Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione

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Insulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione is …
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scholarly articleQ13442814

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P356DOI10.1074/JBC.M112.363960
P932PMC publication ID3390629
P698PubMed publication ID22621923

P50authorAngela M HallQ57320141
P2093author name stringBrian N Finck
Nathan Qi
Mayurranjan S Mitra
Jerry R Colca
Zhouji Chen
Kari T Chambers
William G McDonald
Rolf F Kletzien
Patrick A Vigueira
P2860cites workDeletion of PPARgamma in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistanceQ24555727
Combined analysis of oligonucleotide microarray data from transgenic and knockout mice identifies direct SREBP target genesQ24683425
Identification of a novel mitochondrial protein (“mitoNEET”) cross-linked specifically by a thiazolidinedione photoprobeQ28211498
Isolation and characterization of PBP, a protein that interacts with peroxisome proliferator-activated receptorQ28250779
A targeted apolipoprotein B-38.9-producing mutation causes fatty livers in mice due to the reduced ability of apolipoprotein B-38.9 to transport triglyceridesQ28507306
MitoNEET is an iron-containing outer mitochondrial membrane protein that regulates oxidative capacityQ28507474
Muscle-specific Pparg deletion causes insulin resistanceQ28508726
Lipin 1 is an inducible amplifier of the hepatic PGC-1alpha/PPARalpha regulatory pathwayQ28510620
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)Q29615693
Alterations in hepatic metabolism in fld mice reveal a role for lipin 1 in regulating VLDL-triacylglyceride secretionQ30439917
Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heartQ31939734
Collecting duct-specific deletion of peroxisome proliferator-activated receptor gamma blocks thiazolidinedione-induced fluid retentionQ33878917
Novel PPARγ partial agonists with weak activity and no cytotoxicity; identified by a simple PPARγ ligand screening systemQ33935032
Peroxisome proliferator-activated receptors (PPARs): nuclear receptors at the crossroads between lipid metabolism and inflammationQ34088380
Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical reviewQ34100675
Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5.Q34330155
The Anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.Q34522920
Rosiglitazone-associated fractures in type 2 diabetes: an Analysis from A Diabetes Outcome Progression Trial (ADOPT).Q34587610
Adipose-specific peroxisome proliferator-activated receptor gamma knockout causes insulin resistance in fat and liver but not in muscleQ34790967
Liver-specific disruption of PPARgamma in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypesQ34835012
Regulation of PPARgamma activity during adipogenesisQ36042255
Receptor-independent actions of PPAR thiazolidinedione agonists: is mitochondrial function the key?Q36144641
Implications of rosiglitazone and pioglitazone on cardiovascular risk in patients with type 2 diabetes mellitusQ36390892
Rosiglitazone and pioglitazone utilization from January 2007 through May 2008 associated with five risk-warning eventsQ37240896
Adverse cardiovascular events during treatment with pioglitazone and rosiglitazone: population based cohort studyQ37310162
An emerging role of mTOR in lipid biosynthesis.Q37641438
Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathwaysQ38316513
Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonistsQ38318111
Pioglitazone acutely stimulates adiponectin secretion from mouse and human adipocytes via activation of the phosphatidylinositol 3'-kinaseQ39934578
Hyperinsulinemic-euglycemic clamps in conscious, unrestrained miceQ42575432
PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived proteinQ42826174
Rosiglitazone or pioglitazone in type 2 diabetes?Q43289984
Troglitazone-induced intrahepatic cholestasis by an interference with the hepatobiliary export of bile acids in male and female rats. Correlation with the gender difference in troglitazone sulfate formation and the inhibition of the canalicular bileQ43737515
Hepatic fatty acid synthesis is suppressed in mice with fatty livers due to targeted apolipoprotein B38.9 mutationQ43909354
Liver peroxisome proliferator-activated receptor gamma contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass.Q44477314
The outer mitochondrial membrane protein mitoNEET contains a novel redox-active 2Fe-2S clusterQ44582287
A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 diabetesQ46473134
Thiazolidinediones expand body fluid volume through PPARgamma stimulation of ENaC-mediated renal salt absorptionQ46592677
A potential link between muscle peroxisome proliferator- activated receptor-alpha signaling and obesity-related diabetesQ46626385
What has prevented the expansion of insulin sensitisers?Q46965009
Acute effects of pioglitazone on glucose metabolism in perfused rat liver.Q54152312
The safety of rosiglitazone in the treatment of Type 2 diabetesQ57413490
DNA excision in liver by an albumin-Cre transgene occurs progressively with ageQ61203358
Comparative effects of englitazone and glyburide on gluconeogenesis and glycolysis in the isolated perfused rat liverQ77134058
P4510describes a project that usesImageJQ1659584
P433issue28
P407language of work or nameEnglishQ1860
P921main subjectinsulin resistanceQ1053470
obesityQ12174
P1104number of pages12
P304page(s)23537-23548
P577publication date2012-05-23
P1433published inJournal of Biological ChemistryQ867727
P1476titleInsulin resistance and metabolic derangements in obese mice are ameliorated by a novel peroxisome proliferator-activated receptor γ-sparing thiazolidinedione
P478volume287