Glycosylation of α-dystroglycan: O-mannosylation influences the subsequent addition of GalNAc by UDP-GalNAc polypeptide N-acetylgalactosaminyltransferases

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Glycosylation of α-dystroglycan: O-mannosylation influences the subsequent addition of GalNAc by UDP-GalNAc polypeptide N-acetylgalactosaminyltransferases is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.370387
P932PMC publication ID3375520
P698PubMed publication ID22549772

P2093author name stringKelly G Ten Hagen
Lance Wells
Duy T Tran
David Live
Jae-Min Lim
Mian Liu
Stephanie H Stalnaker
P2860cites workDemonstration of mammalian protein O-mannosyltransferase activity: coexpression of POMT1 and POMT2 required for enzymatic activityQ24303491
Glycopeptide-preferring polypeptide GalNAc transferase 10 (ppGalNAc T10), involved in mucin-type O-glycosylation, has a unique GalNAc-O-Ser/Thr-binding site in its catalytic domain not found in ppGalNAc T1 or T2Q24312926
The catalytic and lectin domains of UDP-GalNAc:polypeptide alpha-N-Acetylgalactosaminyltransferase function in concert to direct glycosylation site selectionQ24322988
Principles of mucin architecture: structural studies on synthetic glycopeptides bearing clustered mono-, di-, tri-, and hexasaccharide glycodomainsQ27639491
Deciphering Structural Elements of Mucin Glycoprotein RecognitionQ27678183
Purification and cDNA Cloning of a Human UDP-N-acetyl-α- D-galactosamine:polypeptide N-AcetylgalactosaminyltransferaseQ28114903
Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virusQ28291275
cDNA cloning and expression of a novel UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferaseQ28504745
Cloning and characterization of a ninth member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family, ppGaNTase-T9Q28587735
Dystroglycan versatility in cell adhesion: a tale of multiple motifsQ30156956
Enrichment and site mapping of O-linked N-acetylglucosamine by a combination of chemical/enzymatic tagging, photochemical cleavage, and electron transfer dissociation mass spectrometryQ30433713
Distinct orders of GalNAc incorporation into a peptide with consecutive threoninesQ30713558
O-GalNAc incorporation into a cluster acceptor site of three consecutive threonines. Distinct specificity of GalNAc-transferase isoformsQ30873427
Functional characterization and expression analysis of members of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase family from Drosophila melanogasterQ30954205
Functional conservation of subfamilies of putative UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferases in Drosophila, Caenorhabditis elegans, and mammals. One subfamily composed of l(2)35Aa is essential in DrosophilaQ31046911
Conformational consequences of protein glycosylation: preparation of O-mannosyl serine and threonine building blocks, and their incorporation into glycopeptide sequences derived from alpha-dystroglycanQ31128799
Cloning and expression of a novel, tissue specifically expressed member of the UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase familyQ32003112
O-glycosylation modulates proprotein convertase activation of angiopoietin-like protein 3: possible role of polypeptide GalNAc-transferase-2 in regulation of concentrations of plasma lipidsQ33691116
An O-glycosyltransferase promotes cell adhesion during development by influencing secretion of an extracellular matrix integrin ligandQ33911414
The role of mucin-type O-glycans in eukaryotic developmentQ33987647
Site mapping and characterization of O-glycan structures on alpha-dystroglycan isolated from rabbit skeletal muscle.Q34042753
O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding.Q34090655
Glycoproteomic characterization of recombinant mouse α-dystroglycanQ34126184
Like-acetylglucosaminyltransferase (LARGE)-dependent modification of dystroglycan at Thr-317/319 is required for laminin binding and arenavirus infection.Q34223029
Characterization of protein tyrosine kinases from human breast cancer: involvement of the c-src oncogene product.Q34250172
Mouse large can modify complex N- and mucin O-glycans on alpha-dystroglycan to induce laminin bindingQ34405965
