Is histone acetylation the most important physiological function for CBP and p300?

scientific article

Is histone acetylation the most important physiological function for CBP and p300? is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.18632/AGING.100453
P932PMC publication ID3371760
P698PubMed publication ID22511639

P2093author name stringPaul K Brindle
David C Bedford
P2860cites workRole of CBP and SATB-1 in aging, dietary restriction, and insulin-like signalingQ21092726
Intrinsically unstructured proteins and their functionsQ22061731
TORCs: transducers of regulated CREB activityQ24297430
Individual CREB-target genes dictate usage of distinct cAMP-responsive coactivation mechanismsQ24306838
Conditional knockout mice reveal distinct functions for the global transcriptional coactivators CBP and p300 in T-cell developmentQ24537650
Discovery and prioritization of somatic mutations in diffuse large B-cell lymphoma (DLBCL) by whole-exome sequencingQ24612248
Histone H3K27ac separates active from poised enhancers and predicts developmental stateQ24628758
Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomasQ24629777
Frequent mutation of histone-modifying genes in non-Hodgkin lymphomaQ24630610
Global transcriptional coactivators CREB-binding protein and p300 are highly essential collectively but not individually in peripheral B cellsQ24685650
The structural basis of protein acetylation by the p300/CBP transcriptional coactivatorQ27649849
Lysine acetylation targets protein complexes and co-regulates major cellular functionsQ27860589
The role of chromatin during transcriptionQ27860995
CBP/p300 in cell growth, transformation, and developmentQ28140313
Extensive brain hemorrhage and embryonic lethality in a mouse null mutant of CREB-binding proteinQ28141517
CREB-binding protein and p300 in transcriptional regulationQ28209056
Structure of histone acetyltransferasesQ28211509
Histone variant H2A.Z is required for early mammalian developmentQ28214088
Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genesQ28255974
CBP histone acetyltransferase activity is a critical component of memory consolidationQ28267700
Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300Q28270979
The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detectorQ28285140
Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBPQ28295041
Distinct roles of GCN5/PCAF-mediated H3K9ac and CBP/p300-mediated H3K18/27ac in nuclear receptor transactivationQ28299905
Point mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- miceQ28593767
The CREB coactivator TORC2 is a key regulator of fasting glucose metabolismQ28594811
Redundant roles for histone H3 N-terminal lysine residues in subtelomeric gene repression in Saccharomyces cerevisiaeQ28768691
Inactivating mutations of acetyltransferase genes in B-cell lymphomaQ29031276
Control of inducible gene expression by signal-dependent transcriptional elongationQ39285490
Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation but does not affect cell viabilityQ39598834
Two transactivation mechanisms cooperate for the bulk of HIF-1-responsive gene expression.Q39705049
Tumors in Rubinstein-Taybi syndromeQ40523618
Defect of histone acetyltransferase activity of the nuclear transcriptional coactivator CBP in Rubinstein-Taybi syndromeQ40808976
Regulation of somatostatin gene transcription by cyclic adenosine monophosphateQ41081338
Regulation of gene transcription by the histone H2A N-terminal domainQ41895677
Double null cells reveal that CBP and p300 are dispensable for p53 targets p21 and Mdm2 but variably required for target genes of other signaling pathwaysQ42141606
A unifying model for the selective regulation of inducible transcription by CpG islands and nucleosome remodelingQ42252373
Increased insulin sensitivity despite lipodystrophy in Crebbp heterozygous miceQ43871563
Loss of CBP acetyltransferase activity by PHD finger mutations in Rubinstein-Taybi syndromeQ44302108
Insulin regulation of hepatic gluconeogenesis through phosphorylation of CREB-binding proteinQ44898066
Yeast histone H4 N-terminal sequence is required for promoter activation in vivoQ45268200
Metformin and insulin meet in a most atypical way.Q45985592
