The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells

scientific article

The cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.348904
P932PMC publication ID3408140
P698PubMed publication ID22665490

P50authorAndreas LudwigQ37378631
Seung-Taek LeeQ38523952
Won-Sik ShinQ55069759
P2093author name stringHye-Won Na
P2860cites workThe many roles of PTK7: A versatile regulator of cell–cell communicationQ21710722
A presenilin-1/gamma-secretase cleavage releases the E-cadherin intracellular domain and regulates disassembly of adherens junctionsQ24294366
The Wnt/planar cell polarity protein-tyrosine kinase-7 (PTK7) is a highly efficient proteolytic target of membrane type-1 matrix metalloproteinase: implications in cancer and embryogenesis.Q24299587
The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesionQ24300435
Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase familyQ24303539
Metalloproteinase/Presenilin1 processing of ephrinB regulates EphB-induced Src phosphorylation and signalingQ24306299
Protein tyrosine kinase 7 has a conserved role in Wnt/β-catenin canonical signallingQ24313083
Dual roles of Sema6D in cardiac morphogenesis through region-specific association of its receptor, Plexin-A1, with off-track and vascular endothelial growth factor receptor type 2Q24607154
A phosphatase associated with metastasis of colorectal cancerQ28198115
The enzymatic activity of ADAM8 and ADAM9 is not regulated by TIMPsQ28215674
A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytesQ28256848
Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brainQ28266755
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domainQ28273268
Biomarker discovery from pancreatic cancer secretome using a differential proteomic approachQ28276398
The ADAM metalloproteinasesQ28292696
Cloning and characterization of the full-length mouse Ptk7 cDNA encoding a defective receptor protein tyrosine kinaseQ28509449
PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebratesQ28587777
An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.Q30160209
Silencing of PTK7 in colon cancer cells: caspase-10-dependent apoptosis via mitochondrial pathwayQ33754728
Dtrk, a Drosophila gene related to the trk family of neurotrophin receptors, encodes a novel class of neural cell adhesion moleculeQ33937330
Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG.Q34403860
Transmodulation of cell surface regulatory molecules via ectodomain sheddingQ34584816
Expression profiling of liposarcoma yields a multigene predictor of patient outcome and identifies genes that contribute to liposarcomagenesis.Q34761951
Global gene expression profiling and validation in esophageal squamous cell carcinoma and its association with clinical phenotypesQ34917292
Intramembrane-cleaving proteases: controlled liberation of proteins and bioactive peptidesQ35057311
The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?Q35206311
ADAM17 mRNA expression and pathological features of hepatocellular carcinomaQ36065819
Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.Q36074351
Shedding light on ADAM metalloproteinasesQ36159565
Substrate specificity of gamma-secretase and other intramembrane proteasesQ37073568
Identification of ligand-induced proteolytic cleavage and ectodomain shedding of VEGFR-1/FLT1 in leukemic cancer cellsQ37173281
The ADAMs: signalling scissors in the tumour microenvironmentQ37324256
The "a disintegrin and metalloprotease" (ADAM) family of sheddases: physiological and cellular functionsQ37339450
Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancerQ37412311
The many substrates of presenilin/γ-secretaseQ37845036
PTK7 recruits dsh to regulate neural crest migrationQ38359072
PTK7/Otk interacts with Wnts and inhibits canonical Wnt signallingQ38441808
The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukemia and impairs clinical outcomeQ39691348
Identification of serum biomarkers for colorectal cancer metastasis using a differential secretome approachQ39772828
ADAM-17 expression in breast cancer correlates with variables of tumor progression.Q40145085
Aberrant expression of a disintegrin and metalloproteinase 17/tumor necrosis factor-alpha converting enzyme increases the malignant potential in human pancreatic ductal adenocarcinomaQ40230508
Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17.Q40243306
Up-regulated expression of ADAM17 in human colon carcinoma: co-expression with EGFR in neoplastic and endothelial cellsQ40393668
Increased expression of ADAM family members in human breast cancer and breast cancer cell linesQ40487746
Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time reverse transcriptase polymerase chain reaction.Q40528644
Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomasQ40628094
PlexinA1 interacts with PTK7 and is required for neural crest migrationQ42858898
High-throughput analysis of genome-wide receptor tyrosine kinase expression in human cancers identifies potential novel drug targetsQ44772602
The membrane proteases adams and hepsin are differentially expressed in renal cell carcinoma. Are they potential tumor markers?Q45147208
Novel regions of chromosomal amplification at 6p21, 5p13, and 12q14 in gastric cancer identified by array comparative genomic hybridizationQ45196334
The transmembrane protein Off-track associates with Plexins and functions downstream of Semaphorin signaling during axon guidanceQ46324780
Soluble PTK7 inhibits tube formation, migration, and invasion of endothelial cells and angiogenesisQ46601425
RACK1 is a novel interaction partner of PTK7 that is required for neural tube closureQ46835728
Differential inhibition of membrane type 3 (MT3)-matrix metalloproteinase (MMP) and MT1-MMP by tissue inhibitor of metalloproteinase (TIMP)-2 and TIMP-3 rgulates pro-MMP-2 activation.Q47846803
Transformation of mammalian cells with genes from prokaryotes and eukaryotes. 1979.Q49011297
TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3Q77357145
P433issue30
P407language of work or nameEnglishQ1860
P921main subjectcell migrationQ189092
colon cancerQ18555025
P304page(s)25001-25009
P577publication date2012-06-04
P1433published inJournal of Biological ChemistryQ867727
P1476titleThe cytosolic domain of protein-tyrosine kinase 7 (PTK7), generated from sequential cleavage by a disintegrin and metalloprotease 17 (ADAM17) and γ-secretase, enhances cell proliferation and migration in colon cancer cells
P478volume287

