Genetic basis of atherosclerosis: insights from mice and humans

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Genetic basis of atherosclerosis: insights from mice and humans is …
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scholarly articleQ13442814

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P356DOI10.1161/CIRCRESAHA.110.230854
P932PMC publication ID3357004
P698PubMed publication ID22267839

P50authorMuredach P. ReillyQ51505621
Daniel RaderQ56255391
P2093author name stringRobert C Bauer
Ioannis M Stylianou
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Biological, clinical and population relevance of 95 loci for blood lipidsQ24622541
Targeted disruption of the class B scavenger receptor CD36 protects against atherosclerotic lesion development in miceQ24623151
Impaired development of atherosclerosis in hyperlipidemic Ldlr-/- and ApoE-/- mice transplanted with Abcg1-/- bone marrowQ80058470
Attenuated expression of profilin-1 confers protection from atherosclerosis in the LDL receptor null mouseQ80576647
Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient miceQ81552542
Quantitative trait locus analysis for obesity reveals multiple networks of interacting lociQ82276606
Lack of support for association between common variation in TNFSF4 and myocardial infarction in a German populationQ82707761
Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cellsQ83305041
Histamine deficiency decreases atherosclerosis and inflammatory response in apolipoprotein E knockout mice independently of serum cholesterol levelQ83313792
Genome-wide association identifies a susceptibility locus for coronary artery disease in the Chinese Han populationQ83543008
Unexpected protective role for Toll-like receptor 3 in the arterial wallQ24624935
Genetic variants in novel pathways influence blood pressure and cardiovascular disease riskQ24630394
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A common allele on chromosome 9 associated with coronary heart diseaseQ24647989
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Lack of macrophage fatty-acid-binding protein aP2 protects mice deficient in apolipoprotein E against atherosclerosisQ28198287
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p47phox is required for atherosclerotic lesion progression in ApoE(-/-) miceQ28364478
A major role for VCAM-1, but not ICAM-1, in early atherosclerosisQ28365883
Ath-1, a gene determining atherosclerosis susceptibility and high density lipoprotein levels in miceQ28505210
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cellsQ28509783
Murine equivalent of the human histo-blood group ABO gene is a cis-AB gene and encodes a glycosyltransferase with both A and B transferase activityQ28511961
Role of leukotriene B4 receptors in the development of atherosclerosis: potential mechanismsQ28579031
A decreased expression of angiopoietin-like 3 is protective against atherosclerosis in apoE-deficient miceQ28589301
A role of CXC chemokine ligand 12/stromal cell-derived factor-1/pre-B cell growth stimulating factor and its receptor CXCR4 in fetal and adult T cell development in vivoQ28592009
Mice lacking serum paraoxonase are susceptible to organophosphate toxicity and atherosclerosisQ28592044
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysmQ28943557
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studiesQ29417010
Large-scale association analysis identifies 13 new susceptibility loci for coronary artery diseaseQ29417023
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery diseaseQ29417111
The ADAMTS metalloproteinasesQ29544428
Missing heritability and strategies for finding the underlying causes of complex diseaseQ29614586
A common variant on chromosome 9p21 affects the risk of myocardial infarctionQ29614954
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene deliveryQ29615235
Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1Q29616092
Sequence variations in PCSK9, low LDL, and protection against coronary heart diseaseQ29616310
Progress and challenges in translating the biology of atherosclerosisQ29619982
Systemic Deficiency of the MAP Kinase–Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic MiceQ57243652
