| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Jose P Lopez-Atalaya | Q58883299 |
| Angel Barco | Q37387292 | ||
| Luis M. Valor | Q43154749 | ||
| P2093 | author name string | Jose Viosca | |
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| Rubinstein-Taybi syndrome: clinical and molecular overview | Q36973859 | ||
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| Beyond transcription factors: the role of chromatin modifying enzymes in regulating transcription required for memory | Q37201297 | ||
| Modulation of long-term memory for object recognition via HDAC inhibition | Q37224213 | ||
| Structure and chemistry of the p300/CBP and Rtt109 histone acetyltransferases: implications for histone acetyltransferase evolution and function | Q37290564 | ||
| Regulation of chromatin structure in memory formation | Q37347946 | ||
| CBP/p300 and associated transcriptional co-activators exhibit distinct expression patterns during murine craniofacial and neural tube development | Q37352828 | ||
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| Histone acetyl transferases as emerging drug targets. | Q37540911 | ||
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| Huntington's gene finally found | Q45291214 | ||
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| p53 mediates cellular dysfunction and behavioral abnormalities in Huntington's disease | Q45297400 | ||
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| Metabolic and glutamatergic disturbances in the Huntington's disease transgenic mouse. | Q45299857 | ||
| Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. | Q45300254 | ||
| Neuronal intranuclear inclusions and neuropil aggregates in HdhCAG(150) knockin mice | Q45303809 | ||
| CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease | Q45304348 | ||
| Long-term memory deficits in Huntington's disease are associated with reduced CBP histone acetylase activity. | Q45305295 | ||
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| Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases. | Q46628836 | ||
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| Stimulation of NF-E2 DNA binding by CREB-binding protein (CBP)-mediated acetylation | Q28142527 | ||
| A CBP binding transcriptional repressor produced by the PS1/epsilon-cleavage of N-cadherin is inhibited by PS1 FAD mutations | Q28185270 | ||
| HATs and HDACs: from structure, function and regulation to novel strategies for therapy and prevention | Q28240437 | ||
| Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes | Q28255974 | ||
| Phosphorylated CREB binds specifically to the nuclear protein CBP | Q28265019 | ||
| CBP histone acetyltransferase activity is a critical component of memory consolidation | Q28267700 | ||
| Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300 | Q28270979 | ||
| Loss of HDAC5 impairs memory function: implications for Alzheimer's disease | Q28273493 | ||
| Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP | Q28295041 | ||
| Selective modulation of some forms of schaffer collateral-CA1 synaptic plasticity in mice with a disruption of the CPEB-1 gene | Q28513435 | ||
| Spatial memory consolidation is associated with induction of several lysine-acetyltransferase (histone acetyltransferase) expression levels and H2B/H4 acetylation-dependent transcriptional events in the rat hippocampus. | Q28564318 | ||
| α-Synuclein negatively regulates protein kinase Cδ expression to suppress apoptosis in dopaminergic neurons by reducing p300 histone acetyltransferase activity | Q28572683 | ||
| Mutant huntingtin represses CBP, but not p300, by binding and protein degradation | Q28574845 | ||
| Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration | Q28590719 | ||
| New nomenclature for chromatin-modifying enzymes | Q29616425 | ||
| Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila | Q29616737 | ||
| Alzheimer's disease | Q29616743 | ||
| p300/CBP proteins: HATs for transcriptional bridges and scaffolds | Q29617981 | ||
| Function and regulation of CREB family transcription factors in the nervous system | Q29619559 | ||
| Recovery of learning and memory is associated with chromatin remodelling | Q29619784 | ||
| Proteome-wide prediction of acetylation substrates | Q30437029 | ||
| Subregion-specific p300 conditional knock-out mice exhibit long-term memory impairments | Q30470054 | ||
| CREB binding protein is required for both short-term and long-term memory formation | Q30476167 | ||
| Inhibitors of class 1 histone deacetylases reverse contextual memory deficits in a mouse model of Alzheimer's disease | Q30498541 | ||
| Quantitative analysis of CBP- and P300-induced histone acetylations in vivo using native chromatin. | Q33193939 | ||
| Virtual ligand screening of the p300/CBP histone acetyltransferase: identification of a selective small molecule inhibitor | Q33599508 | ||
| Transgenic mice expressing a truncated form of CREB-binding protein (CBP) exhibit deficits in hippocampal synaptic plasticity and memory storage. | Q33736104 | ||
| Environmental neurotoxic pesticide increases histone acetylation to promote apoptosis in dopaminergic neuronal cells: relevance to epigenetic mechanisms of neurodegeneration | Q33762517 | ||
