Proteolytic-antiproteolytic balance and its regulation in carcinogenesis.

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Proteolytic-antiproteolytic balance and its regulation in carcinogenesis. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.3748/WJG.V11.I9.1251
P932PMC publication ID4250670
P698PubMed publication ID15761961
P5875ResearchGate publication ID7972367

P50authorElżbieta SkrzydlewskaQ24451883
Mariola SulkowskaQ115945813
Stanisław SulkowskiQ115945836
Mariusz KodaQ57340344
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"In vitro" digestion of intact bovine lens capsules by four human lysosomal cysteine-proteinasesQ68920162
Hypochlorous acid (HOCl) activation of neutrophil collagenase requires cathepsin GQ69357918
Evidence that alpha-tocopherol functions cyclically to quench free radicals in hepatic microsomes. Requirement for glutathione and a heat-labile factorQ69455122
Regulation of cathepsin-D and pS2 gene expression by growth factors in MCF7 human breast cancer cellsQ69518256
Free radicals inactivate human neutrophil elastase and its inhibitors with comparable efficiencyQ69736915
Cathepsin B and cysteine proteinase inhibitors in bronchoalveolar lavage fluid of lung cancer patientsQ70487759
Procathepsin D cannot autoactivate to cathepsin D at acid pHQ70612684
Exposure of cells to nonlethal concentrations of hydrogen peroxide induces degeneration-repair mechanisms involving lysosomal destabilizationQ70954078
Stimulation of gelatinase B and tissue inhibitors of metalloproteinase (TIMP) production in co-culture of human osteosarcoma cells and human fibroblasts: gelatinase B production was stimulated via up-regulation of fibroblast growth factor (FGF) receQ71019291
Biochemical characterization of human collagenase-3Q24318765
Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4Q24322566
Lysosomal cysteine proteases: facts and opportunitiesQ24535678
Tissue inhibitors of metalloproteinases: evolution, structure and functionQ28138083
Variable expression of cathepsin B and D correlates with highly invasive and metastatic phenotype of oral cancerQ28138684
Human procathepsin B interacts with the annexin II tetramer on the surface of tumor cellsQ28142712
Cathepsin B and H activities and cystatin C concentrations in cerebrospinal fluid from patients with leptomeningeal metastasisQ28209992
Analysis of a truncated form of cathepsin H in human prostate tumor cellsQ28215805
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydesQ28241500
Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysisQ28268059
Increased secretion, altered processing, and glycosylation of pro-cathepsin D in human mammary cancer cellsQ28276790
Proteinase requirements of epidermal growth factor-induced ovarian cancer cell invasionQ28284948
Activation of cathepsin B, secreted by a colorectal cancer cell line requires low pH and is mediated by cathepsin DQ28287089
Cathepsin D inactivates cysteine proteinase inhibitors, cystatinsQ28294092
Molecular cloning and sequence analysis of human preprocathepsin CQ28295805
The gene structure of tissue inhibitor of metalloproteinases (TIMP)-3 and its inhibitory activities define the distinct TIMP gene familyQ28303305
Induction of cytochrome P4501A1 by 2,3,7,8-tetrachlorodibenzo-p-dioxin or indolo(3,2-b)carbazole is associated with oxidative DNA damageQ28378843
Matrix metalloproteinase degradation of extracellular matrix: biological consequencesQ28611041
NADPH oxidase: an updateQ28611494
Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloproteaseQ28618841
Matrix metalloproteinase 7 (matrilysin) from human rectal carcinoma cells. Activation of the precursor, interaction with other matrix metalloproteinases and enzymic propertiesQ28618856
AP-1 function and regulationQ29618422
Matrix metalloproteinases: a reviewQ29620220
How matrix metalloproteinases regulate cell behaviorQ29620360
Antisense RNA inhibition of cathepsin L expression reduces tumorigenicity of malignant cellsQ30321132
Cysteine proteinases in cancer progression and their clinical relevance for prognosisQ30430037
Levels of alpha 2 macroglobulin can predict bone metastases in prostate cancer.Q30661648
The prognostic value of polymorphonuclear leukocyte elastase in patients with primary breast cancer.Q33185804
Molecular regulation, membrane association and secretion of tumor cathepsin B.Q33586435
Expression of metalloproteinases and their inhibitors in adenocarcinoma of the uterine cervixQ77452924
Cathepsin D activity in colorectal cancerQ77459540
