| scholarly article | Q13442814 |
| P819 | ADS bibcode | 1997PNAS...94.6456G |
| P356 | DOI | 10.1073/PNAS.94.12.6456 |
| P932 | PMC publication ID | 21071 |
| P698 | PubMed publication ID | 9177239 |
| P5875 | ResearchGate publication ID | 242906777 |
| P50 | author | Gennaro Ciliberto | Q38800176 |
| P2093 | author name string | F Chen | |
| R Cortese | |||
| P Costa | |||
| D Lazzaro | |||
| I Gloaguen | |||
| A Di Marco | |||
| L H Van der Ploeg | |||
| R Laufer | |||
| G Paonessa | |||
| R Graziani | |||
| C I Rosenblum | |||
| A Demartis | |||
| P2860 | cites work | Positional cloning of the mouse obese gene and its human homologue | Q22251285 |
| Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth | Q24313379 | ||
| The full-length leptin receptor has signaling capabilities of interleukin 6-type cytokine receptors | Q24629394 | ||
| A null mutation in the human CNTF gene is not causally related to neurological diseases | Q28247345 | ||
| Single-step assembly of a gene and entire plasmid from large numbers of oligodeoxyribonucleotides | Q28291604 | ||
| Interleukin-6 family of cytokines and gp130 | Q28295098 | ||
| The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development | Q28573544 | ||
| Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6 | Q28637521 | ||
| Serum immunoreactive-leptin concentrations in normal-weight and obese humans | Q29617230 | ||
| Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects | Q29617231 | ||
| Weight-reducing effects of the plasma protein encoded by the obese gene | Q29617934 | ||
| Effects of the obese gene product on body weight regulation in ob/ob mice | Q29617935 | ||
| Identification and expression cloning of a leptin receptor, OB-R | Q29620255 | ||
| Transcriptional responses to polypeptide ligands: the JAK-STAT pathway | Q29620287 | ||
| Systemic administration of ciliary neurotrophic factor induces cachexia in rodents | Q34152969 | ||
| Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action | Q34289416 | ||
| Increased obese mRNA expression in omental fat cells from massively obese humans | Q34297446 | ||
| Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks | Q34301257 | ||
| Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice | Q34376178 | ||
| Abnormal splicing of the leptin receptor in diabetic mice | Q34379335 | ||
| Dietary obesity in nine inbred mouse strains | Q34458771 | ||
| Sensory circumventricular organs and brain homeostatic pathways | Q34731248 | ||
| Ciliary neurotrophic factor is an endogenous pyrogen | Q36542353 | ||
| CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interaction | Q36688377 | ||
| Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters | Q37354703 | ||
| Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists. | Q37391072 | ||
| Defective STAT signaling by the leptin receptor in diabetic mice | Q37509613 | ||
| Decreased food intake does not completely account for adiposity reduction after ob protein infusion | Q37725591 | ||
| The role of neuropeptide Y in the antiobesity action of the obese gene product | Q38290434 | ||
| The TIS11 primary response gene is a member of a gene family that encodes proteins with a highly conserved sequence containing an unusual Cys-His repeat | Q38336281 | ||
| The SIF binding element confers sis/PDGF inducibility onto the c-fos promoter | Q38338025 | ||
| Functional STAT 1 and 3 signaling by the leptin receptor (OB-R); reduced expression of the rat fatty leptin receptor in transfected cells | Q38351998 | ||
| Identification of targets of leptin action in rat hypothalamus | Q38353571 | ||
| Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice | Q38353583 | ||
| Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization | Q38356905 | ||
| Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice | Q38359964 | ||
| Leptin enters the brain by a saturable system independent of insulin | Q38363314 | ||
| Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response | Q40666805 | ||
| Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice | Q40688984 | ||
| Immunohistochemical localization of ciliary neurotrophic factor receptor alpha expression in the rat nervous system | Q40952511 | ||
| The neurotrophins and CNTF: two families of collaborative neurotrophic factors | Q41132721 | ||
| Interleukin 6 receptor superantagonists are potent inducers of human multiple myeloma cell death | Q41167861 | ||
| Regulation of bone marrow stromal cell differentiation by cytokines whose receptors share the gp130 protein | Q41499965 | ||
| Cell-free activation of a DNA-binding protein by epidermal growth factor | Q41566544 | ||
| Immortalized young adult neurons from the septal region: generation and characterization | Q41741200 | ||
| Leukemia inhibitory factor induces changes in lipid metabolism in cultured adipocytes | Q42796154 | ||
| A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study Group | Q46133871 | ||
| The pRSET family of T7 promoter expression vectors for Escherichia coli | Q48133282 | ||
| The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain | Q48615076 | ||
| Permeability at the blood-brain and blood-nerve barriers of the neurotrophic factors: NGF, CNTF, NT-3, BDNF. | Q49067543 | ||
| Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. | Q52510633 | ||
| The influence of genetic background on the expression of the obese (ob) gene in the mouse | Q53909983 | ||
| Leptin activation in hypothalamus. | Q54338591 | ||
| Comparison of the effects of bacterial lipopolysaccharide and muramyl dipeptide on food intake. | Q54713600 | ||
| Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF | Q57198135 | ||
| Ciliary neurotrophic factor: Pharmacokinetics and acute-phase response in rat | Q60215493 | ||
| A simple method for carcass analysis | Q69418202 | ||
| Studies with the mutation, diabetes, in the mouse | Q69900725 | ||
| A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study Group | Q71074210 | ||
| P433 | issue | 12 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | obesity | Q12174 |
| P304 | page(s) | 6456-6461 | |
| P577 | publication date | 1997-06-01 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance | |
| P478 | volume | 94 |
| Q46488637 | A combination of cytokines EGF and CNTF protects the functional beta cell mass in mice with short-term hyperglycaemia. |
| Q48866339 | A putative physiological role of hypothalamic CNTF in the control of energy homeostasis |
| Q42534431 | Action of Administered Ciliary Neurotrophic Factor on the Mouse Dorsal Vagal Complex |
| Q48115865 | Activation of astrocytes by CNTF induces metabolic plasticity and increases resistance to metabolic insults. |
| Q34573045 | Activation of the cardiac ciliary neurotrophic factor receptor reverses left ventricular hypertrophy in leptin-deficient and leptin-resistant obesity |
| Q36099405 | Advances in anti-obesity therapeutics |
| Q34039602 | Afferent signals regulating food intake |
| Q73293527 | Antiobesity and antidiabetic effects of brain-derived neurotrophic factor in rodent models of leptin resistance |
| Q48588727 | CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. |
| Q37062108 | CNTF: a target therapeutic for obesity-related metabolic disease? |
| Q64882139 | Cachexia-associated adipose loss induced by tumor-secreted leukemia inhibitory factor is counterbalanced by decreased leptin. |
| Q37337828 | Can neuropeptides treat obesity? A review of neuropeptides and their potential role in the treatment of obesity |
| Q36118735 | Central regulation of energy balance: inputs, outputs and leptin resistance |
| Q36512624 | Central regulation of metabolism by protein tyrosine phosphatases |
| Q58216984 | Ciliary neurotrophic factor (CNTF) genotype and body composition |
| Q83473619 | Ciliary neurotrophic factor (CNTF) protects non-obese Swiss mice against type 2 diabetes by increasing beta cell mass and reducing insulin clearance |
| Q24635198 | Ciliary neurotrophic factor activates leptin-like pathways and reduces body fat, without cachexia or rebound weight gain, even in leptin-resistant obesity |
| Q33716781 | Ciliary neurotrophic factor improves diabetic parameters and hepatic steatosis and increases basal metabolic rate in db/db mice |
| Q35903196 | Circumventing leptin resistance for weight control |
| Q38294827 | Constitutive activation of STAT-3 and downregulation of SOCS-3 expression induced by adrenalectomy |
| Q35584812 | Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity |
| Q42452665 | Differential expression of suppressors of cytokine signaling-1, -2, and -3 in the rat hippocampus after seizure: implications for neuromodulation by gp130 cytokines |
| Q73337671 | Distribution of the transcription factor signal transducer and activator of transcription 3 in the rat central nervous system and dorsal root ganglia |
| Q55400170 | Effect of human very low-density lipoproteins on cardiotrophin-like cytokine factor 1 (CLCF1) activity. |
| Q34563426 | Effects of detraining on motor unit potential area, muscle function and physical performance based on CNTF gene polymorphism |
| Q35581176 | Emerging antiobesity drugs |
| Q24656029 | Enhancing leptin response by preventing SH2-containing phosphatase 2 interaction with Ob receptor |
| Q40427316 | Expression of functional ciliary neurotrophic factor receptors in immortalized gonadotrophin-releasing hormone-secreting neurones. |
| Q36099461 | Gene therapy for obesity |
| Q48463012 | High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-α on appetite-regulating NPY neurons |
| Q34143823 | How obesity develops: insights from the new biology |
| Q38041229 | Hypothalamic dysfunction in obesity |
| Q36550687 | Hypothalamic integration of immune function and metabolism |
| Q38107692 | Hypothalamic neurogenesis in the adult brain |
| Q36452521 | Hypothalamic regulatory pathways and potential obesity treatment targets |
| Q63437241 | Hypothalamic response to leptin changes during a hormonally induced estrous cycle in rats |
| Q34288655 | IL-6-like cytokines and cancer cachexia: consequences of chronic inflammation |
| Q48368954 | Immune and endocrine regulation of food intake in sick animals |
| Q34167234 | Induction of leptin resistance by activation of cAMP-Epac signaling |
| Q34440657 | Interleukin-6 and new strategies for the treatment of cancer, hyperproliferative diseases and paraneoplastic syndromes |
