The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates

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The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.01395-07
P932PMC publication ID2415776
P698PubMed publication ID18378706

P50authorPeter KraiczyQ104975407
Barbara C. KahlQ41674855
P2093author name stringThomas A Wichelhaus
Volker Brade
Silke Besier
Johannes Zander
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Persistent infection with small colony variant strains of Staphylococcus aureus in patients with cystic fibrosisQ74422423
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Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureusQ80107472
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Distribution of genes encoding resistance to macrolides, lincosamides, and streptogramins among staphylococciQ33976201
Clinical isolates of Staphylococcus aureus with ribosomal mutations conferring resistance to macrolidesQ34112287
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Stage-specific adaptation of hypermutable Pseudomonas aeruginosa isolates during chronic pulmonary infection in patients with cystic fibrosisQ34588476
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Population dynamics of persistent Staphylococcus aureus isolated from the airways of cystic fibrosis patients during a 6-year prospective studyQ35922391
Mutations in the DNA mismatch repair proteins MutS and MutL of oxazolidinone-resistant or -susceptible Enterococcus faeciumQ36048384
Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infectionsQ36422855
DNA mismatch repair system. Classical and fresh rolesQ36453321
Hypermutable bacteria isolated from humans--a critical analysisQ36583214
Prevalence of thymidine-dependent Staphylococcus aureus in patients with cystic fibrosisQ37215494
Dynamics of long-term colonization of respiratory tract by Haemophilus influenzae in cystic fibrosis patients shows a marked increase in hypermutable strainsQ37421041
Bacillus subtilis mutS mutL operon: identification, nucleotide sequence and mutagenesisQ38354717
Dominant negative mutator mutations in the mutL gene of Escherichia coliQ39716760
Thymidine-dependent small-colony variants of Staphylococcus aureus exhibit gross morphological and ultrastructural changes consistent with impaired cell separationQ39732905
Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureusQ40030687
Emergence of phenotypic variants upon mismatch repair disruption in Pseudomonas aeruginosaQ40557981
Prognosis in cystic fibrosis.Q41638180
Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammationQ41825397
In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureusQ41911383
Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infectionsQ41974061
Inactivation of the mismatch repair system in Pseudomonas aeruginosa attenuates virulence but favors persistence of oropharyngeal colonization in cystic fibrosis mice.Q42560500
Role of mutS and mutL genes in hypermutability and recombination in Staphylococcus aureusQ42754912
High Rate of Macrolide Resistance inStaphylococcus aureusStrains from Patients with Cystic Fibrosis Reveals High Proportions of Hypermutable StrainsQ44195004
Multiresistant pulmonary infection in cystic fibrosis--prevention is better than cureQ44600593
Analysis of the quaternary structure of the MutL C-terminal domainQ46604277
Spontaneous mutators in bacteria: insights into pathways of mutagenesis and repairQ46617407
High mutation frequencies among Escherichia coli and Salmonella pathogensQ48057867
Fatal outcome of lung transplantation in cystic fibrosis patients due to small-colony variants of the Burkholderia cepacia complex.Q51678317
Mutations are involved in emergence of aminoglycoside-induced small colony variants of Staphylococcus aureus.Q51715244
Insertional inactivation of mutS in Staphylococcus aureus reveals potential for elevated mutation frequencies, although the prevalence of mutators in clinical isolates is low.Q52861291
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectStaphylococcus aureusQ188121
antibiotic resistanceQ380775
P304page(s)2183-2189
P577publication date2008-03-31
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleThe thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates
P478volume52

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cites work (P2860)
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