| scholarly article | Q13442814 |
| P356 | DOI | 10.1101/CSHPERSPECT.A008979 |
| P8608 | Fatcat ID | release_oxpycbhqera6rlftv3k2gzedoi |
| P3181 | OpenCitations bibliographic resource ID | 3752036 |
| P932 | PMC publication ID | 3783051 |
| P698 | PubMed publication ID | 24086039 |
| P2093 | author name string | G. Carpenter | |
| H.-J. Liao | |||
| P2860 | cites work | Cleavage of the HER2 ectodomain is a pervanadate-activable process that is inhibited by the tissue inhibitor of metalloproteases-1 in breast cancer cells | Q74650838 |
| The ERBB4 intracellular domain (4ICD) regulates NRG1-induced gene expression in hippocampal neurons | Q83479287 | ||
| A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis | Q37233360 | ||
| Transcriptional interaction of an estrogen receptor splice variant and ErbB4 suggests convergence in gene susceptibility pathways in schizophrenia | Q37254085 | ||
| Trafficking of receptor tyrosine kinases to the nucleus | Q37308472 | ||
| Truncated ErbB2 expressed in tumor cell nuclei contributes to acquired therapeutic resistance to ErbB2 kinase inhibitors | Q37332545 | ||
| Presenilin-dependent regulated intramembrane proteolysis and gamma-secretase activity | Q37384320 | ||
| Subcellular localization of the HER4 intracellular domain, 4ICD, identifies distinct prognostic outcomes for breast cancer patients | Q37413628 | ||
| Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase | Q37431688 | ||
| Proteolytic cleavages give receptor tyrosine kinases the gift of ubiquity. | Q37472880 | ||
| Nuclear trafficking and functions of endocytic proteins implicated in oncogenesis | Q37488638 | ||
| The regulatory crosstalk between kinases and proteases in cancer | Q37714303 | ||
| Novel research horizons for presenilins and γ-secretases in cell biology and disease | Q37770248 | ||
| p95HER2 and breast cancer | Q37846003 | ||
| Regulated intramembrane proteolysis: signaling pathways and biological functions | Q37847814 | ||
| Antipsychotic treatment and neuregulin 1-ErbB4 signalling in schizophrenia | Q37868077 | ||
| Intramembrane proteolysis in regulated protein trafficking | Q37876486 | ||
| Function of ERBB4 is determined by alternative splicing | Q37910673 | ||
| Co-regulation of B-Myb expression by E2F1 and EGF receptor | Q38318606 | ||
| Expression and cellular localization of vascular endothelial growth factor A and its receptors in acute and chronic leukemias: an immunohistochemical study | Q38441561 | ||
| Regulated intramembrane cleavage of the EGF receptor | Q39359395 | ||
| EpCAM regulates cell cycle progression via control of cyclin D1 expression | Q39385183 | ||
| ErbB3(80 kDa), a nuclear variant of the ErbB3 receptor, binds to the Cyclin D1 promoter to activate cell proliferation but is negatively controlled by p14ARF. | Q39409637 | ||
| Epidermal growth factor receptors destined for the nucleus are internalized via a clathrin-dependent pathway | Q39494243 | ||
| The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease | Q22254713 | ||
| Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression | Q24292840 | ||
| The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells | Q24293729 | ||
| RET modulates cell adhesion via its cleavage by caspase in sympathetic neurons | Q24294342 | ||
| The phosphoinositide kinase PIKfyve mediates epidermal growth factor receptor trafficking to the nucleus | Q24295651 | ||
| The intracellular domain of ErbB4 induces differentiation of mammary epithelial cells | Q24296970 | ||
| Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor | Q24297204 | ||
| Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease | Q24298408 | ||
| Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3 | Q24301306 | ||
| Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes | Q24301779 | ||
| The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone | Q24313108 | ||
| Cetuximab/C225-induced intracellular trafficking of epidermal growth factor receptor | Q24314620 | ||
| Nuclear signalling by tumour-associated antigen EpCAM | Q24315870 | ||
| Tyrosine phosphorylation controls PCNA function through protein stability | Q24317732 | ||
| Galectin-3 regulates MUC1 and EGFR cellular distribution and EGFR downstream pathways in pancreatic cancer cells | Q24338149 | ||
| EGFR nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment | Q24338426 | ||
| Sequential and gamma-secretase-dependent processing of the betacellulin precursor generates a palmitoylated intracellular-domain fragment that inhibits cell growth | Q24633569 | ||
| Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells | Q24644225 | ||
| Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration | Q24650562 | ||
