Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.

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Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity. is …
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scholarly articleQ13442814

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P356DOI10.1146/ANNUREV-IMMUNOL-020711-075058
P932PMC publication ID3314163
P698PubMed publication ID22224760
P5875ResearchGate publication ID221728858

P50authorYuka KannoQ42642258
Kiyoshi HiraharaQ50751144
Golnaz VahediQ114408444
Kentner L SingletonQ114408448
P2093author name stringJohn J O'Shea
P2860cites workIdentification and analysis of functional elements in 1% of the human genome by the ENCODE pilot projectQ21061203
The majority of total nuclear-encoded non-ribosomal RNA in a human cell is 'dark matter' un-annotated RNAQ21245321
Long noncoding RNA as modular scaffold of histone modification complexesQ22065890
Interchromosomal associations between alternatively expressed lociQ22122480
STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomasQ24295903
TGF-beta-induced Foxp3 inhibits T(H)17 cell differentiation by antagonizing RORgammat functionQ24314628
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosineQ24614582
CTCF: master weaver of the genomeQ24621388
Generation of pathogenic T(H)17 cells in the absence of TGF-β signallingQ24625230
Histone H3K27ac separates active from poised enhancers and predicts developmental stateQ24628758
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cellsQ24632072
Human DNA methylomes at base resolution show widespread epigenomic differencesQ24633677
Genome-wide identification of DNaseI hypersensitive sites using active chromatin sequence librariesQ24633720
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5Q24635387
A mammalian microRNA expression atlas based on small RNA library sequencingQ24644709
Th22 cells represent a distinct human T cell subset involved in epidermal immunity and remodelingQ24647357
Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expressionQ24654249
Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cellsQ24655629
The super elongation complex (SEC) and MLL in development and diseaseQ27692038
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
The transcriptional landscape of the mammalian genomeQ27861110
Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammalsQ28131802
Comprehensive mapping of long-range interactions reveals folding principles of the human genomeQ28131819
Distinct and predictive chromatin signatures of transcriptional promoters and enhancers in the human genomeQ28131828
Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexesQ28214134
T helper type 1-specific Brg1 recruitment and remodeling of nucleosomes positioned at the IFN-gamma promoter are Stat4 dependentQ36228628
CREB/ATF-dependent T cell receptor-induced FoxP3 gene expression: a role for DNA methylation.Q36229540
The role of Brg1, a catalytic subunit of mammalian chromatin-remodeling complexes, in T cell developmentQ36371584
Regulation of Th2 differentiation and Il4 locus accessibility.Q36427376
Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cellsQ36652900
Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiationQ36893499
Primer: epigenetics of autoimmunityQ36925546
Functional and mechanistic diversity of distal transcription enhancersQ37091409
Phenotype switching by inflammation-inducing polarized Th17 cells, but not by Th1 cellsQ37149439
Epigenetic mechanisms in lupusQ37284401
Epigenetic control of T-helper-cell differentiationQ37371624
Epigenetics and T helper 1 differentiationQ37380019
Identification of the human mature B cell miRNomeQ37393607
Runx-CBFbeta complexes control expression of the transcription factor Foxp3 in regulatory T cellsQ37394198
Transforming growth factor beta is dispensable for the molecular orchestration of Th17 cell differentiationQ37402405
Transcription factories: gene expression in unions?Q37511710
Physiological and pathological roles for microRNAs in the immune systemQ37680666
Small RNAs guide hematopoietic cell differentiation and functionQ37756325
Do chromatin loops provide epigenetic gene expression states?Q37769635
Maintaining cell identity through global control of genomic organizationQ37774091
Gene regulation by nucleosome positioningQ37787412
The epigenetic role of non-coding RNA transcription and nuclear organization in immunoglobulin repertoire generationQ37791646
Regulation of the Ifng locus in the context of T-lineage specification and plasticity.Q37802427
Physical and functional HAT/HDAC interplay regulates protein acetylation balanceQ37820140
Structure and function of mammalian DNA methyltransferases.Q37829700
Cancer epigenetics reaches mainstream oncologyQ37851012
Chromatin globules: a common motif of higher order chromosome structure?Q37864798
Determinants and dynamics of genome accessibilityQ37900124
RNA sequencing reveals two major classes of gene expression levels in metazoan cellsQ38253787
Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma geneQ38303440
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling responseQ39048288
Late developmental plasticity in the T helper 17 lineageQ39265291
Gene silencing quantitatively controls the function of a developmental trans-activatorQ40714185
Unexpected characteristics of the IFN-gamma reporters in nontransformed T cellsQ40794215
Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuliQ41400504
The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammationQ41762357
T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3.Q41791616
Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencerQ41839885
The transcription factor STAT3 is required for T helper 2 cell developmentQ42608351
Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineageQ42786917
EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in Th1 cellsQ42812523
Identification and characterization of enhancers controlling the inflammatory gene expression program in macrophages.Q43141233
Histone deacetylation inhibits IL4 gene expression in T cells.Q43884505
Discrete roles for histone acetylation in human T helper 1 cell-specific gene expressionQ44997621
Foxp3(+) regulatory T cells promote T helper 17 cell development in vivo through regulation of interleukin-2.Q46499482
Sequential roles of Brg, the ATPase subunit of BAF chromatin remodeling complexes, in thymocyte developmentQ46661834
Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cellsQ47619638
Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.Q50711339
Active recruitment of DNA methyltransferases regulates interleukin 4 in thymocytes and T cellsQ52098330
A critical role for Dnmt1 and DNA methylation in T cell development, function, and survival.Q52126962
The microRNA miR-182 is induced by IL-2 and promotes clonal expansion of activated helper T lymphocytes.Q52901064
Transforming growth factor-beta 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9-producing subset.Q53446140
Polycomb group protein ezh2 controls actin polymerization and cell signaling.Q53676862
Distinct microRNA signatures in human lymphocyte subsets and enforcement of the naive state in CD4+ T cells by the microRNA miR-125b.Q54362756
Crucial role of MLL for the maintenance of memory T helper type 2 cell responses.Q54600658
Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunityQ60182798
The use of 5-azacytidine to establish constitutive interleukin 2-producing clones of the EL4 thymomaQ72733550
Regulation of the Th2 cytokine locus by a locus control regionQ73691201
Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cellsQ79462842
Regulation of T cell receptor-alpha gene recombination by transcriptionQ80176355
Long-range intrachromosomal interactions in the T helper type 2 cytokine locusQ80587027
Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?Q83125659
ChIP-seq accurately predicts tissue-specific activity of enhancersQ28235102
Histone modifications at human enhancers reflect global cell-type-specific gene expressionQ28238467
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genesQ28255974
Chromosome Conformation Capture Carbon Copy (5C): a massively parallel solution for mapping interactions between genomic elementsQ28262061
A strategy for probing the function of noncoding RNAs finds a repressor of NFATQ28270512
Histone variants--ancient wrap artists of the epigenomeQ28274796
Reversal of histone methylation: biochemical and molecular mechanisms of histone demethylasesQ28278969
Helper T cell differentiation is controlled by the cell cycleQ28281505
Comprehensive methylome map of lineage commitment from haematopoietic progenitorsQ28290899
ChIP-Seq identification of weakly conserved heart enhancersQ28291198
Environmental epigenetics of asthma: an updateQ28388771
Integrating 5-hydroxymethylcytosine into the epigenomic landscape of human embryonic stem cellsQ28478707
Dephosphorylation of the nuclear factor of activated T cells (NFAT) transcription factor is regulated by an RNA-protein scaffold complexQ28505989
MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosisQ28509195
The transcription factor c-Maf controls the production of interleukin-4 but not other Th2 cytokinesQ28509281
STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cellsQ28510023
Bmi1 regulates memory CD4 T cell survival via repression of the Noxa geneQ28588527
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory diseaseQ28591855
An oestrogen-receptor-α-bound human chromatin interactomeQ29541719
The Polycomb complex PRC2 and its mark in lifeQ29547358
Mapping and analysis of chromatin state dynamics in nine human cell typesQ29547552
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expressionQ29614326
A unique chromatin signature uncovers early developmental enhancers in humansQ29614327
Widespread transcription at neuronal activity-regulated enhancersQ29614330