Relationship Between Coronary Artery Calcification and Other Measures of Subclinical Cardiovascular Disease in Older AdultsQ57392457
Locating Ath8, a locus for murine atherosclerosis susceptibility and testing several of its candidate genes in mice and humansQ57607729
A role for macrophage scavenger receptors in atherosclerosis and susceptibility to infectionQ59068486
Lack of the Antioxidant Enzyme Glutathione Peroxidase-1 Accelerates Atherosclerosis in Diabetic Apolipoprotein E–Deficient MiceQ59284858
Fine mapping of Ath6, a quantitative trait locus for atherosclerosis in miceQ59797751
ABO blood group and cardiovacular disease: the Framingham studyQ68229326
Genetic susceptibility to death from coronary heart disease in a study of twinsQ72290929
Hepatic lipase deficiency increases plasma cholesterol but reduces susceptibility to atherosclerosis in apolipoprotein E-deficient miceQ73343248
Absence of ACAT-1 attenuates atherosclerosis but causes dry eye and cutaneous xanthomatosis in mice with congenital hyperlipidemiaQ73703942
Stromal cell-derived factor-1alpha in unstable angina: potential antiinflammatory and matrix-stabilizing effectsQ74397732
Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient miceQ77231603
Severe atherosclerosis and hypoalphalipoproteinemia in the staggerer mouse, a mutant of the nuclear receptor RORalphaQ77677370
Quantitative trait loci analysis for the differences in susceptibility to atherosclerosis and diabetes between inbred mouse strains C57BL/6J and C57BLKS/JQ77959289
Osteoprotegerin inactivation accelerates advanced atherosclerotic lesion progression and calcification in older ApoE-/- miceQ79903873
P-Selectin or intercellular adhesion molecule (ICAM)-1 deficiency substantially protects against atherosclerosis in apolipoprotein E-deficient miceQ36375890
CD1d-dependent activation of NKT cells aggravates atherosclerosis.Q36399122
Applying gene expression, proteomics and single-nucleotide polymorphism analysis for complex trait gene identificationQ36515674
Angiotensin II-accelerated atherosclerosis and aneurysm formation is attenuated in osteopontin-deficient miceQ36524275
Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse modelQ36531841
Plasminogen deficiency accelerates vessel wall disease in mice predisposed to atherosclerosisQ36586261
Fractalkine deficiency markedly reduces macrophage accumulation and atherosclerotic lesion formation in CCR2-/- mice: evidence for independent chemokine functions in atherogenesisQ36660105
Influence of PDZK1 on lipoprotein metabolism and atherosclerosisQ36708971
Nonvalidation of reported genetic risk factors for acute coronary syndrome in a large-scale replication studyQ36787671
Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axisQ36806897
The problem of passenger genes in transgenic miceQ36906551
Lack of Toll-like receptor 4 or myeloid differentiation factor 88 reduces atherosclerosis and alters plaque phenotype in mice deficient in apolipoprotein EQ36986664
Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feedingQ37141472
Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis.Q37169153
Arterial remodeling in vascular disease: a key role for hyaluronan and versicanQ37175421
New susceptibility locus for coronary artery disease on chromosome 3q22.3.Q37225243
Four additional mouse crosses improve the lipid QTL landscape and identify Lipg as a QTL geneQ37337457
IFN-gamma potentiates atherosclerosis in ApoE knock-out miceQ37368296
Farp2 and Stk25 are candidate genes for the HDL cholesterol locus on mouse chromosome 1.Q37435699
Increased ADAM17 mRNA expression and activity is associated with atherosclerosis resistance in LDL-receptor deficient miceQ37461235
Inhibition of arterial lesion progression in CD16-deficient mice: evidence for altered immunity and the role of IL-10.Q37467868
11β-hydroxysteroid dehydrogenase type 2 deficiency accelerates atherogenesis and causes proinflammatory changes in the endothelium in apoe-/- miceQ37687153
The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane proteinQ37794678
Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor.Q38299150
9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling responseQ39048288
