Neurotrophic factors in Huntington's disease

scientific article published on January 2004

Neurotrophic factors in Huntington's disease is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S0079-6123(03)46014-7
P698PubMed publication ID14699966

P2093author name stringJordi Alberch
Josep M Canals
Esther Pérez-Navarro
P2860cites workArtemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complexQ22008642
Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner HippiQ24292161
The receptor for ciliary neurotrophic factorQ24305006
Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNFQ24310580
A GPI-linked protein that interacts with Ret to form a candidate neurturin receptorQ24311883
Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birthQ24313379
GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor familyQ24313994
Molecular cloning, expression and tissue distribution of glial‐cell‐line‐derived neurotrophic factor family receptor α‐3 (GFRα‐3)Q24315361
Persephin, a novel neurotrophic factor related to GDNF and neurturinQ24315831
Neurturin, a relative of glial-cell-line-derived neurotrophic factorQ24324692
GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNFQ24329169
GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neuronsQ24336322
Biochemical and functional interactions between the neurotrophin receptors trk and p75NTRQ24533555
Effects of cerebral ischemia in mice deficient in PersephinQ24534911
The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway.Q24540169
GFRα1 Is an Essential Receptor Component for GDNF in the Developing Nervous System and KidneyQ24649094
Neurotrophins: roles in neuronal development and functionQ24656166
Expression and regulation of GFRalpha3, a glial cell line-derived neurotrophic factor family receptorQ24682581
A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes.Q27860836
Neurotrophin signal transduction in the nervous systemQ27876223
A Kinase Insert Isoform of Rat TrkA Supports Nerve Growth Factor‐Dependent Cell Survival but Not Neurite OutgrowthQ73664236
Differential regulation of ciliary neurotrophic factor and its receptor in the rat hippocampus following transient global ischemiaQ73666003
Is the therapeutic application of neurotrophic factors dead?Q77466542
Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouseQ28140328
The ciliary neurotrophic factor and its receptor, CNTFR alphaQ28144474
In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/arteminQ28144676
The GDNF family ligands and receptors - implications for neural developmentQ28144957
Loss of huntingtin-mediated BDNF gene transcription in Huntington's diseaseQ28202050
The GDNF family: signalling, biological functions and therapeutic valueQ28216478
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptorsQ28235378
The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domainQ28238459
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscleQ28241629
trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factorQ28273781
Neurturin Exerts Potent Actions on Survival and Function of Midbrain Dopaminergic NeuronsQ28274311
Neurotrophin-3: a neurotrophic factor related to NGF and BDNFQ28280663
A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequencesQ28282360
Neurotrophin-4: the odd one out in the neurotrophin familyQ28293752
The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptorQ28295368
Naturally Occurring Tyrosine Kinase Inserts Block High Affinity Binding of Phospholipase Cγ and Shc to TrkC and Neurotrophin-3 SignalingQ28296382
Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cellsQ28297730
trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3Q28301898
Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotesQ28302701
Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesinsQ28305583
Ciliary neurotrophic factorQ28307184
Inactivation of the mouse Huntington's disease gene homolog HdhQ28509662
Identification and Characterization of GFRα-3, a Novel Co-receptor Belonging to the Glial Cell Line-derived Neurotrophic Receptor FamilyQ28513903
Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factorQ28572533
Mammalian GFRalpha -4, a divergent member of the GFRalpha family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is a receptor for the neurotrophic factor persephinQ28577124
Corticostriatopallidal neuroprotection by adenovirus-mediated ciliary neurotrophic factor gene transfer in a rat model of progressive striatal degenerationQ28581577
Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neuronsQ28584797
Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's diseaseQ28588314
Changes in Cortical and Striatal Neurons Predict Behavioral and Electrophysiological Abnormalities in a Transgenic Murine Model of Huntington's DiseaseQ28589793