Mammalian gene expression program resiliency: the roles of multiple coactivator mechanisms in hypoxia-responsive transcriptionQ46853481
Histone H3 amino terminus is required for telomeric and silent mating locus repression in yeastQ46976676
Loss of CBP causes T cell lymphomagenesis in synergy with p27Kip1 insufficiency.Q48006079
Yeast histone H2B containing large amino terminus deletions can function in vivoQ48394496
Differential role for CBP and p300 CREB-binding domain in motor skill learning.Q52015251
Histone modification: cause or cog?Q52613857
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesisQ59098583
p300/CREB-binding protein interacts with ATR and is required for the DNA replication checkpointQ79710648
Lethality and centrality in protein networksQ29547267
A unique chromatin signature uncovers early developmental enhancers in humansQ29614327
CREB regulates hepatic gluconeogenesis through the coactivator PGC-1Q29615692
New nomenclature for chromatin-modifying enzymesQ29616425
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastomaQ29616862
Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutantsQ33370815
Rubinstein-Taybi syndrome. Review of 732 cases and analysis of the typical traitsQ33608737
Genome-wide views of chromatin structureQ33611702
Histone variant macroH2A1 deletion in mice causes female-specific steatosisQ33803202
Genomic characterization reveals a simple histone H4 acetylation code.Q33935027
Genetic heterogeneity in Rubinstein-Taybi syndrome: mutations in both the CBP and EP300 genes cause diseaseQ33942130
Histone deacetylase inhibitors enhance memory and synaptic plasticity via CREB:CBP-dependent transcriptional activationQ34077367
Substitutions in the amino-terminal tail of neurospora histone H3 have varied effects on DNA methylationQ34126327
The Aging Stress ResponseQ34144973
Extremely conserved histone H4 N terminus is dispensable for growth but essential for repressing the silent mating loci in yeastQ34164007
Chromatin acetylation, memory, and LTP are impaired in CBP+/- mice: a model for the cognitive deficit in Rubinstein-Taybi syndrome and its amelioration.Q34327866
Deciphering the roles of the histone H2B N-terminal domain in genome-wide transcriptionQ34717455
CREBBP mutations in relapsed acute lymphoblastic leukaemiaQ34792792
Epigenetic signatures distinguish multiple classes of enhancers with distinct cellular functionsQ35145499
Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic controlQ35185366
Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBPQ35185929
A transcription factor-binding domain of the coactivator CBP is essential for long-term memory and the expression of specific target genesQ35612900
Drosophila dCBP is involved in establishing the DNA replication checkpointQ35641689
Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPKQ35749976
p300/CBP and cancerQ35779695
Developmental changes in histone macroH2A1-mediated gene regulationQ35856757
Chromatin state signatures associated with tissue-specific gene expression and enhancer activity in the embryonic limbQ36021697
Abnormal skeletal patterning in embryos lacking a single Cbp allele: a partial similarity with Rubinstein-Taybi syndrome.Q36584466
Genetic and genomewide analysis of simultaneous mutations in acetylated and methylated lysine residues in histone H3 in Saccharomyces cerevisiaeQ37102604
Histone acetyltransferase CBP is vital to demarcate conventional and innate CD8+ T-cell developmentQ37247908
Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding proteinQ37417220
Target gene context influences the transcriptional requirement for the KAT3 family of CBP and p300 histone acetyltransferases.Q37683304
Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladderQ37730596
Truncated CBP protein leads to classical Rubinstein-Taybi syndrome phenotypes in mice: implications for a dominant-negative mechanismQ38328546
CBP/p300 double null cells reveal effect of coactivator level and diversity on CREB transactivationQ38340711
P433issue4
P921main subjecthistone acetylationQ14908264
P304page(s)247-255
P577publication date2012-04-01
P1433published inAgingQ2845875
P1476titleIs histone acetylation the most important physiological function for CBP and p300?
P478volume4