RNA maps reveal new RNA classes and a possible function for pervasive transcriptionQ29614334
Differentiation of effector CD4 T cell populations (*)Q29614838
Interleukin-2 signaling via STAT5 constrains T helper 17 cell generationQ29614840
Dynamic regulation of nucleosome positioning in the human genomeQ29615046
Follicular helper CD4 T cells (TFH)Q29615063
ChIP-seq: advantages and challenges of a maturing technologyQ29615336
Cohesins functionally associate with CTCF on mammalian chromosome armsQ29618753
RNA sequencing: advances, challenges and opportunitiesQ29619605
Identifying gene regulatory elements by genome-wide recovery of DNase hypersensitive sitesQ31036736
Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions.Q33260024
Epigenetic control of the foxp3 locus in regulatory T cellsQ33273617
CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locusQ33606470
Prolactin inhibits BCL6 expression in breast cancer through a Stat5a-dependent mechanismQ33658181
Foxo transcription factors control regulatory T cell development and functionQ33774905
Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control T(H)2 responsesQ33830564
Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locusQ33847309
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fateQ33908130
The reality of pervasive transcriptionQ33963677
Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiationQ33997593
Regulation of microRNA expression and abundance during lymphopoiesisQ34019233
Forcing cells to change lineagesQ34020397
Determinants of nucleosome organization in primary human cellsQ34027018
Pol II and its associated epigenetic marks are present at Pol III-transcribed noncoding RNA genes.Q34048002
Regulation of Th2 cell differentiation by mel-18, a mammalian polycomb group geneQ34087999
Active DNA demethylation: many roads lead to Rome.Q34129576
Mechanisms underlying lineage commitment and plasticity of helper CD4+ T cellsQ34383385
Chromatin remodeling complex NURF regulates thymocyte maturationQ34557161
Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunityQ34596060
Dicer-dependent microRNA pathway safeguards regulatory T cell functionQ34596070
Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responsesQ34626052
CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection modelQ34627919
Extensive and coordinated transcription of noncoding RNAs within cell-cycle promotersQ34629890
Promoter-associated RNA is required for RNA-directed transcriptional gene silencing in human cellsQ34653770
Chromatin remodelling during developmentQ34698385
Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5).Q34763432
ChIP-based methods for the identification of long-range chromatin interactionsQ34953329
CD4+ regulatory T cells control TH17 responses in a Stat3-dependent manner.Q35006074
The nuclear orphan receptor Nr4a2 induces Foxp3 and regulates differentiation of CD4+ T cellsQ35015109
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cellsQ35071448
Cell type-specific DNA methylation at intragenic CpG islands in the immune system.Q35085275
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.Q35105032
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.Q35141261
T cell factor-1 negatively regulates expression of IL-17 family of cytokines and protects mice from experimental autoimmune encephalomyelitisQ35172187
A BAF-centred view of the immune systemQ35968472
Chromatin remodeling complexes: strength in diversity, precision through specializationQ36083266
Demethylation of a specific hypersensitive site in the Th2 locus control regionQ36089273
RNA meets chromatinQ36197886
CTCF-mediated functional chromatin interactome in pluripotent cellsQ36218315
P304page(s)707-731
P577publication date2012-01-06
P1433published inAnnual Review of ImmunologyQ567362
P1476titleTranscriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity
P478volume30

Reverse relations

cites work (P2860)
Q35668576A Minimal Regulatory Network of Extrinsic and Intrinsic Factors Recovers Observed Patterns of CD4+ T Cell Differentiation and Plasticity.
Q38839507A Novel miR-24-TCF1 Axis in Modulating Effector T Cell Responses.
Q47548194A Reproducibility-Based Computational Framework Identifies an Inducible, Enhanced Antiviral State in Dendritic Cells from HIV-1 Elite Controllers
Q41150151A cohesin-OCT4 complex mediates Sox enhancers to prime an early embryonic lineage
Q35549617A dominant role for the methyl-CpG-binding protein Mbd2 in controlling Th2 induction by dendritic cells
Q36866446A novel differentiation pathway from CD4⁺ T cells to CD4⁻ T cells for maintaining immune system homeostasis
Q35131244A think tank of TINK/TANKs: tumor-infiltrating/tumor-associated natural killer cells in tumor progression and angiogenesis
Q36270111ASPASIA: A toolkit for evaluating the effects of biological interventions on SBML model behaviour.
Q38734677Acetylation Modulates IL-2 Receptor Signaling in T Cells
Q52843083Age-Dependent Metabolic and Immunosuppressive Effects of Tacrolimus.