The trk proto-oncogene encodes a receptor for nerve growth factorQ28609788
The trk Proto-Oncogene Product: a Signal Transducing Receptor for Nerve Growth FactorQ28609789
Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic miceQ29615357
Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brainQ29617982
Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development.Q30488256
Ciliary neurotrophic factor coordinately activates transcription of neuropeptide genes in a neuroblastoma cell lineQ36061465
The neostriatal mosaic: multiple levels of compartmental organization in the basal gangliaQ36064948
Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous systemQ36161670
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistanceQ36188464
Growth of purified astrocytes in a chemically defined mediumQ36380669
Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivoQ36406386
Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness.Q36493889
Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificityQ36935698
Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant miceQ43649918
Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease.Q43665724
TrkB and TrkC are differentially regulated by excitotoxicity during development of the basal gangliaQ43804607
Increased sensitivity to N-methyl-D-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's diseaseQ43925468
Effects of nerve and fibroblast growth factors on the production of nitric oxide in experimental model of Huntington's diseaseQ44020174
Pyramidal cell loss in motor cortices in Huntington's diseaseQ44149293
Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's diseaseQ44195016
Ciliary neurotrophic factor supports target-deprived preganglionic sympathetic spinal cord neuronsQ44440163
Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington's disease, as demonstrated by adenoviral gene transferQ44694208
Purification, cloning, and expression of ciliary neurotrophic factor (CNTF).Q45094286
Degeneration of pyramidal projection neurons in Huntington's disease cortexQ45294227
Huntingtin: a single bait hooks many speciesQ45296265
Experimental Therapeutics of Neurodegenerative Disorders: Unmet NeedsQ45296771
Selective sparing of a class of striatal neurons in Huntington's diseaseQ45297134
Differential regulation of the expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 after excitotoxicity in a rat model of Huntington's diseaseQ45297386
A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration.Q45298582
Intracerebral implantation of NGF-releasing biodegradable microspheres protects striatum against excitotoxic damageQ45299933
Brain-derived neurotrophic factor in Huntington diseaseQ45300415
Neuroprotection of nerve growth factor-loaded microspheres on the D2 dopaminergic receptor positive-striatal neurones in quinolinic acid-lesioned rats: a quantitative autoradiographic assessment with iodobenzamideQ45300665
Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen.Q46030268
Protective effects of neurotrophin-4/5 and transforming growth factor-alpha on striatal neuronal phenotypic degeneration after excitotoxic lesioning with quinolinic acidQ46087231
Maintenance of sympathetic innervation into the hippocampal formation requires a continuous local availability of nerve growth factorQ46155148
Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury.Q46187210
Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNSQ46188017
Stimulation of GABAergic neuron differentiation by NT-4/5 in cultures of rat cerebral cortexQ46302375
Developmental and regional expression of beta-nerve growth factor receptor mRNA in the chick and rat.Q46412140
Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampusQ46743236
Signaling mechanisms through gp130: A model of the cytokine systemQ47992455
GDNF-related factor persephin is widely distributed throughout the nervous systemQ48028240
Nerve growth factor and basic fibroblast growth factor protect cholinergic neurons against quinolinic acid excitotoxicity in rat neostriatumQ48129261
Requirement for BDNF in activity-dependent survival of cortical neuronsQ48156100
NGF facilitates the developmental maturation of the previously committed cholinergic interneurons in the striatal matrixQ48164620
Increased levels of nerve growth factor (NGF) protein and mRNA and reactive gliosis following kainic acid injection into the rat striatumQ48171880
Brain-derived neurotrophic factor, neurotrophin-3 and neurotrophin-4/5 differentially regulate the phenotype and prevent degenerative changes in striatal projection neurons after excitotoxicity in vivoQ48172704
Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro.Q48181177
