Eph/ephrin signaling in epidermal differentiation and disease

scientific article

Eph/ephrin signaling in epidermal differentiation and disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.SEMCDB.2011.10.017
P932PMC publication ID3378995
P698PubMed publication ID22040910
P5875ResearchGate publication ID51758285

P2093author name stringBingcheng Wang
Spiro Getsios
Samantha Lin
P2860cites workEphexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanismQ24294233
Ligand Targeting of EphA2 Enhances Keratinocyte Adhesion and Differentiation via Desmoglein 1Q24300682
Ligand binding induces Cbl-dependent EphB1 receptor degradation through the lysosomal pathwayQ24301313
EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with AktQ24310260
EphA2 is an essential mediator of UV radiation-induced apoptosisQ24311103
EphA1 interacts with integrin-linked kinase and regulates cell morphology and motilityQ24312896
Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptorQ24313139
PTP1B regulates Eph receptor function and traffickingQ24313351
Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complexQ24338237
Integrated network analysis of transcriptomic and proteomic data in psoriasisQ24610642
Eph/ephrin molecules--a hub for signaling and endocytosisQ24611588
Scratching the surface of skin developmentQ24647707
Epidermal homeostasis: a balancing act of stem cells in the skinQ24654755
Expression and functional effects of Eph receptor tyrosine kinase A family members on Langerhans like dendritic cellsQ24799713
Cytoplasmic relaxation of active Eph controls ephrin shedding by ADAM10Q27326381
Atopic dermatitis-like disease and associated lethal myeloproliferative disorder arise from loss of Notch signaling in the murine skinQ27334347
Spatial Structure and pH-dependent Conformational Diversity of Dimeric Transmembrane Domain of the Receptor Tyrosine Kinase EphA1Q27651810
NMR Studies of a Heterotypic Sam−Sam Domain Association: The Interaction between the Lipid Phosphatase Ship2 and the EphA2 Receptor † , ‡Q27652803
Structural Characterization of the EphA4-Ephrin-B2 Complex Reveals New Features Enabling Eph-Ephrin Binding PromiscuityQ27658020
Left-Handed Dimer of EphA2 Transmembrane Domain: Helix Packing Diversity among Receptor Tyrosine KinasesQ27660088
An extracellular steric seeding mechanism for Eph-ephrin signaling platform assemblyQ27660230
Architecture of Eph receptor clustersQ27661948
A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytesQ28141013
Regulated cleavage of a contact-mediated axon repellentQ28144522
Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissuesQ28214281
Coexpressed EphA receptors and ephrin-A ligands mediate opposing actions on growth cone navigation from distinct membrane domainsQ28244322
Repelling class discrimination: ephrin-A5 binds to and activates EphB2 receptor signalingQ28258431
E-cadherin and P-cadherin have partially redundant roles in human epidermal stratificationQ42436287
AKT1 provides an essential survival signal required for differentiation and stratification of primary human keratinocytesQ42491656
Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skinQ42498441
Expression profile of Eph receptors and ephrin ligands in human skin and downregulation of EphA1 in nonmelanoma skin cancerQ42498631
Endocytosis of EphA receptors is essential for the proper development of the retinocollicular topographic map.Q42739460
Distinct membrane compartmentalization and signaling of ephrin-A5 and ephrin-B1.Q42809672
Ephrins negatively regulate cell proliferation in the epidermis and hair follicleQ43053150
c-Cbl-dependent EphA2 protein degradation is induced by ligand binding.Q44259057
EphA receptors regulate growth cone dynamics through the novel guanine nucleotide exchange factor ephexinQ45345123
Mutations of the EPHA2 receptor tyrosine kinase gene cause autosomal dominant congenital cataractQ46078686
Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier functionQ46215921
Vav family GEFs link activated Ephs to endocytosis and axon guidanceQ46453264
Ephrin-A3 not only increases the density of hair follicles but also accelerates anagen development in neonatal miceQ46474306
Phosphoinositide 3-kinase signaling to Akt promotes keratinocyte differentiation versus death.Q46612862
A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis.Q46653193
VE-cadherin regulates EphA2 in aggressive melanoma cells through a novel signaling pathway: implications for vasculogenic mimicryQ46947294