Q36792712Akt1-mediated Gata3 phosphorylation controls the repression of IFNγ in memory-type Th2 cells
Q37409562Analysis of histological and immunological parameters of metastatic lymph nodes from colon cancer patients reveals that T-helper 1 type immune response is associated with improved overall survival
Q33804701Ash1l and lnc-Smad3 coordinate Smad3 locus accessibility to modulate iTreg polarization and T cell autoimmunity
Q33434063Atopic dermatitis and association of risk for primary immune thrombocytopenia and autoimmune diseases among children: A nationwide population-based cohort study
Q41749880BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice
Q35550775CD4(+) T Cell Differentiation in Infection: Amendments to the Th1/Th2 Axiom
Q38674371CD4+ T Cells Mediate Aspergillosis Vaccine Protection
Q38732306CD4+ T-cell subsets in inflammatory diseases: beyond the Th1/Th2 paradigm
Q35059441Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation
Q58122720Cancer Immunity and Immune Evasion Mechanisms
Q84006306Cell type-specific eQTLs in the human immune system
Q39241774Cellular and Molecular Dynamics of Th17 Differentiation and its Developmental Plasticity in the Intestinal Immune Response
Q36895423Changing partners at the dance: Variations in STAT concentrations for shaping cytokine function and immune responses to viral infections
Q38225312Comparative epigenetics: relevance to the regulation of production and health traits in cattle
Q34240220Complex interactions of transcription factors in mediating cytokine biology in T cells
Q34762178Critical role of histone demethylase Jmjd3 in the regulation of CD4+ T-cell differentiation
Q38416948Cross-regulation between cytokine and microRNA pathways in T cells.
Q47414955Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt+ and Follicular Phenotypes.
Q39987703DNA demethylation of the TIM-3 promoter is critical for its stable expression on T cells
Q35082246DNA methylation changes separate allergic patients from healthy controls and may reflect altered CD4+ T-cell population structure
Q88841098DNA methylation in systemic lupus erythematosus
Q35190948Defining CD4 T cell memory by the epigenetic landscape of CpG DNA methylation
Q38069828Defining the molecular blueprint that drives CD8(+) T cell differentiation in response to infection
Q62748170Differential T-cell receptor signals for T helper cell programming
Q30418942Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation
Q36922183Distinct Gene Regulatory Pathways for Human Innate versus Adaptive Lymphoid Cells.
Q51110251Distinct Roles of Brd2 and Brd4 in Potentiating the Transcriptional Program for Th17 Cell Differentiation.
Q34507539Distinctive features of CD4+ T cell dysfunction in chronic viral infections
Q39384272Dynamic balance between master transcription factors determines the fates and functions of CD4 T cell and innate lymphoid cell subsets.
Q36611453ERβ and ERα Differentially Regulate NKT and Vγ4(+) T-cell Activation and T-regulatory Cell Response in Coxsackievirus B3 Infected Mice
Q35758563EZH2 is crucial for both differentiation of regulatory T cells and T effector cell expansion
Q39905612Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.
Q30847621Elevated levels of Bcl-3 inhibits Treg development and function resulting in spontaneous colitis.
Q57293807Elimination of CD4HLA-G T cells overcomes castration-resistance in prostate cancer therapy
Q38290031Engineering CAR-T cells: Design concepts
Q38749824Epi-drugs in combination with immunotherapy: a new avenue to improve anticancer efficacy
Q91670951Epigenetic Regulation in the Pathogenesis of Sjögren Syndrome and Rheumatoid Arthritis
Q34476217Epigenetic control of Ccr7 expression in distinct lineages of lung dendritic cells
Q35940965Epigenetic control of Foxp3 by SMYD3 H3K4 histone methyltransferase controls iTreg development and regulates pathogenic T-cell responses during pulmonary viral infection
Q38107626Epigenetic control of cytokine gene expression: regulation of the TNF/LT locus and T helper cell differentiation
Q38233723Epigenetic pathway targets for the treatment of disease: accelerating progress in the development of pharmacological tools: IUPHAR Review 11.
Q36607880Epigenetic regulation of IL-12-dependent T cell proliferation
Q39402920Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma.
Q38206864Epigenetic regulation of cytokine expression in systemic lupus erythematosus with special focus on T cells
Q38161582Epigenetics and the IRFs: a complex interplay in the control of immunity and autoimmunity
Q38650522Epigenetics in SLE.
