The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.

scientific article published on 09 August 2013

The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M113.497248
P932PMC publication ID3779737
P698PubMed publication ID23935104

P50authorJanice S. BlumQ84562695
Mark H. KaplanQ38326266
Crystal C. WallineQ52727858
A B FirulliQ68144966
P2093author name stringAlexander L Dent
Duy Pham
Kristin Hollister
P2860cites workGATA-3 suppresses Th1 development by downregulation of Stat4 and not through effects on IL-12Rbeta2 chain or T-betQ73153297
The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4Q80737734
STATs shape the active enhancer landscape of T cell populationsQ36431152
Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic functionQ36662693
Dynamic regulatory network controlling TH17 cell differentiationQ36799525
Autoregulation of Th1-mediated inflammation by twist1.Q36851881
Mechanisms regulating regional localization of inflammation during CNS autoimmunity.Q36918129
Stat4 isoforms differentially regulate inflammation and demyelination in experimental allergic encephalomyelitis.Q36968143
IL-23 promotes maintenance but not commitment to the Th17 lineageQ37183888
A twist of insight - the role of Twist-family bHLH factors in developmentQ37332873
Priming for T helper type 2 differentiation by interleukin 2-mediated induction of interleukin 4 receptor alpha-chain expressionQ37387939
Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determinationQ37400372
T(H)17 cytokines in autoimmune neuro-inflammation.Q37930157
Transcriptional regulation of follicular T-helper (Tfh) cellsQ38081173
The opposing roles of the transcription factor E2A and its antagonist Id3 that orchestrate and enforce the naive fate of T cells.Q38546601
Instructive role of the transcription factor E2A in early B lymphopoiesis and germinal center B cell developmentQ39974270
Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.Q41954129
The transcription factor STAT3 is required for T helper 2 cell developmentQ42608351
T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype.Q42742129
Comparative roles of Twist-1 and Id1 in transcriptional regulation by BMP signalingQ42829993
Comparison of ELISA and plaque-forming cell assays for measuring the humoral immune response to SRBC in rats and mice treated with benzo[a]pyrene or cyclophosphamideQ45090832
Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm developmentQ47072340
The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment.Q50736370
Generation of pathogenic T(H)17 cells in the absence of TGF-β signallingQ24625230
Opposing regulation of the locus encoding IL-17 through direct, reciprocal actions of STAT3 and STAT5Q24635387
Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineagesQ24642180
The AP-1 transcription factor Batf controls T(H)17 differentiationQ24644525
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalitiesQ24651500
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cellsQ24655751
The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cellsQ27860620
Transforming growth factor-beta induces development of the T(H)17 lineageQ28237370
TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cellsQ28296956
T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gammaQ28506783
Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1Q28585931
A validated regulatory network for Th17 cell specificationQ28586624
The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gammaQ28590652
Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineagesQ29547871
Differentiation of effector CD4 T cell populations (*)Q29614838
IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathwaysQ29614839
Transcriptional and epigenetic control of T helper cell specification: molecular mechanisms underlying commitment and plasticity.Q34245251
Stat3 and Stat4 direct development of IL-17-secreting Th cells.Q34615064
Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crestQ34650000
RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation.Q34660473
Plasticity of CD4+ T cell lineage differentiation.Q34982725
The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF.Q35049530
Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.Q35117339
Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis.Q35141261
STAT5 is a potent negative regulator of TFH cell differentiationQ35761809
Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineagesQ35831305
STAT5 protein negatively regulates T follicular helper (Tfh) cell generation and function.Q35879641
Functional STAT3 deficiency compromises the generation of human T follicular helper cells.Q35970620
Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cellsQ36376864
P433issue38
P407language of work or nameEnglishQ1860
P921main subjectinterleukinsQ194908
P1104number of pages11
P304page(s)27423-27433
P577publication date2013-08-09
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain
P478volume288

Reverse relations

cites work (P2860)
Q59799457Differential gene expression in human tissue resident regulatory T cells from lung, colon, and blood
Q35080934Myor/ABF-1 mRNA [corrected] Expression Marks Follicular Helper T Cells but Is Dispensable for Tfh Cell Differentiation and Function In Vivo
Q26747534Ocular diseases: immunological and molecular mechanisms
Q41535001Poly-ADP-ribosyl polymerase-14 promotes T helper 17 and follicular T helper development
Q64900474Targeting Twist expression with small molecules.
Q34146417Th17 cells demonstrate stable cytokine production in a proallergic environment
Q47141013The Th17 Lineage: From Barrier Surfaces Homeostasis to Autoimmunity, Cancer, and HIV-1 Pathogenesis
Q26822434The emerging role of Twist proteins in hematopoietic cells and hematological malignancies
Q39006000The transcription factor network in Th9 cells
Q34631682Transcriptional and epigenetic regulation of T-helper lineage specification
Q38552664Twist as a new prognostic marker in hematological malignancies.
Q41500221Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators

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