Its preferential interactions with biopolymers account for diverse observed effects of trehalose

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Its preferential interactions with biopolymers account for diverse observed effects of trehalose is …
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scholarly articleQ13442814

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P356DOI10.1016/J.BPJ.2015.05.037
P932PMC publication ID4572414
P698PubMed publication ID26153711
P5875ResearchGate publication ID279991859

P2093author name stringLila M Gierasch
Zhicheng Liu
Jiang Hong
P2860cites workTryptophan zippers: Stable, monomeric  -hairpinsQ27631564
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β-hairpin-mediated nucleation of polyglutamine amyloid formation.Q41764990
Use of urea and glycine betaine to quantify coupled folding and probe the burial of DNA phosphates in lac repressor-lac operator bindingQ41822855
Thermodynamic origin of hofmeister ion effectsQ41980674
Macromolecular crowding remodels the energy landscape of a protein by favoring a more compact unfolded stateQ42534036
Thermal denaturation of beta-lactoglobulin and stabilization mechanism by trehalose analyzed from Raman spectroscopy investigations.Q43089092
Quantifying additive interactions of the osmolyte proline with individual functional groups of proteins: comparisons with urea and glycine betaine, interpretation of m-valuesQ43134397
Why is trehalose an exceptional protein stabilizer? An analysis of the thermal stability of proteins in the presence of the compatible osmolyte trehaloseQ44408519
Additive transfer free energies of the peptide backbone unit that are independent of the model compound and the choice of concentration scaleQ44751410
Structural characterization of polyglutamine fibrils by solid-state NMR spectroscopyQ45112265
The exclusion of glycine betaine from anionic biopolymer surface: why glycine betaine is an effective osmoprotectant but also a compatible soluteQ45150933
Preferential interactions of glycine betaine and of urea with DNA: implications for DNA hydration and for effects of these solutes on DNA stabilityQ45150935
The role of phospholipid headgroup composition and trehalose in the desiccation tolerance of Caenorhabditis elegansQ46072021
Structural thermodynamics of protein preferential solvation: osmolyte solvation of proteins, aminoacids, and peptidesQ46580532
Modulating membrane properties: the effect of trehalose and cholesterol on a phospholipid bilayerQ46866159
Control of protein stability and reactions by weakly interacting cosolvents: the simplicity of the complicatedQ48007202
Analysis of effects of salts and uncharged solutes on protein and nucleic acid equilibria and processes: a practical guide to recognizing and interpreting polyelectrolyte effects, Hofmeister effects, and osmotic effects of salts.Q48007210
Conformational distribution of a 14-residue peptide in solution: a fluorescence resonance energy transfer study.Q51937330
Gibbs-Duhem-based relationships among derivatives expressing the concentration dependences of selected chemical potentials for a multicomponent system.Q51983240
Novel computer program for fast exact calculation of accessible and molecular surface areas and average surface curvature.Q52013462
Mecbanism of Polyol-Induced Protein Stabilization: Solubility of Amino Acids and Diglycine in Aqueous Polyol Solutions1Q71085136
Thermodynamic analysis of interactions between denaturants and protein surface exposed on unfolding: interpretation of urea and guanidinium chloride m-values and their correlation with changes in accessible surface area (ASA) using preferential inteQ73025534
Vapor pressure osmometry studies of osmolyte-protein interactions: implications for the action of osmoprotectants in vivo and for the interpretation of "osmotic stress" experiments in vitroQ73660237
Urea effects on protein stability: hydrogen bonding and the hydrophobic effectQ74566093
THE SOLUBILITY OF AMINO ACIDS AND RELATED COMPOUNDS IN AQUEOUS UREA SOLUTIONSQ76630251
A toxic monomeric conformer of the polyglutamine proteinQ79976767
Preservation of membranes in anhydrobiotic organisms: the role of trehaloseQ81213064
Application of the transfer model to understand how naturally occurring osmolytes affect protein stabilityQ81309610
The interpretation of protein structures: Estimation of static accessibilityQ27860750
Trehalose is a versatile and long-lived chaperone for desiccation toleranceQ27937215
Multiple effects of trehalose on protein folding in vitro and in vivoQ27938229
Protein misfolding, functional amyloid, and human diseaseQ28131732
