Pleiotropic protective effects of phytochemicals in Alzheimer's disease

scientific article

Pleiotropic protective effects of phytochemicals in Alzheimer's disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1155/2012/386527
P932PMC publication ID3368517
P698PubMed publication ID22690271
P5875ResearchGate publication ID225294067

P50authorGiovanni ScapagniniQ56814243
Sergio DavinelliQ56934618
Renata BracaleQ57328719
P2093author name stringDavide Zella
Nadia Sapere
Mariano Intrieri
P2860cites workEpigallocatechin-3-gallate suppresses NF-kappaB activation and phosphorylation of p38 MAPK and JNK in human astrocytoma U373MG cells.Q50688366
Inhibitory activity of stilbenes on Alzheimer's beta-amyloid fibrils in vitro.Q51930765
Cortical cytochrome oxidase activity is reduced in Alzheimer's disease.Q53204876
Biomarkers: warning signs.Q53213626
Rapid induction of Alzheimer A beta amyloid formation by zinc.Q53316140
Iron chelation in the biological activity of curcumin.Q55041704
Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stressQ61837710
Nitric oxide scavenging by curcuminoidsQ73272444
The dietary pigment curcumin reduces endothelial tissue factor gene expression by inhibiting binding of AP-1 to the DNA and activation of NF-kappa BQ73305343
Curcumin inhibits IL1 alpha and TNF-alpha induction of AP-1 and NF-kB DNA-binding activity in bone marrow stromal cellsQ74080109
Cytotoxicity, antioxidant and anti-inflammatory activities of curcumins I-III from Curcuma longaQ74256041
Inflammatory processes in Alzheimer's diseaseQ79557863
Safety assessment of a solid lipid curcumin particle preparation: acute and subchronic toxicity studiesQ84099656
Activation of nuclear factor erythroid 2-related factor 2 cytoprotective signaling by curcumin protect primary spinal cord astrocytes against oxidative toxicityQ84627293
Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's diseaseQ24305330
Resveratrol improves health and survival of mice on a high-calorie dietQ27860950
Resveratrol potently reduces prostaglandin E2 production and free radical formation in lipopolysaccharide-activated primary rat microgliaQ28222555
Sirtuin activatorsQ28244893
Flavonoids: modulators of brain function?Q28281453
Pharmacology of Curcuma longaQ28328461
Intracellular ROS protection efficiency and free radical-scavenging activity of curcuminQ28477422
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosisQ28583941
Therapeutic potential of resveratrol: the in vivo evidenceQ29547413
Electron transport chain defects in Alzheimer's disease brainQ48107929
Pharmacokinetics of (-)-epigallocatechin-3-gallate in conscious and freely moving rats and its brain regional distributionQ48296640
Neuroprotective effects of resveratrol against intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in ratsQ48352370
Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.Q48446631
Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanismsQ48480979
Green tea (-)-epigallocatechin-3-gallate inhibits beta-amyloid-induced cognitive dysfunction through modification of secretase activity via inhibition of ERK and NF-kappaB pathways in miceQ48493829
ADAM10 activation is required for green tea (-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor proteinQ48577940
Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitionersQ30397380
NMR study of the solution structure of curcuminQ31102198
Curcumin activates defensive genes and protects neurons against oxidative stressQ33242451
Dietary supplementation with resveratrol reduces plaque pathology in a transgenic model of Alzheimer's diseaseQ33944063
The curry spice curcumin reduces oxidative damage and amyloid pathology in an Alzheimer transgenic mouse.Q33955271
Roles of molecular chaperones in the nervous systemQ34067828
Resveratrol differentially modulates inflammatory responses of microglia and astrocytesQ34114119
A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. North American EGb Study GroupQ34443696
Resveratrol promotes clearance of Alzheimer's disease amyloid-beta peptides.Q34450913
Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseasesQ34480991
Phenolic anti-inflammatory antioxidant reversal of Abeta-induced cognitive deficits and neuropathologyQ34520040
Curcumin: the story so far.Q34559908
Modulation of Ca²⁺ signals by epigallocatechin-3-gallate(EGCG) in cultured rat hippocampal neuronsQ34578174
Curcumin labels amyloid pathology in vivo, disrupts existing plaques, and partially restores distorted neurites in an Alzheimer mouse model.Q34579152
Green tea epigallocatechin-3-gallate (EGCG) reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic miceQ34656230
EGCG redirects amyloidogenic polypeptides into unstructured, off-pathway oligomersQ34656396
Mitochondria-targeted antioxidants protect against amyloid-beta toxicity in Alzheimer's disease neuronsQ34772619
Amyloid beta-peptide and amyloid pathology are central to the oxidative stress and inflammatory cascades under which Alzheimer's disease brain exists.Q34844564
Neuroprotective effects of resveratrol against beta-amyloid-induced neurotoxicity in rat hippocampal neurons: involvement of protein kinase CQ35046233
The "Alzheimer's disease signature": potential perspectives for novel biomarkers.Q35339326
Catechin polyphenols: neurodegeneration and neuroprotection in neurodegenerative diseasesQ35820578
Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expressionQ35864100
SIRT1 and neuronal diseasesQ36775876
The redox chemistry of the Alzheimer's disease amyloid beta peptide.Q36791163
Neuroprotective effects of curcuminQ36849490
Resveratrol and its analogs: defense against cancer, coronary disease and neurodegenerative maladies or just a fad?Q36949377
Recent advances in the investigation of curcuminoidsQ36957175
Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implicationsQ36979669
Challenges for research on polyphenols from foods in Alzheimer's disease: bioavailability, metabolism, and cellular and molecular mechanisms.Q37192480
Nutraceutical antioxidants as novel neuroprotective agentsQ37808095
Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disordersQ37866170
Curcumin activates human glutathione S-transferase P1 expression through antioxidant response elementQ38302521