The collagenolytic activity of cathepsin K is unique among mammalian proteinasesQ77581104
Alpha1-antitrypsin deficiency allele carriers among lung cancer patientsQ77817785
Inhibition of mammalian legumain by some cystatins is due to a novel second reactive siteQ77926967
Regulation of cathepsin B activity by cysteine and related thiolsQ77931595
Association of matrilysin expression with recurrence and poor prognosis in human esophageal squamous cell carcinomaQ78029650
High levels of tissue inhibitor of metalloproteinase-1 predict poor outcome in patients with breast cancerQ78167050
Expression of cathepsin D in urothelial carcinoma of the urinary bladder: an immunohistochemical study including correlations with extracellular matrix components, CD44, p53, Rb, c-erbB-2 and the proliferation indicesQ78801720
Serum level of cathepsin B and its density in men with prostate cancer as novel markers of disease progressionQ80493769
Clinicopathological significance of cathepsin D expression in gastric adenocarcinomaQ95721627
Mechanisms for pro matrix metalloproteinase activation.Q33586441
Proteolytic control of growth factor availabilityQ33586464
Cancer invasion and tissue remodeling--cooperation of protease systems and cell types.Q33586489
An odyssey from breast to bone: multi-step control of mammary metastases and osteolysis by matrix metalloproteinasesQ33586496
Membrane-type matrix metalloproteinasesQ33586502
Clinical studies with matrix metalloproteinase inhibitorsQ33586513
Matrix metalloproteinases and their inhibitors in tumour growth and invasionQ33603385
Regulation of matrix metalloproteinase expression in tumor invasion.Q33605726
Measurement of matrix metalloproteinases and tissue inhibitors of metalloproteinases in blood and tissues. Clinical and experimental applicationsQ33692926
Matrix metalloproteinases in tumour invasion and metastasisQ33765792
Unraveling the role of proteases in cancerQ33838143
Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overviewQ33838156
Role of reactive oxygen species in apoptosis: implications for cancer therapy.Q33845327
Lysosomal cysteine proteases: more than scavengersQ33857460
Mitogen-activated protein kinase (MAPK) regulates the expression of progelatinase B (MMP-9) in breast epithelial cellsQ33866629
Role of cysteine endopeptidases in cancerogenesisQ33941771
Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesisQ33989842
Phagocytes and oxidative stressQ33998363
NADPH oxidase: a universal oxygen sensor?Q34054215
Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilizationQ34132949
Protein damage and degradation by oxygen radicals. I. general aspectsQ34163421
The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E.Q34177082
Matrix metalloproteinases and bladder cancerQ34207068
Structure and variation of human alpha 1-antitrypsinQ34277158
Inflammation, carcinogenesis and cancerQ34372773
Inside the neutrophil phagosome: oxidants, myeloperoxidase, and bacterial killing.Q34476924
Implications of the three-dimensional structure of alpha 1-antitrypsin for structure and function of serpinsQ34515383
Cysteine proteinases in tumor cell growth and apoptosisQ34531907
A radical approach to cancer.Q34598467
Inflammation and the development of pancreatic cancerQ34646491
Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3.Q34733220
Myeloperoxidase-mediated protein oxidation: its possible biological functionsQ34734560
Superoxide dismutase: an emerging target for cancer therapeuticsQ35050415
Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasionQ35186457
A novel hypothesis of lipofuscinogenesis and cellular aging based on interactions between oxidative stress and autophagocytosisQ35341297
The role of lipid peroxidation and antioxidants in oxidative modification of LDL.Q35379559
Proteolytic inactivation of alpha-1-proteinase inhibitor by a neutrophil metalloproteinaseQ35588784
Free radical-mediated oxidation of free amino acids and amino acid residues in proteinsQ35602220
The matrix metalloproteinases and their inhibitorsQ35673430
Role of imbalance between neutrophil elastase and alpha 1-antitrypsin in cancer development and progression.Q35683359
Expression of collagenase-3 (matrix metalloproteinase-13) in squamous cell carcinomas of the head and neckQ35763849
Tumor-associated urokinase-type plasminogen activator: biological and clinical significanceQ35777083
Cytokines and proteases in invasive processes: molecular similarities between inflammation and cancer.Q35779496
Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response.Q35782300