The neurotrophin receptors trkA, trkB and trkC are differentially regulated after excitotoxic lesion in rat striatum.Q48188055
Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon.Q48196753
Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system.Q48196786
Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factorQ48208108
Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGFQ48245956
Widespread and developmentally regulated expression of neurotrophin-4 mRNA in rat brain and peripheral tissuesQ48278654
Intrastriatal grafting of a GDNF-producing cell line protects striatonigral neurons from quinolinic acid excitotoxicity in vivoQ48284526
Expression of members of the trk family in the developing postnatal rat brainQ48319176
Rat fetal ventral mesencephalon grown as solid tissue cultures: influence of culture time and BDNF treatment on dopamine neuron survival and functionQ48337282
Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3.Q48353958
Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.Q48373564
Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brainQ48379221
Nerve growth factor selectively prevents excitotoxin induced degeneration of striatal cholinergic neuronesQ48468082
Distribution of the neurotrophins brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the postnatal rat brain: an immunocytochemical studyQ48498182
Anterograde transport of brain-derived neurotrophic factor and its role in the brainQ48539947
Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington diseaseQ37503857
Nerve growth factor promotes cholinergic development in brain striatal culturesQ37556010
Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington's disease patientsQ38288534
Localization of GDNF/neurturin receptor (c-ret, GFRalpha-1 and alpha-2) mRNAs in postnatal rat brain: differential regional and temporal expression in hippocampus, cortex and cerebellumQ38317887
Striatal dopaminergic afferents concentrate in GDNF-positive patches during development and in developing intrastriatal striatal grafts.Q39197001
Huntington's disease. Pathogenesis and managementQ39460676
Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras.Q39630940
The nerve growth factor 35 years laterQ39667849
Development of effective therapy for Alzheimer's disease based on neurotrophic factorsQ40496632
The p75 neurotrophin receptorQ40590902
The Trk family of neurotrophin receptorsQ40590908
The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokinesQ40590933
Neurochemistry and toxin models in Huntington's disease.Q40599311
Oxidative stress, glutamate, and neurodegenerative disordersQ40618533
Glial cell line neurotrophic factor-family receptor alpha-1 is present in central neurons with distinct phenotypesQ40676299
Ciliary neurotrophic factor (CNTF) enhances myelin formation: a novel role for CNTF and CNTF-related molecules.Q40692097
Regulation of c-Ret, GFRalpha1, and GFRalpha2 in the substantia nigra pars compacta in a rat model of Parkinson's diseaseQ40706788
Neurturin is a neuritogenic but not a survival factor for developing and adult central noradrenergic neuronsQ40724503
Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatumQ40741337
Striatopallidal neurons are selectively protected by neurturin in an excitotoxic model of Huntington's diseaseQ40744948
Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinaseQ40745449
GFRα‐1 mRNA in dopaminergic and nondopaminergic neurons in the substantia nigra and ventral tegmental areaQ40763041
Functions of the neurotrophins during nervous system development: what the knockouts are teaching us.Q40763660
Brain-derived neurotrophic factor (BDNF) mediates bone morphogenetic protein-2 (BMP-2) effects on cultured striatal neuronesQ40766507
Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survivalQ40768044
Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease.Q40776566
Neuroprotection of striatal neurons against kainate excitotoxicity by neurotrophins and GDNF family membersQ40777710
Compartmental expression of trkB receptor protein in the developing striatumQ40821499
Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's diseaseQ40826187
Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's diseaseQ40846012
Immunohistochemical localization of glial cell line-derived neurotrophic factor in the human central nervous systemQ40848213
Determinants of ligand binding specificity in the glial cell line-derived neurotrophic factor family receptor alpha S.Q40851328
GDNF enhances the synaptic efficacy of dopaminergic neurons in cultureQ40853630
Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF.Q40859352
Reactive astrocytes of the quinolinic acid-lesioned rat striatum express GFRalpha1 as well as GDNF in vivoQ40870366
Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's diseaseQ40873179
Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease.Q40876522
Wild-type huntingtin protects from apoptosis upstream of caspase-3.Q40880907
GDNF triggers a novel ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor alpha1.Q40911466
Preclinical testing of neuroprotective neurotrophic factors in a model of chronic motor neuron degenerationQ40922137
Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cellsQ40941497
Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neuronsQ40945102
Neuroprotective utility and neurotrophic action of neurturin in postnatal motor neurons: comparison with GDNF and persephinQ40950872
Effects of BDNF on dopaminergic, serotonergic, and GABAergic neurons in cultures of human fetal ventral mesencephalon.Q40987702
GFRα-4 and the tyrosine kinase Ret form a functional receptor complex for persephinQ41008328
Expression of neurturin, GDNF, and their receptors in the adult mouse CNSQ41016790
Expression of GDNF Family Receptor Components during Development: Implications in the Mechanisms of InteractionQ41036193
Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous systemQ41053776
Glial cell line-derived neurotrophic factor attenuates the locomotor hypofunction and striatonigral neurochemical deficits induced by chronic systemic administration of the mitochondrial toxin 3-nitropropionic acidQ41063077
Glial cell line-derived neurotrophic factor attenuates the excitotoxin-induced behavioral and neurochemical deficits in a rodent model of Huntington's diseaseQ41087697
Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAsQ41100969
Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase.Q41105131
Signal transduction mediated by the truncated trkB receptor isoforms, trkB.T1 and trkB.T2.Q41116074
Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's diseaseQ41120174
Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridizationQ41123196
Intracellular signaling pathways activated by neurotrophic factorsQ41132714
The neurotrophins and CNTF: two families of collaborative neurotrophic factorsQ41132721
Dose-dependent responses to nerve growth factor by adult rat cholinergic medial septum and neostriatum neuronsQ41149174
Glial cell line-derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damageQ41154059
Glial-cell-line-derived neurotrophic factor enhances biosynthesis of substance P in striatal neurons in vitroQ41156909
Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous systemQ41156961
Effects of GDNF on fetal septal forebrain transplants in oculoQ41165513
Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's diseaseQ41175238
Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cellsQ41180628
Functional receptor for GDNF encoded by the c-ret proto-oncogeneQ41190489
Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse developmentQ41236657
Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factorQ41340059
Regulation of voltage-gated ion channels by NGF and ciliary neurotrophic factor in SK-N-SH neuroblastoma cellsQ41404665
Neurotrophins and activity-dependent plasticity of cortical interneuronsQ41462642
Nerve growth factor gene expression in the developing rat brainQ41474843
Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesionsQ41564204
Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in cultureQ41576201
Blood-brain barrier penetration and in vivo activity of an NGF conjugateQ41578400
The trkB tyrosine protein kinase is a receptor for neurotrophin-4Q41626768
Cholinergic neuronotrophic factors: intraocular distribution of trophic activity for ciliary neuronsQ41652949
Neurotrophin-5: A novel neurotrophic factor that activates trk and trkBQ41658559
The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3.Q41674996
High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptorQ41687095
Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acidsQ41704517
Phenotypic Alteration of Astrocytes Induced by Ciliary Neurotrophic Factor in the Intact Adult Brain, As Revealed by Adenovirus-Mediated Gene TransferQ48628421
Brain-derived neurotrophic factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons: studies in vivo and in vitroQ48678036
Cells that Express Brain-Derived Neurotrophic Factor mRNA in the Developing Postnatal Rat BrainQ48691261
Opposing roles for endogenous BDNF and NT-3 in regulating cortical dendritic growth.Q48714447
Expression of brain-derived neurotrophic factor protein in the adult rat central nervous systemQ48720818
BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigraQ48767968
Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokinesQ48867473
Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor familyQ48888641