Paraoxonase-2 deficiency aggravates atherosclerosis in mice despite lower apolipoprotein-B-containing lipoproteins: anti-atherogenic role for paraoxonase-2.Q39347729
Genetic Ace2 deficiency accentuates vascular inflammation and atherosclerosis in the ApoE knockout mouse.Q39673704
Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice.Q39961306
A role for the apoptosis inhibitory factor AIM/Spalpha/Api6 in atherosclerosis developmentQ40391470
Role of ADAMTS-1 in atherosclerosis: remodeling of carotid artery, immunohistochemistry, and proteolysis of versican.Q40493102
Early growth response-1 promotes atherogenesis: mice deficient in early growth response-1 and apolipoprotein E display decreased atherosclerosis and vascular inflammationQ40608307
Analysis of glomerulosclerosis and atherosclerosis in lecithin cholesterol acyltransferase-deficient mice.Q40716232
Apolipoprotein E and the apolipoprotein E-deficient mouseQ40926150
Candidate genes, small effects, and the prediction of atherosclerosisQ41588632
MEF2A sequence variants and coronary artery disease: a change of heart?Q42710739
Endothelial-specific deletion of connexin40 promotes atherosclerosis by increasing CD73-dependent leukocyte adhesionQ43212308
Ablation of neutral cholesterol ester hydrolase 1 accelerates atherosclerosis.Q43282401
Genetic locus in mice that blocks development of atherosclerosis despite extreme hyperlipidemiaQ43415395
Reduced atherosclerotic lesion size in P-selectin deficient apolipoprotein E-knockout mice fed a chow but not a fat dietQ34897655
ADAMTS-7 mediates vascular smooth muscle cell migration and neointima formation in balloon-injured rat arteriesQ34929435
Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient miceQ34967612
Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus.Q34991776
Complex genetic architecture revealed by analysis of high-density lipoprotein cholesterol in chromosome substitution strains and F2 crossesQ35083041
Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression.Q35088170
Beta3 integrin deficiency promotes atherosclerosis and pulmonary inflammation in high-fat-fed, hyperlipidemic miceQ35144122
Genetic analysis in the Collaborative Cross breeding population.Q35145484
Collaborative Cross mice and their power to map host susceptibility to Aspergillus fumigatus infectionQ35145488
Role of chemokines in angiogenesis: CXCL12/SDF-1 and CXCR4 interaction, a key regulator of endothelial cell responsesQ35173629
Controversy in human genetics. ABO blood groups and diseaseQ35232224
ABO blood type and arteriosclerosis obliteransQ35569071
Influence of the high density lipoprotein receptor SR-BI on reproductive and cardiovascular pathophysiologyQ35603368
Dietary cholesterol increases transcription of the human cholesteryl ester transfer protein gene in transgenic mice. Dependence on natural flanking sequencesQ35606510
Genetic risk factors for stroke and carotid atherosclerosis: insights into pathophysiology from candidate gene approachesQ35708128
Deletion of the phosphoinositide 3-kinase p110gamma gene attenuates murine atherosclerosisQ35781497
Induction of fatal inflammation in LDL receptor and ApoA-I double-knockout mice fed dietary fat and cholesterol.Q35791953
Strategies for mapping and cloning quantitative trait genes in rodentsQ36085684
Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosisQ36095672
Genetic and genomic insights into the molecular basis of atherosclerosisQ36155114
Bioinformatics toolbox for narrowing rodent quantitative trait lociQ36286902
Diet and murine atherosclerosisQ36350935
Galectin-3 gene inactivation reduces atherosclerotic lesions and adventitial inflammation in ApoE-deficient miceQ36357458
Quantitative trait locus analysis of atherosclerosis in an intercross between C57BL/6 and C3H mice carrying the mutant apolipoprotein E geneQ30439110
Quantitative trait locus analysis of carotid atherosclerosis in an intercross between C57BL/6 and C3H apolipoprotein E-deficient miceQ30443593
Identification of pathways for atherosclerosis in mice: integration of quantitative trait locus analysis and global gene expression dataQ31119283
Discoidin domain receptor 1 (ddr1) deletion decreases atherosclerosis by accelerating matrix accumulation and reducing inflammation in low-density lipoprotein receptor-deficient miceQ33331307
Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studiesQ33381588
Disruption of Nrf2, a key inducer of antioxidant defenses, attenuates ApoE-mediated atherosclerosis in miceQ33386022
Genetic markers in atherosclerosis: a reviewQ33586849
Quantitative trait locus mapping of genetic modifiers of metabolic syndrome and atherosclerosis in low-density lipoprotein receptor-deficient mice: identification of a locus for metabolic syndrome and increased atherosclerosis on chromosome 4.Q33637168
ADAMTS proteases: key roles in atherosclerosis?Q33638605
Differences in DBA/1J and DBA/2J reveal lipid QTL genesQ33712893
Aortic arch curvature and atherosclerosis have overlapping quantitative trait loci in a cross between 129S6/SvEvTac and C57BL/6J apolipoprotein E-null miceQ33767143
T-bet deficiency reduces atherosclerosis and alters plaque antigen-specific immune responsesQ33819043
Adipose tissue deficiency, glucose intolerance, and increased atherosclerosis result from mutation in the mouse fatty liver dystrophy (fld) gene.Q33908525
Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatmentQ33938891
Ath-2, a second gene determining atherosclerosis susceptibility and high density lipoprotein levels in miceQ33955303
Decreased atherosclerosis in mice deficient in both macrophage colony-stimulating factor (op) and apolipoprotein EQ33962949
Lith1, a major gene affecting cholesterol gallstone formation among inbred strains of miceQ34002830
Identifying novel genes for atherosclerosis through mouse-human comparative geneticsQ34021005
Divergent effects of matrix metalloproteinases 3, 7, 9, and 12 on atherosclerotic plaque stability in mouse brachiocephalic arteriesQ34098485
Targeted deletion of the 9p21 non-coding coronary artery disease risk interval in miceQ34121996
LRP6 mutation in a family with early coronary disease and metabolic risk factorsQ34153785
LRP: role in vascular wall integrity and protection from atherosclerosisQ34190034
Atherosclerosis quantitative trait loci are sex- and lineage-dependent in an intercross of C57BL/6 and FVB/N low-density lipoprotein receptor-/- miceQ34248316
Finding the molecular basis of quantitative traits: successes and pitfalls.Q34271555
Deficiency of acyl CoA:cholesterol acyltransferase 2 prevents atherosclerosis in apolipoprotein E-deficient miceQ34330253
Site-specific effects of PECAM-1 on atherosclerosis in LDL receptor-deficient miceQ34455303
ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix proteinQ34508676
A phenotype-sensitizing Apoe-deficient genetic background reveals novel atherosclerosis predisposition loci in the mouseQ34614796
Characterization of a germ-line deletion, including the entire INK4/ARF locus, in a melanoma-neural system tumor family: identification of ANRIL, an antisense noncoding RNA whose expression coclusters with ARF.Q34619960
Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosisQ34652627
The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levelsQ34793225
Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesisQ34828549
Complex inheritance of the 5-lipoxygenase locus influencing atherosclerosis in miceQ34895911
Synthetic low and high fat diets for the study of atherosclerosis in the mouseQ43607933
Genetic deficiency of inducible nitric oxide synthase reduces atherosclerosis and lowers plasma lipid peroxides in apolipoprotein E-knockout mice.Q43653260
Absence of adipocyte fatty acid binding protein prevents the development of accelerated atherosclerosis in hypercholesterolemic mice.Q43693015
Localized reduction of atherosclerosis in von Willebrand factor-deficient miceQ43718531
Ultrafine mapping of SNPs from mouse strains C57BL/6J, DBA/2J, and C57BLKS/J for loci contributing to diabetes and atherosclerosis susceptibilityQ43798122
Increased atherosclerosis in hyperlipidemic mice with inactivation of ABCA1 in macrophagesQ43957626
Identification of 5-lipoxygenase as a major gene contributing to atherosclerosis susceptibility in miceQ44079670
Differences between hepatic and biliary lipid metabolism and secretion in genetically gallstone-susceptible and gallstone-resistant miceQ44201386
Influence of interferon-gamma on the extent and phenotype of diet-induced atherosclerosis in the LDLR-deficient mouseQ44342113