| Ligand binding and calcium influx induce distinct ectodomain/gamma-secretase-processing pathways of EphB2 receptor | Q28115734 | ||
| gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase | Q28202328 | ||
| A novel juxtamembrane domain isoform of HER4/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester | Q28251593 | ||
| Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain | Q28266755 | ||
| Genetic mosaic analysis reveals FGF receptor 2 function in terminal end buds during mammary gland branching morphogenesis | Q36971355 | ||
| Presenilin: running with scissors in the membrane | Q36979995 | ||
| Integrative nuclear signaling in cell development--a role for FGF receptor-1. | Q37004768 | ||
| Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cells | Q37173281 | ||
| Fibroblast growth factor receptor-1 (FGFR1) nuclear dynamics reveal a novel mechanism in transcription control | Q37175392 | ||
| Down-regulation of the met receptor tyrosine kinase by presenilin-dependent regulated intramembrane proteolysis | Q37175416 | ||
| The cytoplasmic tail of MUC1: a very busy place | Q37210822 | ||
| Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2 | Q28283279 | ||
| Pigment epithelium-derived factor inhibits angiogenesis via regulated intracellular proteolysis of vascular endothelial growth factor receptor 1 | Q28285900 | ||
| Proteolytic processing of protocadherin proteins requires endocytosis | Q28294258 | ||
| Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1 | Q28469224 | ||
| Cleavage of the Wnt receptor Ryk regulates neuronal differentiation during cortical neurogenesis | Q28506743 | ||
| The E3 ubiquitin ligase WWP1 selectively targets HER4 and its proteolytically derived signaling isoforms for degradation | Q28511737 | ||
| Presenilin-dependent receptor processing is required for axon guidance | Q28567038 | ||
| Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination | Q28592010 | ||
| Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4 | Q28609073 | ||
| Notch signalling: a simple pathway becomes complex | Q29555851 | ||
| Retrograde transport from endosomes to the trans-Golgi network | Q29617826 | ||
| HER2 carboxyl-terminal fragments regulate cell migration and cortactin phosphorylation | Q30490783 | ||
| Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells | Q30493785 | ||
| Initial activation of EpCAM cleavage via cell-to-cell contact | Q30898801 | ||
| The E3 ligase Aip4/Itch ubiquitinates and targets ErbB-4 for degradation | Q33282972 | ||
| The neogenin intracellular domain regulates gene transcription via nuclear translocation | Q33327050 | ||
| Nuclear localization of the p75 neurotrophin receptor intracellular domain | Q33648352 | ||
| Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes | Q33669979 | ||
| c-Met must translocate to the nucleus to initiate calcium signals | Q33675510 | ||
| Nuclear and cytoplasmic accumulation of Ep-ICD is frequently detected in human epithelial cancers | Q33770286 | ||
| MUC1 regulates nuclear localization and function of the epidermal growth factor receptor | Q33830304 | ||
| FGFR2 protein expression in breast cancer: nuclear localisation and correlation with patient genotype. | Q33850399 | ||
| A novel signaling pathway mediated by the nuclear targeting of C-terminal fragments of mammalian Patched 1 | Q33886788 | ||
| PEDF regulates vascular permeability by a γ-secretase-mediated pathway | Q33939170 | ||
| The ERalpha coactivator, HER4/4ICD, regulates progesterone receptor expression in normal and malignant breast epithelium | Q33951695 | ||
| Ectodomain shedding of interleukin-2 receptor beta and generation of an intracellular functional fragment | Q33991144 | ||
| Nuclear trafficking of the epidermal growth factor receptor family membrane proteins | Q33998459 | ||
| Notch signaling: the core pathway and its posttranslational regulation | Q34017623 | ||
| An unusual function of RON receptor tyrosine kinase as a transcriptional regulator in cooperation with EGFR in human cancer cells | Q34042332 | ||
| VEGFR2 translocates to the nucleus to regulate its own transcription | Q34043465 | ||
| COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport | Q34109724 | ||
| Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors. | Q34289010 | ||
| Type 1 insulin-like growth factor receptor translocates to the nucleus of human tumor cells | Q34308428 | ||
| The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus | Q34352437 | ||
| TRAF6 ubiquitinates TGFβ type I receptor to promote its cleavage and nuclear translocation in cancer. | Q39532727 | ||
| Characterization and comparison of protein complexes initiated by the intracellular domain of individual Notch paralogs. | Q39574701 | ||
