Intra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats: Analyses of Therapeutic Time Window and Its Mechanisms

scientific article published on 15 June 2015

Intra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats: Analyses of Therapeutic Time Window and Its Mechanisms is …
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scholarly articleQ13442814

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P819ADS bibcode2015PLoSO..1027302T
P356DOI10.1371/JOURNAL.PONE.0127302
P932PMC publication ID4468176
P698PubMed publication ID26075717
P5875ResearchGate publication ID280032989

P2093author name stringIsao Date
Jun Morimoto
Akihiko Kondo
Feifei Wang
Tatsuya Sasaki
Cesario V Borlongan
Masahiro Kameda
Takao Yasuhara
Takashi Agari
Aiko Shinko
Takaaki Wakamori
Atsuhiko Toyoshima
Susumu Sasada
Hayato Takeuchi
Mihoko Okazaki
P2860cites workHuman marrow stromal cell therapy for stroke in rat: neurotrophins and functional recoveryQ44115092
Intravenous bone marrow stromal cell therapy reduces apoptosis and promotes endogenous cell proliferation after stroke in female rat.Q44569653
Transplantation of human bone marrow-derived mesenchymal stem cells promotes behavioral recovery and endogenous neurogenesis after cerebral ischemia in rats.Q44658984
Improvement in neurological outcome after administration of atorvastatin following experimental intracerebral hemorrhage in ratsQ44979503
Central nervous system entry of peripherally injected umbilical cord blood cells is not required for neuroprotection in strokeQ45042816
Mannitol enhances therapeutic effects of intra-arterial transplantation of mesenchymal stem cells into the brain after traumatic brain injuryQ46802118
Early transient presence of implanted bone marrow stem cells reduces lesion size after cerebral ischaemia in adult ratsQ47197553
BDNF gene-modified mesenchymal stem cells promote functional recovery and reduce infarct size in the rat middle cerebral artery occlusion model.Q47226339
One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with strokeQ48156405
Intra-arterial cell transplantation provides timing-dependent cell distribution and functional recovery after strokeQ48188339
Intra-arterial infusion of human bone marrow-derived mesenchymal stem cells results in transient localization in the brain after cerebral ischemia in ratsQ48339506
Intracerebral injection of human mesenchymal stem cells impacts cerebral microvasculature after experimental stroke: MRI studyQ48545692
Timing of intra-arterial neural stem cell transplantation after hypoxia-ischemia influences cell engraftment, survival, and differentiationQ48548383
Intravenous administration of human umbilical cord blood reduces behavioral deficits after stroke in ratsQ48721941
Intra-arterial transplantation of bone marrow mononuclear cells immediately after reperfusion decreases brain injury after focal ischemia in ratsQ48951431
Intravenous autologous bone marrow mononuclear cells for ischemic strokeQ49015926
Comparison of ischemia-directed migration of neural precursor cells after intrastriatal, intraventricular, or intravenous transplantation in the rat.Q49087443
Permeating the blood brain barrier and abrogating the inflammation in stroke: implications for stroke therapyQ26865517
Dual-modality monitoring of targeted intraarterial delivery of mesenchymal stem cells after transient ischemiaQ33322707
Intravenous administration of mesenchymal stem cells exerts therapeutic effects on parkinsonian model of rats: focusing on neuroprotective effects of stromal cell-derived factor-1alphaQ33564990
Intra-arterial injection of neural stem cells using a microneedle technique does not cause microembolic strokesQ33771764
Intracarotid transplantation of bone marrow stromal cells increases axon-myelin remodeling after strokeQ34468850
Ex vivo gene therapy: transplantation of neurotrophic factor-secreting cells for cerebral ischemia.Q36251075
Transplanted stem cell-secreted vascular endothelial growth factor effects poststroke recovery, inflammation, and vascular repair.Q36472907
Intravascular cell replacement therapy for strokeQ37110216
Stem cell transplantation for neuroprotection in stroke.Q37238494
Mannitol enhances delivery of marrow stromal cells to the brain after experimental intracerebral hemorrhageQ37265516
Blood-brain barrier, reperfusion injury, and hemorrhagic transformation in acute ischemic stroke.Q38046199
Intra-arterial bone marrow mononuclear cells in ischemic stroke: a pilot clinical trial.Q38468496
Electrical stimulation of the cerebral cortex exerts antiapoptotic, angiogenic, and anti-inflammatory effects in ischemic stroke rats through phosphoinositide 3-kinase/Akt signaling pathwayQ39798227
Intracarotid injection of fluorescence activated cell-sorted CD49d-positive neural stem cells improves targeted cell delivery and behavior after stroke in a mouse stroke modelQ40007652
Adult neural stem and progenitor cells modified to secrete GDNF can protect, migrate and integrate after intracerebral transplantation in rats with transient forebrain ischemiaQ40078558
Reduction of infarct volume and apoptosis by grafting of encapsulated basic fibroblast growth factor-secreting cells in a model of middle cerebral artery occlusion in ratsQ40602391
Autologous bone marrow mononuclear cells enhance recovery after acute ischemic stroke in young and middle-aged rats.Q41522029
Neuroprotective effects of liraglutide for stroke model of ratsQ42704044
Therapeutic time window of mesenchymal stem cells derived from bone marrow after cerebral ischemia.Q43103917
Transplantation of human mesenchymal stem cells promotes functional improvement and increased expression of neurotrophic factors in a rat focal cerebral ischemia modelQ43249693
SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model.Q50649521
Stromal cell-derived factor-1 alpha promotes neuroprotection, angiogenesis, and mobilization/homing of bone marrow-derived cells in stroke rats.Q50656814
Intra-Arterial Infusion of Autologous Bone Marrow Mononuclear Cells in Patients with Moderate to Severe Middle Cerebral Artery Acute Ischemic StrokeQ62109410
Regulation of human chemokine receptors CXCR4. Role of phosphorylation in desensitization and internalizationQ73836239
Evidence of reperfusion injury, exacerbated by thrombolytic therapy, in human focal brain ischemia using a novel imaging marker of early blood-brain barrier disruptionQ80837184
Safety of autologous bone marrow mononuclear cell transplantation in patients with nonacute ischemic strokeQ82980062
Timing and dose regimens of marrow mesenchymal stem cell transplantation affect the outcomes and neuroinflammatory response after ischemic strokeQ87041085
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectmesenchymal stem cellQ1922379
P304page(s)e0127302
P577publication date2015-06-15
P1433published inPLOS OneQ564954
P1476titleIntra-Arterial Transplantation of Allogeneic Mesenchymal Stem Cells Mounts Neuroprotective Effects in a Transient Ischemic Stroke Model in Rats: Analyses of Therapeutic Time Window and Its Mechanisms
P478volume10