| Membrane-associated glucocorticoid activity is necessary for modulation of long-term memory via chromatin modification | Q33817894 | ||
| Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration | Q33854083 | ||
| HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. | Q33908350 | ||
| CREB is a key regulator of striatal vulnerability in chemical and genetic models of Huntington's disease | Q33908482 | ||
| Epigenetic alterations are critical for fear memory consolidation and synaptic plasticity in the lateral amygdala | Q33916385 | ||
| Dynamic epigenetic regulation in neurons: enzymes, stimuli and signaling pathways | Q37803122 | ||
| Targeting the correct HDAC(s) to treat cognitive disorders | Q37803453 | ||
| CREB: a multifaceted regulator of neuronal plasticity and protection | Q37806285 | ||
| Chemical biology of histone acetyltransferase natural compounds modulators | Q37825449 | ||
| Epigenetic regulation of gene expression in physiological and pathological brain processes | Q37870034 | ||
| Genetic approaches to investigate the role of CREB in neuronal plasticity and memory. | Q37938886 | ||
| Challenges associated with curcumin therapy in Alzheimer disease | Q37952439 | ||
| The potential of HDAC inhibitors as cognitive enhancers. | Q38072102 | ||
| Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanism | Q38328546 | ||
| CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivation | Q38340711 | ||
| Suppression of aggregate formation of mutant huntingtin potentiates CREB-binding protein sequestration and apoptotic cell death | Q39436375 | ||
| Histone acetylation deficits in lymphoblastoid cell lines from patients with Rubinstein-Taybi syndrome. | Q39460830 | ||
| Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viability | Q39598834 | ||
| Partial depletion of CREB-binding protein reduces life expectancy in a mouse model of Huntington disease. | Q39706773 | ||
| The identification of a novel natural activator of p300 histone acetyltranferase provides new insights into the modulation mechanism of this enzyme. | Q39717695 | ||
| HDAC inhibitor trichostatin A-inhibited survival of dopaminergic neuronal cells | Q39786674 | ||
| p300 activation by Presenilin 1 but not by its M146L mutant. | Q40188420 | ||
| Distribution of histone deacetylases 1-11 in the rat brain | Q40225359 | ||
| Depletion of CBP is directly linked with cellular toxicity caused by mutant huntingtin | Q40269204 | ||
| CREB-binding protein activation by presenilin 1 but not by its M146L mutant | Q40273213 | ||
| Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration. | Q40323686 | ||
| Using proteomics and network analysis to elucidate the consequences of synaptic protein oxidation in a PS1 + AbetaPP mouse model of Alzheimer's disease | Q40366410 | ||
| Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease | Q40782711 | ||
| CREB binding protein recruitment to the transcription complex requires growth factor-dependent phosphorylation of its GF box. | Q40791260 | ||
| CREB-binding protein sequestration by expanded polyglutamine | Q40859094 | ||
| Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator | Q41133317 | ||
| Acetylation of general transcription factors by histone acetyltransferases | Q41586010 | ||
| The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories. | Q41652035 | ||
| Acetylation targets mutant huntingtin to autophagosomes for degradation | Q41773329 | ||
| Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory | Q41873212 | ||
| Histone modifications around individual BDNF gene promoters in prefrontal cortex are associated with extinction of conditioned fear | Q42628513 | ||
| Regulation of activity of the transcription factor GATA-1 by acetylation | Q42823439 | ||
| Alteration of working memory but not in anxiety or stress response in p300/CBP associated factor (PCAF) histone acetylase knockout mice bred on a C57BL/6 background. | Q43108180 | ||
| Genetic heterogeneity in Rubinstein-Taybi syndrome: delineation of the phenotype of the first patients carrying mutations in EP300. | Q43163937 | ||
| Histone acetylation is recruited in consolidation as a molecular feature of stronger memories | Q43268931 | ||
| Beta -amyloid-(1-42) impairs activity-dependent cAMP-response element-binding protein signaling in neurons at concentrations in which cell survival Is not compromised | Q43559766 | ||
| Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease | Q43648215 | ||
| Phosphorylation of CBP mediates transcriptional activation by neural activity and CaM kinase IV. | Q43968740 | ||
| Integration of long-term-memory-related synaptic plasticity involves bidirectional regulation of gene expression and chromatin structure | Q44220427 | ||
| Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndrome | Q44302108 | ||
| Small molecule modulators of histone acetyltransferase p300. | Q44353899 | ||
| Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice | Q44619618 | ||
| Chromatin remodeling and neuronal response: multiple signaling pathways induce specific histone H3 modifications and early gene expression in hippocampal neurons | Q44660996 | ||
