Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Induced by Trimethoprim-Sulfamethoxazole (SXT) and Have Increased Fitness during SXT Challenge

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Thymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Induced by Trimethoprim-Sulfamethoxazole (SXT) and Have Increased Fitness during SXT Challenge is …
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scholarly articleQ13442814

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P356DOI10.1128/AAC.00742-15
P932PMC publication ID4649163
P698PubMed publication ID26369968

P50authorKarsten BeckerQ39501983
Barbara C. KahlQ41674855
Alessandra BragonziQ43269735
Nicola Ivan LorèQ57630158
Georg PetersQ64010237
P2093author name stringRichard A Proctor
Andre Kriegeskorte
Camilla Riva
Marco Kelkenberg
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Inactivation of thyA in Staphylococcus aureus attenuates virulence and has a strong impact on metabolism and virulence gene expression.Q34026284
Nonmucoid Pseudomonas aeruginosa expresses alginate in the lungs of patients with cystic fibrosis and in a mouse model.Q34232085
sigmaB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4.Q34319176
Randomized, controlled trial of antibiotics in the management of community-acquired skin abscesses in the pediatric patient.Q34978780
Prevalence and clinical significance of Staphylococcus aureus small-colony variants in cystic fibrosis lung diseaseQ35690337
Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infectionQ36090341
Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infectionsQ36422855
Thymidine-dependent Staphylococcus aureus small-colony variants: human pathogens that are relevant not only in cases of cystic fibrosis lung diseaseQ36957900
Role of folate antagonists in the treatment of methicillin-resistant Staphylococcus aureus infectionQ37058032
Prevalence of thymidine-dependent Staphylococcus aureus in patients with cystic fibrosisQ37215494
Staphylococcus aureus small-colony variants are independently associated with worse lung disease in children with cystic fibrosisQ37463364
Randomized controlled trial of trimethoprim-sulfamethoxazole for uncomplicated skin abscesses in patients at risk for community-associated methicillin-resistant Staphylococcus aureus infectionQ37719880
Antimicrobial resistance: Not community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA)! A clinician's guide to community MRSA - its evolving antimicrobial resistance and implications for therapyQ37819539
The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolatesQ38898519
Thymidine-dependent small-colony variants of Staphylococcus aureus exhibit gross morphological and ultrastructural changes consistent with impaired cell separationQ39732905
Influence of dTMP on the phenotypic appearance and intracellular persistence of Staphylococcus aureusQ40030687
Growth characteristics of group A streptococci in a new chemically defined mediumQ41155677
In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureusQ41911383
Antibiotic susceptibility survey of blood-borne MRSA isolates in Japan from 2008 through 2011.Q42204317
Thymidine-dependent Staphylococcus aureus small-colony variants are associated with extensive alterations in regulator and virulence gene expression profilesQ42587250
Enhanced post-stationary-phase survival of a clinical thymidine-dependent small-colony variant of Staphylococcus aureus results from lack of a functional tricarboxylic acid cycleQ42845429
Anti-CD3 antibody decreases inflammation and improves outcome in a murine model of Pneumocystis pneumoniaQ42948319
Molecular epidemiology and antimicrobial susceptibility profiles of methicillin-resistant Staphylococcus aureus blood culture isolates: results of the Quebec Provincial Surveillance ProgrammeQ43942393
Clinical trial: comparative effectiveness of cephalexin plus trimethoprim-sulfamethoxazole versus cephalexin alone for treatment of uncomplicated cellulitis: a randomized controlled trialQ45247343
Prevalence and genetic diversity of Staphylococcus aureus small-colony variants in cystic fibrosis patientsQ48689549
Treatment of Skin and Soft Tissue Infections Due to Community-Associated Methicillin-Resistant Staphylococcus aureus in Europe: The Role of Trimethoprim-sulfamethoxazoleQ57849011
Antibiotic pressure compensates the biological cost associated with Pseudomonas aeruginosa hypermutable phenotypes in vitro and in a murine model of chronic airways infectionQ61477464
Pseudomonas aeruginosaMicroevolution during Cystic Fibrosis Lung Infection Establishes Clones with Adapted VirulenceQ61477540
Biological cost of hypermutation in Pseudomonas aeruginosa strains from patients with cystic fibrosisQ61477562
Persistent infection with small colony variant strains of Staphylococcus aureus in patients with cystic fibrosisQ74422423
National survey of molecular epidemiology of Staphylococcus aureus colonization in Belgian cystic fibrosis patientsQ79886453
Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureusQ80107472
Comparison of Staphylococcus aureus from skin and soft-tissue infections in US emergency department patients, 2004 and 2008Q84402006
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectStaphylococcus aureusQ188121
P304page(s)7265-7272
P577publication date2015-09-14
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleThymidine-Dependent Staphylococcus aureus Small-Colony Variants Are Induced by Trimethoprim-Sulfamethoxazole (SXT) and Have Increased Fitness during SXT Challenge
P478volume59

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