The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice

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The X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice is …
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scholarly articleQ13442814

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P356DOI10.1155/2015/564042
P932PMC publication ID4539506
P698PubMed publication ID26347311
P5875ResearchGate publication ID281622931

P50authorEgon PerilliQ51064305
Melissa CantleyQ59701602
P2093author name stringAnak A S S K Dharmapatni
David R Haynes
Malcolm D Smith
Tania N Crotti
Victor Marino
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An inhibitor of cathepsin K, icariin suppresses cartilage and bone degradation in mice of collagen-induced arthritis.Q46012525
Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingivaQ46357914
Embelin derivatives and their anticancer activity through microtubule disassemblyQ46778667
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Preparation and characterization of a mouse osteoclast-like multinucleated cell population.Q54259715
Histochemical demonstration of acid phosphatases with naphthol AS-phosphates.Q54426327
Inhibitor of apoptosis proteins as novel targets in inflammatory processes.Q54569705
High Survivin Levels Predict Poor Clinical Response to Infliximab Treatment in Patients with Rheumatoid ArthritisQ60194288
Demonstration of tartrate-resistant acid phosphatase in un-decalcified, glycolmethacrylate-embedded mouse bone: a possible marker for (pre)osteoclast identificationQ69594105
Antitumor, anti-inflammatory and analgesic property of embelin, a plant productQ71614217
Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factorQ73490934
Collagen antibody-induced arthritisQ80093305
Quantitative analysis of micro-CT imaging and histopathological signatures of experimental arthritis in ratsQ81599103
Protective effect of embelin against acetic acid induced ulcerative colitis in ratsQ83032315
Increased extracellular survivin in the synovial fluid of rheumatoid arthritis patients: fibroblast-like synoviocytes as a potential source of extracellular survivinQ83096737
Pre-existing periodontitis exacerbates experimental arthritis in a mouse modelQ83703488
Embelin reduces cutaneous TNF-α level and ameliorates skin edema in acute and chronic model of skin inflammation in miceQ84057850
Synthesis and evaluation of analgesic and anti-inflammatory activities of most active free radical scavenging derivatives of embelin-A structure-activity relationshipQ84627355
Low-dose prednisolone in early rheumatoid arthritis inhibits collagen type I degradation by matrix metalloproteinases as assessed by serum 1CTP--a possible mechanism for specific inhibition of radiological destructionQ85813330
The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspasesQ24532851
XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathwayQ24533501
Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritisQ24804174
XIAP regulates cytosol-specific innate immunity to Listeria infectionQ27318530
XIAP Induces NF-κB Activation via the BIR1/TAB1 Interaction and BIR1 DimerizationQ27645534
X-linked inhibitor of apoptosis protein functions as a cofactor in transforming growth factor-beta signalingQ28189393
Measurement of cytokine and adhesion molecule expression in synovial tissue by digital image analysisQ28348514
Anti-DR5 mAb ameliorate adjuvant arthritis rats through inducing synovial cells apoptosisQ28581237
IAP proteins: blocking the road to death's doorQ29619844
Collagen type II-specific monoclonal antibody-induced arthritis in mice: description of the disease and the influence of age, sex, and genesQ31017238
Characterization of XIAP-deficient miceQ33559119
Apoptosis control by death and decoy receptorsQ33597389
ARG098, a novel anti-human Fas antibody, suppresses synovial hyperplasia and prevents cartilage destruction in a severe combined immunodeficient-HuRAg mouse modelQ33704469
Optical tomographic imaging discriminates between disease-modifying anti-rheumatic drug (DMARD) and non-DMARD efficacy in collagen antibody-induced arthritisQ34027551
Embelin suppresses osteoclastogenesis induced by receptor activator of NF-κB ligand and tumor cells in vitro through inhibition of the NF-κB cell signaling pathwayQ34279869
The IAP proteins: caspase inhibitors and beyondQ34467672
Rodent preclinical models for developing novel antiarthritic molecules: comparative biology and preferred methods for evaluating efficacyQ34497135
Apoptosis as a therapeutic tool in rheumatoid arthritisQ34718143
Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.Q34982664
Methotrexate ameliorates T cell dependent autoimmune arthritis and encephalomyelitis but not antibody induced or fibroblast induced arthritis.Q35555358
X-linked inhibitor of apoptosis protein (XIAP) regulation of cyclin D1 protein expression and cancer cell anchorage-independent growth via its E3 ligase-mediated protein phosphatase 2A/c-Jun axisQ37012399
Elevated expression of caspase-3 inhibitors, survivin and xIAP correlates with low levels of apoptosis in active rheumatoid synoviumQ37207081
Embelin induces apoptosis in human glioma cells through inactivating NF-κB.Q39178057
Co-expression of XIAP and cyclin D1 complex correlates with a poor prognosis in patients with hepatocellular carcinomaQ39377020
Embelin induces apoptosis through down-regulation of XIAP in human leukemia cellsQ39681016
Design, synthesis, and characterization of new embelin derivatives as potent inhibitors of X-linked inhibitor of apoptosis proteinQ40233896
Embelin ameliorates dextran sodium sulfate-induced colitis in mice.Q40334962
Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure databaseQ40561637
Inhibitor of apoptosis protein cIAP2 is essential for lipopolysaccharide-induced macrophage survivalQ43181903
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
P304page(s)564042
P577publication date2015-08-04
P1433published inMediators of InflammationQ2144494
P1476titleThe X-Linked Inhibitor of Apoptosis Protein Inhibitor Embelin Suppresses Inflammation and Bone Erosion in Collagen Antibody Induced Arthritis Mice
P478volume2015

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cites work (P2860)
Q90446123Assessing the Effects of Parthenolide on Inflammation, Bone Loss, and Glial Cells within a Collagen Antibody-Induced Arthritis Mouse Model
Q38965233Embelin and Its Role in Chronic Diseases
Q59138486Histopathological Evaluation of Dental Pulp of Primary Teeth Pulpotomized with Formocresol with/without a Capping Agent: A Randomized Clinical Trial
Q38974466Impact of inhibitor of apoptosis proteins on immune modulation and inflammation
Q64100827In vitro and in vivo assessment of the proresolutive and antiresorptive actions of resolvin D1: relevance to arthritis
Q47375377Intracellular apoptotic pathways: a potential target for reducing joint damage in rheumatoid arthritis.
Q48024495Mixed effects of caffeic acid phenethyl ester (CAPE) on joint inflammation, bone loss and gastrointestinal inflammation in a murine model of collagen antibody-induced arthritis.
Q41123652Nano-hydroxyapatite and calcium-enriched mixture for pulp capping of sound primary teeth: a randomized clinical trial
Q39154718Negative Regulators of JAK/STAT Signaling in Rheumatoid Arthritis and Osteoarthritis

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