Immunohistochemical localization of brain-derived neurotrophic factor in adult rat brainQ48906109
Cellular expression of ionotropic glutamate receptor subunits on specific striatal neuron types and its implication for striatal vulnerability in glutamate receptor-mediated excitotoxicityQ48955052
Delayed death of septal cholinergic neurons after excitotoxic ablation of hippocampal neurons during early postnatal development in the rat.Q48983239
Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor familyQ49053110
Intrastriatal and intraventricular infusion of brain-derived neurotrophic factor in the cynomologous monkey: distribution, retrograde transport and co-localization with substantia nigra dopamine-containing neuronsQ49076744
Differential trophic effects of basic fibroblast growth factor, insulin-like growth factor-1, and neurotrophin-3 on striatal neurons in cultureQ49109125
The survival of striatal cholinergic neurons cultured from postnatal 2-week-old rats is promoted by neurotrophinsQ49111888
Spatiotemporal expression of noncatalytic TrkC NC2 isoform during early and late CNS neurogenesis: a comparative study with TrkC catalytic and p75NTR receptors.Q52165103
Developmental regulation of BDNF and NT-3 expression by quinolinic acid in the striatum and its main connectionsQ52165694
Truncated and full-length TrkB receptors regulate distinct modes of dendritic growthQ52169905
Neural Differentiation Promoted by Truncated trkC Receptors in Collaboration with p75NTRQ52184656
Proliferation and differentiation of embryonic chick sympathetic neurons: effects of ciliary neurotrophic factorQ52247249
Disruption of the CNTF gene results in motor neuron degenerationQ52516638
NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum.Q54168901
Potentiation of transmitter release by ciliary neurotrophic factor requires somatic signalingQ54590336
Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIFQ57198135
Essential function of LIF receptor in motor neuronsQ59065862
CNTF is a major protective factor in demyelinating CNS disease: A neurotrophic cytokine as modulator in neuroinflammationQ60215313
Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult miceQ60215454
Opposite Regulation of Calbindin and Calretinin Expression by Brain-Derived Neurotrophic Factor in Cortical NeuronsQ61774072
Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factorQ70132556
The molecular biology of the CNTF receptorQ70458874
Purification of the chick eye ciliary neuronotrophic factorQ70650968
Nerve growth factor protects the neonatal brain against hypoxic-ischemic injuryQ70928177
The distribution of brain-derived neurotrophic factor and its receptor trkB in parvalbumin-containing neurons of the rat visual cortexQ71383340
Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acidQ71511467
Up-regulation of trkB mRNA expression in the rat striatum after seizuresQ71526004
Intrastriatal Infusions of Brain-Derived Neurotrophic Factor: Retrograde Transport and Colocalization with Dopamine Containing Substantia Nigra Neurons in RatQ71650088
Protective Role of Nerve Growth Factor against Excitatory Amino Acid Injury during Neostriatal Cholinergic Neurons Postnatal DevelopmentQ71815652
Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF ResponsesQ72074174
Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acidQ72098398
Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNFQ72142043
Time course of ciliary neurotrophic factor mRNA expression is coincident with the presence of protoplasmic astrocytes in traumatized rat striatumQ72151741
Brain-derived neurotrophic factor promotes differentiation of striatal GABAergic neuronsQ72194700
The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons in vitroQ72254050
Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neuronsQ72643375
ObituaryQ73459586
Brain-derived neurotrophic factor requirement for activity-dependent maturation of glutamatergic synapse in developing mouse somatosensory cortexQ73505736
Expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the somatosensory cortex of the mature rat: coexpression with high-affinity neurotrophin receptorsQ73508855
Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area.Q31813509
GDNF rescues nonpeptidergic unmyelinated primary afferents in streptozotocin-treated diabetic miceQ31848096
Differential expression of GDNF, BDNF, and NT-3 in the aging nigrostriatal system following a neurotoxic lesionQ31873597
GFRα-4, a New GDNF Family ReceptorQ32058878
Cloning and characterization of glial cell line-derived neurotrophic factor receptor-B: A novel receptor for members of glial cell line-derived neurotrophic factor family of neurotrophic factorsQ32122155