| Translocation of the cytoplasmic domain of ADAM13 to the nucleus is essential for Calpain8-a expression and cranial neural crest cell migration | Q39593323 | ||
| Caspase cleavage of HER-2 releases a Bad-like cell death effector | Q39600380 | ||
| Over-accumulation of nuclear IGF-1 receptor in tumor cells requires elevated expression of the receptor and the SUMO-conjugating enzyme Ubc9. | Q39621670 | ||
| Inhibition of neurotrophin receptor p75 intramembran proteolysis by gamma-secretase inhibitor reduces medulloblastoma spinal metastasis | Q39632426 | ||
| Nuclear EGFR shuttling induced by ionizing radiation is regulated by phosphorylation at residue Thr654 | Q39670051 | ||
| Transportin Regulates Nuclear Import of CD44 | Q39675125 | ||
| Phosphorylation of the MET receptor on juxtamembrane tyrosine residue 1001 inhibits its caspase-dependent cleavage. | Q39849915 | ||
| Toll-like receptors stimulate regulated intramembrane proteolysis of the CSF-1 receptor through Erk activation | Q40009739 | ||
| CSF-1 and TPA stimulate independent pathways leading to lysosomal degradation or regulated intramembrane proteolysis of the CSF-1 receptor | Q40060773 | ||
| Generation of intracellular domain of insulin receptor tyrosine kinase by gamma-secretase. | Q40118088 | ||
| The insulin-like growth factor 1 (IGF-1) receptor is a substrate for gamma-secretase-mediated intramembrane proteolysis. | Q40128252 | ||
| Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor | Q40191055 | ||
| Met, the hepatocyte growth factor receptor, localizes to the nucleus in cells at low density | Q40243343 | ||
| Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1. | Q40301251 | ||
| Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase | Q40401323 | ||
| Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway | Q40410769 | ||
| Proapoptotic function of the MET tyrosine kinase receptor through caspase cleavage | Q40418357 | ||
| Presenilin-dependent gamma-secretase processing regulates multiple ERBB4/HER4 activities. | Q40450911 | ||
| Nuclear accumulation of epidermal growth factor receptor and acceleration of G1/S stage by Epstein-Barr-encoded oncoprotein latent membrane protein 1. | Q40470698 | ||
| Caspase-8-dependent HER-2 cleavage in response to tumor necrosis factor alpha stimulation is counteracted by nuclear factor kappaB through c-FLIP-L expression | Q40566278 | ||
| Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways | Q40598952 | ||
| Nuclear localization of EGF receptor and its potential new role as a transcription factor | Q40782527 | ||
| ADAM10, the rate-limiting protease of regulated intramembrane proteolysis of Notch and other proteins, is processed by ADAMS-9, ADAMS-15, and the gamma-secretase | Q42059040 | ||
| Klotho is a substrate for alpha-, beta- and gamma-secretase | Q42078322 | ||
| Cdc37 regulates Ryk signaling by stabilizing the cleaved Ryk intracellular domain | Q42143319 | ||
| Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. | Q42188322 | ||
| Mutational analysis of the membrane-proximal cleavage site of L-selectin: relaxed sequence specificity surrounding the cleavage site | Q42246729 | ||
| Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion | Q42264802 | ||
| Role of the ErbB-4 carboxyl terminus in gamma-secretase cleavage | Q42528205 | ||
| Selective cleavage of the heregulin receptor ErbB-4 by protein kinase C activation | Q42810137 | ||
| SUMOylation mediates the nuclear translocation and signaling of the IGF-1 receptor | Q43166800 | ||
| Caspase-dependent cleavage of ErbB-2 by geldanamycin and staurosporin | Q43636937 | ||
| Ectodomain cleavage of ErbB-4: characterization of the cleavage site and m80 fragment | Q44517519 | ||
| Gamma-secretase: proteasome of the membrane? | Q44918417 | ||
| Carcinoma-associated fibroblasts activate progesterone receptors and induce hormone independent mammary tumor growth: A role for the FGF-2/FGFR-2 axis. | Q46394153 | ||
| Nicastrin functions as a gamma-secretase-substrate receptor | Q46646587 | ||
| Implication of gamma-secretase in neuregulin-induced maturation of oligodendrocytes | Q47253607 | ||
| Nontraditional signaling mechanisms of lipoprotein receptors | Q47920574 | ||
| Phosphorylated KDR is expressed in the neoplastic and stromal elements of human renal tumours and shuttles from cell membrane to nucleus | Q48019480 | ||
| The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling | Q48173730 | ||
| Characterization of a novel tripartite nuclear localization sequence in the EGFR family. | Q50698452 | ||
| Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. | Q52583319 | ||
