Mucoidy, quorum sensing, mismatch repair and antibiotic resistance in Pseudomonas aeruginosa from cystic fibrosis chronic airways infections

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Mucoidy, quorum sensing, mismatch repair and antibiotic resistance in Pseudomonas aeruginosa from cystic fibrosis chronic airways infections is …
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scholarly articleQ13442814

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P819ADS bibcode2010PLoSO...512669F
P356DOI10.1371/JOURNAL.PONE.0012669
P932PMC publication ID2937033
P698PubMed publication ID20844762
P5875ResearchGate publication ID46282121

P50authorJose Luis BoccoQ37838190
P2093author name stringCarlos E Argaraña
Patricia Montanaro
Adela M Luján
Alejandro J Moyano
Andrea M Smania
Claudia Sola
Liliana Fernández Canigia
Sofía Feliziani
P2860cites workCrystal structures of mismatch repair protein MutS and its complex with a substrate DNAQ27627633
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Quorum-sensing-deficient (lasR) mutants emerge at high frequency from a Pseudomonas aeruginosa mutS strain.Q52575837
MutS deficiency and activity of the error-prone DNA polymerase IV are crucial for determining mucA as the main target for mucoid conversion in Pseudomonas aeruginosa.Q52579021
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Sequence variability and functional analysis of MutS of hypermutable Pseudomonas aeruginosa cystic fibrosis isolatesQ82856564
Effect of mutator P. aeruginosa on antibiotic resistance acquisition and respiratory function in cystic fibrosisQ84219534
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High frequency of hypermutable Pseudomonas aeruginosa in cystic fibrosis lung infection.Q34508854
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Genetic diversity of Pseudomonas aeruginosa strains isolated from patients with cystic fibrosis revealed by restriction fragment length polymorphism of the rRNA gene regionQ36522578
Mechanism of conversion to mucoidy in Pseudomonas aeruginosa infecting cystic fibrosis patientsQ36528781
Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosaQ36933558
Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression.Q37074619
Pseudomonas aeruginosa isolates from patients with cystic fibrosis: a class of serum-sensitive, nontypable strains deficient in lipopolysaccharide O side chainsQ37103851
Growth phenotypes of Pseudomonas aeruginosa lasR mutants adapted to the airways of cystic fibrosis patientsQ37342706
Hypermutation and the preexistence of antibiotic-resistant Pseudomonas aeruginosa mutants: implications for susceptibility testing and treatment of chronic infectionsQ37598703
Use of the rpoB gene to determine the specificity of base substitution mutations on the Escherichia coli chromosomeQ38355288
Vanadate inhibits the ATPase activity and DNA binding capability of bacterial MutS. A structural model for the vanadate-MutS interaction at the Walker A motifQ38361436
Achieving 100% typeability of Pseudomonas aeruginosa by pulsed-field gel electrophoresisQ39468249
Mucoid Pseudomonas aeruginosa and cystic fibrosis: resistance of the mucoid form to carbenicillin, flucloxacillin and tobramycin and the isolation of mucoid variants in vitroQ39607438
Contribution of the MexXY Multidrug Transporter to Aminoglycoside Resistance in Pseudomonas aeruginosa Clinical IsolatesQ39913368
A major Pseudomonas aeruginosa clone common to patients and aquatic habitatsQ39915020
Lack of association between hypermutation and antibiotic resistance development in Pseudomonas aeruginosa isolates from intensive care unit patientsQ39955018
Auxotrophic variants of Pseudomonas aeruginosa are selected from prototrophic wild-type strains in respiratory infections in patients with cystic fibrosis.Q40006567
Flagella and motility alterations in Pseudomonas aeruginosa strains from patients with cystic fibrosis: relationship to patient clinical conditionQ40170508
Emergence of phenotypic variants upon mismatch repair disruption in Pseudomonas aeruginosaQ40557981
Detection and susceptibility testing of hypermutable Pseudomonas aeruginosa strains with the Etest and disk diffusionQ40968218
Genetic adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutationQ41366386
Occurrence of hypermutable Pseudomonas aeruginosa in cystic fibrosis patients is associated with the oxidative stress caused by chronic lung inflammationQ41825397
Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.Q41937031
Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infectionsQ41974061
Fidelity of replication of repetitive DNA in mutS and repair proficient Escherichia coliQ42644527
Pseudomonas aeruginosa MutL protein functions in Escherichia coliQ42932258
Genetic adaptation of Pseudomonas aeruginosa during chronic lung infection of patients with cystic fibrosis: strong and weak mutators with heterogeneous genetic backgrounds emerge in mucA and/or lasR mutantsQ43216787
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectPseudomonas aeruginosaQ31856
DNA mismatch repairQ2984243
cystic fibrosisQ178194
antibiotic resistanceQ380775
quorum sensingQ905754
P304page(s)e815
P577publication date2010-09-10
P1433published inPLOS OneQ564954
P1476titleMucoidy, quorum sensing, mismatch repair and antibiotic resistance in Pseudomonas aeruginosa from cystic fibrosis chronic airways infections
P478volume5

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cites work (P2860)
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