Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis.

scientific article

Autophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4161/AUTO.7.11.17660
P932PMC publication ID3359483
P698PubMed publication ID21997369
P5875ResearchGate publication ID51715351

P50authorBenjamin T KoppQ56450375
Christie A NewlandQ125021807
Roberto Rosales-ReyesQ40923268
Miguel A. ValvanoQ42124313
P2093author name stringAmal O Amer
Larry S Schlesinger
Mikhail A Gavrilin
Mark D Wewers
Anwari Akhter
Basant A Abdulrahman
Karen McCoy
Kyle Caution
Richard Montione
Arwa Abu Khweek
Sheetal Kotrange
Dalia H A Abdelaziz
P2860cites workInfection Control in Cystic Fibrosis: Cohorting, Cross-Contamination, and the Respiratory TherapistQ22305423
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A protein conjugation system essential for autophagyQ27940154
Microarray analysis of human monocytes infected with Francisella tularensis identifies new targets of host response subversionQ28473308
Autophagy in infectionQ28752279
Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophagesQ29547420
The role of autophagy during the early neonatal starvation periodQ29547489
Dissection of the autophagosome maturation process by a novel reporter protein, tandem fluorescent-tagged LC3Q29614176
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta productionQ29614472
Autophagy defends cells against invading group A StreptococcusQ29615620
Potential therapeutic applications of autophagyQ29622862
Role for Rab7 in maturation of late autophagic vacuolesQ30014819
Burkholderia and emerging pathogens in cystic fibrosisQ30998871
Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infectionQ33426360
Burkholderia cenocepacia creates an intramacrophage replication niche in zebrafish embryos, followed by bacterial dissemination and establishment of systemic infection.Q33768965
Inflammation and CFTR: might neutrophils be the key in cystic fibrosis?Q33855072
The role of PI3P phosphatases in the regulation of autophagyQ33914205
Role of the Apg12 conjugation system in mammalian autophagyQ34187946
Internalization and phagosome escape required for Francisella to induce human monocyte IL-1beta processing and releaseQ34248184
Inactivation of macrophage Rab7 by Burkholderia cenocepacia.Q34316026
The molecular mechanism of autophagyQ34520654
Pulmonary infections in patients with cystic fibrosisQ34561212
Inflammatory mediators in cystic fibrosis lung diseaseQ34564124
Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf.Q34567184
Autophagy controls IL-1beta secretion by targeting pro-IL-1beta for degradationQ34684708
Autophagy is an immediate macrophage response to Legionella pneumophilaQ35060246
Lower airway inflammation in infants and young children with cystic fibrosis.Q50625944
Clinical outcome after acquisition of Burkholderia cepacia in patients with cystic fibrosis.Q50677136
Induction of autophagy via innate bacterial recognition.Q52693494
Between canonical and antibacterial autophagy: Rab7 is required for GAS-containing autophagosome-like vacuole formationQ57274139
Cystic fibrosis: A disorder with defective autophagyQ57663495
Antibody Response to Burkholderia cepacia in Patients with Cystic Fibrosis Colonized with Burkholderia cepacia and Pseudomonas aeruginosaQ57913785
Cystic fibrosis: inflammatory response to infection with Burkholderia cepacia and Pseudomonas aeruginosaQ57913803
Cytokines in sputum and serum from patients with cystic fibrosis and chronicpseudomonas aeruginosa infection as markers of destructive inflammation in the lungsQ60227850
Autophagy in the intestinal epithelium reduces endotoxin-induced inflammatory responses by inhibiting NF-κB activationQ63609779
Early Pulmonary Inflammation in Infants with Cystic FibrosisQ72111638
Population screening of F508del (DeltaF508), the most frequent mutation in the CFTR gene associated with cystic fibrosis in ArgentinaQ74231233
Intracellular survival and saprophytic growth of isolates from the Burkholderia cepacia complex in free-living amoebaeQ78104247
Distinct cytokine production by lung and blood neutrophils from children with cystic fibrosisQ78840949
Autophagy limits Listeria monocytogenes intracellular growth in the early phase of primary infectionQ79495029
The molecular machinery of autophagy and its role in physiology and diseaseQ84132053
Macrophages rapidly transfer pathogens from lipid raft vacuoles to autophagosomesQ35060254
Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapyQ35107703
Outcome of Burkholderia cepacia colonisation in an adult cystic fibrosis centreQ35534997