Eliminating atherogenesis in mice by switching off hepatic lipoprotein secretionQ44357150
Tissue angiotensin-converting-enzyme (ACE) deficiency leads to a reduction in oxidative stress and in atherosclerosis: studies in ACE-knockout mice type 2.Q44606455
Genetic ablation of caveolin-1 confers protection against atherosclerosisQ44620779
Quantitative Trait Loci Analysis for Plasma HDL-Cholesterol Concentrations and Atherosclerosis Susceptibility Between Inbred Mouse Strains C57BL/6J and 129S1/SvImJQ44639031
Deletion of the alternatively spliced fibronectin EIIIA domain in mice reduces atherosclerosisQ44771606
ANRIL expression is associated with atherosclerosis risk at chromosome 9p21.Q44836516
Genetic loci for diet-induced atherosclerotic lesions and plasma lipids in miceQ45000599
Endothelial lipase modulates susceptibility to atherosclerosis in apolipoprotein-E-deficient miceQ45013809
Alpha(1,3)fucosyltransferases FucT-IV and FucT-VII control susceptibility to atherosclerosis in apolipoprotein E-/- miceQ45016522
The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm.Q45025551
Impact of interleukin-6 on plaque development and morphology in experimental atherosclerosis.Q45158735
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesisQ45165256
Regulation of cholesterol 7alpha-hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet.Q45253376
Positional identification of TNFSF4, encoding OX40 ligand, as a gene that influences atherosclerosis susceptibilityQ45306054
Deletion of LOX-1 reduces atherogenesis in LDLR knockout mice fed high cholesterol dietQ45867832
Genetic analysis of strains C57BL/6J and BALB/cJ for Ath-1, a gene determining atherosclerosis susceptibility in mice.Q46003130
ApoE-/-Fas-/- C57BL/6 mice: a novel murine model simultaneously exhibits lupus nephritis, atherosclerosis, and osteopenia.Q46014277
Analysis of atherosclerosis susceptibility in mice with genetic defects in platelet functionQ46122913
Angptl 4 deficiency improves lipid metabolism, suppresses foam cell formation and protects against atherosclerosisQ46191272
Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H miceQ46492183
Lack of the cysteine protease inhibitor cystatin C promotes atherosclerosis in apolipoprotein E-deficient mice.Q46624696
Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient miceQ46722608
A mouse model of human familial hypercholesterolemia: markedly elevated low density lipoprotein cholesterol levels and severe atherosclerosis on a low-fat chow diet.Q46778536
Association between ADAMTS1 matrix metalloproteinase gene variation, coronary heart disease, and benefit of statin therapyQ46823870
Atherosclerosis susceptibility loci identified from a strain intercross of apolipoprotein E-deficient mice via a high-density genome scan.Q46864803
Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosisQ46897070
Leukocyte-derived interleukin 10 is required for protection against atherosclerosis in low-density lipoprotein receptor knockout miceQ47392093
Traditional risk factors and subclinical disease measures as predictors of first myocardial infarction in older adults: the Cardiovascular Health Study.Q51562630
Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers.Q53460669
Loss of the lysophosphatidylcholine effector, G2A, ameliorates aortic atherosclerosis in low-density lipoprotein receptor knockout mice.Q53588364
The p16INK4a/CDKN2A tumor suppressor and its relatives.Q54317457
ATH-3, a new gene for atherosclerosis in the mouse.Q54356341
Apoptosis signal-regulating kinase 1 deficiency accelerates hyperlipidemia-induced atheromatous plaques via suppression of macrophage apoptosis.Q54593658
Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis.Q54689510
The Collaborative Cross, a community resource for the genetic analysis of complex traitsQ56896214
The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and strokeQ56944340
P433issue2
P921main subjectatherosclerosisQ12252367
P304page(s)337-355
P577publication date2012-01-01
P1433published inCirculation ResearchQ2599020
P1476titleGenetic basis of atherosclerosis: insights from mice and humans
P478volume110

Reverse relations

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