Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections

scientific article published on August 2005

Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections is …
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scholarly articleQ13442814

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P356DOI10.1128/AAC.49.8.3382-3386.2005
P932PMC publication ID1196247
P698PubMed publication ID16048951

P2093author name stringJaume Sauleda
Antonio Oliver
María D Maciá
José L Pérez
Bernat Togores
David Blanquer
P2860cites workCosts and Benefits of High Mutation Rates: Adaptive Evolution of Bacteria in the Mouse GutQ56944626
Highly Variable Mutation Rates in Commensal and Pathogenic Escherichia coliQ56944671
Small-Colony Variants of Pseudomonas aeruginosa in Cystic FibrosisQ57542653
Epidemiology Of Chronic Pseudomonas aeruginosa Infections In Cystic FibrosisQ59334968
Pulsed-Field Gel ElectrophoresisQ59509098
Role of chronic Pseudomonas aeruginosa infection in the development of bronchiectasisQ67574773
Computed tomography of bronchiectasisQ70403810
Bronchiectasis: comparison of preoperative thin-section CT and pathologic findings in resected specimensQ72246081
Association between airway bacterial load and markers of airway inflammation in patients with stable chronic bronchitisQ74341827
Hypermutation as a Factor Contributing to the Acquisition of Antimicrobial ResistanceQ79162727
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogenQ22122393
The mismatch repair system (mutS, mutL and uvrD genes) in Pseudomonas aeruginosa: molecular characterization of naturally occurring mutantsQ28492576
Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typingQ29614699
Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paperQ29614960
Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepaciaQ29615286
Lung infections associated with cystic fibrosisQ30080000
Escherichia coli mutator genesQ33539352
Epidemiological analysis of sequential Pseudomonas aeruginosa isolates from chronic bronchiectasis patients without cystic fibrosisQ33961155
Mutator clones of Neisseria meningitidis in epidemic serogroup A diseaseQ34028018
Evolution of high mutation rates in experimental populations of E. coliQ34429727
High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection.Q34508854
Nosocomial infections in adult intensive-care unitsQ35157647
The role of mutators in the emergence of antibiotic-resistant bacteriaQ35177659
Pathophysiology and Management of Pulmonary Infections in Cystic FibrosisQ35557791
Pseudomonal infections in patients with COPD: epidemiology and managementQ35627613
Genome macrorestriction analysis of sequential Pseudomonas aeruginosa isolates from bronchiectasis patients without cystic fibrosisQ36528124
Dynamics of long-term colonization of respiratory tract by Haemophilus influenzae in cystic fibrosis patients shows a marked increase in hypermutable strainsQ37421041
Hypermutation and the preexistence of antibiotic-resistant Pseudomonas aeruginosa mutants: implications for susceptibility testing and treatment of chronic infectionsQ37598703
Lack of association between hypermutation and antibiotic resistance development in Pseudomonas aeruginosa isolates from intensive care unit patientsQ39955018
Clinical, pathophysiologic, and microbiologic characterization of bronchiectasis in an aging cohortQ40412050
Development of resistance during antimicrobial therapy: a review of antibiotic classes and patient characteristics in 173 studiesQ40477935
Transformation of Pseudomonas aeruginosa by electroporationQ40540293
Emergence of phenotypic variants upon mismatch repair disruption in Pseudomonas aeruginosaQ40557981
Detection and susceptibility testing of hypermutable Pseudomonas aeruginosa strains with the Etest and disk diffusionQ40968218
Antimicrobial susceptibility of Pseudomonas aeruginosa: results of a UK survey and evaluation of the British Society for Antimicrobial Chemotherapy disc susceptibility testQ43627836
Effect of inhaled tobramycin on early Pseudomonas aeruginosa colonisation in patients with cystic fibrosisQ43754593
Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?Q43874264
High Rate of Macrolide Resistance inStaphylococcus aureusStrains from Patients with Cystic Fibrosis Reveals High Proportions of Hypermutable StrainsQ44195004
Spontaneous mutators in bacteria: insights into pathways of mutagenesis and repairQ46617407
High mutation frequencies among Escherichia coli and Salmonella pathogensQ48057867
Effect of sputum bacteriology on the quality of life of patients with bronchiectasis.Q53592119
Efficacy of aerosolized tobramycin in patients with cystic fibrosis.Q54237890
Role of mutator alleles in adaptive evolution.Q54564129
Lung function in bronchiectasis: the influence of Pseudomonas aeruginosa.Q55066725
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectPseudomonas aeruginosaQ31856
P304page(s)3382-3386
P577publication date2005-08-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleHypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections
P478volume49

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