Burkholderia cenocepacia ET12 strain activates TNFR1 signalling in cystic fibrosis airway epithelial cellsQ35580629
Survival and persistence of opportunistic Burkholderia species in host cells.Q36032395
AutophagyQ36108100
Interleukin-1 beta converting enzyme: a novel cysteine protease required for IL-1 beta production and implicated in programmed cell deathQ36278873
Inflammasome mRNA expression in human monocytes during early septic shockQ36614655
Autophagy and human diseaseQ36900047
IL1B polymorphisms modulate cystic fibrosis lung disease.Q37027691
Human immunodeficiency virus type-1 infection inhibits autophagyQ37393602
Pyrin critical to macrophage IL-1beta response to Francisella challengeQ37661273
Autophagy and Crohn's disease: at the crossroads of infection, inflammation, immunity, and cancerQ37764367
Autophagy targeting of Listeria monocytogenes and the bacterial countermeasureQ37824809
Defective CFTR induces aggresome formation and lung inflammation in cystic fibrosis through ROS-mediated autophagy inhibitionQ39667316
Characterization of macrophage activation states in patients with cystic fibrosisQ39861115
Delayed association of the NADPH oxidase complex with macrophage vacuoles containing the opportunistic pathogen Burkholderia cenocepaciaQ39866283
Francisella tularensis regulates autophagy-related host cell signaling pathwaysQ40025482
Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptorQ40174308
Intracellular trafficking and replication of Burkholderia cenocepacia in human cystic fibrosis airway epithelial cellsQ40241360
Intracellular survival of Burkholderia cenocepacia in macrophages is associated with a delay in the maturation of bacteria-containing vacuolesQ40251339
The DeltaF508 cystic fibrosis mutation impairs domain-domain interactions and arrests post-translational folding of CFTR.Q40477013
Construction of aminoglycoside-sensitive Burkholderia cenocepacia strains for use in studies of intracellular bacteria with the gentamicin protection assay.Q40527719
Early pulmonary infection, inflammation, and clinical outcomes in infants with cystic fibrosisQ40682137
The difficulties of treating infection in adults with cystic fibrosis.Q40723100
DeltaF508-CFTR causes constitutive NF-kappaB activation through an ER-overload response in cystic fibrosis lungsQ40740154
Intracellular survival of Burkholderia cepacia complex isolates in the presence of macrophage cell activationQ40907519
Identification of Burkholderia cenocepacia genes required for bacterial survival in vivoQ40936162
Regulation of translational effectors by amino acid and mammalian target of rapamycin signaling pathways. Possible involvement of autophagy in cultured hepatoma cellsQ40984582
Inflammatory cytokines in cystic fibrosis lungsQ41266633
Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1beta production in macrophages.Q42097637
Serum interleukin-1 alpha and soluble interleukin-2 receptor concentrations in cystic fibrosisQ42154817
CFTR inhibition mimics the cystic fibrosis inflammatory profileQ42500060
Current understanding of the inflammatory process in cystic fibrosis: onset and etiologyQ44248066
CFTR mutation distribution among U.S. Hispanic and African American individuals: evaluation in cystic fibrosis patient and carrier screening populationsQ46498400
Mammalian target of rapamycin and S6 kinase 1 positively regulate 6-thioguanine-induced autophagyQ46604826
Can health-related quality of life predict survival in adults with cystic fibrosis?Q46707042
Variation of the antimicrobial susceptibility profiles of Burkholderia cepacia complex clonal isolates obtained from chronically infected cystic fibrosis patients: a five-year survey in the major Portuguese treatment center.Q47594950
Lower airway inflammation in infants with cystic fibrosis detected by newborn screening.Q47715284
Burkholderia cenocepacia-induced delay of acidification and phagolysosomal fusion in cystic fibrosis transmembrane conductance regulator (CFTR)-defective macrophagesQ50057909
Autophagy controls Salmonella infection in response to damage to the Salmonella-containing vacuoleQ50083524
P433issue11
P921main subjectsirolimusQ32089
cystic fibrosisQ178194
autophagyQ288322
Burkholderia cenocepaciaQ4810500
P304page(s)1359-1370
P577publication date2011-11-01
P1433published inAutophagyQ1255295
P1476titleAutophagy stimulation by rapamycin suppresses lung inflammation and infection by Burkholderia cenocepacia in a model of cystic fibrosis
P478volume7

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