Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis

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Eosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1097/MIB.0000000000000512
P932PMC publication ID4567482
P698PubMed publication ID26218140
P5875ResearchGate publication ID280535561

P50authorEóin N McNameeQ42582545
Edwin F de ZoetenQ57345364
P2093author name stringGlenn T Furuta
Kelley E Capocelli
James J Lee
Rachel Harris
Joanne C Masterson
Paul Jedlicka
Cheryl Protheroe
Lindsay Hosford
Shahan D Fernando
Kathryn Biette
P2860cites workMouse and human eosinophils degranulate in response to platelet-activating factor (PAF) and lysoPAF via a PAF-receptor-independent mechanism: evidence for a novel receptorQ24629279
A novel IL-1 family cytokine, IL-33, potently activates human eosinophilsQ24647672
Human eosinophils express and release IL-13 following CD28-dependent activationQ28207371
IL-13 signaling through the IL-13alpha2 receptor is involved in induction of TGF-beta1 production and fibrosisQ28285105
Interleukin-33 enhances adhesion, CD11b expression and survival in human eosinophilsQ28292740
Epithelial-derived IL-33 and its receptor ST2 are dysregulated in ulcerative colitis and in experimental Th1/Th2 driven enteritisQ30434426
Human eosinophil major basic protein is an endogenous allosteric antagonist at the inhibitory muscarinic M2 receptorQ33894905
Activation of eosinophils interacting with dermal fibroblasts by pruritogenic cytokine IL-31 and alarmin IL-33: implications in atopic dermatitisQ34137362
Risk factors associated with progression to intestinal complications of Crohn's disease in a population-based cohortQ34175981
Inflammatory bowel disease-associated interleukin-33 is preferentially expressed in ulceration-associated myofibroblasts.Q34358060
IL-13 promotes collagen accumulation in Crohn's disease fibrosis by down-regulation of fibroblast MMP synthesis: a role for innate lymphoid cells?Q34540573
IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in miceQ34647885
Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertensionQ35175427
CCR3 Blockade Attenuates Eosinophilic Ileitis and Associated Remodeling.Q35475346
Incidence of stricturing and penetrating complications of Crohn's disease diagnosed in pediatric patients.Q35673366
IL-33 induces IL-13-dependent cutaneous fibrosisQ82370239
Interleukin-13 and transforming growth factor β synergise in the pathogenesis of human intestinal fistulaeQ83355378
IL-33 Exacerbates Eosinophil-Mediated Airway InflammationQ84698017
Modulation of IL-33/ST2 system in postinfarction heart failure: correlation with cardiac remodelling markersQ87895868
Ultrastructural features of eosinophilic oesophagitis: impact of treatment on desmosomesQ35864150
Eosinophil-mediated signalling attenuates inflammatory responses in experimental colitisQ35891878
Eosinophilic esophagitis: epithelial mesenchymal transition contributes to esophageal remodeling and reverses with treatment.Q35923340
Opposing roles for IL-13 and IL-13 receptor alpha 2 in health and diseaseQ35951827
Epithelial exposure to hypoxia modulates neutrophil transepithelial migrationQ36367344
Cytokines mediating the induction of chronic colitis and colitis-associated fibrosisQ36905414
Human eosinophils constitutively express multiple Th1, Th2, and immunoregulatory cytokines that are secreted rapidly and differentiallyQ37062148
Human basophils and eosinophils are the direct target leukocytes of the novel IL-1 family member IL-33.Q37100750
Novel model of TH2-polarized chronic ileitis: the SAMP1 mouse.Q37206843
Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical scienceQ37214366
CT imaging features of eosinophilic colitis in childrenQ37275429
Interleukin-33 overexpression is associated with liver fibrosis in mice and humans.Q37311036
Neutralisation of the interleukin-33/ST2 pathway ameliorates experimental colitis through enhancement of mucosal healing in miceQ37345931
Interleukin-33 potentiates bleomycin-induced lung injuryQ37596499
T-helper 2 cytokines, transforming growth factor β1, and eosinophil products induce fibrogenesis and alter muscle motility in patients with eosinophilic esophagitis.Q37710944
Genetics of childhood-onset inflammatory bowel diseaseQ37788639
A novel histologic scoring system to evaluate mucosal biopsies from patients with eosinophilic esophagitisQ38422089
Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33: implications for allergic inflammationQ39026926
IL-33 is upregulated in colonocytes of ulcerative colitis.Q39929368
Mast cells and eosinophils have a potential profibrogenic role in Crohn diseaseQ40548817
Development and validation of a pediatric Crohn's disease activity indexQ40749458
Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosisQ41945735
IL-33 markedly activates murine eosinophils by an NF-κB-dependent mechanism differentially dependent upon an IL-4-driven autoinflammatory loop.Q42935119
Regulation of eotaxin-3/CC chemokine ligand 26 expression by T helper type 2 cytokines in human colonic myofibroblastsQ44967205
Esophageal remodeling in pediatric eosinophilic esophagitisQ46304660
IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitisQ46306807
Eosinophils alter colonic epithelial barrier function: role for major basic proteinQ46755349
Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-β1, and increase esophageal smooth muscle contractionQ46969232
Interleukin-5 participates in the pathogenesis of ileitis in SAMP1/Yit miceQ47431206
Human basophils interact with memory T cells to augment Th17 responses.Q50932746
Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis.Q54431742
Eosinophils Express Functional IL-13 in Eosinophilic Inflammatory DiseasesQ61959803
A new murine model of accelerated senescenceQ71011567
Eosinophil granule-derived major basic protein induces IL-8 expression in human intestinal myofibroblastsQ73023721
Ablation of eosinophils leads to a reduction of allergen-induced pulmonary pathologyQ78396719
Induction of IL-13 triggers TGF-beta1-dependent tissue fibrosis in chronic 2,4,6-trinitrobenzene sulfonic acid colitisQ80178424
Eosinophil-fibroblast interactions induce fibroblast IL-6 secretion and extracellular matrix gene expression: implications in fibrogenesisQ81321357
Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel diseaseQ82257596
P433issue10
P407language of work or nameEnglishQ1860
P304page(s)2429-2440
P577publication date2015-07-25
P1433published inInflammatory Bowel DiseasesQ15749161
P1476titleEosinophils and IL-33 Perpetuate Chronic Inflammation and Fibrosis in a Pediatric Population with Stricturing Crohn's Ileitis
P478volume21

