The genetics of hiding the corpse: engulfment and degradation of apoptotic cells in C. elegans and D. melanogaster.

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The genetics of hiding the corpse: engulfment and degradation of apoptotic cells in C. elegans and D. melanogaster. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1016/S0070-2153(04)63004-3
P698PubMed publication ID15536015

P50authorPaolo M MangahasQ80566132
P2093author name stringZheng Zhou
Xiaomeng Yu
P2860cites workMolecular characterization of mitochondrial apoptosis-inducing factorQ22001452
Activation of Rac1 by a Crk SH3-binding protein, DOCK180Q22007972
Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans.Q47069436
Phagocytosis promotes programmed cell death in C. elegansQ47069455
The Snail-like CES-1 protein of C. elegans can block the expression of the BH3-only cell-death activator gene egl-1 by antagonizing the function of bHLH proteinsQ47069456
Mutations affecting programmed cell deaths in the nematode Caenorhabditis elegansQ47069600
Requirement for DCP-1 caspase during Drosophila oogenesisQ47072155
Requirement for croquemort in phagocytosis of apoptotic cells in Drosophila.Q47072359
Regulated nuclear import of Rel proteins in the Drosophila immune responseQ47072818
The Caenorhabditis elegans gene sem-4 controls neuronal and mesodermal cell development and encodes a zinc finger proteinQ48061840
Worms, life, and death (Nobel lecture).Q48235550
Apoptosis of nurse cells at the late stages of oogenesis of Drosophila melanogaster.Q48940062
Macrophages and glia participate in the removal of apoptotic neurons from the Drosophila embryonic nervous system.Q52536008
Cell surface exposure of phosphatidylserine during apoptosis is phylogenetically conserved.Q52641900
The Caenorhabditis elegans male: Postembryonic development of nongonadal structuresQ56268223
Epidermal growth factor-like modulesQ56918749
Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodiesQ57089602
Dominant cell death induction by extramitochondrially targeted apoptosis-inducing factorQ57185203
Engulfment genes cooperate with ced-3 to promote cell death in Caenorhabditis elegansQ57939426
The identification and suppression of inherited neurodegeneration in Caenorhabditis elegansQ59088240
An endonuclease from Caenorhabditis elegans: partial purification and characterizationQ64390261
Developing Caenorhabditis elegans neurons may contain both cell-death protective and killer activitiesQ70993637
Neuropathology of degenerative cell death in Caenorhabditis elegansQ71971010
Activated macrophages direct apoptosis and suppress mitosis of mesangial cellsQ73407093
GEF without a Dbl domain?Q74543058
Recognizing death: the phagocytosis of apoptotic cellsQ77203130
Impaired thymic development in mouse embryos deficient in apoptotic DNA degradationQ78782078
The human homologue of Caenorhabditis elegans CED-6 specifically promotes phagocytosis of apoptotic cellsQ22010844
Human CED-6 encodes a functional homologue of the Caenorhabditis elegans engulfment protein CED-6Q22010846
CED-12/ELMO, a novel member of the CrkII/Dock180/Rac pathway, is required for phagocytosis and cell migrationQ24291780
Interaction of CED-6/GULP, an adapter protein involved in engulfment of apoptotic cells with CED-1 and CD91/low density lipoprotein receptor-related protein (LRP)Q24291952
Unconventional Rac-GEF activity is mediated through the Dock180-ELMO complexQ24301883
Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome cQ24309066
Expression cloning of a novel scavenger receptor from human endothelial cellsQ24312598
DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosisQ24313625
Myoblast city, the Drosophila homolog of DOCK180/CED-5, is required in a Rac signaling pathway utilized for multiple developmental processesQ24596003
Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentationQ24642901
Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure, and cytoskeletal organizationQ24676790
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factorsQ27860467
Rho GTPases and the actin cytoskeletonQ27860579
The small GTP-binding protein rac regulates growth factor-induced membrane rufflingQ27861063
Signaling through scaffold, anchoring, and adaptor proteinsQ28131792
alphavbeta5 integrin recruits the CrkII-Dock180-rac1 complex for phagocytosis of apoptotic cellsQ28142034
Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitroQ28188392
The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathwayQ28204737
Essential role of the mitochondrial apoptosis-inducing factor in programmed cell deathQ28209183
Identification of a factor that links apoptotic cells to phagocytesQ28217034
A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICADQ28258328
Mechanisms and Functions of Cell DeathQ28261655
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activationQ28263551
The embryonic cell lineage of the nematode Caenorhabditis elegansQ28271877
The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9Q28272159
ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserineQ28505233
A receptor for phosphatidylserine-specific clearance of apoptotic cellsQ28586441
Rho GTPases and signaling networksQ28646215
Post-embryonic cell lineages of the nematode, Caenorhabditis elegansQ29547748
Programmed cell death in animal developmentQ29616430
Cell death: the significance of apoptosisQ29617620
Recognition and specificity in protein tyrosine kinase-mediated signallingQ30192978
The TRA-1A sex determination protein of C. elegans regulates sexually dimorphic cell deaths by repressing the egl-1 cell death activator geneQ38321297
Genetic control of programmed cell death in DrosophilaQ38468332
Post-embryonic development in the ventral cord of Caenorhabditis elegansQ39110153
CED-2/CrkII and CED-10/Rac control phagocytosis and cell migration in Caenorhabditis elegansQ39749591
C. elegans CED-12 acts in the conserved crkII/DOCK180/Rac pathway to control cell migration and cell corpse engulfment.Q39750201
Structures and functions of multiligand lipoprotein receptors: macrophage scavenger receptors and LDL receptor-related protein (LRP).Q40643050
Genetics of programmed cell death in C. elegans: past, present and future.Q40835187