| γ-Secretase-mediated growth hormone receptor proteolysis: mapping of the intramembranous cleavage site. | Q53252389 | ||
| Up-regulation of nuclear IGF-I receptor by short term exposure of stilbene estrogen, diethylstilbestrol. | Q53455069 | ||
| Heregulin-dependent Trafficking and Cleavage of ErbB-4 | Q57371902 | ||
| The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study | Q58212050 | ||
| VEGF and VEGFR-2 (KDR) internalization is required for endothelial recovery during wound healing | Q61697432 | ||
| The N-end rule pathway of protein degradation | Q34422495 | ||
| Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events | Q34551375 | ||
| Anaplastic lymphoma kinase is a dependence receptor whose proapoptotic functions are activated by caspase cleavage. | Q34552993 | ||
| Presenilin-1 processing of ErbB4 in fetal type II cells is necessary for control of fetal lung maturation. | Q34612339 | ||
| The TrkC receptor induces apoptosis when the dependence receptor notion meets the neurotrophin paradigm. | Q34661111 | ||
| Is gamma-secretase a multienzyme complex for membrane protein degradation? Models and speculations | Q34750615 | ||
| Biosynthesis of tumorigenic HER2 C-terminal fragments by alternative initiation of translation. | Q34767641 | ||
| Presenilin-dependent intramembrane cleavage of ephrin-B1. | Q34803510 | ||
| A nuclear variant of ErbB3 receptor tyrosine kinase regulates ezrin distribution and Schwann cell myelination | Q34907703 | ||
| Transport of protein toxins into cells: pathways used by ricin, cholera toxin and Shiga toxin | Q34922115 | ||
| Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells | Q35063410 | ||
| Nuclear localization and possible functions of receptor tyrosine kinases | Q35089368 | ||
| Estrogen-induced upregulation of Sftpb requires transcriptional control of neuregulin receptor ErbB4 in mouse lung type II epithelial cells | Q35198204 | ||
| Presenilin1/gamma-secretase promotes the EphB2-induced phosphorylation of ephrinB2 by regulating phosphoprotein associated with glycosphingolipid-enriched microdomains/Csk binding protein | Q35225098 | ||
| Epithelial cell adhesion molecule (EpCAM) complex proteins promote transcription factor-mediated pluripotency reprogramming | Q35312062 | ||
| Ligand activation leads to regulated intramembrane proteolysis of fibroblast growth factor receptor 3 | Q35340703 | ||
| Neuregulin receptor ErbB4 functions as a transcriptional cofactor for the expression of surfactant protein B in the fetal lung | Q35528090 | ||
| Oxygen-dependent cleavage of the p75 neurotrophin receptor triggers stabilization of HIF-1α. | Q35540353 | ||
| γ-Secretase and presenilin mediate cleavage and phosphorylation of vascular endothelial growth factor receptor-1. | Q35604861 | ||
| Interaction with ErbB4 promotes hypoxia-inducible factor-1α signaling. | Q35879939 | ||
| Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. | Q35956440 | ||
| Identification of function for CD44 intracytoplasmic domain (CD44-ICD): modulation of matrix metalloproteinase 9 (MMP-9) transcription via novel promoter response element | Q36003640 | ||
| A novel epidermal growth factor receptor variant lacking multiple domains directly activates transcription and is overexpressed in tumors | Q36010772 | ||
| Cooperation of nuclear fibroblast growth factor receptor 1 and Nurr1 offers new interactive mechanism in postmitotic development of mesencephalic dopaminergic neurons. | Q36016749 | ||
| Nuclear translocation of type I transforming growth factor β receptor confers a novel function in RNA processing | Q36023325 | ||
| FGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior | Q36027395 | ||
| ErbB4 isoforms selectively regulate growth factor induced Madin-Darby canine kidney cell tubulogenesis | Q36095732 | ||
| The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells | Q36126992 | ||
| Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. | Q36225686 | ||
| c-erbB-3: a nuclear protein in mammary epithelial cells. | Q36325718 | ||
| Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1 | Q36421137 | ||
| Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7) | Q36451958 | ||
| Wingless signaling at synapses is through cleavage and nuclear import of receptor DFrizzled2. | Q36503006 | ||
| HER4 intracellular domain (4ICD) activity in the developing mammary gland and breast cancer | Q36742363 | ||
| P433 | issue | 10 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | a008979 | |
| P577 | publication date | 2013-10-01 | |
| P1433 | published in | Cold Spring Harbor Perspectives in Biology | Q3927509 |
| P1476 | title | Receptor tyrosine kinases in the nucleus | |
| P478 | volume | 5 |
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