Tissue transglutaminase clusters soluble A-type ephrins into functionally active high molecular weight oligomersQ47273883
Eph-ephrin promiscuity is now crystal clearQ47683124
Ephrin-A4 inhibits sensory neurite outgrowth and is regulated by neonatal skin wounding.Q52033339
Expression of Eph receptors and ephrins is differentially regulated by E-cadherin.Q52169127
Ephrin-mediated cis-attenuation of Eph receptor signaling is essential for spinal motor axon guidance.Q54575179
Different gene expression profile observed in dermal papilla cells related to androgenic alopecia by DNA macroarray analysis.Q54697168
The Differential Fate of Cadherins during T-Cell-Induced Keratinocyte Apoptosis Leads to Spongiosis in Eczematous DermatitisQ61959828
Up-regulation of ephrin-A1 during melanoma progressionQ73032207
E-cadherin regulates the function of the EphA2 receptor tyrosine kinaseQ73053220
Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activationQ79393705
Gene expression profiling of Japanese psoriatic skin reveals an increased activity in molecular stress and immune response signalsQ81470429
Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma modelQ82490722
Cadherin-mediated regulation of tight junctions in stratifying epitheliaQ84086686
The axon's balancing act: cis- and trans-interactions between Ephs and ephrinsQ84538815
RNA interference in keratinocytes and an organotypic model of human epidermisQ84889456
Cell-specific information processing in segregating populations of Eph receptor ephrin-expressing cellsQ28267574
Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in transQ28278222
Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesisQ28286738
The skin: an indispensable barrierQ28302280
The SAM domains of Anks family proteins are critically involved in modulating the degradation of EphA receptorsQ28507101
E-cadherin is essential for in vivo epidermal barrier function by regulating tight junctionsQ28593264
Transient expression of ephrin b2 in perinatal skin is required for maintenance of keratinocyte homeostasisQ28593395
Regulation of cadherin-mediated adhesion in morphogenesisQ29614940
Defining the epithelial stem cell niche in skinQ29614985
Eph-ephrin bidirectional signaling in physiology and diseaseQ29617975
Eph receptor signalling casts a wide net on cell behaviourQ29619988
EphA2 engages Git1 to suppress Arf6 activity modulating epithelial cell-cell contactsQ30486775
Restriction of receptor movement alters cellular response: physical force sensing by EphA2.Q30495246
Kinase-dependent and kinase-independent functions of EphA4 receptors in major axon tract formation in vivo.Q31965129
External antigen uptake by Langerhans cells with reorganization of epidermal tight junction barriersQ33590480
Eph receptors and ephrins in cancer: bidirectional signalling and beyondQ34021365
Notch signaling is a direct determinant of keratinocyte growth arrest and entry into differentiationQ34077697
ABCA12 mutations and autosomal recessive congenital ichthyosis: A review of genotype/phenotype correlations and of pathogenetic conceptsaQ34128802
Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesisQ34162269
Crystal structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformationsQ34170551
Antigen-specific immunoadsorption of pathogenic autoantibodies in pemphigus foliaceusQ34293969
Signaling downstream of Eph receptors and ephrin ligandsQ34300573
Tight junction defects in patients with atopic dermatitis.Q34629278
Epidermal Notch signalling: differentiation, cancer and adhesionQ34761852
Eph/ephrin signaling in epithelial development and homeostasisQ35026768
Molecular plasticity of human melanoma cellsQ35146549
Remodeling of the microenvironment by aggressive melanoma tumor cellsQ35157766
Hair follicle stem cells.Q35190534
EphA2 is a critical oncogene in melanomaQ35218960
Ephrin signaling: One raft to rule them all? One raft to sort them? One raft to spread their call and in signaling bind them?Q35579626
Eph receptor-ephrin bidirectional signals that target Ras and Rho proteinsQ35749432
New exchanges in eph-dependent growth cone dynamicsQ36105204
EphA kinase activation regulates HGF-induced epithelial branching morphogenesisQ36325486
Autoantibodies against adhesion molecules and structures in blistering skin diseasesQ36364297
EphA2 as a promoter of melanoma tumorigenicityQ36379022
Expression and activation of ephexin is altered after spinal cord injuryQ36445643