Q26828350Epigenetics of inflammation, maternal infection, and nutrition
Q39287039Expanding Diversity and Common Goal of Regulatory T and B Cells. I: Origin, Phenotype, Mechanisms
Q34403006Expansion or depletion of T follicular helper cells during HIV infection: consequences for B cell responses
Q34660705Expression profiling of lymph node cells from deer mice infected with Andes virus
Q38172563Forkhead box P3: the peacekeeper of the immune system.
Q37336620From a gene-centric to whole-proteome view of differentiation of T helper cell subsets
Q27025284Fueling immunity: insights into metabolism and lymphocyte function
Q42370776Genetic variation associated with cardiovascular risk in autoimmune diseases
Q51415619Genomic Effects of the Vitamin D Receptor: Potentially the Link between Vitamin D, Immune Cells, and Multiple Sclerosis.
Q40884196Grb2 Is Important for T Cell Development, Th Cell Differentiation, and Induction of Experimental Autoimmune Encephalomyelitis.
Q38960902Gut memories do not fade: epigenetic regulation of lasting gut homing receptor expression in CD4+ memory T cells
Q36706314HIV Skews the Lineage-Defining Transcriptional Profile of Mycobacterium tuberculosis-Specific CD4+ T Cells.
Q34356521Helper T cell plasticity: impact of extrinsic and intrinsic signals on transcriptomes and epigenomes
Q36623362Helper T-cell identity and evolution of differential transcriptomes and epigenomes.
Q38591399Histone Modifications and Asthma. The Interface of the Epigenetic and Genetic Landscapes
Q57143889Histone deacetylase function in CD4 T cells
Q33702880Histone demethylases UTX and JMJD3 are required for NKT cell development in mice
Q53712816How epigenetic imprinting contributes to stabilizing the Th2 phenotype.
Q34148906IL-21 induces IL-22 production in CD4+ T cells.
Q40284562IL-36γ signaling controls the induced regulatory T cell-Th9 cell balance via NFκB activation and STAT transcription factors.
Q36304015Identification of global regulators of T-helper cell lineage specification
Q37368649Ikaros sets the potential for Th17 lineage gene expression through effects on chromatin state in early T cell development
Q28084366Immune-mediated vascular injury and dysfunction in transplant arteriosclerosis
Q40963902Impact of Enhancer of Zeste Homolog 2 on T Helper Cell-Mediated Allergic Rhinitis
Q36404704JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
Q38217532Linking immunity, epigenetics, and cancer in inflammatory bowel disease
Q38810913Lymph node - an organ for T-cell activation and pathogen defense.
Q58662245Lymphocytes: Antigen-Induced Gene Activation
Q35915068Mechanisms of Jak/STAT signaling in immunity and disease
Q39313214Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity
Q40065267Metabolism in Immune Cell Differentiation and Function.
Q38997053Methyltransferase G9A regulates T cell differentiation during murine intestinal inflammation
Q35877614MicroRNA-31 negatively regulates peripherally derived regulatory T-cell generation by repressing retinoic acid-inducible protein 3.
Q37693699MicroRNA-mediated regulation of T helper cell differentiation and plasticity.
Q56889651Modulation of EZH2 expression in T cells improves efficacy of anti-CTLA-4 therapy
Q35156478Modulation of dendritic cell function by Trichomonas vaginalis-derived secretory products.
Q38090202Natural killer cells: walking three paths down memory lane
Q41459008New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis.
Q45382914New opportunities for organ transplantation research: epigenetics is likely to be an important determinant of the host immune response
Q50858344New roles for cyclin-dependent kinases in T cell biology: linking cell division and differentiation.
Q36605117Nuclear matrix binding protein SMAR1 regulates T-cell differentiation and allergic airway disease
Q40723195Oct-1 regulates IL-17 expression by directing interchromosomal associations in conjunction with CTCF in T cells
Q30252507Pathogenic CD4+ T cells in patients with asthma
Q33573890Phenotypes of Th lineages generated by the commonly used activation with anti-CD3/CD28 antibodies differ from those generated by the physiological activation with the specific antigen
Q38310232Plasticity of human CD4 T cell subsets
Q51239492Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?
