| scholarly article | Q13442814 |
| review article | Q7318358 |
| P50 | author | Jean-Paul Concordet | Q56650883 |
| Maximilian Haeussler | Q91308875 | ||
| P2860 | cites work | CCTop: An Intuitive, Flexible and Reliable CRISPR/Cas9 Target Prediction Tool | Q21131779 |
| Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems | Q21508512 | ||
| A conditional knockout resource for the genome-wide study of mouse gene function | Q21735918 | ||
| Genome engineering using the CRISPR-Cas9 system | Q22122027 | ||
| Highly efficient Cas9-mediated gene drive for population modification of the malaria vector mosquito Anopheles stephensi | Q24456431 | ||
| RNA-guided human genome engineering via Cas9 | Q24598394 | ||
| Multiplex genome engineering using CRISPR/Cas systems | Q24609428 | ||
| Efficient genome editing in zebrafish using a CRISPR-Cas system | Q24610828 | ||
| Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system | Q24669821 | ||
| A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity | Q24669850 | ||
| Characterization of dystrophin deficient rats: a new model for Duchenne muscular dystrophy | Q27335054 | ||
| Structures of Cas9 Endonucleases Reveal RNA-Mediated Conformational Activation | Q27681624 | ||
| Crystal Structure of Cas9 in Complex with Guide RNA and Target DNA | Q27681727 | ||
| Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease | Q27684893 | ||
| Structures of a CRISPR-Cas9 R-loop complex primed for DNA cleavage | Q27703932 | ||
| Development and applications of CRISPR-Cas9 for genome engineering | Q28241526 | ||
| Genetic manipulation of genomes with rare-cutting endonucleases | Q28297326 | ||
| Dynamic imaging of genomic loci in living human cells by an optimized CRISPR/Cas system | Q29615782 | ||
| DNA targeting specificity of RNA-guided Cas9 nucleases | Q29615793 | ||
| High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells | Q29616045 | ||
| Genetic screens in human cells using the CRISPR-Cas9 system | Q29617411 | ||
| High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. | Q30407556 | ||
| Ten years of gene targeting: targeted mouse mutants, from vector design to phenotype analysis | Q33650414 | ||
| Highly efficient RNA-guided genome editing in human cells via delivery of purified Cas9 ribonucleoproteins | Q33657682 | ||
| CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences | Q33791286 | ||
| Gene conversion tracts from double-strand break repair in mammalian cells | Q33995776 | ||
| Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis | Q34037839 | ||
| In vivo genome editing using Staphylococcus aureus Cas9 | Q34043628 | ||
| Identification and characterization of essential genes in the human genome. | Q34045164 | ||
| Rationally engineered Cas9 nucleases with improved specificity | Q34045530 | ||
| Genome-wide binding of the CRISPR endonuclease Cas9 in mammalian cells | Q34093413 | ||
| Saturation editing of genomic regions by multiplex homology-directed repair | Q34143368 | ||
| Simple methods for generating and detecting locus-specific mutations induced with TALENs in the zebrafish genome | Q34390580 | ||
| Rational design of highly active sgRNAs for CRISPR-Cas9-mediated gene inactivation. | Q34436638 | ||
| Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line | Q34446440 | ||
| GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases | Q34454104 | ||
| Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining | Q34468164 | ||
| Engineered CRISPR-Cas9 nucleases with altered PAM specificities | Q34481737 | ||
| Unraveling CRISPR-Cas9 genome engineering parameters via a library-on-library approach | Q34484605 | ||
| CRISPR/Cas9: An inexpensive, efficient loss of function tool to screen human disease genes in Xenopus. | Q34500979 | ||
| High-fidelity CRISPR-Cas9 nucleases with no detectable genome-wide off-target effects. | Q34507554 | ||
| Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells. | Q38895804 | ||
| Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells | Q38911544 | ||
| Surrogate reporters for enrichment of cells with nuclease-induced mutations | Q39461040 | ||
| Mutagenic consequences of a single G-quadruplex demonstrate mitotic inheritance of DNA replication fork barriers. | Q40326687 | ||
| Unbiased detection of off-target cleavage by CRISPR-Cas9 and TALENs using integrase-defective lentiviral vectors. | Q42174678 | ||
| Targeted gene editing by transfection of in vitro reconstituted Streptococcus thermophilus Cas9 nuclease complex | Q42595840 | ||
| RNA events. Cas9 targeting and the CRISPR revolution | Q44873775 | ||
| Mammalian Reverse Genetics without Crossing Reveals Nr3a as a Short-Sleeper Gene. | Q47898396 | ||
| Off-target mutations are rare in Cas9-modified mice. | Q48181926 | ||
| E-CRISP: fast CRISPR target site identification | Q48332892 | ||
| Rapid and highly efficient mammalian cell engineering via Cas9 protein transfection. | Q52423691 | ||
| Nucleosomes Inhibit Cas9 Endonuclease Activity in Vitro. | Q52424426 | ||
| Microhomology-based choice of Cas9 nuclease target sites. | Q53515678 | ||
| Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA parameters in Drosophila | Q34605914 | ||
| Easy quantitative assessment of genome editing by sequence trace decomposition | Q34712139 | ||
| Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans | Q34755256 | ||
| Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. | Q35060760 | ||
| Comparison of T7E1 and surveyor mismatch cleavage assays to detect mutations triggered by engineered nucleases | Q35145824 | ||
| Dramatic enhancement of genome editing by CRISPR/Cas9 through improved guide RNA design | Q35342386 | ||
| Cloning-free CRISPR/Cas system facilitates functional cassette knock-in in mice. | Q35552238 | ||
| Efficient Multiple Genome Modifications Induced by the crRNAs, tracrRNA and Cas9 Protein Complex in Zebrafish | Q35641056 | ||
| Fast and sensitive detection of indels induced by precise gene targeting | Q35786073 | ||
| Rapid characterization of CRISPR-Cas9 protospacer adjacent motif sequence elements | Q35846582 | ||
| Genome editing through large insertion leads to the skipping of targeted exon | Q35874929 | ||
| Sequence determinants of improved CRISPR sgRNA design | Q35876047 | ||
| Optimized sgRNA design to maximize activity and minimize off-target effects of CRISPR-Cas9. | Q35896845 | ||
| High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes. | Q36050136 | ||
| CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo | Q36109068 | ||
| Homology-directed repair in rodent zygotes using Cas9 and TALEN engineered proteins | Q36128900 | ||
| WU-CRISPR: characteristics of functional guide RNAs for the CRISPR/Cas9 system | Q36238544 | ||
| Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi | Q36274085 | ||
| PAM multiplicity marks genomic target sites as inhibitory to CRISPR-Cas9 editing | Q36392460 | ||
| Broadening the targeting range of Staphylococcus aureus CRISPR-Cas9 by modifying PAM recognition | Q36398694 | ||
| Synthetic CRISPR RNA-Cas9-guided genome editing in human cells | Q36419827 | ||
| Optimizing sgRNA structure to improve CRISPR-Cas9 knockout efficiency. | Q36425176 | ||
| RS-1 enhances CRISPR/Cas9- and TALEN-mediated knock-in efficiency | Q36536499 | ||
| Genome-wide target specificities of CRISPR-Cas9 nucleases revealed by multiplex Digenome-seq | Q36633212 | ||
| Streptococcus thermophilus CRISPR-Cas9 Systems Enable Specific Editing of the Human Genome | Q36675308 | ||
| In vivo gene editing in dystrophic mouse muscle and muscle stem cells | Q37045850 | ||
| High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity | Q37196274 | ||
| Optimization of scarless human stem cell genome editing | Q37236715 | ||
| Analysis of off-target effects of CRISPR/Cas-derived RNA-guided endonucleases and nickases. | Q37420333 | ||
| Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells | Q37634254 | ||
| Highly specific and efficient CRISPR/Cas9-catalyzed homology-directed repair in Drosophila | Q37696355 | ||
| Orthogonal gene knockout and activation with a catalytically active Cas9 nuclease | Q38323654 | ||
| Recent Progress in CRISPR/Cas9 Technology | Q38754222 | ||
| P433 | issue | 5 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | CRISPR | Q412563 |
| Cas9 | Q16965677 | ||
| CRISPR-Cas method | Q17310682 | ||
| P304 | page(s) | 239-250 | |
| P577 | publication date | 2016-04-24 | |
| P1433 | published in | Journal of Genetics and Genomics | Q15751819 |
| P1476 | title | Genome Editing with CRISPR-Cas9: Can It Get Any Better? | |
| P478 | volume | 43 |
| Q55309854 | Application of the CRISPR/Cas9 System to Drug Resistance in Breast Cancer. |
| Q59791747 | Application of the CRISPR/Cas9 system for modification of flower color in Torenia fournieri |
| Q40100879 | CRISPR-Cas based antiviral strategies against HIV-1. |
| Q90596404 | CRISPR-Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV-host factor interactions |
| Q58114063 | CRISPR-Cas9 off-targeting assessment with nucleic acid duplex energy parameters |
| Q92509562 | CRISPR/CAS9 mutagenesis of a single r-opsin gene blocks phototaxis in a marine larva |
| Q88718519 | Characterization of noncoding regulatory DNA in the human genome |
| Q64375251 | Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing |
| Q47733382 | Does the Genetic Feature of the Chinese Tree Shrew (Tupaia belangeri chinensis) Support Its Potential as a Viable Model for Alzheimer's Disease Research? |
| Q59358840 | Efficient Genome Engineering of a Virulent Klebsiella Bacteriophage Using CRISPR-Cas9 |
| Q39171937 | Emerging tools to study enteric neuromuscular function |
| Q41888137 | Fluorescent RNA cytosine analogue - an internal probe for detailed structure and dynamics investigations. |
| Q91310613 | Interdependent Factors of Demand-Side Rationale for Chemical, Biological, Radiological, and Nuclear Medical Countermeasures |
| Q58728468 | Multiplexed CRISPR/Cas9 Targeting of Genes Implicated in Retinal Regeneration and Degeneration |
| Q28078150 | Patterns of CRISPR/Cas9 activity in plants, animals and microbes |
| Q90001445 | Phytochrome Coordinates with a hnRNP to Regulate Alternative Splicing via an Exonic Splicing Silencer |
| Q89185622 | Synthetic Biology of Small RNAs and Riboswitches |
| Q39288205 | Towards mastering CRISPR-induced gene knock-in in plants: Survey of key features and focus on the model Physcomitrella patens. |
| Q46302986 | Use of the Cas9 Orthologs from Streptococcus thermophilus and Staphylococcus aureus for Non-Homologous End-Joining Mediated Site-Specific Mutagenesis in Arabidopsis thaliana |
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