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cites work (P2860)
Q47112549Antibody-drug conjugate targeting protein tyrosine kinase 7, a receptor tyrosine kinase-like molecule involved in WNT and vascular endothelial growth factor signaling: effects on cancer stem cells, tumor microenvironment and whole-body homeostasis
Q37687371Catalytically defective receptor protein tyrosine kinase PTK7 enhances invasive phenotype by inducing MMP-9 through activation of AP-1 and NF-κB in esophageal squamous cell carcinoma cells
Q39016511Downstream signaling and genome-wide regulatory effects of PTK7 pseudokinase and its proteolytic fragments in cancer cells.
Q39162354Fine Tuning Cell Migration by a Disintegrin and Metalloproteinases.
Q48087924Fluorescence Sensing Using DNA Aptamers in Cancer Research and Clinical Diagnostics.
Q91239717Gamma-secretase-dependent signaling of receptor tyrosine kinases
Q47989436Genome-wide screen of gamma-secretase-mediated intramembrane cleavage of receptor tyrosine kinases.
Q37500185Growth arrest specific 2 is up-regulated in chronic myeloid leukemia cells and required for their growth
Q47391313Harnessing BET Inhibitor Sensitivity Reveals AMIGO2 as a Melanoma Survival Gene
Q36451958Insights into ectodomain shedding and processing of protein-tyrosine pseudokinase 7 (PTK7)
Q36324512Matrix metalloproteinases - From the cleavage data to the prediction tools and beyond
Q39153742Oncogenic role of protein tyrosine kinase 7 in esophageal squamous cell carcinoma.
Q35593473Overexpression of the Promigratory and Prometastatic PTK7 Receptor Is Associated with an Adverse Clinical Outcome in Colorectal Cancer
Q37444908PTK 7 is a transforming gene and prognostic marker for breast cancer and nodal metastasis involvement
Q48220908PTK6 Localized at the Plasma Membrane Promotes Cell Proliferation and MigratiOn Through Phosphorylation of Eps8.
Q92271121PTK7 proteolytic fragment proteins function during early Xenopus development
Q30586597Protein-tyrosine pseudokinase 7 (PTK7) directs cancer cell motility and metastasis
Q36113481Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases
Q26738712Ptk7 and Mcc, Unfancied Components in Non-Canonical Wnt Signaling and Cancer
Q26830216Receptor tyrosine kinases in the nucleus
Q30411399Simultaneous profiling of 194 distinct receptor transcripts in human cells
Q34981717The Coxsackievirus and Adenovirus Receptor (CAR) undergoes ectodomain shedding and regulated intramembrane proteolysis (RIP).
Q36381975The PTK7 and ROR2 Protein Receptors Interact in the Vertebrate WNT/Planar Cell Polarity (PCP) Pathway.
Q38690911Therapeutic Targeting of PTK7 is Cytotoxic in Atypical Teratoid Rhabdoid Tumors
Q29615666WNT signalling pathways as therapeutic targets in cancer
Q50421596miR‑205‑5p/PTK7 axis is involved in the proliferation, migration and invasion of colorectal cancer cells

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