Identification and developmental expression of inhibitor of caspase-activated DNase (ICAD) in Drosophila melanogasterQ40883875
A novel activation mechanism of caspase-activated DNase from Drosophila melanogasterQ40884583
Croquemort, a novel Drosophila hemocyte/macrophage receptor that recognizes apoptotic cells.Q41202883
Sequential activation of ICE-like and CPP32-like proteases during Fas-mediated apoptosisQ41204766
Large-scale fragmentation of mammalian DNA in the course of apoptosis proceeds via excision of chromosomal DNA loops and their oligomersQ41302228
Mechanism of action of deoxyribonuclease II from human lymphoblastsQ41653274
Mitochondrial endonuclease G is important for apoptosis in C. elegans.Q43673192
ced-10 Rac and mig-2 function redundantly and act with unc-73 trio to control the orientation of vulval cell divisions and migrations in Caenorhabditis elegansQ43849683
Macrophage-mediated corpse engulfment is required for normal Drosophila CNS morphogenesis.Q44480688
Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA endsQ44847681
The netrin receptor UNC-40/DCC stimulates axon attraction and outgrowth through enabled and, in parallel, Rac and UNC-115/AbLIM.Q46349589
Phosphatidylserine expression on apoptotic lymphocytes of Xenopus laevis, the South African clawed toad, as a signal for macrophage recognitionQ46943082
Functional genomic analysis of apoptotic DNA degradation in C. elegans.Q47068768
The C. elegans cell corpse engulfment gene ced-7 encodes a protein similar to ABC transporters.Q47068900
Mechanisms of AIF-mediated apoptotic DNA degradation in Caenorhabditis elegansQ47069202
Distinct rac activation pathways control Caenorhabditis elegans cell migration and axon outgrowthQ47069232
Translocation of C. elegans CED-4 to nuclear membranes during programmed cell deathQ47069246
A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans.Q47069318
CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegansQ47069350
Identification and characterization of a dimerization domain in CED-6, an adapter protein involved in engulfment of apoptotic cellsQ30305505
Complement-dependent clearance of apoptotic cells by human macrophagesQ30442812
Caspase-independent cell engulfment mirrors cell death pattern in Drosophila embryosQ33193772
Signaling pathways in phagocytosisQ33665066
An inventory of the human ABC proteinsQ33784414
Death by design: mechanism and control of apoptosisQ33803998
Specific chaperone-like activity of inhibitor of caspase-activated DNase for caspase-activated DNaseQ33893046
The ced-8 gene controls the timing of programmed cell deaths in C. elegans.Q33908341
Corpse clearance defines the meaning of cell deathQ33922730
The Caenorhabditis elegans gonad: a test tube for cell and developmental biologyQ33924971
A common set of engulfment genes mediates removal of both apoptotic and necrotic cell corpses in C. elegansQ33930492
Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.Q34059976
Rho GTPases: molecular switches that control the organization and dynamics of the actin cytoskeletonQ34112824
EMI domains are widespread and reveal the probable orthologs of the Caenorhabditis elegans CED-1 proteinQ34167757
Annexin I Is an Endogenous Ligand that Mediates Apoptotic Cell EngulfmentQ34189926
Genetic control of programmed cell death in the nematode C. elegans.Q34196702
The postembryonic cell lineages of the hermaphrodite and male gonads in Caenorhabditis elegansQ34218631
The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell deathQ34306496
Phagocyte recognition of cells undergoing apoptosisQ34355692
Phosphatidylserine, a death knellQ34355981
Apoptotic cell removalQ34395484
Expression cloning of dSR-CI, a class C macrophage-specific scavenger receptor from Drosophila melanogasterQ34407998
p140Sra-1 (specifically Rac1-associated protein) is a novel specific target for Rac1 small GTPase.Q34451019
Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosisQ34451533
CPAN, a human nuclease regulated by the caspase-sensitive inhibitor DFF45.Q34465617
With a little help from your friends: cells don't die aloneQ34664921
The GEX-2 and GEX-3 proteins are required for tissue morphogenesis and cell migrations in C. elegansQ35005742
Dying for a cause: invertebrate genetics takes on human neurodegenerationQ35074847
CRN-1, a Caenorhabditis elegans FEN-1 homologue, cooperates with CPS-6/EndoG to promote apoptotic DNA degradationQ35160522
Cell-death alternative model organisms: why and which?Q35564610
Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosisQ35607206
Activation of the innate immunity in Drosophila by endogenous chromosomal DNA that escaped apoptotic degradationQ35804630
malvolio, the Drosophila homologue of mouse NRAMP-1 (Bcg), is expressed in macrophages and in the nervous system and is required for normal taste behaviour.Q37619472
P921main subjectCaenorhabditis elegansQ91703
apoptotic processQ14599311
engulfment of apoptotic cellQ14906363
recognition of apoptotic cellQ21101390
P304page(s)91-143
P577publication date2004-01-01
P1433published inCurrent Topics in Developmental BiologyQ15745419
P1476titleThe genetics of hiding the corpse: engulfment and degradation of apoptotic cells in C. elegans and D. melanogaster
P478volume63

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cites work (P2860)
Q29547320A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function
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Q37817075Keeping the CNS clear: glial phagocytic functions in Drosophila
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Q27333604Phagocytic receptor CED-1 initiates a signaling pathway for degrading engulfed apoptotic cells
Q24602890Phagosome maturation during the removal of apoptotic cells: receptors lead the way
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Q58716051The small GTPase RAB-35 defines a third pathway that is required for the recognition and degradation of apoptotic cells
Q36404856The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans.
Q35942369Two alternative mechanisms that regulate the presentation of apoptotic cell engulfment signal in Caenorhabditis elegans
Q30417167Unexpected requirement for ELMO1 in clearance of apoptotic germ cells in vivo

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