Decoding arenavirus pathogenesis: essential roles for alpha-dystroglycan-virus interactions and the immune response.Q34626030
Emerging paradigms for the initiation of mucin-type protein O-glycosylation by the polypeptide GalNAc transferase family of glycosyltransferasesQ34800380
Mutational and functional analysis of Large in a novel CHO glycosylation mutantQ34983110
Dystrophin-glycoprotein complex: post-translational processing and dystroglycan function.Q35056189
Glycomic analyses of mouse models of congenital muscular dystrophyQ35065134
Reduced glycosylation of α-dystroglycans on carcinoma cells contributes to formation of highly infiltrative histological patterns in prostate cancerQ35216105
Synthetic, structural, and biosynthetic studies of an unusual phospho-glycopeptide derived from α-dystroglycanQ35222634
UDP-N-acetyl-α-D-galactosamine:polypeptide N-acetylgalactosaminyltransferases: completion of the family treeQ35913331
Dystroglycan: from biosynthesis to pathogenesis of human disease.Q36367346
Molecular cloning of a rat submandibular gland apomucinQ36752592
Cloning and expression of mouse UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3.Q36831741
Recent insights into the biological roles of mucin-type O-glycosylationQ37130137
Dystroglycan glycosylation and muscular dystrophy.Q37261423
Protein O-mannosylation in animal development and physiology: from human disorders to Drosophila phenotypesQ37723603
Dystroglycanopathies: coming into focusQ37852376
Detection of O-mannosyl glycans in rabbit skeletal muscle alpha-dystroglycanQ38330780
Electron microscopy of an alpha-dystroglycan fragment containing receptor sites for lymphocytic choriomeningitis virus and laminin, and use of the receptoid body as a reagent to neutralize virusQ38339100
Combining high-energy C-trap dissociation and electron transfer dissociation for protein O-GlcNAc modification site assignmentQ38403960
Regulation of O-glycosylation through Golgi-to-ER relocation of initiation enzymesQ39700918
Initiation of mammalian O-mannosylation in vivo is independent of a consensus sequence and controlled by peptide regions within and upstream of the alpha-dystroglycan mucin domainQ39985380
Proteolytic enzymes and altered glycosylation modulate dystroglycan function in carcinoma cells.Q40519860
Purification, cloning, and expression of a bovine UDP-GalNAc: polypeptide N-acetyl-galactosaminyltransferase.Q41528434
Defective glycosylation of α-dystroglycan contributes to podocyte flatteningQ42478287
A UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase is essential for viability in Drosophila melanogasterQ42673462
Characterization of site-specific O-glycan structures within the mucin-like domain of alpha-dystroglycan from human skeletal muscleQ43052323
Mucin core O-glycosylation is modulated by neighboring residue glycosylation status. Kinetic modeling of the site-specific glycosylation of the apo-porcine submaxillary mucin tandem repeat by UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferasesQ44192048
Role of peptide sequence and neighboring residue glycosylation on the substrate specificity of the uridine 5'-diphosphate-alpha-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyl transferases T1 and T2: kinetic modeling of the porcine and caniQ44993663
Characterization of a UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase that displays glycopeptide N-acetylgalactosaminyltransferase activityQ47928425
High prevalence of 2-mono- and 2,6-di-substituted manol-terminating sequences among O-glycans released from brain glycopeptides by reductive alkaline hydrolysisQ48123397
O-linked glycan expression during Drosophila development.Q51985076
Electron microscopic evidence for a mucin-like region in chick muscle alpha-dystroglycanQ71889901
P433issue25
P407language of work or nameEnglishQ1860
P921main subjectglycosylationQ898365
P304page(s)20967-20974
P577publication date2012-05-01
P1433published inJournal of Biological ChemistryQ867727
P1476titleGlycosylation of α-dystroglycan: O-mannosylation influences the subsequent addition of GalNAc by UDP-GalNAc polypeptide N-acetylgalactosaminyltransferases
P478volume287