Reverse relations

cites work (P2860)
Q36094441Activation of Nrf2 contributes to the protective effect of Exendin-4 against angiotensin II-induced vascular smooth muscle cell senescence
Q38185355Bromodomains and their pharmacological inhibitors
Q47369126CREBBP and p300 lysine acetyl transferases in the DNA damage response
Q47746875Chemical Control of a CRISPR-Cas9 Acetyltransferase.
Q92696047Combination Targeting of the Bromodomain and Acetyltransferase Active Site of p300/CBP
Q47251689Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells
Q33671971Crebbp loss cooperates with Bcl2 overexpression to promote lymphoma in mice.
Q41939319DNA methylation pattern in overweight women under an energy-restricted diet supplemented with fish oil.
Q64082872DNA polymerase ι is acetylated in response to S2 alkylating agents
Q37423469Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor
Q28080288Deciphering the Epigenetic Code in Embryonic and Dental Pulp Stem Cells
Q45353204Degradation of CREB-binding protein and modulation of type I interferon induction by the zinc finger motif of the porcine reproductive and respiratory syndrome virus nsp1α subunit
Q93117000Discovery of novel CBP bromodomain inhibitors through TR-FRET-based high-throughput screening
Q47144438Dysregulation of Sirtuin 2 (SIRT2) and histone H3K18 acetylation pathways associates with adverse prostate cancer outcomes
Q50559758Early stress evokes dysregulation of histone modifiers in the medial prefrontal cortex across the life span.
Q91587544Epigenetic Programing of B-Cell Lymphoma by BCL6 and Its Genetic Deregulation
Q50588458Epigenetic Regulation of Memory-Therapeutic Potential for Disorders.
Q38046794Epigenetic alterations in hematopoietic malignancies
Q49738731Epigenetic control of microsomal prostaglandin E synthase-1 by HDAC-mediated recruitment of p300.
Q28536743Genetic interaction between mutations in c-Myb and the KIX domains of CBP and p300 affects multiple blood cell lineages and influences both gene activation and repression
Q34313018Genome-wide and single-cell analyses reveal a context dependent relationship between CBP recruitment and gene expression
Q43690913Genomic landscape of transcriptional and epigenetic dysregulation in early onset polyglutamine disease.
Q37197807Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition
Q42692796Insights into genotype-phenotype correlations from CREBBP point mutation screening in a cohort of 46 Rubinstein-Taybi syndrome patients
Q48248047Integrating genomic alterations in diffuse large B-cell lymphoma identifies new relevant pathways and potential therapeutic targets.
Q50645739Interlocked loops trigger lineage specification and stable fates in the Drosophila nervous system.
Q35932148KRAS and CREBBP mutations: a relapse-linked malicious liaison in childhood high hyperdiploid acute lymphoblastic leukemia
Q38692163Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP.
Q38085375Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders.
Q57298963Maternal obesity impairs skeletal development in adult offspring
Q58581275Novel Transcriptional Mechanisms for Regulating Metabolism by Thyroid Hormone
Q49896590P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-promoting Myofibroblasts.
Q36674365Phospho-ΔNp63α/microRNA feedback regulation in squamous carcinoma cells upon cisplatin exposure
Q27021749Protein lysine acetylation by p300/CBP
Q101354739Pseudorabies virus glycoprotein gE suppresses interferon-β production via CREB-binding protein degradation
Q92344797Role of Resveratrol and Selenium on Oxidative Stress and Expression of Antioxidant and Anti-Aging Genes in Immortalized Lymphocytes from Alzheimer's Disease Patients
Q99364934Selective inhibition of CBP/p300 HAT by A-485 results in suppression of lipogenesis and hepatic gluconeogenesis
Q37421692Shifting transcriptional machinery is required for long-term memory maintenance and modification in Drosophila mushroom bodies
Q39113316Stepwise acetyltransferase association and histone acetylation at the Myod1 locus during myogenic differentiation.
Q27685367Structure of the p300 catalytic core and implications for chromatin targeting and HAT regulation
Q52868803Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation.
Q40101973Suppression of type I interferon production by porcine epidemic diarrhea virus and degradation of CREB-binding protein by nsp1.
Q28593879T-cells null for the MED23 subunit of mediator express decreased levels of KLF2 and inefficiently populate the peripheral lymphoid organs
Q92641642TNF-α inhibits glucocorticoid receptor-induced gene expression by reshaping the GR nuclear cofactor profile
Q63383561Time-Resolved Analysis Reveals Rapid Dynamics and Broad Scope of the CBP/p300 Acetylome
Q34037768Transcription coactivators p300 and CBP are necessary for photoreceptor-specific chromatin organization and gene expression
Q57464876Transcription factor dimerization activates the p300 acetyltransferase

Search more.