Insights into the putative catechin and epicatechin transport across blood-brain barrierQ39504007
Green tea epigallocatechin-3-gallate (EGCG) and other flavonoids reduce Alzheimer's amyloid-induced mitochondrial dysfunctionQ39520490
The major green tea polyphenol, (-)-epigallocatechin-3-gallate, induces heme oxygenase in rat neurons and acts as an effective neuroprotective agent against oxidative stress.Q39722953
Fish oil enhances anti-amyloidogenic properties of green tea EGCG in Tg2576 miceQ39748836
Neuroprotective effect of epigallocatechin-3-gallate against beta-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacityQ39832887
Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation.Q40021673
The application of proteomics for studying the neurorescue activity of the polyphenol (-)-epigallocatechin-3-gallateQ40022059
Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells.Q40068052
Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microgliaQ40078008
Protective effect of (-)-epigallocatechin gallate against advanced glycation endproducts-induced injury in neuronal cellsQ40099990
Resveratrol inhibits inducible nitric oxide synthase and cyclooxygenase-2 expression in beta-amyloid-treated C6 glioma cellsQ40281856
Curcumin (Diferuloylmethane) Inhibits Constitutive and IL-6-Inducible STAT3 Phosphorylation in Human Multiple Myeloma CellsQ40633129
Potent anti-amyloidogenic and fibril-destabilizing effects of polyphenols in vitro: implications for the prevention and therapeutics of Alzheimer's diseaseQ40635431
The flavanol (-)-epicatechin prevents stroke damage through the Nrf2/HO1 pathwayQ41185723
Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophagesQ41380057
Protective effect of green tea (-)-epigallocatechin-3-gallate against the monoamine oxidase B enzyme activity increase in adult rat brainsQ43062406
Severe motor neuron degeneration in the spinal cord of the Tg2576 mouse model of Alzheimer diseaseQ43084838
Relationship between the tautomeric structures of curcumin derivatives and their Abeta-binding activities in the context of therapies for Alzheimer's diseaseQ43151191
Resveratrol inhibits beta-amyloid oligomeric cytotoxicity but does not prevent oligomer formationQ43278469
Involvement of protein kinase C activation and cell survival/ cell cycle genes in green tea polyphenol (-)-epigallocatechin 3-gallate neuroprotective actionQ44023075
Curcumin (diferuloylmethane), a singlet oxygen ((1)O(2)) quencherQ44041028
Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stabilityQ44120619
Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-kappa B-dependent genesQ44185416
(-)-Epigallocatechin gallate protects against NO stress-induced neuronal damage after ischemia by acting as an anti-oxidantQ44225330
Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expressionQ44270060
cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cellsQ44355279
Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol (-)-epigallocatechin-3-gallateQ44387375
Potential mechanism by which resveratrol, a red wine constituent, protects neuronsQ44508329
The neuroprotection of resveratrol in the experimental cerebral ischemiaQ44530331
Green tea catechins as a BACE1 (β-Secretase) inhibitorQ44638638
Brain protection by resveratrol and fenofibrate against stroke requires peroxisome proliferator-activated receptor alpha in miceQ44660671
Curcumin has potent anti-amyloidogenic effects for Alzheimer's beta-amyloid fibrils in vitroQ44782704
Curcumin suppresses lipopolysaccharide-induced cyclooxygenase-2 expression by inhibiting activator protein 1 and nuclear factor kappab bindings in BV2 microglial cellsQ44810239
Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models.Q45042828
Structural basis for antioxidant activity of trans-resveratrol: ab initio calculations and crystal and molecular structureQ45162337
Curcumin protects mitochondria from oxidative damage and attenuates apoptosis in cortical neurons.Q45166299
Peroxynitrite interaction with curcumin solubilized in ethanolic solutionQ45217597
Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's diseaseQ45223637
Gender differences in glutathione metabolism in Alzheimer's diseaseQ45251935
EF24, a novel synthetic curcumin analog, induces apoptosis in cancer cells via a redox-dependent mechanismQ45265258
Long-term green tea catechin administration prevents spatial learning and memory impairment in senescence-accelerated mouse prone-8 mice by decreasing Abeta1-42 oligomers and upregulating synaptic plasticity-related proteins in the hippocampus.Q45930606
Amelioration of cognitive deficits and neurodegeneration by curcumin in rat model of sporadic dementia of Alzheimer's type (SDAT).Q46070569
Epigallocatechin-3-gallate induced primary cultures of rat hippocampal neurons death linked to calcium overload and oxidative stressQ46120065
Caloric restriction attenuates Abeta-deposition in Alzheimer transgenic modelsQ46142687
Neuroprotective effects of (-)-epigallocatechin-3-gallate on aging mice induced by D-galactoseQ46175842
Effect of resveratrol on antioxidant enzyme activities in the brain of healthy rat.Q46253330
(-)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiencyQ46257745
Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cellsQ46481176
Predicting how polyphenol antioxidants prevent DNA damage by binding to ironQ46540481
Green tea epigallocatechin-3-gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice.Q46715173
Curcumin and its analogues as potent inhibitors of low density lipoprotein oxidation: H-atom abstraction from the phenolic groups and possible involvement of the 4-hydroxy-3-methoxyphenyl groupsQ46916498
Amyloid plaques arise from zinc-enriched cortical layers in APP/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiencyQ46940568
Mitochondrial function, GSH and iron in neurodegeneration and Lewy body diseases.Q47830583
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P921main subjectAlzheimer's diseaseQ11081
phytochemistryQ640068
pleiotropyQ1134884
neuroprotective agentQ50377190
P304page(s)386527
P577publication date2012-05-28
P1433published inOxidative medicine and cellular longevityQ26840015
P1476titlePleiotropic protective effects of phytochemicals in Alzheimer's disease
P478volume2012

