Intra-Arterially Delivered Mesenchymal Stem Cells Are Not Detected in the Brain Parenchyma in an Alzheimer's Disease Mouse Model

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Intra-Arterially Delivered Mesenchymal Stem Cells Are Not Detected in the Brain Parenchyma in an Alzheimer's Disease Mouse Model is …
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scholarly articleQ13442814

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P819ADS bibcode2016PLoSO..1155912L
P356DOI10.1371/JOURNAL.PONE.0155912
P932PMC publication ID4874686
P698PubMed publication ID27203695

P50authorWonil OhQ50617251
Duk Lyul NaQ92140074
Soo Jin ChoiQ96194661
Jong Wook ChangQ101239049
P2093author name stringEun Hyuk Chang
Na Kyung Lee
Jehoon Yang
Jeongmin Lee
Sang Eon Park
P2860cites workRapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assaysQ25939005
Noninvasive and transient blood-brain barrier opening in the hippocampus of Alzheimer's double transgenic mice using focused ultrasoundQ30443217
Mouse heart rate in a human: diagnostic mystery of an extreme tachyarrhythmia.Q33161016
Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemiaQ33322707
Efficacy and dose-dependent safety of intra-arterial delivery of mesenchymal stem cells in a rodent stroke modelQ33577748
Drugs for Alzheimer's disease: are they effective?Q33865325
A randomized trial of mesenchymal stem cells in multiple system atrophy.Q34290126
The MSC: an injury drugstoreQ35130445
The cerebral embolism evoked by intra-arterial delivery of allogeneic bone marrow mesenchymal stem cells in rats is related to cell dose and infusion velocityQ35631025
Intra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats: Analyses of Therapeutic Time Window and Its MechanismsQ35663793
Soluble intracellular adhesion molecule-1 secreted by human umbilical cord blood-derived mesenchymal stem cell reduces amyloid-β plaquesQ35840532
Mesenchymal stem cells stabilize the blood-brain barrier through regulation of astrocytesQ36107139
GDF-15 secreted from human umbilical cord blood mesenchymal stem cells delivered through the cerebrospinal fluid promotes hippocampal neurogenesis and synaptic activity in an Alzheimer's disease modelQ36139553
Umbilical cord blood mesenchymal stem cells protect amyloid-β42 neurotoxicity via paracrineQ36507936
BLOOD FLOW IN THE CIRCLE OF WILLIS: MODELING AND CALIBRATIONQ36984195
A novel method for efficient delivery of stem cells to the ischemic brainQ37372190
Implications of the immunoregulatory functions of mesenchymal stem cells in the treatment of human liver diseasesQ37729256
Characterization, in vitro cytotoxicity assessment, and in vivo visualization of multimodal, RITC-labeled, silica-coated magnetic nanoparticles for labeling human cord blood-derived mesenchymal stem cellsQ38492876
Distribution of human umbilical cord blood-derived mesenchymal stem cells in the Alzheimer's disease transgenic mouse after a single intravenous injectionQ38922350
MSCs: Delivery Routes and Engraftment, Cell-Targeting Strategies, and Immune ModulationQ39356606
Development and in vivo imaging of a PET/MRI nanoprobe with enhanced NIR fluorescence by dye encapsulationQ39427154
Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats.Q41522029
The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer's disease.Q45377927
Biodistribution of bone marrow mononuclear cells after intra-arterial or intravenous transplantation in subacute stroke patients.Q46265702
Mannitol enhances therapeutic effects of intra-arterial transplantation of mesenchymal stem cells into the brain after traumatic brain injuryQ46802118
Altered cerebral vascular volumes and solute transport at the blood-brain barriers of two transgenic mouse models of Alzheimer's diseaseQ47898570
Blood-brain barrier impairment is functionally correlated with clinical severity in patients of multiple system atrophy.Q48311455
Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in ratsQ48339506
Blood-brain barrier disruption using mannitol: time course and electron microscopy studies.Q50890487
Mesenchymal stem/progenitor cells developed in cultures from UC blood.Q51591926
Permeability of proteins at the blood-brain barrier in the normal adult mouse and double transgenic mouse model of Alzheimer's disease.Q53243442
Stereotactic brain injection of human umbilical cord blood mesenchymal stem cells in patients with Alzheimer's disease dementia: A phase 1 clinical trial.Q55099772
Differential Clearance of Rat and Human Bone Marrow-Derived Mesenchymal Stem Cells from the Brain after Intra-arterial Infusion in RatsQ60202986
Fate of intravenously injected mesenchymal stem cells and significance for clinical applicationQ85924925
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
mesenchymal stem cellQ1922379
P304page(s)e0155912
P577publication date2016-05-20
P1433published inPLOS OneQ564954
P1476titleIntra-Arterially Delivered Mesenchymal Stem Cells Are Not Detected in the Brain Parenchyma in an Alzheimer's Disease Mouse Model
P478volume11

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cites work (P2860)
Q61444174Cerebrospinal fluid from Alzheimer's disease patients as an optimal formulation for therapeutic application of mesenchymal stem cells in Alzheimer's disease
Q64065446Challenges and Controversies in Human Mesenchymal Stem Cell Therapy
Q58775148In vivo distribution of U87MG cells injected into the lateral ventricle of rats with spinal cord injury
Q89762309Intrathecal Injection in A Rat Model: A Potential Route to Deliver Human Wharton's Jelly-Derived Mesenchymal Stem Cells into the Brain
Q64105384Intravenously Injected Mesenchymal Stem Cells Penetrate the Brain and Treat Inflammation-Induced Brain Damage and Memory Impairment in Mice
Q42317100Magnetic Resonance Imaging of Ferumoxytol-Labeled Human Mesenchymal Stem Cells in the Mouse Brain