| Decreased cAMP response element-mediated transcription: an early event in exon 1 and full-length cell models of Huntington's disease that contributes to polyglutamine pathogenesis | Q44662096 | ||
| Sodium butyrate ameliorates phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy | Q44854729 | ||
| Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction | Q44930696 | ||
| Regulation of histone acetylation during memory formation in the hippocampus. | Q44992481 | ||
| Neuroprotective effects of phenylbutyrate in the N171-82Q transgenic mouse model of Huntington's disease | Q45115023 | ||
| Inducible PC12 cell model of Huntington's disease shows toxicity and decreased histone acetylation | Q45288904 | ||
| Alcohol exposure decreases CREB binding protein expression and histone acetylation in the developing cerebellum | Q33927405 | ||
| Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause disease | Q33942130 | ||
| CBP and p300: HATs for different occasions | Q33980693 | ||
| CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement | Q34028180 | ||
| Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activation | Q34077367 | ||
| A transcriptional switch mediated by cofactor methylation | Q34101080 | ||
| Viral replication and the coactivators p300 and CBP. | Q34104253 | ||
| Altered histone acetylation is associated with age-dependent memory impairment in mice. | Q34114011 | ||
| Tuning acetylation levels with HAT activators: Therapeutic strategy in neurodegenerative diseases | Q34137377 | ||
| HDAC3 is a critical negative regulator of long-term memory formation | Q34158695 | ||
| Histone deacetylase complexes promote trinucleotide repeat expansions | Q34169694 | ||
| Epigenetic changes induced by curcumin and other natural compounds. | Q34180255 | ||
| Amyloid beta -peptide inhibition of the PKA/CREB pathway and long-term potentiation: reversibility by drugs that enhance cAMP signaling | Q34192226 | ||
| CREB-binding protein controls response to cocaine by acetylating histones at the fosB promoter in the mouse striatum | Q34245266 | ||
| Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration. | Q34327866 | ||
| Crebinostat: a novel cognitive enhancer that inhibits histone deacetylase activity and modulates chromatin-mediated neuroplasticity | Q34329880 | ||
| Cellular targets for transformation by the adenovirus E1A proteins | Q34438094 | ||
| Histone deactylase inhibition combined with behavioral therapy enhances learning and memory following traumatic brain injury | Q34441350 | ||
| CBP gene transfer increases BDNF levels and ameliorates learning and memory deficits in a mouse model of Alzheimer's disease | Q34450215 | ||
| The versatile functions of the transcriptional coactivators p300 and CBP and their roles in disease | Q34606655 | ||
| Curcumin: a potential neuroprotective agent in Parkinson's disease | Q34634749 | ||
| Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease | Q34763178 | ||
| CREBBP mutations in relapsed acute lymphoblastic leukaemia | Q34792792 | ||
| Experience-dependent epigenetic modifications in the central nervous system. | Q34954649 | ||
| Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP | Q34977966 | ||
| CBP-mediated acetylation of histone H3 lysine 27 antagonizes Drosophila Polycomb silencing. | Q34998982 | ||
| Hippocampal focal knockout of CBP affects specific histone modifications, long-term potentiation, and long-term memory | Q35112173 | ||
| Protective effects of valproic acid on the nigrostriatal dopamine system in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease | Q35385117 | ||
| A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genes | Q35612900 | ||
| Drosophila dCBP is involved in establishing the DNA replication checkpoint | Q35641689 | ||
| Increased EID1 nuclear translocation impairs synaptic plasticity and memory function associated with pathogenesis of Alzheimer's disease | Q35748624 | ||
| Alpha-synuclein: normal function and role in neurodegenerative diseases. | Q35749928 | ||
| The effects of ethanol on the developing cerebellum and eyeblink classical conditioning. | Q35949348 | ||
| P275 | copyright license | Creative Commons Attribution 2.5 Generic | Q18810333 |
| P433 | issue | 28 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | transcription factor | Q407384 |
| targeted therapy | Q492646 | ||
| neurodegeneration | Q1755122 | ||
| cell | Q7868 | ||
| cognitive disorder | Q3065932 | ||
| nerve tissue protein | Q6996861 | ||
| enzyme | Q8047 | ||
| nervous system | Q9404 | ||
| P5008 | on focus list of Wikimedia project | ScienceSource | Q55439927 |
| P304 | page(s) | 5051-5064 | |
| P577 | publication date | 2013-01-01 | |
| P1433 | published in | Current Pharmaceutical Design | Q5195068 |
| P1476 | title | Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders | |
| P478 | volume | 19 |
| Q38766912 | A Small Molecule Activator of p300/CBP Histone Acetyltransferase Promotes Survival and Neurite Growth in a Cellular Model of Parkinson's Disease. |