Reverse relations

cites work (P2860)
Q48060692Antidepressant-Like Effect of Ropren® in β-Amyloid-(25-35) Rat Model of Alzheimer's Disease with Altered Levels of Androgens
Q38658008Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases.
Q48949629Beneficial effects of an Andrographis paniculata extract and andrographolide on cognitive functions in streptozotocin-induced diabetic rats
Q42701797Bisphenol-A Mediated Inhibition of Hippocampal Neurogenesis Attenuated by Curcumin via Canonical Wnt Pathway
Q36891064Curcumin: a natural substance with potential efficacy in Alzheimer's disease
Q47855717Diet-induced non-alcoholic fatty liver disease affects expression of major cytochrome P450 genes in a mouse model
Q26747783Dietary phytochemicals and neuro-inflammaging: from mechanistic insights to translational challenges
Q60617431Different Conformation of Thiol Protease Inhibitor During Amyloid Formation: Inhibition by Curcumin and Quercetin
Q38267471Epigenetic nutraceutical diets in Alzheimer's disease.
Q40257007Family lifestyle and childhood obesity in an urban city of Northern Italy.
Q36119633Improvement in Long-Term Memory following Chronic Administration of Eryngium planum Root Extract in Scopolamine Model: Behavioral and Molecular Study
Q38085375Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.
Q43590947Mechanisms and effects of curcumin on spatial learning and memory improvement in APPswe/PS1dE9 mice
Q26824709Mitochondrial dysfunction and tissue injury by alcohol, high fat, nonalcoholic substances and pathological conditions through post-translational protein modifications
Q91781508Modifiable Risk Factors for Alzheimer's Disease
Q64232099Modulating Effect of Diet on Alzheimer's Disease
Q26750581Natural Phytochemicals in the Treatment and Prevention of Dementia: An Overview
Q33785583Plant-based nutrition for healthcare professionals: implementing diet as a primary modality in the prevention and treatment of chronic disease
Q35034790Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice
Q39204729Recent Advances in Nanoparticle-Mediated Delivery of Anti-Inflammatory Phytocompounds
Q34535918Redox-based therapeutics in neurodegenerative disease
Q55073180Resveratrol attenuates neurological deficit and neuroinflammation following intracerebral hemorrhage.
Q36590615Role of CYP2E1 in mitochondrial dysfunction and hepatic tissue injury in alcoholic and non-alcoholic diseases
Q26800947Role of Polyphenols and Other Phytochemicals on Molecular Signaling
Q26859305Successful therapies for Alzheimer's disease: why so many in animal models and none in humans?
Q27496021The Benefits and Risks of Consuming Brewed Tea: Beware of Toxic Element Contamination
Q53084951The nutrient density approach to healthy eating: challenges and opportunities.
Q37387226Trans-Resveratrol Enhances the Anticoagulant Activity of Warfarin in a Mouse Model
Q90088394Zataria multiflora could improve hippocampal tau protein and TNFα levels and cognitive behavior defects in a rat model of Alzheimer's disease

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