Activation of pro-urokinase and plasminogen on human sarcoma cells: a proteolytic system with surface-bound reactantsQ36220582
Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosisQ36235778
Expression of MMP-2,TIMP-2 protein and the ratio of MMP-2/TIMP-2 in gallbladder carcinoma and their significanceQ36308445
TIMP-3 mRNA expression is regionally increased in moderately and poorly differentiated colorectal adenocarcinomaQ36421730
Relationship between cathepsin-D content and disease-free survival in node-negative breast cancer patients: a meta-analysis.Q36431062
A novel amplicon at 8p22-23 results in overexpression of cathepsin B in esophageal adenocarcinoma.Q36524591
Cysteine proteinase cathepsin H in tumours and sera of lung cancer patients: relation to prognosis and cigarette smokingQ36641357
Cathepsin D protease mediates programmed cell death induced by interferon-gamma, Fas/APO-1 and TNF-alphaQ36803725
Autocatalytic activation of human cathepsin K.Q36861164
Hyperexpression of mitogen-activated protein kinase in human breast cancerQ37365431
Isolation of cDNA sequences coding for a part of human tissue plasminogen activatorQ37601324
Role of oxidatively modified LDL in atherosclerosisQ37978587
Structure, function, and control of neutrophil proteinasesQ38189037
Tissue destruction by neutrophilsQ38264463
Interactions between oxygen free radicals and proteins. Implications for rheumatoid arthritis. An overviewQ38760764
Plasminogen activators, tissue degradation, and cancerQ39476382
Plasminogen activator inhibitorsQ39592746
Lipid peroxidation and mechanisms of toxicityQ39673575
Elastase in tissue injuryQ39819526
Further studies on the activation of procollagenase, the latent precursor of bone collagenase. Effects of lysosomal cathepsin B, plasmin and kallikrein, and spontaneous activationQ40096626
Human plasma proteinase inhibitorsQ40107740
Superoxide Radical: An Endogenous ToxicantQ40135917
Tumor invasion and the extracellular matrixQ40139457
Serine protease inhibitors inhibit superoxide production by human polymorphonuclear leukocytes and monocytes stimulated by various surface active agentsQ40274090
Cleavage and inactivation of alpha 1-antitrypsin by metalloproteinases released from neutrophilsQ40377931
Lipid peroxidation and antioxidants as biomarkers of tissue damageQ40381864
The structure and function of the urokinase receptor, a membrane protein governing plasminogen activation on the cell surface.Q40475378
Oxidation of methionyl residues in proteins: tools, targets, and reversalQ40615542
Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitorsQ40652154
The oxidative inactivation of human alpha-1-proteinase inhibitor. Further evidence for methionine at the reactive centerQ40709282
H(2)O(2)-induced AP-1 activation and its effect on p21(WAF1/CIP1)-mediated G2/M arrest in a p53-deficient human lung cancer cellQ40726746
Modulation of redox signal transduction pathways in the treatment of cancerQ40787729
Evidence for the photoprotective effects of vitamin E.Q40866769
Biology and biochemistry of proteinases in tumor invasion.Q40868702
Molecular aspects of tumor cell invasion and metastasisQ40877783
Epidermal growth factor-like ligands differentially up-regulate matrix metalloproteinase 9 in head and neck squamous carcinoma cellsQ40895491
Expression of collagenase-3 (MMP-13) and collagenase-1 (MMP-1) by transformed keratinocytes is dependent on the activity of p38 mitogen-activated protein kinaseQ40906347
Pro-oxidants and mitochondrial Ca2+: their relationship to apoptosis and oncogenesisQ40918506
EGF induces the expression of matrilysin in the human prostate adenocarcinoma cell line, LNCaP.Q40943385
Transforming growth factor beta1 acts as an inducer of matrix metalloproteinase expression and activity in human bone-metastasizing cancer cellsQ40944816
Host TIMP-1 overexpression confers resistance to experimental brain metastasis of a fibrosarcoma cell lineQ41035774
72-kD (MMP-2) and 92-kD (MMP-9) type IV collagenase production and activity in different histologic types of lung cancer cellsQ41044903
Photo-Oxidative Disruption of Lysosomal Membranes Causes Apoptosis of Cultured Human FibroblastsQ41138991
Cathepsin B expression in human tumorsQ41154912
Cystatins in health and diseaseQ41161690
Proteolysis regulates exposure of the IIICS-1 adhesive sequence in plasma fibronectinQ41174195
Biological and clinical significance of cathepsin D in breast cancer metastasisQ41248368
Overexpression of metalloproteinase inhibitor in B16F10 cells does not affect extravasation but reduces tumor growth.Q41444177
