q54976972A Neutrophil Proteomic Signature in Surgical Trauma Wounds.
Q92408517Common and Specific Functions of Nonmuscle Myosin II Paralogs in Cells
Q89741538Direct interaction of metastasis-inducing S100P protein with tubulin causes enhanced cell migration without changes in cell adhesion
Q37722174Effects of S100A6 gene silencing on the biological features of eutopic endometrial stromal cells and β‑catenin expression
Q35651091Efficient inhibition of tumor angiogenesis and growth by a synthetic peptide blocking S100A4-methionine aminopeptidase 2 interaction
Q36369093Ezrin interacts with S100A4 via both its N- and C-terminal domains.
Q36410591Functional profile of S100A4-deficient T cells
Q37001259Functions of S100 proteins.
Q53081345Increased expression of S100A6 promotes cell proliferation and migration in human hepatocellular carcinoma.
Q48136210Interplay between Trx-1 and S100P promotes colorectal cancer cell epithelial-mesenchymal transition by up-regulating S100A4 through AKT activation
Q38118075Joining S100 proteins and migration: for better or for worse, in sickness and in health.
Q33852054Life without double-headed non-muscle myosin II motor proteins
Q92987379LncRNA NORAD is repressed by the YAP pathway and suppresses lung and breast cancer metastasis by sequestering S100P
Q52650595Mammalian nonmuscle myosin II comes in three flavors.
Q57181491Multiple S100 protein isoforms and C-terminal phosphorylation contribute to the paralog-selective regulation of nonmuscle myosin 2 filaments
Q35613068Myosin II isoform co-assembly and differential regulation in mammalian systems
Q92987394NMIIA promotes tumor growth and metastasis by activating the Wnt/β-catenin signaling pathway and EMT in pancreatic cancer
Q29347045Non-muscle myosin IIA is involved in focal adhesion and actin remodelling controlling glucose-stimulated insulin secretion
Q38061123S100 proteins as diagnostic and prognostic markers in colorectal and hepatocellular carcinoma
Q37660289S100A4 Elevation Empowers Expression of Metastasis Effector Molecules in Human Breast Cancer
Q64947085S100P enhances the motility and invasion of human trophoblast cell lines.
Q34778723S100P expression is a novel prognostic factor in hepatocellular carcinoma and predicts survival in patients with high tumor stage or early recurrent tumors
Q36557373S100P interacts with integrin α7 and increases cancer cell migration and invasion in lung cancer
Q41030727Significance of S100P as a biomarker in diagnosis, prognosis and therapy of opisthorchiasis-associated cholangiocarcinoma
Q97520547The Expressions and Mechanisms of Sarcomeric Proteins in Cancers
Q26851306The heavy chain has its day: regulation of myosin-II assembly
Q26749135The life and works of S100P - from conception to cancer

Search more.