| Q43833014 | A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice. |
| Q47575767 | A role for histone acetylation mechanisms in adolescent alcohol exposure-induced deficits in hippocampal brain-derived neurotrophic factor expression and neurogenesis markers in adulthood |
| Q37249167 | Acetyltransferases (HATs) as targets for neurological therapeutics |
| Q28070096 | Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior |
| Q92237346 | CBP and SRF co-regulate dendritic growth and synaptic maturation |
| Q38815116 | CREB-binding protein regulates lung cancer growth by targeting MAPK and CPSF4 signaling pathway |
| Q39423291 | Chemical modulators for epigenome reader domains as emerging epigenetic therapies for cancer and inflammation |
| Q47128083 | Chemical probes and inhibitors of bromodomains outside the BET family |
| Q35112822 | Curcumin alleviates neuropathic pain by inhibiting p300/CBP histone acetyltransferase activity-regulated expression of BDNF and cox-2 in a rat model. |
| Q49949196 | Discovery of Spiro Oxazolidinediones as Selective, Orally Bioavailable Inhibitors of p300/CBP Histone Acetyltransferases |
| Q48701393 | Dissociable roles for histone acetyltransferases p300 and PCAF in hippocampus and perirhinal cortex-mediated object memory |
| Q35772931 | Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer's Disease |
| Q28088777 | Drosophila as an In Vivo Model for Human Neurodegenerative Disease |
| Q28077090 | Dysregulation of Acetylation Enzymes Inanimal Models of Psychostimulant use Disorders: Evolving Stories |
| Q90388893 | Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors |
| Q47423681 | Epigenetic Etiology of Intellectual Disability |
| Q30358152 | Epigenetic assays for chemical biology and drug discovery. |
| Q34323841 | Epigenetic memory: the Lamarckian brain |
| Q54765415 | Epigenetics, fragile X syndrome and transcriptional therapy. |
| Q97533922 | Expanding the phenotype associated to KMT2A variants: overlapping clinical signs between Wiedemann-Steiner and Rubinstein-Taybi syndromes |
| Q38246625 | Genetic findings in obsessive-compulsive disorder connect to brain-derived neutrophic factor and mammalian target of rapamycin pathways: implications for drug development |
| Q43690913 | Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease. |
| Q91655544 | Histone Acetyltransferase p300 Induces De Novo Super-Enhancers to Drive Cellular Senescence |
| Q35853603 | Histone acetylation inhibitors promote axon growth in adult dorsal root ganglia neurons |
| Q34683308 | Histone hyperacetylation up-regulates protein kinase Cδ in dopaminergic neurons to induce cell death: relevance to epigenetic mechanisms of neurodegeneration in Parkinson disease |
| Q27003952 | Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases |
| Q96134406 | Identification of lysine acetylome in cervical cancer by label-free quantitative proteomics |
| Q38363468 | Inhibition of different histone acetyltransferases (HATs) uncovers transcription-dependent and -independent acetylation-mediated mechanisms in memory formation |
| Q47869988 | Insights into intermolecular interactions, electrostatic properties and the stability of C646 in the binding pocket of p300 histone acetyltransferase enzyme: a combined molecular dynamics and charge density study |
| Q39376004 | Integration of Bioorthogonal Probes and Q-FRET for the Detection of Histone Acetyltransferase Activity |
| Q36812681 | Involvement of phosphorylated Apis mellifera CREB in gating a honeybee's behavioral response to an external stimulus |
| Q95660209 | KAT3-dependent acetylation of cell type-specific genes maintains neuronal identity in the adult mouse brain |
| Q90643583 | Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy |
| Q89459080 | MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways |
| Q60458527 | Modulating the masters: chemical tools to dissect CBP and p300 function |
| Q29247921 | Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases |
| Q33972484 | Molecular targets of chromatin repressive mark H3K9me3 in primate progenitor cells within adult neurogenic niches. |
| Q60924003 | Nutrient-Dependent Changes of Protein Palmitoylation: Impact on Nuclear Enzymes and Regulation of Gene Expression |
| Q30405868 | Prefrontal consolidation supports the attainment of fear memory accuracy |
| Q92450973 | Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy |
| Q55248558 | Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. |
| Q57054631 | Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator |
| Q91755231 | Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure |
| Q27026861 | Sirtuins in epigenetic regulation |
| Q38973220 | Spatial genome organization and cognition |
| Q40271872 | Structure-Activity Relationships on Cinnamoyl Derivatives as Inhibitors of p300 Histone Acetyltransferase. |
| Q58546879 | The Epigenetic Factor CBP Is Required for the Differentiation and Function of Medial Ganglionic Eminence-Derived Interneurons |
| Q64898882 | The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain. |
| Q35111862 | The epigenetic landscape of alcoholism |
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