FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior

scientific article

FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1083/JCB.201108077
P932PMC publication ID3373409
P698PubMed publication ID22665522
P5875ResearchGate publication ID225186517

P2093author name stringRichard Grose
Athina-Myrto Chioni
P2860cites workCellular signaling by fibroblast growth factor receptorsQ24301087
A novel interleukin-12 p40-related protein induced by latent Epstein-Barr virus infection in B lymphocytesQ24315666
Fibroblast growth factorsQ24542507
Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF familyQ24676527
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancerQ27851554
90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signalingQ28259259
Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2Q28283279
Cloning of cDNA for the glutamate-binding subunit of an NMDA receptor complexQ28574514
Spatial and temporal patterns of ERK signaling during mouse embryogenesisQ28594004
Notch signalling: a simple pathway becomes complexQ29555851
Fibroblast growth factor signalling: from development to cancerQ29616827
A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosisQ29617776
Structural characterization of the circulating soluble FGF receptors reveals multiple isoforms generated by secretion and ectodomain sheddingQ30651053
Granzyme B proteolyzes receptors important to proliferation and survival, tipping the balance toward apoptosisQ33247896
Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia.Q33414759
Regulation of endocytosis, nuclear translocation, and signaling of fibroblast growth factor receptor 1 by E-cadherinQ33564095
Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain.Q33889677
Nuclear trafficking of the epidermal growth factor receptor family membrane proteinsQ33998459
Extracellular matrix remodeling by human granzyme B via cleavage of vitronectin, fibronectin, and laminin.Q34412822
Mechanisms underlying differential responses to FGF signalingQ34415005
Regulation of G(1) cell-cycle progression by oncogenes and tumor suppressor genesQ34493133
Novel nuclear signaling pathway mediates activation of fibroblast growth factor-2 gene by type 1 and type 2 angiotensin II receptorsQ34983958
Dipeptidyl peptidase I is required for the processing and activation of granzymes A and B in vivoQ35558255
FGFR1 amplification in breast carcinomas: a chromogenic in situ hybridisation analysisQ35794378
Nuclear Translocation of fibroblast growth factor (FGF) receptors in response to FGF-2.Q36236991
Nuclear translocation of cell-surface receptors: lessons from fibroblast growth factorQ36247430
Importin beta-mediated nuclear import of fibroblast growth factor receptor: role in cell proliferationQ36381086
Expression of endogenous granzyme B in a subset of human primary breast carcinomasQ36670835
Receptor trafficking controls weak signal delivery: a strategy used by c-Met for STAT3 nuclear accumulation.Q36860354
Integrative nuclear signaling in cell development--a role for FGF receptor-1.Q37004768
Fibroblast growth factor receptor-1 (FGFR1) nuclear dynamics reveal a novel mechanism in transcription controlQ37175392
Negative regulation of fibroblast growth factor 10 (FGF-10) by polyoma enhancer activator 3 (PEA3).Q37215604
Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancerQ37282661
Trafficking of receptor tyrosine kinases to the nucleusQ37308472
Organotypic modelling as a means of investigating epithelial-stromal interactions during tumourigenesisQ37348888
Nuclear accumulation of fibroblast growth factor receptors is regulated by multiple signals in adrenal medullary cellsQ37382062
Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1.Q37486259
Internalization of fibroblast growth factor receptor is inhibited by a point mutation at tyrosine 766.Q38307028
High expression of stratifin is a universal abnormality during the course of malignant progression of early-stage lung adenocarcinomaQ39612023
Vesicle transmembrane potential is required for translocation to the cytosol of externally added FGF-1.Q39648002
Development of a quantitative method to analyse tumour cell invasion in organotypic cultureQ39706819
Granzyme B is expressed in urothelial carcinoma and promotes cancer cell invasion.Q39760255
Protein kinase A and regulation of neonatal Nav1.5 expression in human breast cancer cells: activity-dependent positive feedback and cellular migrationQ39769255
Nuclear EGFR contributes to acquired resistance to cetuximabQ39812008
FGFR1 emerges as a potential therapeutic target for lobular breast carcinomasQ40205335
A novel polyclonal antibody specific for the Na(v)1.5 voltage-gated Na(+) channel 'neonatal' splice formQ40383358
Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathwayQ40410769
Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer.Q40467153
Nuclear trafficking of FGFR1: a role for the transmembrane domainQ40662478
A nuclear form of the heparin-binding epidermal growth factor-like growth factor precursor is a feature of aggressive transitional cell carcinoma.Q40675300
Nuclear localization of EGF receptor and its potential new role as a transcription factorQ40782527
Membrane oligomerization and cleavage activates the caspase-8 (FLICE/MACHalpha1) death signalQ41059135
Nuclear localization of p185neu tyrosine kinase and its association with transcriptional transactivationQ41441273
Reaction of serine proteases with substituted isocoumarins: discovery of 3,4-dichloroisocoumarin, a new general mechanism based serine protease inhibitorQ42225238
Dual mode of signal transduction by externally added acidic fibroblast growth factorQ42800548
Ligand dependent and independent internalization and nuclear translocation of fibroblast growth factor (FGF) receptor 1.Q42825244
Integrative nuclear FGFR1 signaling (INFS) pathway mediates activation of the tyrosine hydroxylase gene by angiotensin II, depolarization and protein kinase C.Q44028783
The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating woundsQ46140598
Control of CREB-binding protein signaling by nuclear fibroblast growth factor receptor-1: a novel mechanism of gene regulationQ46522283
Elements controlling the expression and induction of the skin hyperproliferation-associated keratin K6.Q48070735
Nuclear localization of functional FGF receptor 1 in human astrocytes suggests a novel mechanism for growth factor actionQ71339849
In vitro invasiveness of DU-145 human prostate carcinoma cells is modulated by EGF receptor-mediated signalsQ71808981
Altered intracellular localization of fibroblast growth factor receptor 3 in human breast cancerQ73820422
P4510describes a project that usesImageJQ1659584
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectbreast cancerQ128581
P1104number of pages17
P304page(s)801-817
P577publication date2012-06-04
P1433published inJournal of Cell BiologyQ1524550
P1476titleFGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior
P478volume197

