Brain transplantation of neural stem cells cotransduced with tyrosine hydroxylase and GTP cyclohydrolase 1 in Parkinsonian rats

scientific article

Brain transplantation of neural stem cells cotransduced with tyrosine hydroxylase and GTP cyclohydrolase 1 in Parkinsonian rats is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3727/000000005783983133
P698PubMed publication ID15929554

P2093author name stringKim KS
Yoon SH
Kim SU
Lee MA
Snyder EY
Ahn YH
Cho KG
Ryu MY
P2860cites workEngraftable human neural stem cells respond to developmental cues, replace neurons, and express foreign genes.Q45890216
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Uneven pattern of dopamine loss in the striatum of patients with idiopathic Parkinson's disease. Pathophysiologic and clinical implicationsQ48088787
Multipotent stem/progenitor cells with similar properties arise from two neurogenic regions of adult human brainQ48210082
Multipotent neural cell lines can engraft and participate in development of mouse cerebellumQ28290006
Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell lineQ29547239
Mammalian neural stem cellsQ29547657
Pathogenesis of Parkinson's disease: dopamine, vesicles and alpha-synucleinQ31120123
Prospects for the clinical application of neural transplantation with the use of conditionally immortalized neuroepithelial stem cellsQ33748682
Cell replacement therapies for central nervous system disorders.Q33921503
Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomasQ35827956
"Global" cell replacement is feasible via neural stem cell transplantation: evidence from the dysmyelinated shiverer mouse brainQ36389958
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Grafts of fetal dopamine neurons survive and improve motor function in Parkinson's diseaseQ39519102
Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxylase gene: in vitro characterization and in vivo effects in the rat Parkinson modelQ40941898
Dopamine turnover and metabolism in the striatum of parkinsonian rats grafted with genetically-modified human astrocytesQ41035398
Stem cells in the central nervous systemQ41116811
Neuronal progenitors as tools for cell replacement in the nervous systemQ41235622
Fetal nigral transplantation as a therapy for Parkinson's diseaseQ41367101
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Use of retroviral vectors for gene transfer and expressionQ41582824
Immortalized neural progenitor cells for CNS gene transfer and repair.Q41639955
L-3,4-dihydroxyphenylalanine synthesis by genetically modified Schwann cellsQ41694260
Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transferQ41741592
Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brainQ42280576
In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via coexpression of GTPcyclohydrolase I with tyrosine hydroxylaseQ42828882
In vivo release of dopa and dopamine from genetically engineered cells grafted to the denervated rat striatumQ42831252
Long-term behavioral recovery in parkinsonian rats by an HSV vector expressing tyrosine hydroxylaseQ43185222
Gene therapy of experimental brain tumors using neural progenitor cellsQ44761775
Neural-targeted gene therapy for rodent and primate hemiparkinsonismQ45866224
P433issue4
P921main subjectParkinson's diseaseQ11085
neural stem cellQ2944097
P304page(s)193-202
P577publication date2005-01-01
P1433published inCell TransplantationQ15761863
P1476titleBrain transplantation of neural stem cells cotransduced with tyrosine hydroxylase and GTP cyclohydrolase 1 in Parkinsonian rats
P478volume14

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cites work (P2860)
Q37003823Article Commentary: Regenerative Medicine: An Analysis of Cell Transplantation's Impact
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Q38079295Neural stem cell-based treatment for neurodegenerative diseases

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