Rapid Acquisition of Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus: Role of Hypermutation and Homologous Recombination

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Rapid Acquisition of Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus: Role of Hypermutation and Homologous Recombination is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1155512I
P356DOI10.1371/JOURNAL.PONE.0155512
P932PMC publication ID4868352
P698PubMed publication ID27182700

P50authorKeiichi HiramatsuQ106083013
P2093author name stringKen Kikuchi
Tomonori Mizutani
Shigekazu Iguchi
P2860cites workThe RecQ DNA Helicases in DNA RepairQ24561510
Whole genome sequencing of meticillin-resistant Staphylococcus aureusQ28202807
Complete genome sequence of USA300, an epidemic clone of community-acquired meticillin-resistant Staphylococcus aureusQ28300379
In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agentsQ28379204
Single and dual mutations at positions 2058, 2503 and 2504 of 23S rRNA and their relationship to resistance to antibiotics that target the large ribosomal subunit.Q54358724
The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria.Q54441462
Genetic analysis of Bacillus subtilis mutator genesQ78666892
Evolution of paralogous genes: Reconstruction of genome rearrangements through comparison of multiple genomes within Staphylococcus aureusQ83117331
Genome sequence of Staphylococcus aureus strain Newman and comparative analysis of staphylococcal genomes: polymorphism and evolution of two major pathogenicity islandsQ28493270
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Novel mechanism of resistance to oxazolidinones, macrolides, and chloramphenicol in ribosomal protein L4 of the pneumococcusQ33938088
Linezolid: the first oxazolidinone antimicrobialQ34170643
Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistanceQ34289995
DNA end resection controls the balance between homologous and illegitimate recombination in Escherichia coliQ34312102
Emergence of linezolid-resistant Staphylococcus aureus after prolonged treatment of cystic fibrosis patients in Cleveland, OhioQ34737606
Reporter metabolite analysis of transcriptional profiles of a Staphylococcus aureus strain with normal phenotype and its isogenic hemB mutant displaying the small-colony-variant phenotypeQ35130278
Identifying mutator phenotypes among fluoroquinolone-resistant strains of Streptococcus pneumoniae using fluctuation analysis.Q36094891
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The multifaceted mismatch-repair systemQ36448284
Hypermutable bacteria isolated from humans--a critical analysisQ36583214
Collaborating functions of BLM and DNA topoisomerase I in regulating human rDNA transcriptionQ36794626
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Hypermutation and the preexistence of antibiotic-resistant Pseudomonas aeruginosa mutants: implications for susceptibility testing and treatment of chronic infectionsQ37598703
Bacterial hypermutation in cystic fibrosis, not only for antibiotic resistanceQ37794342
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The emerging problem of linezolid-resistant StaphylococcusQ38040775
The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolatesQ38898519
Recombination Proficiency Influences Frequency and Locus of Mutational Resistance to Linezolid in Enterococcus faecalisQ39913327
Genetic adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutationQ41366386
Influence of recombination on development of mutational resistance to linezolid in Enterococcus faecalis JH2-2.Q41853120
Mutations in ribosomal protein L3 are associated with oxazolidinone resistance in staphylococci of clinical origin.Q41897387
Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).Q42024058
Distribution of florfenicol resistance genes fexA and cfr among chloramphenicol-resistant Staphylococcus isolatesQ42106186
Elevated Linezolid Resistance in Clinical cfr -Positive Staphylococcus aureus Isolates Is Associated with Co-Occurring Mutations in Ribosomal Protein L3Q42363575
Selection for high-level telithromycin resistance in Staphylococcus aureus yields mutants resulting from an rplB-to-rplV gene conversion-like eventQ43063841
Acquisition of a natural resistance gene renders a clinical strain of methicillin-resistant Staphylococcus aureus resistant to the synthetic antibiotic linezolidQ43092355
Linezolid resistance in a clinical isolate of Staphylococcus aureusQ43690311
Linezolid resistance in Staphylococcus aureus: characterization and stability of resistant phenotypeQ44226632
Linezolid resistance in sequential Staphylococcus aureus isolates associated with a T2500A mutation in the 23S rRNA gene and loss of a single copy of rRNA.Q44951049
Spontaneous mutators in bacteria: insights into pathways of mutagenesis and repairQ46617407
Typing of Staphylococcus aureus strains by PCR-amplification of variable-length 16S-23S rDNA spacer regions: characterization of spacer sequencesQ48073869
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectStaphylococcus aureusQ188121
linezolidQ411377
methicillin-resistant Staphylococcus aureusQ595158
P304page(s)e0155512
P577publication date2016-05-16
P1433published inPLOS OneQ564954
P1476titleRapid Acquisition of Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus: Role of Hypermutation and Homologous Recombination
P478volume11

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cites work (P2860)
Q40230898Adaptive tuning of mutation rates allows fast response to lethal stress in Escherichia coli
Q100635733Characterization of compound A, a novel lincomycin derivative active against methicillin-resistant Staphylococcus aureus
Q40053813Diabetic foot infection: Antibiotic therapy and good practice recommendations.
Q57052032Emergence and within-host genetic evolution of methicillin-resistant resistant to linezolid in a cystic fibrosis patient

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