Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis

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Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1053/J.GASTRO.2015.05.012
P932PMC publication ID4560830
P698PubMed publication ID26001927
P5875ResearchGate publication ID276923782

P50authorUwe VölkerQ58949104
Julia MayerleQ65559556
Henry VölzkeQ28039332
Claudia SchurmannQ28833429
Markus M LerchQ38327735
P2093author name stringGeorg Beyer
Georg Homuth
Vivien Kauschke
Thomas Wartmann
Walter Halangk
Peter Hegyi
Ujjwal M Mahajan
Matthias Sendler
Frank-Ulrich Weiss
Sandrina Maertin
P2860cites workAngiopoietin-2, a regulator of vascular permeability in inflammation, is associated with persistent organ failure in patients with acute pancreatitis from the United States and Germany.Q51771520
Autoimmune pancreatitis in MRL/Mp mice is a T cell-mediated disease responsive to cyclosporine A and rapamycin treatmentQ56897015
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Toll-like receptor 4 polymorphisms in German and US patients are not associated with occurrence or severity of acute pancreatitisQ58436119
Transcriptome analysis of human hepatic and pancreatic stellate cells: organ-specific variations of a common transcriptional phenotypeQ60609526
Balance of expression of genes coding for extracellular matrix proteins and extracellular matrix degrading proteases in chronic pancreatitisQ60609552
Does alcohol directly stimulate pancreatic fibrogenesis? Studies with rat pancreatic stellate cellsQ60961219
Anaphylatoxin generation in acute pancreatitisQ69742106
Complement component C5 deficiency reduces edema formation in murine ligation-induced acute pancreatitisQ73154847
Early complement system activation and neutrophil priming in acute pancreatitis: participation of trypsinQ73880761
Upregulation of fibronectin but not of entactin, collagen IV and smooth muscle actin by anaphylatoxin C5a in rat hepatic stellate cellsQ80581322
Fibrogenesis in alcoholic chronic pancreatitis: the role of tissue necrosis, macrophages, myofibroblasts and cytokinesQ83299268
Withdrawal of alcohol promotes regression while continued alcohol intake promotes persistence of LPS-induced pancreatic injury in alcohol-fed ratsQ85093731
Complement 5a stimulates hepatic stellate cells in vitro, and is increased in the plasma of patients with chronic hepatitis BQ85323799
Senescence of activated stellate cells limits liver fibrosisQ24621822
Mechanisms of hepatic fibrogenesisQ29619336
Transient receptor potential ankyrin 1 mediates chronic pancreatitis pain in mice.Q30437425
Treatment of severe neurological deficits with IgG depletion through immunoadsorption in patients with Escherichia coli O104:H4-associated haemolytic uraemic syndrome: a prospective trialQ33397004
Identification of a potent and orally active non-peptide C5a receptor antagonistQ34154819
Periacinar stellate shaped cells in rat pancreas: identification, isolation, and culture.Q34475071
Pancreatic stellate cells respond to inflammatory cytokines: potential role in chronic pancreatitisQ35594510
StellaTUM: current consensus and discussion on pancreatic stellate cell researchQ35633517
Activation of pancreatic stellate cells in human and experimental pancreatic fibrosisQ35788265
Mononuclear cells modulate the activity of pancreatic stellate cells which in turn promote fibrosis and inflammation in chronic pancreatitisQ36446987
IL-6 trans-signaling promotes pancreatitis-associated lung injury and lethalityQ36638151
Inhibition of biomaterial-induced complement activation attenuates the inflammatory host response to implantationQ36945134
Chronic pancreatitis--definition, etiology, investigation and treatmentQ36974615
Animal models for investigating chronic pancreatitis.Q37963556
Models of acute and chronic pancreatitis.Q38102103
Role of cathepsin B in intracellular trypsinogen activation and the onset of acute pancreatitisQ40735691
The role of C5 in septic lung injuryQ41507371
Evaluation of complement factor 5 variants as genetic risk factors for the development of advanced fibrosis in chronic hepatitis C infectionQ41604038
Pancreatic stellate cells are activated by proinflammatory cytokines: implications for pancreatic fibrogenesisQ42116957
Protective effects of MCP-1 inhibitor on a rat model of severe acute pancreatitis.Q43103762
The morphological basis for the evolution of acute pancreatitis into chronic pancreatitisQ43541521
Complement factor C5a exerts an anti-inflammatory effect in acute pancreatitis and associated lung injuryQ43568320
Identification of mediators stimulating proliferation and matrix synthesis of rat pancreatic stellate cellsQ43666355
Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humansQ44042948
Pancreatic neuropathy and neuropathic pain--a comprehensive pathomorphological study of 546 casesQ44124539
Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15.Q44231634
Anaphylatoxins and terminal complement complexes in pancreatitis. Evidence of complement activation in plasma and ascites fluid of patients with acute pancreatitisQ44521059
Correlation among complement activation, protease inhibitors, and clinical course in acute pancreatitis in man.Q44523799
Tumour necrosis factor α secretion induces protease activation and acinar cell necrosis in acute experimental pancreatitis in miceQ45056690
Camostat, an oral trypsin inhibitor, reduces pancreatic fibrosis induced by repeated administration of a superoxide dismutase inhibitor in ratsQ46536581
Identification of genetic loci associated with Helicobacter pylori serologic status.Q51012428
P4510describes a project that usesImageJQ1659584
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectchronic pancreatitisQ1996053
P304page(s)765-76.e10
P577publication date2015-05-19
P1433published inGastroenterologyQ4039279
P1476titleComplement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis
P478volume149

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cites work (P2860)
Q28392302Animal models of gastrointestinal and liver diseases. Animal models of acute and chronic pancreatitis
Q41862502Cathepsin B Activity Initiates Apoptosis via Digestive Protease Activation in Pancreatic Acinar Cells and Experimental Pancreatitis.
Q45991735Cathepsin B-mediated Activation of Trypsinogen in Endocytosing Macrophages Increases Severity of Pancreatitis in Mice.
Q52519464Chronic pancreatitis.
Q47238226Complement C5a inhibition moderates lipid metabolism and reduces tubulointerstitial fibrosis in diabetic nephropathy.
Q38988021Complement in Pancreatic Disease-Perpetrator or Savior?
Q36913772Contribution of the anaphylatoxin receptors, C3aR and C5aR, to the pathogenesis of pulmonary fibrosis
Q93222396Deficiency of cathepsin C ameliorates severity of acute pancreatitis by reduction of neutrophil elastase activation and cleavage of E-cadherin
Q38656177Do Animal Models of Acute Pancreatitis Reproduce Human Disease?
Q36583714Higher plasma levels of complement C3a, C4a and C5a increase the risk of subretinal fibrosis in neovascular age-related macular degeneration: Complement activation in AMD.
Q33687509Inhibition of Jak/STAT signaling reduces the activation of pancreatic stellate cells in vitro and limits caerulein-induced chronic pancreatitis in vivo
Q36357685Lysosome associated membrane proteins maintain pancreatic acinar cell homeostasis: LAMP-2 deficient mice develop pancreatitis
Q38900762New insights into the pathways initiating and driving pancreatitis.
Q58712490RB1CC1-enhanced autophagy facilitates PSCs activation and pancreatic fibrogenesis in chronic pancreatitis
Q52946378Systems Genetics of Liver Fibrosis.
Q28066426The Immune System in Tissue Environments Regaining Homeostasis after Injury: Is "Inflammation" Always Inflammation?

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