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cites work (P2860)
Q89804518Clinical Implications of Pediatric Colonic Eosinophilia
Q42368405Editorial: Factors Promoting Development of Fibrosis in Crohn's Disease
Q99237529Eosinophilic Colitis and Clostridioides difficile Sepsis With Rapid Remission After Antimicrobial Treatment; A Rare Coincidence and Its Pathogenic Implications
Q92323510Eosinophils in the gastrointestinal tract and their role in the pathogenesis of major colorectal disorders
Q59804799Host Regulators of Liver Fibrosis During Human Schistosomiasis
Q39974669IL-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis.
Q58566658IL-33/ST2 Axis in Organ Fibrosis
Q54240796ILC2s in infectious diseases and organ-specific fibrosis.
Q90385665Immunological roles of intestinal mesenchymal cells
Q26774652Macrophage and Innate Lymphoid Cell Interplay in the Genesis of Fibrosis
Q41273741The Role of Cytokines in the Fibrotic Responses in Crohn's Disease
Q90208339The emerging roles of eosinophils in mucosal homeostasis
Q40103784The orphan nuclear receptor RORα and group 3 innate lymphoid cells drive fibrosis in a mouse model of Crohn's disease
Q40074887Type 2 immunity in tissue repair and fibrosis
Q33711741Uncovering Pathogenic Mechanisms of Inflammatory Bowel Disease Using Mouse Models of Crohn's Disease-Like Ileitis: What is the Right Model?

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