Structural and functional aspects of papain-like cysteine proteinases and their protein inhibitorsQ41482008
Activation mechanisms of matrix metalloproteinases.Q41482018
Membrane association of cathepsin B can be induced by transfection of human breast epithelial cells with c-Ha-ras oncogene.Q41489908
Computational sequence analysis of the tissue inhibitor of metalloproteinase familyQ41502913
The urokinase-type plasminogen activator system in cancer metastasis: A reviewQ41522331
Integrins and anoikisQ41612562
Tissue inhibitors of metalloproteinases: structure, regulation and biological functions.Q41628042
Tissue inhibitors of metalloproteinases (TIMP) in invasion and proliferationQ41643679
Physiological mechanisms for metalloproteinase activationQ41647723
Role of the urokinase receptor in facilitating extracellular matrix invasion by cultured colon cancerQ41674938
Characterization of a cathepsin-H-like enzyme from a human melanoma cell lineQ41675121
MCF7 mammary cancer cells respond to bFGF and internalize it following its release from extracellular matrix: a permissive role of cathepsin D.Q41681960
Candidate genes for the hypoxic tumor phenotype.Q41723494
Cathepsin B and human tumor progressionQ41730404
Degradation of extracellular-matrix proteins by human cathepsin B from normal and tumour tissuesQ41849893
Biosynthesis of lysosomal cathepsins B and H in cultured rat hepatocytesQ41912213
Immunodetection of cathepsins B and L present in and secreted from human pre-malignant and malignant colorectal tumour cell linesQ42050993
Fragmentation of proteins by free radicals and its effect on their susceptibility to enzymic hydrolysisQ42064268
Expression of matrix metalloproteinases (MMP-1 and -2) and their inhibitors (TIMP-1, -2 and -3) in oral lichen planus, dysplasia, squamous cell carcinoma and lymph node metastasisQ42064476
Protein damage and degradation by oxygen radicals. II. Modification of amino acidsQ42206650
Are cancer cells acidic?Q42372356
Dysregulation of DNA repair pathways in a transforming growth factor alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesis.Q42441199
Oxidative stress activates the human histidine decarboxylase promoter in AGS gastric cancer cellsQ42460524
Growth factors and cytokines upregulate gelatinase expression in bone marrow CD34(+) cells and their transmigration through reconstituted basement membraneQ42471774
Localization of a biotinylated cathepsin B oligonucleotide probe in human prostate including invasive cells and invasive edges by in situ hybridizationQ42482705
Immunohistochemical localization of cathepsin D in colorectal tumorsQ42485500
Cathepsin D expression as a possible predictor of lymph node metastasis in submucosal colorectal cancerQ42498864
Identification and characterization of a novel human cathepsin L splice variantQ42812237
Multiple processing of procathepsin L to cathepsin L in vivoQ42824669
Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation.Q43507844
The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress.Q43654457
Antioxidant status and lipid peroxidation in colorectal cancer.Q43762098
Activation of progelatinase A (MMP-2) by neutrophil elastase, cathepsin G, and proteinase-3: a role for inflammatory cells in tumor invasion and angiogenesisQ43765113
A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells.Q43785805
Inhibition of osteoclast differentiation and bone resorption by cathepsin K antisense oligonucleotidesQ43825780
Activity of cathepsin H in blood and biopsies of patients with precancerous conditions and mouth cancerQ43850330
Cathepsin D in breast cancer: a tissue marker associated with metastasisQ43902552
Activation of matrix metalloproteinase-2 by overexpression of manganese superoxide dismutase in human breast cancer MCF-7 cells involves reactive oxygen speciesQ43945265
Higher oxidation and lower antioxidant levels in peripheral blood plasma and bone marrow plasma from advanced cancer patientsQ44062343
Expression of cysteine peptidase cathepsin L and its inhibitors stefins A and B in relation to tumorigenicity of breast cancer cell linesQ44164221
Cathepsin K mRNA and protein expression in prostate cancer progressionQ44303172
Marked increases in cathepsin B and L activities distinguish papillary carcinoma of the thyroid from normal thyroid or thyroid with non-neoplastic diseaseQ71091006
Formation of alpha-tocopherol complexes with fatty acids. A hypothetical mechanism of stabilization of biomembranes by vitamin EQ71385811
Integrin signalingQ71443713
Glutathione-dependent protection against lipid peroxidation in sheep liver microsomesQ71585808
