| P50 | author | Ailsa Hart | Q92024668 |
| P2093 | author name string | Trevor A Graham | |
| | Ibrahim Al Bakir | |
| | Chang-Ho R Choi | |
| P2860 | cites work | K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients | Q73436985 |
| | Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, B-catenin and p53 expression and the role of inflammation | Q73641172 |
| | Diverse p53 alterations in ulcerative colitis-associated low-grade dysplasia: full-length gene sequencing in microdissected single crypts | Q78813023 |
| | Interleukin 10-deficient mice exhibit defective colonic Muc2 synthesis before and after induction of colitis by commensal bacteria | Q81217137 |
| | Colorectal cancer in colonic Crohn's disease--high frequency of DNA-aneuploidy | Q81586546 |
| | Methylation status of genes in non-neoplastic mucosa from patients with ulcerative colitis-associated colorectal cancer | Q82923299 |
| | Thirty-year analysis of a colonoscopic surveillance program for neoplasia in ulcerative colitis | Q83161259 |
| | The role of endoscopy in inflammatory bowel disease | Q86977676 |
| | Cancer as an evolutionary and ecological process | Q22122026 |
| | Non steroidal anti-inflammatory drugs (NSAID) and aspirin for preventing colorectal adenomas and carcinomas | Q24247367 |
| | Intestinal tumorigenesis initiated by dedifferentiation and acquisition of stem-cell-like properties | Q24307391 |
| | Comprehensive molecular characterization of human colon and rectal cancer | Q24630415 |
| | Robustness and evolvability | Q24634833 |
| | The risk of colorectal cancer in ulcerative colitis: a meta-analysis | Q24669747 |
| | Microenvironmental control of stem cell fate in intestinal homeostasis and disease | Q26999226 |
| | Systematic review with meta-analysis: the declining risk of colorectal cancer in ulcerative colitis | Q27011853 |
| | Genomic Classification and Prognosis in Acute Myeloid Leukemia | Q27853389 |
| | Identification of stem cells in small intestine and colon by marker gene Lgr5 | Q28131701 |
| | The clonal evolution of tumor cell populations | Q28271546 |
| | Crypt stem cells as the cells-of-origin of intestinal cancer | Q28304418 |
| | Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. | Q28307731 |
| | Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration | Q28587140 |
| | Signatures of mutational processes in human cancer | Q29547191 |
| | Clonal evolution in cancer | Q29547696 |
| | IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer | Q29614599 |
| | Inflammatory bowel disease | Q29615500 |
| | Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells | Q29619410 |
| | Intra-tumour heterogeneity: a looking glass for cancer? | Q29620149 |
| | NSAIDs modulate clonal evolution in Barrett's esophagus. | Q31119674 |
| | The microbiome in inflammatory bowel disease: current status and the future ahead | Q33664898 |
| | Synchronous colorectal cancer: clinical, pathological and molecular implications. | Q33735244 |
| | A prospective cohort study shows unique epigenetic, genetic, and prognostic features of synchronous colorectal cancers | Q33808550 |
| | A genetic explanation of Slaughter's concept of field cancerization: evidence and clinical implications | Q33965561 |
| | Field cancerization in oral stratified squamous epithelium; clinical implications of multicentric origin | Q33968610 |
| | Ordering of mutations in preinvasive disease stages of esophageal carcinogenesis. | Q33975855 |
| | Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis | Q34091635 |
| | Mesalamine inhibits epithelial beta-catenin activation in chronic ulcerative colitis | Q41904328 |
| | Pan-colonic field defects are detected by CGH in the colons of UC patients with dysplasia/cancer. | Q42252707 |
| | Transition from colitis to cancer: high Wnt activity sustains the tumor-initiating potential of colon cancer stem cell precursors | Q42530938 |
| | Accelerated age-related CpG island methylation in ulcerative colitis | Q43828587 |
| | Chromosomal instability in ulcerative colitis is related to telomere shortening | Q44159326 |
| | 5-aminosalicylic acid inhibits colitis-associated colorectal dysplasias in the mouse model of azoxymethane/dextran sulfate sodium-induced colitis | Q45268161 |
| | Chromosomal alterations in ulcerative colitis-related neoplastic progression. | Q46026186 |
| | Large chromosome deletions, duplications, and gene conversion events accumulate with age in normal human colon crypts | Q46129242 |
| | Characterization of tumour-infiltrating lymphocytes and apoptosis in colitis-associated neoplasia: comparison with sporadic colorectal cancer | Q46825790 |
| | Risk factors of colorectal cancer in inflammatory bowel disease | Q48636895 |
| | Chromoendoscopy for Surveillance in Inflammatory Bowel Disease Does Not Increase Neoplasia Detection Compared With Conventional Colonoscopy With Random Biopsies: Results From a Large Retrospective Study | Q50215957 |
| | Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell. | Q50501047 |
| | Invasive potential of gut mucosa-derived Fusobacterium nucleatum positively correlates with IBD status of the host. | Q51174426 |
| | Colitis-associated DNA aneuploidy and dysplasia in Crohnʼs disease and risk of colorectal cancer | Q51751367 |
| | Degeneration of the pericryptal myofibroblast sheath by proinflammatory cytokines in inflammatory bowel diseases. | Q52590045 |
| | An epithelial niche in the Drosophila ovary undergoes long-range stem cell replacement. | Q52689872 |
| | Neoplastic progression in ulcerative colitis: histology, DNA content, and loss of a p53 allele. | Q52860008 |
| | Defining stem cell dynamics in models of intestinal tumor initiation. | Q53130842 |
| | Loss of p53 enhances the induction of colitis-associated neoplasia by dextran sulfate sodium. | Q53332561 |
| | gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. | Q53418407 |
| | Comparative analysis of histology, DNA content, p53 and Ki-ras mutations in colectomy specimens with long-standing ulcerative colitis. | Q53435738 |
| | Sialosyl-Tn antigen is prevalent and precedes dysplasia in ulcerative colitis: a retrospective case-control study. | Q53456394 |
| | Biomarker-based prediction of inflammatory bowel disease-related colorectal cancer: a case-control study | Q57259815 |
| | Clonality, Founder Mutations, and Field Cancerization in Human Ulcerative Colitis–Associated Neoplasia | Q58104226 |
| | Chromosomal and Microsatellite Instability of Adenocarcinomas and Dysplastic Lesions (DALM) in Ulcerative Colitis | Q59196052 |
| | Molecular Phenotype of Inflammatory Bowel Disease-Associated Neoplasms With Microsatellite Instability | Q63407631 |
| | DNA aneuploidy in ulcerative colitis: reproducibility, topographic distribution, and relation to dysplasia | Q68079089 |
| | Crypt production in normal and diseased human colonic epithelium | Q70307766 |
| | Microsatellite instability in nonneoplastic mucosa from patients with chronic ulcerative colitis | Q71102439 |
| | The demonstration of pericryptal fibroblasts in background mucosa and dysplasia complicating ulcerative colitis | Q71327895 |
| | Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis. | Q34104498 |
| | Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancer | Q34137586 |
| | Current management of inflammatory bowel disease and colorectal cancer | Q34192660 |
| | Clonal expansion of early to mid-life mitochondrial DNA point mutations drives mitochondrial dysfunction during human ageing. | Q34213867 |
| | A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable | Q34217232 |
| | Mitochondrial DNA mutations are established in human colonic stem cells, and mutated clones expand by crypt fission. | Q34248675 |
| | Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials | Q34263014 |
| | Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity | Q34287934 |
| | Mutations in the p53 gene: an early marker of neoplastic progression in ulcerative colitis. | Q34330775 |
| | Clonality and life cycles of intestinal crypts explained by a state dependent stochastic model of epithelial stem cell organization | Q34428129 |
| | Genetic clonal diversity predicts progression to esophageal adenocarcinoma | Q34505745 |
| | Fusobacterium is associated with colorectal adenomas | Q34555713 |
| | Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer | Q34596148 |
| | Ulcerative colitis and colorectal cancer. A population-based study | Q34634203 |
| | Ulcerative colitis-associated colorectal cancer arises in a field of short telomeres, senescence, and inflammation. | Q34802663 |
| | Colonic mucosa-associated diffusely adherent afaC+ Escherichia coli expressing lpfA and pks are increased in inflammatory bowel disease and colon cancer. | Q34813547 |
| | New regulators of NF-kappaB in inflammation | Q34858737 |
| | APC mutations are sufficient for the growth of early colorectal adenomas | Q35051664 |
| | 5-Aminosalicylates reduce the risk of colorectal neoplasia in patients with ulcerative colitis: an updated meta-analysis | Q35142116 |
| | Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis | Q35168290 |
| | Increased expression of IL-16 in inflammatory bowel disease | Q35565705 |
| | Risk of oesophageal cancer in Barrett's oesophagus and gastro-oesophageal reflux | Q35596721 |
| | DNA fingerprinting abnormalities can distinguish ulcerative colitis patients with dysplasia and cancer from those who are dysplasia/cancer-free | Q35748992 |
| | Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer | Q35762264 |
| | Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia | Q35787099 |
| | Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation | Q35803526 |
