Experimental surgical therapies for Huntington's disease

scientific article published on 28 December 2010

Experimental surgical therapies for Huntington's disease is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1755-5949.2010.00209.X
P932PMC publication ID6493825
P698PubMed publication ID21199443

P2093author name stringWim Vandenberghe
Jelle Demeestere
P2860cites workHuntington diseaseQ48465200
Long-term pallidal deep brain stimulation in patients with advanced Parkinson disease: 1-year follow-up studyQ48608882
Deep-brain stimulation of the subthalamic nucleus or the pars interna of the globus pallidus in Parkinson's diseaseQ48774077
Unified Huntington's disease rating scale: Reliability and consistencyQ57422462
Therapeutic interventions for symptomatic treatment in Huntington's diseaseQ24239893
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.Q27860836
Induction of pluripotent stem cells from adult human fibroblasts by defined factorsQ27860967
Stem and progenitor cells: the premature desertion of rigorous definitionsQ28210270
Huntington's diseaseQ28284355
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotesQ28302701
Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologueQ28506834
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's diseaseQ28588314
Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in miceQ28594828
Transplantation of embryonic dopamine neurons for severe Parkinson's diseaseQ29617304
The functional anatomy of basal ganglia disordersQ29617461
Intrabody gene therapy ameliorates motor, cognitive, and neuropathological symptoms in multiple mouse models of Huntington's diseaseQ30493159
AAV vector-mediated RNAi of mutant huntingtin expression is neuroprotective in a novel genetic rat model of Huntington's diseaseQ30549911
Unilateral transplantation of human primary fetal tissue in four patients with Huntington's disease: NEST-UK safety report ISRCTN no 36485475.Q31118947
Lentiviral gene delivery of GDNF into the striatum of R6/2 Huntington mice fails to attenuate behavioral and neuropathological changesQ31158487
Human multipotent stromal cells (MSCs) increase neurogenesis and decrease atrophy of the striatum in a transgenic mouse model for Huntington's diseaseQ33533774
Differential loss of striatal projection neurons in Huntington diseaseQ33637273
Nonallele-specific silencing of mutant and wild-type huntingtin demonstrates therapeutic efficacy in Huntington's disease mice.Q33713689
RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse modelQ33936969
Effect of fetal neural transplants in patients with Huntington's disease 6 years after surgery: a long-term follow-up studyQ33994217
Bilateral deep-brain stimulation of the globus pallidus in primary generalized dystoniaQ34554762
Pallidal deep-brain stimulation in primary generalized or segmental dystoniaQ34580380
Viral delivery of glial cell line-derived neurotrophic factor improves behavior and protects striatal neurons in a mouse model of Huntington's diseaseQ34695123
Artificial miRNAs mitigate shRNA-mediated toxicity in the brain: implications for the therapeutic development of RNAiQ34768688
Antisense oligonucleotide therapy for neurodegenerative disease.Q34830633
Progress and challenges in RNA interference therapy for Huntington diseaseQ34996510
GPi-DBS in Huntington's disease: results on motor function and cognition in a 72-year-old caseQ45289694
Identification and allele-specific silencing of the mutant huntingtin allele in Huntington's disease patient-derived fibroblasts.Q45289792
Long-term follow-up of Huntington disease treated by bilateral deep brain stimulation of the internal globus pallidusQ45289913
Stereotactic technique and pathophysiological mechanisms of neurotransplantation in Huntington's choreaQ45291572
Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's diseaseQ45292300
Histological findings on fetal striatal grafts in a Huntington's disease patient early after transplantationQ45292873
A majority of Huntington's disease patients may be treatable by individualized allele-specific RNA interference.Q45293098
Bilateral globus pallidus stimulation for Huntington's diseaseQ45294322
Neuropsychological functioning following fetal striatal transplantation in Huntington's chorea: three case presentationsQ45294365
Safety of intrastriatal neurotransplantation for Huntington's disease patientsQ45295583
Striatal transplantation in a transgenic mouse model of Huntington's diseaseQ45297047
In vivo magnetic resonance spectroscopy of human fetal neural transplantsQ45298655
Widespread decrease of type 1 cannabinoid receptor availability in Huntington disease in vivoQ45299326
Safety and tolerability assessment of intrastriatal neural allografts in five patients with Huntington's diseaseQ45299926
Bilateral stimulation of the globus pallidus internus to treat choreathetosis in Huntington's disease: technical case reportQ45300029
Tetrabenazine as antichorea therapy in Huntington disease: a randomized controlled trialQ45300094
rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouseQ45300326
Porcine xenografts in Parkinson's disease and Huntington's disease patients: preliminary resultsQ45300364
