Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche.

scientific article

Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1371/JOURNAL.PBIO.1002491
P932PMC publication ID4922642
P698PubMed publication ID27348469

P50authorInke NathkeQ51915592
P2093author name stringIan P Newton
James M Osborne
Paul L Appleton
Alistair J Langlands
Axel A Almet
P2860cites workRegulation of mammary gland branching morphogenesis by the extracellular matrix and its remodeling enzymesQ21092901
Structural basis of the interaction between integrin alpha6beta4 and plectin at the hemidesmosomesQ24314867
Hemidesmosome formation is initiated by the beta4 integrin subunit, requires complex formation of beta4 and HD1/plectin, and involves a direct interaction between beta4 and the bullous pemphigoid antigen 180Q24682604
β1 and β4 integrins: from breast development to clinical practiceQ27000311
Colon cryptogenesis: asymmetric buddingQ27303102
A two-dimensional model of the colonic crypt accounting for the role of the basement membrane and pericryptal fibroblast sheathQ27330614
High-resolution quantification of focal adhesion spatiotemporal dynamics in living cellsQ27332337
Fiji: an open-source platform for biological-image analysisQ27860912
Identification of stem cells in small intestine and colon by marker gene Lgr5Q28131701
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheQ28239639
Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging.Q28307731
Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinBQ28508041
SOX9 is required for the differentiation of paneth cells in the intestinal epitheliumQ28586813
Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiationQ28587525
Sox9 regulates cell proliferation and is required for Paneth cell differentiation in the intestinal epitheliumQ28588362
APC in the regulation of intestinal crypt fissionQ28591276
Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survivalQ28592841
Myc regulates keratinocyte adhesion and differentiation via complex formation with Miz1Q30480348
Wnt-reporter expression pattern in the mouse intestine during homeostasisQ33389500
Preparation of wholemount mouse intestine for high-resolution three-dimensional imaging using two-photon microscopy.Q33435618
Expansion of intestinal epithelial stem cells during murine developmentQ34079249
Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission.Q34248675
Live and let die in the intestinal epitheliumQ35595940
Repression of SRF target genes is critical for Myc-dependent apoptosis of epithelial cellsQ35761146
Porcupine inhibitor suppresses paracrine Wnt-driven growth of Rnf43;Znrf3-mutant neoplasiaQ35764241
Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cellsQ35845010
Paneth cell differentiation in the developing intestine of normal and transgenic miceQ35849239
Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in miceQ35913691
Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1).Q36061304
Developmental regulation of cryptdin, a corticostatin/defensin precursor mRNA in mouse small intestinal crypt epitheliumQ36220600
Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.Q36991078
Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in miceQ37548319
Gut commensal bacteria and regional Wnt gene expression in the proximal versus distal colonQ37605980
Paneth cells: maestros of the small intestinal cryptsQ38080558
Selection of multipotent stem cells during morphogenesis of small intestinal crypts of Lieberkuhn is perturbed by stimulation of Lef-1/beta-catenin signalingQ38291853
The effect of growth and of fasting on the number of villi and crypts in the small intestine of the albino ratQ39304241
EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin {beta}4.Q39651560
Integrin alpha 6 beta 4 forms a complex with the cytoskeletal protein HD1 and induces its redistribution in transfected COS-7 cellsQ40243433
Upregulation of a functional form of the beta4 integrin subunit in colorectal cancers correlates with c-Myc expressionQ40399589
Crypt fission in the small intestine and colon. A mechanism for the emergence of G6PD locus-mutated crypts after treatment with mutagensQ40968491
The crypt cycle. Crypt and villus production in the adult intestinal epitheliumQ41172360
An individual based computational model of intestinal crypt fission and its application to predicting unrestrictive growth of the intestinal epitheliumQ41653467
Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lostQ42242504
Epithelial detachment due to absence of hemidesmosomes in integrin beta 4 null miceQ42519143
Analysis of integrin beta4 expression in human breast cancer: association with basal-like tumors and prognostic significanceQ42524837
Effects of epidermal growth factor and dimethylhydrazine on crypt size, cell proliferation, and crypt fission in the rat colon. Cell proliferation and crypt fission are controlled independently.Q42840209
Lgr5+ stem cells are indispensable for radiation-induced intestinal regenerationQ43548445
Both suboptimal and elevated vitamin intake increase intestinal neoplasia and alter crypt fission in the ApcMin/+ mouse.Q44796954
Modelling the role of the basement membrane beneath a growing epithelial monolayerQ48774109
Use of methylation patterns to determine expansion of stem cell clones in human colon tissue.Q50690099
Beta 4 integrin amplifies ErbB2 signaling to promote mammary tumorigenesis.Q52572763
Neurogenin 3 and the enteroendocrine cell lineage in the adult mouse small intestinal epithelium.Q53596578
Development of aberrant crypt foci involves a fission mechanism as revealed by isolation of aberrant crypts.Q55351769
EphB receptors coordinate migration and proliferation in the intestinal stem cell nicheQ60721106
Origin, differentiation and renewal of the four main epithelial cell types in the mouse small intestine. IV. Paneth cellsQ68853970
Crypt fission and crypt number in the small and large bowel of postnatal ratsQ70085116
The kinetics of villus cell populations in the mouse small intestine. I. Normal villi: the steady state requirementQ70596216
The stem-cell zone of the small intestinal epithelium. II. Evidence from paneth cells in the newborn mouseQ70714558
Renewal of Paneth cells in the small intestine of the mouseQ71284243
Difluoromethylornithine inhibits crypt fissionQ73164030
Bottom-up histogenesis of colorectal adenomas: origin in the monocryptal adenoma and initial expansion by crypt fissionQ73608628
Examining the role of Paneth cells in the small intestine by lineage ablation in transgenic miceQ73692219
Altered stem cell regeneration in irradiated intestinal crypts of senescent miceQ74820982
Differences in the effects of age on intestinal proliferation, crypt fission and apoptosis on the small intestine and the colon of the ratQ81614779
Postnatal epithelial growth of the small intestine in the rat occurs by both crypt fission and crypt hyperplasiaQ83155297
Observations on the generation time of paneth cells in miceQ93795062
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectstem cell nicheQ16729831
P304page(s)e1002491
P577publication date2016-06-27
P1433published inPLOS BiologyQ1771695
P1476titlePaneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche
P478volume14