Endogenous cathepsin D-mediated hydrolysis of insulin-like growth factor-binding proteins in cultured human prostatic carcinoma cellsQ71679363
Regulation of the activity of lysosomal cysteine proteinases by pH-induced inactivation and/or endogenous protein inhibitors, cystatinsQ71935429
Immunohistochemical localization of human alpha 2Macroglobulin in connective tissueQ72626598
Stromal expression of c-Ets1 transcription factor correlates with tumor invasionQ72710487
Isolation and properties of oxidized alpha-1-proteinase inhibitor from human rheumatoid synovial fluidQ72871320
Free radical and enzymatic mechanisms for the generation of protein bound reducing moietiesQ72947369
Growth factors in the extracellular matrixQ73075408
VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrixQ73119438
Prediction of the extent of prostate cancer by the combined use of systematic biopsy and serum level of cathepsin DQ73173195
Cathepsin D cytosol content in colorectal cancerQ73199449
Epidermal growth factor and amphiregulin up-regulate matrix metalloproteinase-9 (MMP-9) in human breast cancer cellsQ73209050
Higher risk of mismatch repair-deficient colorectal cancer in alpha(1)-antitrypsin deficiency carriers and cigarette smokersQ73341681
Collagenolytic activity of cathepsin K is specifically modulated by cartilage-resident chondroitin sulfatesQ73371430
Cathepsin B-like activity as a serum tumour marker in ovarian carcinomaQ73374461
Prognostic significance of DNA ploidy, S-phase fraction, and tissue levels of aspartic, cysteine, and serine proteases in operable gastric carcinomaQ73404082
Activation of human neutrophil procollagenase by nitrogen dioxide and peroxynitrite: a novel mechanism for procollagenase activation involving nitric oxideQ73422907
Membrane-type matrix metalloproteinases (MT-MMPs) in cell invasionQ73447520
Inactivation of cathepsin B by oxidized LDL involves complex formation induced by binding of putative reactive sites exposed at low pH to thiols on the enzymeQ73451641
Cells producing cathepsins D, B, and L in human breast carcinoma and their association with prognosisQ73471075
Cathepsin B, a prognostic indicator in lymph node-negative breast carcinoma patients: comparison with cathepsin D, cathepsin L, and other clinical indicatorsQ73483295
Cathepsin B and cysteine proteinase inhibitors in human lung cancer cell linesQ73502998
Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1-matrix metalloproteinase in esophageal squamous cell carcinomasQ73812406
Imbalance of expression of matrix metalloproteinases (MMPs) and tissue inhibitors of the matrix metalloproteinases (TIMPs) in human pancreatic carcinomaQ73828612
Regulation of collagenase-3 expression in human breast carcinomas is mediated by stromal-epithelial cell interactionsQ73838292
Granulocyte-macrophage colony-stimulating factor upregulates matrix metalloproteinase-2 (MMP-2) and membrane type-1 MMP (MT1-MMP) in human head and neck cancer cellsQ73855117
Analysis of cathepsin D in human breast cancer: usefulness of the processed 31 kDa active form of the enzyme as a prognostic indicator in node-negative and node-positive patientsQ73875608
Differential modulation of proliferation, matrix metalloproteinase expression and invasion of human head and neck squamous carcinoma cells by c-erbB ligandsQ73876250
Immunohistochemical evaluation of cathepsin D expression in colorectal cancerQ73931435
Expression and activation of matrix metalloproteinase-2 (MMP-2) and its co-localization with membrane-type 1 matrix metalloproteinase (MT1-MMP) correlate with melanoma progressionQ73949261
Association of expression of metalloproteinases and their inhibitors with the metastatic potential of squamous-cell lung carcinomas. A molecular and immunohistochemical studyQ73977482
Immunostained cathepsins B and L correlate with depth of invasion and different metastatic pathways in early stage gastric carcinomaQ74130349
Comparison of hydrogen peroxide generation and the content of lipid peroxidation products in lung cancer tissue and pulmonary parenchymaQ74215987
Cathepsin D expression in early cutaneous malignant melanomaQ74261737
Angiostatin generation by cathepsin D secreted by human prostate carcinoma cellsQ74312758
Comparative localization of cathepsin B protein and activity in colorectal cancerQ74320260
Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosisQ74625032
Insulin-like growth factor I-triggered cell migration and invasion are mediated by matrix metalloproteinase-9Q74657550