Inhibition of Huntington synthesis by antisense oligodeoxynucleotidesQ45301678
Internal globus pallidotomy in dystonia secondary to Huntington's diseaseQ45301763
Motor and cognitive improvements in patients with Huntington's disease after neural transplantationQ45301920
Motor and cognitive improvement by deep brain stimulation in a transgenic rat model of Huntington's diseaseQ45302126
Anterior cingulate cortical transplantation in transgenic Huntington's disease miceQ45304732
Neural transplantation in Huntington disease: long-term grafts in two patientsQ45305355
Bilateral human fetal striatal transplantation in Huntington's disease.Q45305502
Fetal striatal homotransplantation for Huntington's disease: first two case reports.Q45307105
Antisense gene therapy for neurodegenerative disease?Q45881518
Progress in antisense technology.Q46033759
???Q64781363
Neural transplantation in patients with Huntington's diseaseQ35214572
Alloimmunisation to donor antigens and immune rejection following foetal neural grafts to the brain in patients with Huntington's diseaseQ35575249
Transplanted fetal striatum in Huntington's disease: phenotypic development and lack of pathologyQ35579484
Neurotrophic factors in Huntington's diseaseQ35618345
Cell therapy in Huntington's disease.Q36045364
Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficitsQ36089160
Intrabodies as drug discovery tools and therapeuticsQ36175301
Suppression of neuropil aggregates and neurological symptoms by an intracellular antibody implicates the cytoplasmic toxicity of mutant huntingtinQ36677547
Age‐Dependent Striatal Excitotoxic Lesions Produced by the Endogenous Mitochondrial Inhibitor MalonateQ36696707
Stem cell transplantation for Huntington's disease.Q36701470
Striatal progenitors derived from human ES cells mature into DARPP32 neurons in vitro and in quinolinic acid-lesioned rats.Q36954944
Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic miceQ37131550
A patient with Huntington's disease and long-surviving fetal neural transplants that developed mass lesionsQ37178480
The current clinical management of Huntington's diseaseQ37200714
Pathophysiology of Huntington's disease: from huntingtin functions to potential treatmentsQ37209427
Rodent genetic models of Huntington diseaseQ37220633
Neural transplants in patients with Huntington's disease undergo disease-like neuronal degenerationQ37268805
Lost in a jungle of evidence: we need a compassQ37322986
Intracerebral transplantation of neural stem cells combined with trehalose ingestion alleviates pathology in a mouse model of Huntington's disease.Q37494307
Biochemical principles of small RNA pathwaysQ37703232
Lesion of striatal neurons with kainic acid provides a model for Huntington's choreaQ39109797
Ex vivo delivery of GDNF maintains motor function and prevents neuronal loss in a transgenic mouse model of Huntington's disease.Q39728016
Slowed progression in models of Huntington disease by adipose stem cell transplantationQ39770706
Sustained effects of nonallele-specific Huntingtin silencingQ39866098
BDNF regulation under GFAP promoter provides engineered astrocytes as a new approach for long-term protection in Huntington's disease.Q39932912
Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicityQ39943981
Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA.Q40397746
Neuroprotective gene therapy for Huntington's disease, using polymer-encapsulated cells engineered to secrete human ciliary neurotrophic factor: results of a phase I study.Q40462605
Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysisQ40585913
Antisense downregulation of mutant huntingtin in a cell model.Q40641130
Antisense-mediated down-regulation of the human huntingtin geneQ40854760
Striatal and nigral neuron subpopulations in rigid Huntington's disease: implications for the functional anatomy of chorea and rigidity-akinesiaQ41174270
Five siRNAs targeting three SNPs may provide therapy for three-quarters of Huntington's disease patientsQ42559350
Human striatal neuroblasts develop and build a striatal-like structure into the brain of Huntington's disease patients after transplantationQ43212739
Viral delivery of recombinant short hairpin RNAsQ43546899
High-capacity adenoviral vector-mediated reduction of huntingtin aggregate load in vitro and in vivoQ44162261
Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's disease.Q44213139
A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's diseaseQ44571920
Can lesions of GPe correct HD deficits?Q44774622
RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia.Q44964949
Sustained striatal ciliary neurotrophic factor expression negatively affects behavior and gene expression in normal and R6/1 miceQ45288789
Long-term clinical and positron emission tomography outcome of fetal striatal transplantation in Huntington's disease.Q45289044
P433issue6
P921main subjectHuntington's diseaseQ190564
P304page(s)705-713
P577publication date2010-12-28
P1433published inCNS Neuroscience & TherapeuticsQ5013184
P1476titleExperimental surgical therapies for Huntington's disease
P478volume17