Reverse relations

cites work (P2860)
Q47578090A Multicellular Model of Intestinal Crypt Buckling and Fission
Q91619531A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion
Q58087672Active β-Catenin Signaling in the Small Intestine of Humans During Infancy
Q60916638Adaptive Physiological and Morphological Adjustments Mediated by Intestinal Stem Cells in Response to Food Availability in Mice
Q39189772Asymmetry at cell-cell interfaces direct cell sorting, boundary formation, and tissue morphogenesis.
Q39395695Bioengineering for intestinal organoid cultures
Q38973304Clonal evolution of colorectal cancer in IBD.
Q55411157Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells.
Q92886864Deficiency in intestinal epithelial Reg4 ameliorates intestinal inflammation and alters the colonic bacterial composition
Q91278013Development and organization of the zebrafish intestinal epithelial stem cell niche
Q58553780From Colitis to Cancer: An Evolutionary Trajectory That Merges Maths and Biology
Q92203595Glyco-conjugated bile acids drive the initial metaplastic gland formation from multi-layered glands through crypt-fission in a murine model
Q49967516In Vivo Imaging Reveals Existence of Crypt Fission and Fusion in Adult Mouse Intestine
Q42516364Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids
Q47289883Linking stem cell function and growth pattern of intestinal organoids
Q90580539Mathematical Models of Organoid Cultures
Q61798124Msx1 loss suppresses formation of the ectopic crypts developed in the Apc-deficient small intestinal epithelium
Q89573485Multivariate discriminant analysis for branching classification of colonic tubular adenoma glands
Q102152352Organoid-based modeling of intestinal development, regeneration, and repair
Q47133948Paneth cells in intestinal physiology and pathophysiology
Q39285342Quantification of epithelial cell proliferation, cell dynamics, and cell kinetics in vivo.
Q64105061Role of β-Catenin Activation Levels and Fluctuations in Controlling Cell Fate
Q92286526Second-generation Probiotics Producing IL-22 Increase Survival of Mice After Total Body Irradiation
Q93081285Tales from the crypt: new insights into intestinal stem cells

Search more.