The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice

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The Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1155307J
P356DOI10.1371/JOURNAL.PONE.0155307
P932PMC publication ID4865084
P698PubMed publication ID27171180

P50authorBram GeenenQ56921744
P2093author name stringAmanda J Kiliaan
Diane Jansen
Carola I F Janssen
Martina P C Mutsaers
Monique T Mulder
Pieter J W C Dederen
P2860cites workAR, apoE, and cognitive functionQ24646534
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Severe learning deficits in apolipoprotein E-knockout mice in a water maze task.Q48759623
Apolipoprotein E4 enhances brain inflammation by modulation of the NF-kappaB signaling cascadeQ48832930
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Apolipoprotein E protects against neuropathology induced by a high-fat diet and maintains the integrity of the blood-brain barrier during agingQ49239959
Altered endocannabinoid signalling after a high-fat diet in Apoe(-/-) mice: relevance to adipose tissue inflammation, hepatic steatosis and insulin resistance.Q51369429
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Apolipoprotein E exhibits isoform-specific promotion of lipid efflux from astrocytes and neurons in cultureQ73491113
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Isoform-specific effects of human apolipoprotein E on brain function revealed in ApoE knockout mice: increased susceptibility of femalesQ33563135
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Human apolipoprotein E ɛ4 expression impairs cerebral vascularization and blood-brain barrier function in miceQ34976193
Sex Differences in Presynaptic Density and Neurogenesis in Middle-Aged ApoE4 and ApoE Knockout MiceQ35623424
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A High-Fat Diet Causes Impairment in Hippocampal Memory and Sex-Dependent Alterations in Peripheral MetabolismQ36447187
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Update on hypertension and Alzheimer's diseaseQ36582774
Generation of mice carrying a mutant apolipoprotein E gene inactivated by gene targeting in embryonic stem cellsQ37011453
Low cerebral blood flow is associated with lower memory function in metabolic syndromeQ37093208
Immune effector mechanisms implicated in atherosclerosis: from mice to humansQ37150605
Western-type diet modulates inflammatory responses and impairs functional outcome following permanent middle cerebral artery occlusion in aged mice expressing the human apolipoprotein E4 alleleQ37153326
Does vascular pathology contribute to Alzheimer changes?Q38033859
Apolipoprotein E, amyloid-beta, and neuroinflammation in Alzheimer's diseaseQ38197948
A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learningQ38287648
Cumulative effects of the ApoE genotype and gender on the synaptic proteome and oxidative stress in the mouse brain.Q39196057
Reversal of cognitive deficit of apolipoprotein E knockout mice after repeated exposure to a common environmental experienceQ42513784
Impact of a multi-nutrient diet on cognition, brain metabolism, hemodynamics, and plasticity in apoE4 carrier and apoE knockout miceQ42607789
Putting cholesterol in its place: apoE and reverse cholesterol transportQ42824183
Differential effect of corticosterone on spatial learning abilities in apolipoprotein E knockout and C57BL/6J miceQ44182865
Increased corticosterone secretion and early-onset of cognitive decline in female apolipoprotein E-knockout mice.Q44698537
Differential effects of apolipoproteins E3 and E4 on neuronal growth in vitroQ45081026
Absence of ApoE upregulates murine brain ApoD and ABCA1 levels, but does not affect brain sterol levels, while human ApoE3 and human ApoE4 upregulate brain cholesterol precursor levels.Q45936545
Sex, apolipoprotein E epsilon 4 status, and hippocampal volume in mild cognitive impairmentQ46819942
Implication of apoE isoforms in cholesterol metabolism by primary rat hippocampal neurons and astrocytesQ46866662
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectneuroplasticityQ849491
knockout mouseQ1364740
P304page(s)e0155307
P577publication date2016-05-12
P1433published inPLOS OneQ564954
P1476titleThe Effect of a High-Fat Diet on Brain Plasticity, Inflammation and Cognition in Female ApoE4-Knockin and ApoE-Knockout Mice
P478volume11

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