The ciliary neurotrophic factor and its receptor, CNTFR alpha

scientific article (publication date: March 2000)

The ciliary neurotrophic factor and its receptor, CNTFR alpha is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1016/S0031-6865(99)00050-3
P3181OpenCitations bibliographic resource ID479355
P698PubMed publication ID10812968

P2093author name stringG D Yancopoulos
S J Wiegand
K D Anderson
M W Sleeman
P D Lambert
P2860cites workThe receptor for ciliary neurotrophic factorQ24305006
Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birthQ24313379
A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injuryQ24563422
A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis. ALS CNTF Treatment Study GroupQ71074210
Ciliary neurotrophic factor stimulates the expression of glial fibrillary acidic protein by brain astrocytes in vivoQ71410617
Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acidQ71511467
Ciliary neurotrophic factor induces down-regulation of its receptor and desensitization of signal transduction pathways in vivo: non-equivalence with pharmacological activityQ71514678
Localization of functional receptor epitopes on the structure of ciliary neurotrophic factor indicates a conserved, function-related epitope topography among helical cytokinesQ71696303
Released Form of CNTF Receptor α Component as a Soluble Mediator of CNTF ResponsesQ72074174
Trophic effect of ciliary neurotrophic factor on denervated skeletal muscleQ72785885
Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasingQ24568241
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptorsQ28235378
A null mutation in the human CNTF gene is not causally related to neurological diseasesQ28247345
CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130Q28273498
Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factorQ28572533
The alpha component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during developmentQ28573544
Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathyQ29397966
Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6.Q30322247
Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistanceQ36188464
Ciliary neurotrophic factor is an endogenous pyrogenQ36542353
CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interactionQ36688377
Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists.Q37391072
Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington diseaseQ37503857
Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factorQ38325407
Trophic protection of motor neurons: clinical potential in motor neuron diseasesQ40496013
The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokinesQ40590933
Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in miceQ40688984
The CIS family: negative regulators of JAK-STAT signalingQ40827478
Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's diseaseQ41120174
Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's diseaseQ41175238
Cytokines affecting survival and differentiation of an astrocyte progenitor cell lineQ41513756
Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in cultureQ41576201
Cytokines and cachexiaQ41588874
Cholinergic neuronotrophic factors: intraocular distribution of trophic activity for ciliary neuronsQ41652949
In vitro binding of ciliary neurotrophic factor to its receptors: evidence for the formation of an IL-6-type hexameric complexQ42673314
Purification, cloning, and expression of ciliary neurotrophic factor (CNTF).Q45094286
CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death.Q46020332
A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in amyotrophic lateral sclerosis. rhCNTF ALS Study GroupQ46133871
Signaling mechanisms through gp130: A model of the cytokine systemQ47992455
Ciliary neurotrophic factor enhances the survival of Purkinje cells in vitroQ48115106
Control of Na+, K+-pump activity in dorsal root ganglionic neurons by different neuronotrophic agentsQ48286432
The neurotrophins BDNF, NT-3 and NT-4/5, but not NGF, up-regulate the cholinergic phenotype of developing motor neuronsQ48300378
Increased appetite augments hypothalamic NPY Y1 receptor gene expression: effects of anorexigenic ciliary neurotropic factorQ48359447
Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal culturesQ48641587
Proliferation and differentiation of embryonic chick sympathetic neurons: effects of ciliary neurotrophic factorQ52247249
Ciliary neurotrophic factor induces type-2 astrocyte differentiation in cultureQ52250289
Disruption of the CNTF gene results in motor neuron degenerationQ52516638
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptidesQ54107503
Identification and Characterization of Two Distinct Truncated Forms of gp130 and a Soluble Form of Leukemia Inhibitory Factor Receptor α-Chain in Normal Human Urine and PlasmaQ58039498
Essential function of LIF receptor in motor neuronsQ59065862
Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injuryQ60066037
Type-2 astrocyte development in rat brain cultures is initiated by a CNTF like protein produced by type-1 astrocytesQ60215556
Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivoQ68009162
Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factorQ70132556
Ciliary neurotrophic factor regulates fibrinogen gene expression in hepatocytes by binding to the interleukin-6 receptorQ70547124
P433issue2-3
P407language of work or nameEnglishQ1860
P304page(s)265-72
P577publication date2000-03-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inPharmaceutica acta HelvetiaeQ27712609
P1476titleThe ciliary neurotrophic factor and its receptor, CNTFR alpha
P478volume74

Reverse relations

cites work (P2860)
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