Q38806412Protein Kinase CK2 Controls the Fate between Th17 Cell and Regulatory T Cell Differentiation.
Q27334727Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells
Q91763128Redefining the IBDs using genome-scale molecular phenotyping
Q43563597Regulatory T cells and transplantation tolerance.
Q36576196Role of miRNAs in CD4 T cell plasticity during inflammation and tolerance.
Q38095498Role of microRNAs and long-non-coding RNAs in CD4(+) T-cell differentiation.
Q27329934S. mansoni bolsters anti-viral immunity in the murine respiratory tract
Q38835846STAT3 signaling in immunity
Q56373513Schistosomiasis Induces Persistent DNA Methylation and Tuberculosis-Specific Immune Changes
Q34501482Spatial congregation of STAT binding directs selective nuclear architecture during T-cell functional differentiation.
Q38239869Staying innate: transcription factor maintenance of innate lymphoid cell identity.
Q35975551System-Wide Associations between DNA-Methylation, Gene Expression, and Humoral Immune Response to Influenza Vaccination
Q37298122T cell immunity as a tool for studying epigenetic regulation of cellular differentiation
Q36823844T follicular helper cell diversity and plasticity
Q38940412T follicular helper cells in space-time.
Q35940715T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production
Q37250335T helper cell polarization in healthy people: implications for cardiovascular disease
Q38522520T-cell plasticity in inflammatory skin diseases--the good, the bad, and the chameleons
Q34327596T-cell subsets in the germinal center.
Q26772704TCR Signal Strength Alters T-DC Activation and Interaction Times and Directs the Outcome of Differentiation
Q46372601TET proteins in natural and induced differentiation
Q90540850Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
Q37046035The 4E-BP-eIF4E axis promotes rapamycin-sensitive growth and proliferation in lymphocytes
Q92988123The Conserved Non-Coding Sequence 2 (CNS2) Enhances CD69 Transcription through Cooperation between the Transcription Factors Oct1 and RUNX1
Q89977564The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment
Q38439641The IL-23-IL-17 axis in inflammatory arthritis
Q46003771The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate.
Q60956635The Role of Histone Methyltransferases and Long Non-coding RNAs in the Regulation of T Cell Fate Decisions
Q91277717The contribution of active and passive mechanisms of 5mC and 5hmC removal in human T lymphocytes is differentiation- and activation-dependent
Q34712267The interface between transcriptional and epigenetic control of effector and memory CD8⁺ T-cell differentiation
Q96294061The liver-brain-gut neural arc maintains the Treg cell niche in the gut
Q42084982The long intergenic noncoding RNA landscape of human lymphocytes highlights the regulation of T cell differentiation by linc-MAF-4.
Q37116560The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells
Q34460673The oncoprotein and transcriptional regulator Bcl-3 governs plasticity and pathogenicity of autoimmune T cells
Q38926320The therapeutic potential of epigenetic manipulation during infectious diseases.
Q33634144The transcription factor GATA3 is critical for the development of all IL-7Rα-expressing innate lymphoid cells
Q37189548The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.
Q42333838The tumor microenvironment disarms CD8+ T lymphocyte function via a miR-26a-EZH2 axis
Q36490256Therapeutic targeting of the inflammome
Q40188158Tonic LAT-HDAC7 Signals Sustain Nur77 and Irf4 Expression to Tune Naive CD4 T Cells
Q38097109Transcriptional and epigenetic networks in the development and maturation of dendritic cells
Q35064355Transcriptional and epigenetic networks of helper T and innate lymphoid cells.
Q34631682Transcriptional and epigenetic regulation of T-helper lineage specification
Q61649466Transcriptional network profile on synovial fluid T cells in psoriatic arthritis
Q38525099Transcriptional regulation of innate lymphoid cell fate.
Q34848279Transiently reduced PI3K/Akt activity drives the development of regulatory function in antigen-stimulated Naïve T-cells
Q34144612Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells.
Q38530619Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system
Q38212817Unconventional post-translational modifications in immunological signaling
Q46337864miR-146a modulates autoreactive Th17 cell differentiation and regulates organ-specific autoimmunity
Q33882867miR-155 activates cytokine gene expression in Th17 cells by regulating the DNA-binding protein Jarid2 to relieve polycomb-mediated repression
Q40378528p(⁷⁰S⁶K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice

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