Prognostic significance of stromelysin 3, gelatinase A, and urokinase expression in breast cancerQ77321922
Matrix metalloproteinase-1 is associated with poor prognosis in oesophageal cancerQ77407088
[The activity of cathepsin B in colorectal adenocarcinomas]Q77430901
Expression of matrix metalloproteinase-7 and tissue inhibitor of metalloproteinase-1 in human prostateQ77449371
Expression of metalloproteinase 2 and 9 and their inhibitors in renal cell carcinomaQ77449401
Reactive oxygen species, antioxidant mechanisms, and serum cytokine levels in cancer patients: impact of an antioxidant treatmentQ44392056
Plasma concentrations of coenzyme Q10 and tocopherols in cervical intraepithelial neoplasia and cervical cancerQ44527477
Neutrophil elastase and cathepsin G: structure, function, and biological control.Q44568294
Overexpression and hormonal regulation of pro-cathepsin D in mammary and endometrial cancer.Q44607068
Adenovirus-mediated gene delivery of tissue inhibitor of metalloproteinases-3 inhibits invasion and induces apoptosis in melanoma cells.Q45887759
Increased proteolytic cleavage of alpha 1-antitrypsin (alpha 1-proteinase inhibitor) in knee-joint synovial fluid from patients with rheumatoid arthritis.Q45992111
Mature cathepsin L is substantially active in the ionic milieu of the extracellular medium.Q46214973
Superoxide dismutase undergoes proteolysis and fragmentation following oxidative modification and inactivationQ46314983
The secretion of high molecular weight cathepsin B from cultured human liver cancersQ47174373
Disruption of redox homeostasis in the transforming growth factor-alpha/c-myc transgenic mouse model of accelerated hepatocarcinogenesisQ47981823
The direct cause of photodamage-induced lysosomal destabilization.Q50528374
Cathepsins B, H, and L and their inhibitors stefin A and cystatin C in sera of melanoma patients.Q50857430
Further evidence for oxidant-induced vascular endothelial growth factor up-regulation in the bronchoalveolar lavage fluid of lung cancer patients undergoing radio-chemotherapy.Q52971270
Constitutive activation of mitogen-activated protein (MAP) kinases in human renal cell carcinomaQ53461208
Evidence for the regulation of urokinase and tissue type plasminogen activators by the serpin, protein C inhibitor, in semen and blood plasma.Q53730579
Expression and the role of cathepsin H in human glioma progression and invasion.Q55479498
Cathepsin B expression and localization in glioma progression and invasion.Q55481523
Stimulation of angiogenesis through cathepsin B inactivation of the tissue inhibitors of matrix metalloproteinasesQ57696102
Proteolytic inactivation of human α1 antitrypsin by human stromelysinQ57925646
Inhibition of neutrophil superoxide production by human plasma α1 -antitrypsinQ57925662
Comparison of potential biological markers cathepsin B, cathepsin L, stefin A and stefin B with urokinase and plasminogen activator inhibitor-1 and clinicopathological data of breast carcinoma patientsQ59709159
Lysosomal Cathepsins B and L and Stef in A Blood Levels in Patients with Hepatocellular Carcinoma and/or Liver Cirrhosis: Potential Clinical ImplicationsQ60245921
Cathepsins B, H and L in human breast carcinomaQ67848008
A possible role for cysteine proteinase and its inhibitors in motility of malignant melanoma and other tumour cellsQ67919923
Antileukoprotease, its role in the human lungQ67988520
Stage-specific increases in cathepsin B messenger RNA content in human colorectal carcinomaQ68201720
Plasminogen activator inhibitor 2 (PAI-2) is not inactivated by exposure to oxidants which can be released from activated neutrophilsQ68448621
Activation of latent human neutrophil collagenase by reactive oxygen species and serine proteasesQ68482295
Glutathione disulfide enhances the reduced glutathione inhibition of lipid peroxidation in rat liver microsomesQ68706266
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectcarcinogenesisQ1637543
proteolysisQ33123
P304page(s)1251-1266
P577publication date2005-03-01
P1433published inWorld Journal of GastroenterologyQ15708885
P1476titleProteolytic-antiproteolytic balance and its regulation in carcinogenesis
P478volume11

Reverse relations

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Q38855481Sohlh2 inhibits human ovarian cancer cell invasion and metastasis by transcriptional inactivation of MMP9.
Q33664639Synergistic antitumor effects of combined cathepsin B and cathepsin Z deficiencies on breast cancer progression and metastasis in mice.
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