Reverse relations

cites work (P2860)
Q38287257"Nuclear FGF receptor-1 and CREB binding protein: an integrative signaling module".
Q527856613D Organotypic Culture Model to Study Components of ERK Signaling.
Q93064606A gain-of-functional screen identifies the Hippo pathway as a central mediator of receptor tyrosine kinases during tumorigenesis
Q37600446Activation of the FGFR-STAT3 pathway in breast cancer cells induces a hyaluronan-rich microenvironment that licenses tumor formation.
Q38656592Association of FGFR1 with ERαmaintains ligand-independent ER transcription and mediates resistance to estrogen deprivation in ER+ breast cancer.
Q93145965Catalytically inactive receptor tyrosine kinase PTK7 activates FGFR1 independent of FGF
Q34077207Chromatin-associated CSF-1R binds to the promoter of proliferation-related genes in breast cancer cells
Q38475854Coalition of Nuclear Receptors in the Nervous System.
Q39017298Common developmental genome deprogramming in schizophrenia - Role of Integrative Nuclear FGFR1 Signaling (INFS).
Q58566489Emerging Roles of Fibroblast Growth Factor 10 in Cancer
Q35816309Engineering targeted chromosomal amplifications in human breast epithelial cells
Q38905296EphB4 localises to the nucleus of prostate cancer cells.
Q28078898Evidence-Based Theory for Integrated Genome Regulation of Ontogeny--An Unprecedented Role of Nuclear FGFR1 Signaling
Q90133145Expression of FGFR1-4 in Malignant Pleural Mesothelioma Tissue and Corresponding Cell Lines and its Relationship to Patient Survival and FGFR Inhibitor Sensitivity
Q98906651FGF/FGFR signaling in health and disease
Q33935206FGF10: Type III Epithelial Mesenchymal Transition and Invasion in Breast Cancer Cell Lines
Q38766035FGFR-targeted therapeutics for the treatment of breast cancer.
Q52714441FGFR1 fusion kinase regulation of MYC expression drives development of stem cell leukemia/lymphoma syndrome.
Q38644648FGFR1 is critical for the anti-endothelial mesenchymal transition effect of N-acetyl-seryl-aspartyl-lysyl-proline via induction of the MAP4K4 pathway
Q37620612Fibroblast growth factor receptor 4 (FGFR4): a targetable regulator of drug resistance in colorectal cancer
Q38959812Fibroblast growth factor receptor inhibition is active against mesothelioma and synergizes with radio- and chemotherapy.
Q37716969Fibroblast growth factor signaling regulates the expansion of A6-expressing hepatocytes in association with AKT-dependent β-catenin activation
Q39282670Fibroblast growth factor-mediated crosstalk in cancer etiology and treatment.
Q28554418Genome Analysis of Osteosarcoma Progression Samples Identifies FGFR1 Overexpression as a Potential Treatment Target and CHM as a Candidate Tumor Suppressor Gene
Q35552948Global Developmental Gene Programing Involves a Nuclear Form of Fibroblast Growth Factor Receptor-1 (FGFR1).
Q35672982HPV16 Down-Regulates the Insulin-Like Growth Factor Binding Protein 2 to Promote Epithelial Invasion in Organotypic Cultures
Q33569831Improved HSC reconstitution and protection from inflammatory stress and chemotherapy in mice lacking granzyme B.
Q40463360Integrative meta-modeling identifies endocytic vesicles, late endosome and the nucleus as the cellular compartments primarily directing RTK signaling.
Q37396056Interactions between FGFR2 and RSK2-implications for breast cancer prognosis.
Q37717525Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function
Q64092327Membrane-Associated, Not Cytoplasmic or Nuclear, FGFR1 Induces Neuronal Differentiation
Q34851892NGF-induced cell differentiation and gene activation is mediated by integrative nuclear FGFR1 signaling (INFS).
Q37710812Nuclear translocation of FGFR1 and FGF2 in pancreatic stellate cells facilitates pancreatic cancer cell invasion
Q53705802PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer.
Q33886981Pancreatic cancer organotypics: High throughput, preclinical models for pharmacological agent evaluation
Q34724831Phosphorylation and nuclear translocation of integrin β4 induced by a chemical small molecule contribute to apoptosis in vascular endothelial cells
Q36113481Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases
Q26830216Receptor tyrosine kinases in the nucleus
Q90706409Targeting Cellular Trafficking of Fibroblast Growth Factor Receptors as a Strategy for Selective Cancer Treatment
Q38212165Targeting fibroblast growth factor receptor in breast cancer: a promise or a pitfall?
Q34495216The FGF/FGFR axis as a therapeutic target in breast cancer
Q91783996The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT
Q37235526The FGFR1 inhibitor PD173074 induces mesenchymal-epithelial transition through the transcription factor AP-1.
Q34467171The Fibroblast Growth Factor signaling pathway
Q38208062The ins and outs of fibroblast growth factor receptor signalling.
Q36471425Treatment of Triple-Negative Breast Cancer with TORC1/2 Inhibitors Sustains a Drug-Resistant and Notch-Dependent Cancer Stem Cell Population
Q37159039Tyrosine kinase receptors as molecular targets in pheochromocytomas and paragangliomas.

Search more.