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cites work (P2860)
Q90599623Activated Mesenchymal Stem Cells Induce Recovery Following Stroke Via Regulation of Inflammation and Oligodendrogenesis
Q47797257Age of donor of human mesenchymal stem cells affects structural and functional recovery after cell therapy following ischaemic stroke.
Q45740164Cell Therapy for Parkinson's Disease
Q35737488Differential Migration of Mesenchymal Stem Cells to Ischemic Regions after Middle Cerebral Artery Occlusion in Rats
Q92756924Early Transplantation of Human Cranial Bone-derived Mesenchymal Stem Cells Enhances Functional Recovery in Ischemic Stroke Model Rats
Q64118806Exosomes Derived from Human Primed Mesenchymal Stem Cells Induce Mitosis and Potentiate Growth Factor Secretion
Q26747560Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools
Q47405412Getting Closer to an Effective Intervention of Ischemic Stroke: The Big Promise of Stem Cell
Q36024051Intra-Arterially Delivered Mesenchymal Stem Cells Are Not Detected in the Brain Parenchyma in an Alzheimer's Disease Mouse Model
Q42697924Intra-arterial transplantation of human bone marrow mesenchymal stem cells (hBMMSCs) improves behavioral deficits and alters gene expression in rodent stroke model
Q50419940Long-Term Potentiation Enhances Neuronal Differentiation in the Chronic Hypoperfusion Model of Rats
Q33887223Mesenchymal Stem Cells Overexpressing Interleukin-10 Promote Neuroprotection in Experimental Acute Ischemic Stroke
Q47146569Methodological aspects of MRI of transplanted superparamagnetic iron oxide-labeled mesenchymal stem cells in live rat brain.
Q38843840Moving from the Dish to the Clinical Practice: A Decade of Lessons and Perspectives from the Pre-Clinical and Clinical Stem Cell Studies for Alzheimer's Disease
Q41429849Neural differentiation of human Wharton's jelly-derived mesenchymal stem cells improves the recovery of neurological function after transplantation in ischemic stroke rats
Q46490500Real-time MRI for precise and predictable intra-arterial stem cell delivery to the central nervous system.
Q54120749Recombinant Osteopontin Improves Neurological Functional Recovery and Protects Against Apoptosis via PI3K/Akt/GSK-3β Pathway Following Intracerebral Hemorrhage.
Q51760255Regulatory T-cells within bone marrow-derived stem cells actively confer immunomodulatory and neuroprotective effects against stroke.
Q89763856Role and therapeutic effects of skeletal muscle-derived non-myogenic cells in a rat myocardial infarction model
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Q38708452Suppression of Basic Fibroblast Growth Factor Expression by Antisense Oligonucleotides Inhibits Neural Stem Cell Proliferation and Differentiation in Rat models With Focal Cerebral Infarction
Q88696073The therapeutic potential of the mesenchymal stem cell secretome in ischaemic stroke
Q91894595Therapeutic Potential of Human Amniotic Epithelial Cells on Injuries and Disorders in the Central Nervous System
Q57296288Transplantation of a bone marrow mesenchymal stem cell line increases neuronal progenitor cell migration in a cerebral ischemia animal model

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