| | K-ras mutations and p53 alterations in neoplastic and nonneoplastic lesions associated with longstanding ulcerative colitis | Q35833643 |
| | Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: An Updated Overview. | Q35896390 |
| | Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche. | Q36062403 |
| | Prospective study of the progression of low-grade dysplasia in ulcerative colitis using current cancer surveillance guidelines | Q36110108 |
| | Histologic inflammation is a risk factor for progression to colorectal neoplasia in ulcerative colitis: a cohort study | Q36328183 |
| | Age at diagnosis of inflammatory bowel disease influences early development of colorectal cancer in inflammatory bowel disease patients: a nationwide, long-term survey | Q36468969 |
| | Inflammation and colorectal cancer: colitis-associated neoplasia | Q36597803 |
| | Clock-like mutational processes in human somatic cells | Q36666868 |
| | Intestinal inflammation targets cancer-inducing activity of the microbiota. | Q36819342 |
| | Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury | Q36997442 |
| | NF-kappaB in inflammatory bowel disease | Q37163422 |
| | Colonic crypt organization and tumorigenesis | Q37164065 |
| | Dynamic clonal equilibrium and predetermined cancer risk in Barrett's oesophagus | Q37191910 |
| | Cancer as an overhealing wound: an old hypothesis revisited | Q37217254 |
| | Lectin-epithelial interactions in the human colon. | Q37330503 |
| | Clonal expansions in ulcerative colitis identify patients with neoplasia | Q37426977 |
| | Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis | Q37451607 |
| | Temporal and spatial evolution of somatic chromosomal alterations: a case-cohort study of Barrett's esophagus | Q37524048 |
| | The continuing uncertainty about cancer risk in inflammatory bowel disease | Q37580031 |
| | Endoscopic and pathological aspects of colitis-associated dysplasia | Q37601306 |
| | Whole-Exome Sequencing Analyses of Inflammatory Bowel Disease-Associated Colorectal Cancers | Q37610120 |
| | Colorectal dysplasia in chronic inflammatory bowel disease: pathology, clinical implications, and pathogenesis | Q37762821 |
| | Pathogenesis and biomarkers of carcinogenesis in ulcerative colitis. | Q37885729 |
| | Review article: colorectal neoplasia in patients with primary sclerosing cholangitis and inflammatory bowel disease | Q37892612 |
| | Deep remission in inflammatory bowel disease: looking beyond symptoms | Q38077111 |
| | Stem cell dynamics in homeostasis and cancer of the intestine | Q38219625 |
| | Histological evaluation in ulcerative colitis | Q38221351 |
| | SCENIC international consensus statement on surveillance and management of dysplasia in inflammatory bowel disease | Q38363644 |
| | Risk of colorectal cancer in patients with ulcerative colitis: a meta-analysis of population-based cohort studies | Q38434726 |
| | Evaluation of the usefulness of testing for p53 mutations in colorectal cancer surveillance for ulcerative colitis | Q38469363 |
| | Sialosyl-Tn antigen: initial report of a new marker of malignant progression in long-standing ulcerative colitis. | Q38480333 |
| | The global burden of IBD: from 2015 to 2025. | Q38577572 |
| | Biased competition between Lgr5 intestinal stem cells driven by oncogenic mutation induces clonal expansion. | Q38710117 |
| | IL-16 induces intestinal inflammation via PepT1 upregulation in a pufferfish model: new insights into the molecular mechanism of inflammatory bowel disease | Q39132012 |
| | Cell cycle heterogeneity in the small intestinal crypt and maintenance of genome integrity | Q39658586 |
| | Activation pattern of signal transducers and activators of transcription (STAT) factors in inflammatory bowel diseases. | Q40453982 |
| | Genomic Alterations Observed in Colitis-Associated Cancers Are Distinct From Those Found in Sporadic Colorectal Cancers and Vary by Type of Inflammatory Bowel Disease | Q40808084 |
| | Outcome of "indefinite for dysplasia" in inflammatory bowel disease: correlation with DNA flow cytometry and other risk factors of colorectal cancer. | Q40952296 |
| | Incidence of Interval Colorectal Cancer Among Inflammatory Bowel Disease Patients Undergoing Regular Colonoscopic Surveillance | Q40958550 |
| | DNA aneuploidy in colonic biopsies predicts future development of dysplasia in ulcerative colitis. | Q41104513 |
| | Distribution of aneuploid cell populations in ulcerative colitis with dysplasia or cancer. | Q41169541 |
| | Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis | Q41698505 |
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | colorectal cancer | Q188874 |
| | colorectal carcinoma | Q25493920 |
| P304 | page(s) | 218-229 | |
| P577 | publication date | 2017-02-08 | |
| P1433 | published in | Nature Reviews Gastroenterology & Hepatology | Q2108255 |
| P1476 | title | Clonal evolution of colorectal cancer in IBD. | |
| P478 | volume | 14 | |