| scholarly article | Q13442814 |
| P2093 | author name string | Kevin Wilhelmsen | |
| Peter van der Geer | |||
| P2860 | cites work | Metalloprotease-disintegrin MDC9: intracellular maturation and catalytic activity | Q22008720 |
| The gamma -secretase-cleaved C-terminal fragment of amyloid precursor protein mediates signaling to the nucleus | Q24292016 | ||
| A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctions | Q24294366 | ||
| Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development | Q24533474 | ||
| Presenilin-mediated transmembrane cleavage is required for Notch signal transduction in Drosophila | Q24546116 | ||
| Shc, Grb2, Sos1, and a 150-kilodalton tyrosine-phosphorylated protein form complexes with Fms in hematopoietic cells | Q24610231 | ||
| Synthesis of membrane-bound colony-stimulating factor 1 (CSF-1) and downmodulation of CSF-1 receptors in NIH 3T3 cells transformed by cotransfection of the human CSF-1 and c-fms (CSF-1 receptor) genes | Q24628100 | ||
| Notch signaling: from the outside in | Q28139768 | ||
| A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE | Q28139998 | ||
| A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain | Q28141707 | ||
| Presenilin is required for activity and nuclear access of Notch in Drosophila | Q28141718 | ||
| Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi | Q28141775 | ||
| Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans | Q28145545 | ||
| gamma -Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase | Q28202328 | ||
| A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60 | Q28205099 | ||
| The SREBP pathway: regulation of cholesterol metabolism by proteolysis of a membrane-bound transcription factor | Q28238069 | ||
| Nucleotide sequence and structural organization of the human FMS proto-oncogene | Q28248369 | ||
| The colony-stimulating factor 1 (CSF-1) receptor (c-fms proto-oncogene product) and its ligand | Q28286236 | ||
| Constitutive shedding of the amyloid precursor protein ectodomain is up-regulated by tumour necrosis factor-alpha converting enzyme | Q28344424 | ||
| The intracellular domain of the beta-amyloid precursor protein is stabilized by Fe65 and translocates to the nucleus in a notch-like manner | Q28510317 | ||
| A growing family of Notch ligands | Q28510402 | ||
| Sequence requirements for binding of Src family tyrosine kinases to activated growth factor receptors | Q28513453 | ||
| Presenilin-dependent "gamma-secretase" processing of deleted in colorectal cancer (DCC) | Q28579098 | ||
| Mutation of Tyr697, a GRB2-binding site, and Tyr721, a PI 3-kinase binding site, abrogates signal transduction by the murine CSF-1 receptor expressed in Rat-2 fibroblasts | Q28587864 | ||
| Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4 | Q28609073 | ||
| Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity | Q29616491 | ||
| The cell biology of beta-amyloid precursor protein and presenilin in Alzheimer's disease | Q30432239 | ||
| TNF-alpha-converting enzyme cleaves the macrophage colony-stimulating factor receptor in macrophages undergoing activation. | Q31838070 | ||
| Adamalysins. A family of metzincins including TNF-alpha converting enzyme (TACE). | Q33692956 | ||
| A point mutation at tyrosine-809 in the human colony-stimulating factor 1 receptor impairs mitogenesis without abrogating tyrosine kinase activity, association with phosphatidylinositol 3-kinase, or induction of c-fos and junB genes | Q33769954 | ||
| Early events in M-CSF receptor signaling | Q33855769 | ||
| Cell surface presenilin-1 participates in the gamma-secretase-like proteolysis of Notch | Q33883369 | ||
| Sequential activation of phoshatidylinositol 3-kinase and phospholipase C-gamma2 by the M-CSF receptor is necessary for differentiation signaling | Q33887555 | ||
| Tyr721 regulates specific binding of the CSF-1 receptor kinase insert to PI 3′-kinase SH2 domains: a model for SH2-mediated receptor-target interactions | Q33937612 | ||
| Notch signal transduction: a real rip and more | Q33964063 | ||
| Intramembrane proteolysis controls diverse signalling pathways throughout evolution | Q34146440 | ||
| The Notch ligands, Delta1 and Jagged2, are substrates for presenilin-dependent "gamma-secretase" cleavage | Q34173117 | ||
| Evidence that tumor necrosis factor alpha converting enzyme is involved in regulated alpha-secretase cleavage of the Alzheimer amyloid protein precursor | Q34475374 | ||
| Transmodulation of cell surface regulatory molecules via ectodomain shedding | Q34584816 | ||
| gamma-Secretase, Notch, Abeta and Alzheimer's disease: where do the presenilins fit in? | Q34609917 | ||
| Gamma-secretase-mediated proteolysis in cell-surface-receptor signalling | Q34810184 | ||
| Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins | Q34838458 | ||
| Mechanism of the cleavage specificity of Alzheimer's disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein | Q35065215 | ||
| Sterols regulate cycling of SREBP cleavage-activating protein (SCAP) between endoplasmic reticulum and Golgi | Q35644888 | ||
| Tumor necrosis factor alpha directly and indirectly regulates hematopoietic progenitor cell proliferation: role of colony-stimulating factor receptor modulation | Q36231361 | ||
| Proteolytic release of CD44 intracellular domain and its role in the CD44 signaling pathway | Q36294160 | ||
| Proteolytic release and nuclear translocation of Notch-1 are induced by presenilin-1 and impaired by pathogenic presenilin-1 mutations | Q36386575 | ||
| Macrophage colony-stimulating factor-induced tyrosine phosphorylation of c-fms proteins expressed in FDC-P1 and BALB/c 3T3 cells | Q36709950 | ||
| Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line. | Q36711242 | ||
| Tyrosine 706 and 807 phosphorylation site mutants in the murine colony-stimulating factor-1 receptor are unaffected in their ability to bind or phosphorylate phosphatidylinositol-3 kinase but show differential defects in their ability to induce earl | Q36732582 | ||
| Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms | Q36769339 | ||
| Biosynthesis of macrophage colony-stimulating factor (CSF-1): differential processing of CSF-1 precursors suggests alternative mechanisms for stimulating CSF-1 receptors | Q38253810 | ||
| CSF-1 and its receptor in ovarian, endometrial and breast cancer | Q40520354 | ||
| Proteolytic processing of low density lipoprotein receptor-related protein mediates regulated release of its intracellular domain | Q40743382 | ||
| C-Cbl binds the CSF-1 receptor at tyrosine 973, a novel phosphorylation site in the receptor's carboxy-terminus | Q40750172 | ||
| L-685,458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity | Q40865987 | ||
| Presenilin 1 regulates pharmacologically distinct gamma -secretase activities. Implications for the role of presenilin in gamma -secretase cleavage | Q40879070 | ||
| Requirement for Y706 of the murine (or Y708 of the human) CSF-1 receptor for STAT1 activation in response to CSF-1. | Q41144580 | ||
| Interleukin-4 rapidly down-modulates the macrophage colony-stimulating factor receptor in murine macrophages. | Q41154149 | ||
| CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract | Q41289962 | ||
| IFN-gamma/lipopolysaccharide activation of macrophages is associated with protein kinase C-dependent down-modulation of the colony-stimulating factor-1 receptor | Q41598528 | ||
| Presenilin 1 controls gamma-secretase processing of amyloid precursor protein in pre-golgi compartments of hippocampal neurons | Q42056692 | ||
| Antibodies to distal carboxyl terminal epitopes in the v-fms-coded glycoprotein do not cross-react with the c-fms gene product | Q43626307 | ||
| Targeted disruption of the mouse colony-stimulating factor 1 receptor gene results in osteopetrosis, mononuclear phagocyte deficiency, increased primitive progenitor cell frequencies, and reproductive defects | Q43833399 | ||
| Nectin-1alpha, an immunoglobulin-like receptor involved in the formation of synapses, is a substrate for presenilin/gamma-secretase-like cleavage | Q44177137 | ||
| Notch and the amyloid precursor protein are cleaved by similar gamma-secretase(s). | Q44270913 | ||
| Reconstitution of gamma-secretase activity | Q44393107 | ||
| Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. | Q45345845 | ||
| Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins. | Q52583319 | ||
| INTERLEUKIN 2 DOWN-MODULATES THE MACROPHAGE COLONY-STIMULATING FACTOR RECEPTOR IN MURINE MACROPHAGES | Q57771827 | ||
| Lipopolysaccharide inhibits the binding of colony-stimulating factor (CSF-1) to murine peritoneal exudate macrophages | Q67278005 | ||
| Granulocyte/macrophage colony-stimulating factor stimulates monocyte and tissue macrophage proliferation and enhances their responsiveness to macrophage colony-stimulating factor | Q69823389 | ||
| Tumor-promoting phorbol esters inhibit the binding of colony-stimulating factor (CSF-1) to murine peritoneal exudate macrophages | Q70149349 | ||
| CSF-1--a mononuclear phagocyte lineage-specific hemopoietic growth factor | Q70158879 | ||
| Protein topology of presenilin 1 | Q71821474 | ||
| Modulation of receptors for the colony-stimulating factor, CSF-1, by bacterial lipopolysaccharide and CSF-1 | Q72398069 | ||
| Mutations in the transmembrane domain of APP altering gamma-secretase specificity | Q73940417 | ||
| P433 | issue | 1 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 454-464 | |
