Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease.

scientific article published on January 2009

Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/JNR.21817
P932PMC publication ID3895944
P698PubMed publication ID18683244

P50authorChia-Ron YangQ59692485
P2093author name stringRobert K Yu
P2860cites workASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeatsQ24298956
Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse modelQ24535603
Multiple effects of trehalose on protein folding in vitro and in vivoQ27938229
Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's diseaseQ28114818
Huntingtin aggregation and toxicity in Huntington's diseaseQ28204163
Protein AggregationQ58030632
Intraspinal delivery of neurotrophin-3 using neural stem cells genetically modified by recombinant retrovirusQ78128999
Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicityQ95721056
Neurodegenerative disorders of protein aggregationQ28212108
Folding proteins in fatal waysQ28235206
Multipotent neural cell lines can engraft and participate in development of mouse cerebellumQ28290006
Impairment of the ubiquitin-proteasome system by protein aggregationQ29614556
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic miceQ29615357
IAPs are essential for GDNF-mediated neuroprotective effects in injured motor neurons in vivoQ30670979
Characterization of progressive motor deficits in mice transgenic for the human Huntington's disease mutation.Q33857802
Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington diseaseQ33908944
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Stem cell therapy for human neurodegenerative disorders-how to make it workQ35844778
Role of trehalose phosphate synthase and trehalose during hypoxia: from flies to mammalsQ35857970
Cell therapy in Huntington's disease.Q36045364
Multipotent neural precursors can differentiate toward replacement of neurons undergoing targeted apoptotic degeneration in adult mouse neocortexQ36605438
Age‐Dependent Striatal Excitotoxic Lesions Produced by the Endogenous Mitochondrial Inhibitor MalonateQ36696707
Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington diseaseQ38345839
Lesion of striatal neurons with kainic acid provides a model for Huntington's choreaQ39109797
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Experimental traumatic brain injury modulates the survival, migration, and terminal phenotype of transplanted epidermal growth factor receptor-activated neural stem cells.Q40477461
Neural stem cells constitutively secrete neurotrophic factors and promote extensive host axonal growth after spinal cord injuryQ40643190
Protection against ischemic brain damage by GDNF affecting cell survival and death signalsQ40648835
Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injuryQ40703966
Stem cells in the central nervous systemQ41116811
Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brainQ41605555
Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transferQ41741592
Neural stem cells spontaneously express dopaminergic traits after transplantation into the intact or 6-hydroxydopamine-lesioned rat.Q44214555
Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders.Q44286601
Effects of systemic 3-nitropropionic acid-induced lesions of the dorsal striatum on cannabinoid and mu-opioid receptor binding in the basal ganglia.Q44330257
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The cortical lesion of Huntington's disease: further neurochemical characterization, and reproduction of some of the histological and neurochemical features by N-methyl-D-aspartate lesions of rat cortexQ45290847
Mitochondrial defect in Huntington's disease caudate nucleusQ45291734
Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's diseaseQ45292219
Hyperactivity and hypoactivity in a rat model of Huntington's disease: the systemic 3-nitropropionic acid modelQ45295346
Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testingQ45298349
Aggregation in Huntington's disease: insights through modellingQ45299452
Trehalose, a novel mTOR-independent autophagy enhancer, accelerates the clearance of mutant huntingtin and alpha-synuclein.Q45303665
Brain transplantation of genetically engineered human neural stem cells globally corrects brain lesions in the mucopolysaccharidosis type VII mouseQ45869109
Brain transplantation of neural stem cells cotransduced with tyrosine hydroxylase and GTP cyclohydrolase 1 in Parkinsonian ratsQ45883914
Engraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes.Q45890216
Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.Q46695611
Human neural stem cell transplantation promotes functional recovery in rats with experimental intracerebral hemorrhageQ48244314
Differentiation of engrafted multipotent neural progenitors towards replacement of missing granule neurons in meander tail cerebellum may help determine the locus of mutant gene action.Q48617389
Histopathological and behavioral improvement of murine mucopolysaccharidosis type VII by intracerebral transplantation of neural stem cells.Q50469125
Reestablishment of damaged adult motor pathways by grafted embryonic cortical neurons.Q50666206
Prolonged intracerebroventricular infusion of neurosteroids affects cognitive performances in the mouse.Q51413132
Behavioral characterization of the Tg2576 transgenic model of Alzheimer's disease through 19 months.Q52012764
P4510describes a project that usesImageJQ1659584
ImageQuantQ112270642
P433issue1
P921main subjectpathologyQ7208
Huntington's diseaseQ190564
alpha,alpha-trehaloseQ421773
neural stem cellQ2944097
stem cell transplantationQ65592366
P304page(s)26-33
P577publication date2009-01-01
P1433published inJournal of Neuroscience ResearchQ6295654
P1476titleIntracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease
P478volume87

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cites work (P2860)
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