Optimization of a meropenem plus tobramycin combination dosage regimen against hypermutable and non-hypermutable Pseudomonas aeruginosa via mechanism-based modeling and the hollow-fiber infection model.

scientific article published on 5 February 2018

Optimization of a meropenem plus tobramycin combination dosage regimen against hypermutable and non-hypermutable Pseudomonas aeruginosa via mechanism-based modeling and the hollow-fiber infection model. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/AAC.02055-17
P932PMC publication ID5913933
P698PubMed publication ID29437610

P50authorBeom Soo ShinQ48508209
Juergen BulittaQ52063271
Cornelia Barbara LandersdorferQ56769943
Rajbharan YadavQ57423359
Roger L NationQ58329346
Vanessa E ReesQ60621528
Antonio OliverQ87773226
Phillip J BergenQ104482981
John D. BoyceQ37376174
Anton Y. PelegQ42220362
P2093author name stringTae Hwan Kim
Soon-Ee Cheah
Kate E Rogers
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Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosaQ36933558
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Mutators in cystic fibrosis chronic lung infection: Prevalence, mechanisms, and consequences for antimicrobial therapyQ37788421
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Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspectiveQ38059441
Substantial Impact of Altered Pharmacokinetics in Critically Ill Patients on the Antibacterial Effects of Meropenem Evaluated via the Dynamic Hollow-Fiber Infection ModelQ40306198
Pharmacodynamics of β-lactamase inhibition by NXL104 in combination with ceftaroline: examining organisms with multiple types of β-lactamasesQ40325943
Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patienQ40470332
Development of resistance during antimicrobial therapy: a review of antibiotic classes and patient characteristics in 173 studiesQ40477935
Polymyxin B in combination with doripenem against heteroresistant Acinetobacter baumannii: pharmacodynamics of new dosing strategiesQ40587067
Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling.Q40657200
Continuous-infusion antipseudomonal Beta-lactam therapy in patients with cystic fibrosisQ41063056
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Development of a new pre- and post-processing tool (SADAPT-TRAN) for nonlinear mixed-effects modeling in S-ADAPT.Q41987074
Performance and robustness of the Monte Carlo importance sampling algorithm using parallelized S-ADAPT for basic and complex mechanistic models.Q42143847
Comparative antibiotic dose-effect relations at several dosing intervals in murine pneumonitis and thigh-infection modelsQ42169493
Resistance suppression by high-intensity, short-duration aminoglycoside exposure against hypermutable and non-hypermutable Pseudomonas aeruginosaQ42717931
Suboptimal ciprofloxacin dosing as a potential cause of decreased Pseudomonas aeruginosa susceptibility in children with cystic fibrosisQ42790860
Development and qualification of a pharmacodynamic model for the pronounced inoculum effect of ceftazidime against Pseudomonas aeruginosaQ43215544
A survey of the utilization of anti-pseudomonal beta-lactam therapy in cystic fibrosis patientsQ43425473
Pharmacokinetics of high-dose meropenem in adult cystic fibrosis patientsQ43578365
Multiple mechanisms of antimicrobial resistance in Pseudomonas aeruginosa: our worst nightmare?Q43874264
Mathematical modelling response of Pseudomonas aeruginosa to meropenemQ43967705
Meropenem dosing in critically ill patients with sepsis and without renal dysfunction: intermittent bolus versus continuous administration? Monte Carlo dosing simulations and subcutaneous tissue distribution.Q46034494
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectPseudomonas aeruginosaQ31856
meropenemQ421670
P577publication date2018-03-27
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleOptimization of a Meropenem-Tobramycin Combination Dosage Regimen against Hypermutable and Nonhypermutable Pseudomonas aeruginosa via Mechanism-Based Modeling and the Hollow-Fiber Infection Model
P478volume62

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cites work (P2860)
Q57240383Four Decades of β-Lactam Antibiotic Pharmacokinetics in Cystic Fibrosis
Q92127147Generating Robust and Informative Nonclinical In Vitro and In Vivo Bacterial Infection Model Efficacy Data To Support Translation to Humans
Q58164270Meropenem Combined with Ciprofloxacin Combats Hypermutable Pseudomonas aeruginosa from Respiratory Infections of Cystic Fibrosis Patients
Q57169588Meropenem combined with ciprofloxacin combats hypermutable from respiratory infections of cystic fibrosis patients
Q92620539Pharmacodynamic Drug-Drug Interactions
Q92707838Synergistic Meropenem-Tobramycin Combination Dosage Regimens against Clinical Hypermutable Pseudomonas aeruginosa at Simulated Epithelial Lining Fluid Concentrations in a Dynamic Biofilm Model

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