| P577 | publication date | 2004-01-01 | |
| P1433 | published in | Molecular and Cellular Biology | Q3319478 |
| P1476 | title | Phorbol 12-myristate 13-acetate-induced release of the colony-stimulating factor 1 receptor cytoplasmic domain into the cytosol involves two separate cleavage events | |
| P478 | volume | 24 |
| Q39203918 | Anti-Notch treatment prevents multiple myeloma cells localization to the bone marrow via the chemokine system CXCR4/SDF-1. |
| Q37598601 | BACE and gamma-secretase characterization and their sorting as therapeutic targets to reduce amyloidogenesis |
| Q45786963 | Blocking of the Ubiquitin-Proteasome System Prevents Inflammation-Induced Bone Loss by Accelerating M-CSF Receptor c-Fms Degradation in Osteoclast Differentiation |
| Q40384003 | CD74 is a member of the regulated intramembrane proteolysis-processed protein family |
| Q40060773 | CSF-1 and TPA stimulate independent pathways leading to lysosomal degradation or regulated intramembrane proteolysis of the CSF-1 receptor |
| Q36356977 | Caveolin-1 regulates osteoclast differentiation by suppressing cFms degradation |
| Q63739995 | Dengue virus reduces expression of low-density lipoprotein receptor-related protein 1 to facilitate replication in Aedes aegypti |
| Q33991144 | Ectodomain shedding of interleukin-2 receptor beta and generation of an intracellular functional fragment |
| Q91239717 | Gamma-secretase-dependent signaling of receptor tyrosine kinases |
| Q44918417 | Gamma-secretase: proteasome of the membrane? |
| Q47989436 | Genome-wide screen of gamma-secretase-mediated intramembrane cleavage of receptor tyrosine kinases. |
| Q46117855 | KIT variants in bovine ovarian cells and corpus luteum |
| Q40143907 | M-CSF-mediated macrophage differentiation but not proliferation is correlated with increased and prolonged ERK activation |
| Q37267025 | MicroRNA-Mediated Down-Regulation of M-CSF Receptor Contributes to Maturation of Mouse Monocyte-Derived Dendritic Cells |
| Q41916650 | Molecular cloning, pathologically-correlated expression and functional characterization of the colonystimulating factor 1 receptor (CSF-1R) gene from a teleost, Plecoglossus altivelis |
| Q30479973 | Polyductin undergoes notch-like processing and regulated release from primary cilia |
| Q54341722 | Possible mechanisms and function of nuclear trafficking of the colony-stimulating factor-1 receptor. |
| Q36113481 | Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases |
| Q37472880 | Proteolytic cleavages give receptor tyrosine kinases the gift of ubiquity. |
| Q40541990 | Purification and identification of protein-tyrosine kinase-binding proteins using synthetic phosphopeptides as affinity reagents |
| Q42143882 | Quantification of gamma-secretase modulation differentiates inhibitor compound selectivity between two substrates Notch and amyloid precursor protein |
| Q26830216 | Receptor tyrosine kinases in the nucleus |
| Q37847814 | Regulated intramembrane proteolysis: signaling pathways and biological functions |
| Q40403940 | Secretase-dependent tyrosine phosphorylation of Mdm2 by the ErbB-4 intracellular domain fragment |
| Q39372364 | Sequential proteolytic processing of an interferon-alpha receptor subunit by TNF-alpha converting enzyme and presenilins |
| Q39336251 | Shedding-generated Met receptor fragments can be routed to either the proteasomal or the lysosomal degradation pathway |
| Q64064585 | Specific targeting of PKCδ suppresses osteoclast differentiation by accelerating proteolysis of membrane-bound macrophage colony-stimulating factor receptor |
| Q37073568 | Substrate specificity of gamma-secretase and other intramembrane proteases |
| Q24315646 | THOC5 couples M-CSF receptor signaling to transcription factor expression |
| Q35832938 | Targeting the degradation of AXL receptor tyrosine kinase to overcome resistance in gefitinib-resistant non-small cell lung cancer |
| Q33734632 | The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation |
| Q83150764 | The developing role of receptors and adaptors |
| Q37845036 | The many substrates of presenilin/γ-secretase |
| Q34123640 | The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling |
| Q37961985 | The physiology of the β-amyloid precursor protein intracellular domain AICD. |
| Q37643736 | The structure and function of Alzheimer's gamma secretase enzyme complex. |
| Q40009739 | Toll-like receptors stimulate regulated intramembrane proteolysis of the CSF-1 receptor through Erk activation |
| Q37308472 | Trafficking of receptor tyrosine kinases to the nucleus |
| Q34602706 | gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells |
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