Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection

scientific article

Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/MI.2015.4
P2888exact matchhttps://scigraph.springernature.com/pub.10.1038/mi.2015.4
P932PMC publication ID4532649
P698PubMed publication ID25669152

P2093author name stringS L Kunkel
S Mukherjee
N W Lukacs
H-A Ting
C Ptaschinski
D E de Almeida Nagata
K A Cavassani
M A Schaller
P2860cites workEpigenetic mechanisms of regulation of Foxp3 expressionQ37412329
Plasticity of CD4(+) FoxP3(+) T cellsQ37509592
Influence of FOXP3 on CD4+CD25+ regulatory T cellsQ37755254
Reprogramming chromatinQ38023496
Transcriptional control of regulatory T-cell differentiationQ38204700
SMYD3 promotes cancer invasion by epigenetic upregulation of the metalloproteinase MMP-9.Q39423473
FoxP3 maintains Treg unresponsiveness by selectively inhibiting the promoter DNA-binding activity of AP-1.Q40020219
Th17 cells express interleukin-10 receptor and are controlled by Foxp3⁻ and Foxp3+ regulatory CD4+ T cells in an interleukin-10-dependent mannerQ42107193
EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cellsQ42812523
Maintenance of the Foxp3-dependent developmental program in mature regulatory T cells requires continued expression of Foxp3.Q51997055
Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.Q54600658
Adaptive Foxp3+ regulatory T cell-dependent and -independent control of allergic inflammationQ81617509
Variable number of tandem repeats polymorphism in the SMYD3 promoter region and the risk of familial breast cancerQ82100390
Constitutive nuclear localization of NFAT in Foxp3+ regulatory T cells independent of calcineurin activityQ83849603
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell developmentQ85350477
FOXP3 controls regulatory T cell function through cooperation with NFATQ24298179
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat functionQ24314628
Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cellsQ27860460
The lifestyle of naturally occurring CD4+ CD25+ Foxp3+ regulatory T cellsQ28257250
SMYD3 encodes a histone methyltransferase involved in the proliferation of cancer cellsQ28270360
Cutting edge: TGF-beta induces a regulatory phenotype in CD4+CD25- T cells through Foxp3 induction and down-regulation of Smad7Q28591451
Cancer epigenetics: from mechanism to therapyQ29614799
Epigenetic control of the foxp3 locus in regulatory T cellsQ33273617
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fateQ33908130
Foxp3+ CD4 regulatory T cells limit pulmonary immunopathology by modulating the CD8 T cell response during respiratory syncytial virus infectionQ34072674
Regulatory T-cell stability and plasticity in mucosal and systemic immune systemsQ34075568
Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.Q34245251
A variable number of tandem repeats polymorphism in an E2F-1 binding element in the 5' flanking region of SMYD3 is a risk factor for human cancersQ34450067
Coordination of early protective immunity to viral infection by regulatory T cellsQ34591024
The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repressionQ34594597
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancerQ34729938
Cutting edge: all-trans retinoic acid sustains the stability and function of natural regulatory T cells in an inflammatory milieu.Q34994485
Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypesQ35035956
IL-17-induced pulmonary pathogenesis during respiratory viral infection and exacerbation of allergic disease.Q35069985
Regulatory T cells expressing granzyme B play a critical role in controlling lung inflammation during acute viral infection.Q35765491
Mechanisms of respiratory syncytial virus modulation of airway immune responsesQ36203787
Transcription factor Foxp3 and its protein partners form a complex regulatory networkQ36250037
Transforming growth factor (TGF)-beta1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-beta1-mediated fibrosisQ36371784
Foxp3 exploits a pre-existent enhancer landscape for regulatory T cell lineage specificationQ36383859
FOXP3: of mice and men.Q36427333
Epigenetic regulation of dendritic cell-derived interleukin-12 facilitates immunosuppression after a severe innate immune responseQ36445801
Hsp90 affecting chromatin remodeling might explain transgenerational epigenetic inheritance in DrosophilaQ37214963
Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapyQ37246484
Regulatory T cells prevent Th2 immune responses and pulmonary eosinophilia during respiratory syncytial virus infection in miceQ37252618
Nine lives: plasticity among T helper cell subsetsQ37292800
Epigenetic control of T-helper-cell differentiationQ37371624
P433issue5
P304page(s)1131-1143
P577publication date2015-02-11
P1433published inMucosal ImmunologyQ15817743
P1476titleEpigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection
P478volume8

Reverse relations

cites work (P2860)
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Q26781235FOXP3(+) Treg Cells and Gender Bias in Autoimmune Diseases
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Q37536404New open conformation of SMYD3 implicates conformational selection and allostery
Q59356160Notch ligand Delta-like 4 induces epigenetic regulation of Treg cell differentiation and function in viral infection
Q92840828Novel karyotypes of partial monosomy 21 and partial monosomy 1 and underlying etiology
Q55354251Quantitative proteomic characterization and comparison of T helper 17 and induced regulatory T cells.
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Q55129685Small molecule inhibitors and CRISPR/Cas9 mutagenesis demonstrate that SMYD2 and SMYD3 activity are dispensable for autonomous cancer cell proliferation.
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Q36113037The Helminth-Derived Immunomodulator AvCystatin Reduces Virus Enhanced Inflammation by Induction of Regulatory IL-10+ T Cells
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Q39163678Transcriptional and epigenetic regulation of follicular T-helper cells and their role in autoimmunity
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