trkB, a neural receptor protein-tyrosine kinase: evidence for a full-length and two truncated receptorsQ33332038
Neurotrophic factors and diabetic peripheral neuropathyQ33534157
Recent advances on the pathogenesis of Huntington's diseaseQ33604650
Differential loss of striatal projection neurons in Huntington diseaseQ33637273
Recent advances in understanding the pathogenesis of Huntington's diseaseQ33650539
p75 neurotrophin receptor as a modulator of survival and death decisionsQ33670585
Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible?Q33732493
Replicating Huntington's disease phenotype in experimental animalsQ33749061
Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseasesQ33851629
Glial cell line-derived neurotrophic factor promotes the survival and morphologic differentiation of Purkinje cellsQ33884388
Released GFRalpha1 potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts.Q33933786
Trk receptors: mediators of neurotrophin actionQ33950703
The basal gangliaQ33970931
Loss of normal huntingtin function: new developments in Huntington's disease researchQ34142361
Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approachesQ34156542
Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathwayQ34278037
Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene.Q34338664
Characterization of a multicomponent receptor for GDNF.Q34383378
Replication of the neurochemical characteristics of Huntington's disease by quinolinic acidQ34384772
TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret.Q34428727
The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3Q34497200
Huntington's disease: new hope for therapeuticsQ34553826
Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington's disease.Q34657624
Neurotrophin signaling through the p75 neurotrophin receptorQ34778209
Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disordersQ34952853
Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injuryQ35002869
Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington diseaseQ35761924
The epidemiology of Huntington's diseaseQ35882166
An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3.Q35897889
Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB.Q41734248
Effects of ciliary neurotrophic factor (CNTF) and depolarization on neuropeptide expression in cultured sympathetic neuronsQ42013685
A Role for TrkA during Maturation of Striatal and Basal Forebrain Cholinergic NeuronsIn VivoQ42444980
Expression of Brain-Derived Neurotrophic Factor and TrkB Neurotrophin Receptors after Striatal Injury in the MouseQ42448123
Molecular cloning of rat trkC and distribution of cells expressing messenger RNAs for members of the trk family in the rat central nervous systemQ42458072
p140trk mRNA marks NGF-responsive forebrain neurons: evidence that trk gene expression is induced by NGFQ42458990
Differential regulation of the low-affinity nerve growth factor receptor during postnatal development of the rat brainQ42463884
Survival of Adult Basal Forebrain Cholinergic Neurons After Loss of Target NeuronsQ42465160
Cellular localization of brain-derived neurotrophic factor-like immunoreactivity in adult monkey brainQ42468669
Two components from eye tissue that differentially stimulate the growth and development of ciliary ganglion neurons in cell culture.Q42472375
Destabilization of cortical dendrites and spines by BDNF.Q42474475
Neurotrophins regulate dendritic growth in developing visual cortexQ42479052
BDNF is needed for postnatal maturation of basal forebrain and neostriatum cholinergic neurons in vivoQ42485788
Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administrationQ42496429
High-affinity nerve growth factor receptor (Trk) immunoreactivity is localized in cholinergic neurons of the basal forebrain and striatum in the adult rat brainQ42505736
Striatal dopamine output is compromised within +/− BDNF miceQ42514742
Neurotrophins stimulate the release of dopamine from rat mesencephalic neurons via Trk and p75Lntr receptorsQ42519834
Survival of cholinergic forebrain neurons in developing p75NGFR-deficient miceQ42527534
Functional properties of AMPA and NMDA receptors expressed in identified types of basal ganglia neurons.Q42528666
Nerve growth factor effects on cholinergic neurons of neostriatum and nucleus accumbens in the adult rat.Q43482932
The uniqueness of being a neurotrophin receptorQ43635038
P921main subjectHuntington's diseaseQ190564
P304page(s)195-229
P577publication date2004-01-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inProgress in Brain ResearchQ15800382
P1476titleNeurotrophic factors in Huntington's disease
P478volume146

Reverse relations

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