| Q43851625 | Interleukin-6-deficient mice develop mature-onset obesity |
| Q59649473 | Intracerebroventricular interleukin-6 treatment decreases body fat in rats |
| Q36543067 | Investigational therapies in the treatment of obesity |
| Q40880499 | Leptin receptor-mediated regulation of cholinergic neurotransmitter phenotype in cells of central nervous system origin |
| Q33590455 | Leptin: in search of role(s) in human physiology and pathophysiology |
| Q38307702 | Long-term differential modulation of genes encoding orexigenic and anorexigenic peptides by leptin delivered by rAAV vector in ob/ob mice. Relationship with body weight change |
| Q41045705 | Loss of Oncostatin M Signaling in Adipocytes Induces Insulin Resistance and Adipose Tissue Inflammation in Vivo |
| Q59800515 | MANF: A New Player in the Control of Energy Homeostasis, and Beyond |
| Q40750850 | Mitogen-activated protein kinase kinase negatively modulates ciliary neurotrophic factor-activated choline acetyltransferase gene expression. |
| Q38056233 | Molecular pathways linking metabolic inflammation and thermogenesis. |
| Q34234175 | Molecular regulation of eating behavior: new insights and prospects for therapeutic strategies |
| Q48415057 | Neuroendocrine regulation of eating behavior |
| Q47230371 | Neuropeptide Y counteracts the anorectic and weight reducing effects of ciliary neurotropic factor |
| Q33592561 | Neuropeptide Y: a key molecule in anorexia and cachexia in wasting disorders? |
| Q36825535 | Neuropoietin attenuates adipogenesis and induces insulin resistance in adipocytes |
| Q36983344 | Neurotrophic factor control of satiety and body weight |
| Q35618345 | Neurotrophic factors in Huntington's disease |
| Q36862777 | Neurotrophism and energy homeostasis: perfect together |
| Q53954131 | Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males. |
| Q30080025 | Obesity and the regulation of energy balance |
| Q36377258 | Obesity drugs and their targets: correlation of mouse knockout phenotypes with drug effects in vivo |
| Q28240764 | Obesity wars: molecular progress confronts an expanding epidemic |
| Q34014388 | Obesity: an epidemic in need of therapeutics |
| Q35197837 | On the site and mechanism of action of the anti-obesity effects of interleukin-6. |
| Q37554810 | Oncostatin m is produced in adipose tissue and is regulated in conditions of obesity and type 2 diabetes |
| Q38358416 | Oncostatin m modulation of lipid storage |
| Q42774590 | Opposite effects of a high-fat diet and calorie restriction on ciliary neurotrophic factor signaling in the mouse hypothalamus |
| Q83289833 | Overcoming insulin resistance with CNTF |
| Q35760298 | Peptides and their potential role in the treatment of diabetes and obesity |
| Q34585198 | Pharmacological approaches for the treatment of obesity |
| Q34243168 | Pharmacotherapy of obesity: targets and perspectives |
| Q91736923 | Recent insights into targeting the IL-6 cytokine family in inflammatory diseases and cancer |
| Q54107503 | Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. |
| Q73599752 | Restoration of fertility in young obese (Lep(ob) Lep(ob)) male mice with low dose recombinant mouse leptin treatment |
| Q24297991 | Signaling of human ciliary neurotrophic factor (CNTF) revisited. The interleukin-6 receptor can serve as an alpha-receptor for CTNF |
| Q41847430 | The amino acid exchange R28E in ciliary neurotrophic factor (CNTF) abrogates interleukin-6 receptor-dependent but retains CNTF receptor-dependent signaling via glycoprotein 130 (gp130)/leukemia inhibitory factor receptor (LIFR). |
| Q35986141 | The anorectic effect of CNTF does not require action in leptin-responsive neurons. |
| Q48795590 | The anorexigenic cytokine ciliary neurotrophic factor stimulates POMC gene expression via receptors localized in the nucleus of arcuate neurons. |
| Q28144474 | The ciliary neurotrophic factor and its receptor, CNTFR alpha |
| Q42494038 | The effects of ciliary neurotrophic factor on the hypothalamo-pituitary gonadal axis in vitro in female rats |
| Q34163354 | The future of leptin and leptin analogues in the treatment of obesity |
| Q35059389 | The gp130 receptor cytokine family: regulators of adipocyte development and function. |
| Q42808517 | The regulation and activation of ciliary neurotrophic factor signaling proteins in adipocytes |
| Q26770548 | The role of gp130 receptor cytokines in the regulation of metabolic homeostasis |
| Q36979956 | The role of interleukin-6 in insulin resistance, body fat distribution and energy balance |
| Q36876828 | The role of leptin on the organization and expression of cytoskeleton elements in nucleus pulposus cells |
| Q35547260 | The therapeutic potential of interleukin-6 in treating obesity |
| Q45324474 | Transcription analysis of the interaction between chicken thymus and recombinant avian leukosis virus isolate FJ15HT0. |
| Q33897644 | Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice |
| Q59062529 | Whatever happened to leptin? |
| Q35723440 | gp130 receptor ligands as potential therapeutic targets for obesity |
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