Regulation of keratinocyte intercellular junction organization and epidermal morphogenesis by E-cadherinQ36531255
Identification and functional analysis of phosphorylated tyrosine residues within EphA2 receptor tyrosine kinase.Q36701792
Mechanisms regulating epithelial stratificationQ36816002
New insights into cadherin function in epidermal sheet formation and maintenance of tissue integrityQ36899981
Desmosomes: new perspectives on a classicQ36970223
Tight junctions/adherens junctions: basic structure and functionQ36970229
Eph-ephrin signalling in adult tissues and cancerQ37114287
Eph, a protein family coming of age: more confusion, insight, or complexity?Q37138899
Desmoglein 1-dependent suppression of EGFR signaling promotes epidermal differentiation and morphogenesisQ37267606
What are melanocytes really doing all day long...?Q37472801
Emerging role of Notch signaling in epidermal differentiation and skin cancerQ37604150
The role of Eph receptors and ephrin ligands in colorectal cancerQ37663912
Contrasting pathogenesis of atopic dermatitis and psoriasis--part I: clinical and pathologic conceptsQ37851196
Specific and shared targets of ephrin A signaling in epidermal keratinocytesQ38503847
The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cellsQ39750269
Cell adhesion and EGFR activation regulate EphA2 expression in cancerQ39769263
Ephrin-independent regulation of cell substrate adhesion by the EphB4 receptorQ39833824
EphA2 reexpression prompts invasion of melanoma cells shifting from mesenchymal to amoeboid-like motility styleQ39879644
Oncogenic NRAS has multiple effects on the malignant phenotype of human melanoma cells cultured in vitroQ39936278
Elevated protein tyrosine phosphatase activity provokes Eph/ephrin-facilitated adhesion of pre-B leukemia cells.Q39995504
Overexpression of EPHA2 receptor destabilizes adherens junctions via a RhoA-dependent mechanism.Q40024688
Comparison of EphA receptor tyrosine kinases and ephrinA ligand expression to EphB-ephrinB in vascularized corneas.Q40127999
Activation of the EGFR gene target EphA2 inhibits epidermal growth factor-induced cancer cell motilityQ40156318
Expression profiling of UVB response in melanocytes identifies a set of p53-target genesQ40247632
EphA2 phosphorylates the cytoplasmic tail of Claudin-4 and mediates paracellular permeabilityQ40360123
A conditional feedback loop regulates Ras activity through EphA2.Q40385854
Hypoxia up-regulates expression of Eph receptors and ephrins in mouse skinQ40388669
EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphataseQ40392006
Ligation of EphA2 by Ephrin A1-Fc inhibits pancreatic adenocarcinoma cellular invasivenessQ40536598
Ephrin-A1 induces c-Cbl phosphorylation and EphA receptor down-regulation in T cellsQ40641471
Negative regulation of EphA2 receptor by Cbl.Q40714708
Activation of EphA receptor tyrosine kinase inhibits the Ras/MAPK pathwayQ40808897
Epithelial cell kinase-B61: an autocrine loop modulating intestinal epithelial migration and barrier functionQ41081184
The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signalingQ41602986
Kinase-dependent and -independent roles of EphA2 in the regulation of prostate cancer invasion and metastasisQ42045872
P433issue1
P304page(s)92-101
P577publication date2011-10-21
P1433published inSeminars in Cell & Developmental BiologyQ14330411
P1476titleEph/ephrin signaling in epidermal differentiation and disease
P478volume23

Reverse relations

cites work (P2860)
Q36605256Alteration of the EphA2/Ephrin-A signaling axis in psoriatic epidermis
Q39189772Asymmetry at cell-cell interfaces direct cell sorting, boundary formation, and tissue morphogenesis.
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Q39872161Ephrin-B/EphB Signaling Is Required for Normal Innervation of Lingual Gustatory Papillae
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Q39886331Point mutations in dimerization motifs of the transmembrane domain stabilize active or inactive state of the EphA2 receptor tyrosine kinase.
Q36124917Regulation of cell differentiation by Eph receptor and ephrin signaling
Q37584993Roles of EphA2 in Development and Disease
Q38150596The role of EPH receptors in cancer-related epithelial-mesenchymal transition
Q38174793Therapeutic targeting of EPH receptors and their ligands
Q35596485Transcriptional profiling of ectoderm specification to keratinocyte fate in human embryonic stem cells