Adapting proteostasis for disease interventionQ28131818
Organic osmolytes as compatible, metabolic and counteracting cytoprotectants in high osmolarity and other stressesQ28263589
Structure of the complex between adenylate kinase from Escherichia coli and the inhibitor Ap5A refined at 1.9 A resolution. A model for a catalytic transition stateQ28288099
Thermodynamics of interactions of urea and guanidinium salts with protein surface: relationship between solute effects on protein processes and changes in water-accessible surface areaQ28364507
Denaturant m values and heat capacity changes: relation to changes in accessible surface areas of protein unfoldingQ29620340
Distribution of molecular size within an unfolded state ensemble using small-angle X-ray scattering and pulse field gradient NMR techniquesQ30167627
Stabilization of the ribosomal protein S6 by trehalose is counterbalanced by the formation of a putative off-pathway species.Q30351006
Structure of a fluid dioleoylphosphatidylcholine bilayer determined by joint refinement of x-ray and neutron diffraction data. III. Complete structureQ30968829
Urea-amide preferential interactions in water: quantitative comparison of model compound data with biopolymer results using water accessible surface areasQ31119973
ProtSA: a web application for calculating sequence specific protein solvent accessibilities in the unfolded ensemble.Q33428317
Why Hofmeister effects of many salts favor protein folding but not DNA helix formation.Q33842896
Predicting the energetics of osmolyte-induced protein folding/unfolding.Q34085063
Interpretation of preferential interaction coefficients of nonelectrolytes and of electrolyte ions in terms of a two-domain modelQ34128620
Chemical and Pharmacological Chaperones: Application for Recombinant Protein Production and Protein Folding DiseasesQ34151992
Betaine can eliminate the base pair composition dependence of DNA meltingQ34359134
Lessons from nature: the role of sugars in anhydrobiosisQ34545014
Reconciliation of opposing views on membrane-sugar interactionsQ34550129
A compact beta model of huntingtin toxicityQ34624307
Urea unfolding of peptide helices as a model for interpreting protein unfoldingQ34825588
Inhibition of protein aggregation in vitro and in vivo by a natural osmoprotectantQ35037232
Quantifying why urea is a protein denaturant, whereas glycine betaine is a protein stabilizerQ35345924
LINKED FUNCTIONS AND RECIPROCAL EFFECTS IN HEMOGLOBIN: A SECOND LOOK.Q35493170
THERMODYNAMIC ANALYSIS OF MULTICOMPONENT SOLUTIONS.Q35493193
Interactions of the osmolyte glycine betaine with molecular surfaces in water: thermodynamics, structural interpretation, and prediction of m-values.Q37440942
Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease.Q37494307
Structural motif of polyglutamine amyloid fibrils discerned with mixed-isotope infrared spectroscopy.Q37725285
Physical chemistry of polyglutamine: intriguing tales of a monotonous sequenceQ37981477
The therapeutic potential of chemical chaperones in protein folding diseases.Q38211124
Osmolyte effects on protein stability and solubility: a balancing act between backbone and side-chains.Q38306573
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington diseaseQ38345839
The thermodynamic mechanism of protein stabilization by trehaloseQ38348255
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectalpha,alpha-trehaloseQ421773
biopolymerQ422649
P1104number of pages10
P304page(s)144-153
P577publication date2015-07-01
P1433published inBiophysical JournalQ2032955
P1476titleIts preferential interactions with biopolymers account for diverse observed effects of trehalose
P478volume109

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cites work (P2860)
Q39223635Basis of Protein Stabilization by K Glutamate: Unfavorable Interactions with Carbon, Oxygen Groups
Q47749210Collaborative routes to clarifying the murky waters of aqueous supramolecular chemistry.
Q38693016Experimental Atom-by-Atom Dissection of Amide-Amide and Amide-Hydrocarbon Interactions in H2O.
Q47974258Inhibition of GNNQQNY prion peptide aggregation by trehalose: a mechanistic view.
Q38652096Preferential interactions of trehalose, L-arginine.HCl and sodium chloride with therapeutically relevant IgG1 monoclonal antibodies
Q39223628TMAO-Protein Preferential Interaction Profile Determines TMAO's Conditional In Vivo Compatibility
Q58322327Titration of Folate Pathway Enzymes
Q46273450Trehalose acts as a uridine 5'-diphosphoglucose-competitive inhibitor of trehalose 6-phosphate synthase in Corynebacterium glutamicum

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