Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities

scientific article published on March 1, 1992

Amyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1016/0165-6147(92)90039-9
P698PubMed publication ID1574806

P50authorPaul GreengardQ309979
P2093author name stringS. Gandy
P2860cites workRegulation of chloride channels by protein kinase C in normal and cystic fibrosis airway epitheliaQ58113284
Cyclic AMP-dependent protein kinase opens chloride channels in normal but not cystic fibrosis airway epitheliumQ58113448
Phosphorylation fails to activate chloride channels from cystic fibrosis airway cellsQ59062031
Familial Alzheimer's diseaseQ80506284
Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's diseaseQ28241772
Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein geneQ28245149
Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid proteinQ29547803
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptorQ29618322
Amyloid deposition as the central event in the aetiology of Alzheimer's diseaseQ29619450
Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's diseaseQ34415666
A mutation in the amyloid precursor protein associated with hereditary Alzheimer's diseaseQ34955569
Protease inhibitor domain encoded by an amyloid protein precursor mRNA associated with Alzheimer's diseaseQ36415791
Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activityQ36415795
Characterization and chromosomal localization of a cDNA encoding brain amyloid of Alzheimer's diseaseQ36482688
Alzheimer plaques and tangles: advances on both frontsQ36679256
Hereditary cerebral hemorrhage with amyloidosis — Dutch type: its importance for Alzheimer researchQ36679296
Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanismsQ36769339
Deciphering Alzheimer's disease: the amyloid precursor protein yields new cluesQ37813340
Colocalized transmembrane determinants for ER degradation and subunit assembly explain the intracellular fate of TCR chainsQ41715231
Cleavage of amyloid beta peptide during constitutive processing of its precursorQ41852594
Cl- channels in CF: lack of activation by protein kinase C and cAMP-dependent protein kinaseQ41924485
Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185.Q42811529
The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II.Q43466747
Deposits of Amyloid β Protein in the Central Nervous System of Transgenic MiceQ43905949
Amyloid beta protein enhances the survival of hippocampal neurons in vitroQ44109304
Mis-sense mutation Val→Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's diseaseQ44230499
Formation of beta-amyloid protein deposits in brains of transgenic miceQ44671370
Evidence that beta-amyloid protein in Alzheimer's disease is not derived by normal processingQ45039717
Activation of chloride channels in normal and cystic fibrosis airway epithelial cells by multifunctional calcium/calmodulin-dependent protein kinaseQ45948349
A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitorsQ46046983
Relation of neuronal APP-751/APP-695 mRNA ratio and neuritic plaque density in Alzheimer's diseaseQ46121331
Protease nexin-II, a potent antichymotrypsin, shows identity to amyloid beta-protein precursorQ46359315
The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groupsQ48214753
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch typeQ48265529
Amyloid beta protein gene: cDNA, mRNA distribution, and genetic linkage near the Alzheimer locusQ48349302
RETRACTED ARTICLE: Amyloid plaques, neurofibrillary tangles and neuronal loss in brains of transgenic mice overexpressing a C-terminal fragment of human amyloid precursor proteinQ48610295
Alzheimer's mutation.Q53182897
Differential expression of amyloid precursor protein mRNAs in cases of Alzheimer's disease and in aged nonhuman primates.Q53184432
Soluble derivatives of the beta amyloid protein precursor of Alzheimer's disease are labeled by antisera to the beta amyloid protein.Q53186852
Identification, biogenesis, and localization of precursors of Alzheimer's disease A4 amyloid protein.Q53188216
Expression of the Alzheimer amyloid precursor gene transcripts in the human brain.Q53190283
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectAlzheimer's diseaseQ11081
P304page(s)108-113
P577publication date1992-03-01
P1433published inTrends in Pharmacological SciencesQ2451474
P1476titleAmyloidogenesis in Alzheimer's disease: some possible therapeutic opportunities
P478volume13

Reverse relations

cites work (P2860)
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Q38315976High-level expression and in vitro mutagenesis of a fibrillogenic 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein
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