scholarly article | Q13442814 |
P819 | ADS bibcode | 2012PNAS..109E1820M |
P356 | DOI | 10.1073/PNAS.1207829109 |
P932 | PMC publication ID | 3390855 |
P698 | PubMed publication ID | 22689960 |
P5875 | ResearchGate publication ID | 225293762 |
P50 | author | Peter Dedon | Q30069658 |
Erin G. Prestwich | Q60042374 | ||
Aswin Mangerich | Q60909094 | ||
Nicola M Parry | Q62747784 | ||
P2093 | author name string | James G Fox | |
Sureshkumar Muthupalani | |||
Steven R Tannenbaum | |||
John S Wishnok | |||
Gerald N Wogan | |||
Zhongming Ge | |||
Liang Cui | |||
Charles G Knutson | |||
Koli Taghizadeh | |||
Jose L McFaline | |||
Wenjie Ye | |||
Melissa Mobley | |||
P2860 | cites work | A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging | Q22337238 |
Helicobacter hepaticus sp. nov., a microaerophilic bacterium isolated from livers and intestinal mucosal scrapings from mice | Q24657755 | ||
Immunity, Inflammation, and Cancer | Q27861048 | ||
Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissue | Q28216656 | ||
The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo | Q28586574 | ||
Mice with combined disruption of Gpx1 and Gpx2 genes have colitis | Q28593227 | ||
Base-excision repair of oxidative DNA damage | Q29615373 | ||
Inflammatory bowel disease | Q29616286 | ||
Quantification of DNA damage products resulting from deamination, oxidation and reaction with products of lipid peroxidation by liquid chromatography isotope dilution tandem mass spectrometry | Q33706263 | ||
SCID/NCr mice naturally infected with Helicobacter hepaticus develop progressive hepatitis, proliferative typhlitis, and colitis. | Q33767950 | ||
Roles for inflammation and regulatory T cells in colon cancer | Q33796554 | ||
Fluorogenic PCR-based quantitative detection of a murine pathogen, Helicobacter hepaticus | Q33972933 | ||
The phagocytes: neutrophils and monocytes | Q34013216 | ||
Four faces of cellular senescence. | Q34025754 | ||
Cellular background level of 8-oxo-7,8-dihydro-2'-deoxyguanosine: an isotope based method to evaluate artefactual oxidation of DNA during its extraction and subsequent work-up. | Q34158024 | ||
Nei deficient Escherichia coli are sensitive to chromate and accumulate the oxidized guanine lesion spiroiminodihydantoin | Q34231955 | ||
Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. | Q34574880 | ||
Biological reactivity and biomarkers of the neutrophil oxidant, hypochlorous acid | Q35035511 | ||
17β-estradiol and tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice | Q35199750 | ||
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cells | Q35202611 | ||
Reactive nitrogen species in the chemical biology of inflammation | Q35677801 | ||
CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient mice | Q35748975 | ||
Increased oxidative DNA damage and hepatocyte overexpression of specific cytochrome P450 isoforms in hepatitis of mice infected with Helicobacter hepaticus. | Q35763940 | ||
Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fates | Q35906815 | ||
Mechanisms of formation, genotoxicity, and mutation of guanine oxidation products | Q36445449 | ||
Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitis | Q36513088 | ||
RNA damage and surveillance under oxidative stress | Q36627867 | ||
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice | Q36711322 | ||
Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter species | Q36735237 | ||
Relatively small increases in the steady-state levels of nucleobase deamination products in DNA from human TK6 cells exposed to toxic levels of nitric oxide | Q36835682 | ||
Inflammation-mediated cytosine damage: a mechanistic link between inflammation and the epigenetic alterations in human cancers | Q36851776 | ||
Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel disease | Q36973466 | ||
Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient mice | Q37079014 | ||
RNA base damage and repair | Q37090166 | ||
Incorporation of 5-chlorocytosine into mammalian DNA results in heritable gene silencing and altered cytosine methylation patterns | Q37175511 | ||
Glutathione peroxidases in different stages of carcinogenesis | Q37415671 | ||
Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer | Q37464715 | ||
Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease. | Q37557637 | ||
Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancer | Q37612291 | ||
Human myeloperoxidase in innate and acquired immunity | Q37732701 | ||
Inflammation and colon cancer | Q37737408 | ||
Phagocyte partnership during the onset and resolution of inflammation. | Q37760424 | ||
Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a). | Q39605512 | ||
Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammation | Q40161658 | ||
Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study | Q40494299 | ||
Quantitation of four guanine oxidation products from reaction of DNA with varying doses of peroxynitrite | Q42044944 | ||
Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice. | Q42569411 | ||
Aberrant repair of etheno-DNA adducts in leukocytes and colon tissue of colon cancer patients | Q42987583 | ||
Characterization of hydantoin products from one-electron oxidation of 8-oxo-7,8-dihydroguanosine in a nucleoside model | Q43674222 | ||
The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivo | Q44537507 | ||
Imbalanced secondary mucosal antioxidant response in inflammatory bowel disease | Q44569723 | ||
Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidants | Q44569726 | ||
Endogenous formation of novel halogenated 2'-deoxycytidine. Hypohalous acid-mediated DNA modification at the site of inflammation | Q45057161 | ||
Spiroiminodihydantoin and guanidinohydantoin are the dominant products of 8-oxoguanosine oxidation at low fluxes of peroxynitrite: mechanistic studies with 18O. | Q45148716 | ||
Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: an important role for H2O2? | Q46604024 | ||
Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophages | Q46834806 | ||
Hepatocellular carcinoma associated with liver-gender disruption in male mice. | Q46843494 | ||
Aberrant expression of selenoproteins in the progression of colorectal cancer | Q46870085 | ||
Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer. | Q53260087 | ||
Evidence for upregulated repair of oxidatively induced DNA damage in human colorectal cancer. | Q53281593 | ||
Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis. | Q53334428 | ||
Nitric oxide inhibits DNA ligase activity: potential mechanisms for NO-mediated DNA damage. | Q53449877 | ||
Inhibition by nitric oxide of the repair protein, O6-methylguanine-DNA-methyltransferase. | Q53473778 | ||
Decreased levels of lipid peroxidation-induced DNA damage in the onset of atherogenesis in apolipoprotein E deficient mice. | Q53560580 | ||
Increased etheno-DNA adducts in affected tissues of patients suffering from Crohn's disease, ulcerative colitis, and chronic pancreatitis. | Q53618244 | ||
Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells. | Q54485899 | ||
Helicobacter pylori impairs DNA mismatch repair in gastric epithelial cells. | Q54541008 | ||
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing | Q59086518 | ||
Selective depletion of neutrophils by a monoclonal antibody, RP-3, suppresses dextran sulphate sodium-induced colitis in rats. | Q64917143 | ||
Inflammatory large bowel disease in immunodeficient mice naturally infected with Helicobacter hepaticus | Q71238899 | ||
Characterization of spiroiminodihydantoin as a product of one-electron oxidation of 8-Oxo-7,8-dihydroguanosine | Q73799886 | ||
Regulation of neutrophils in ulcerative colitis by colonic factors: a possible mechanism of neutrophil activation and tissue damage | Q74015342 | ||
Lipid peroxidation-derived etheno-DNA adducts in human atherosclerotic lesions | Q80106845 | ||
P433 | issue | 27 | |
P407 | language of work or name | English | Q1860 |
P921 | main subject | colitis | Q2453464 |
DNA damage | Q5205747 | ||
P304 | page(s) | E1820-9 | |
P577 | publication date | 2012-06-11 | |
P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
P1476 | title | Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer | |
P478 | volume | 109 |
Q35871453 | 5-Carboxamido-5-formamido-2-iminohydantoin, in Addition to 8-oxo-7,8-Dihydroguanine, Is the Major Product of the Iron-Fenton or X-ray Radiation-Induced Oxidation of Guanine under Aerobic Reducing Conditions in Nucleoside and DNA Contexts |
Q46303021 | 8-Oxo-7,8-dihydro-2'-deoxyguanosine and abasic site tandem lesions are oxidation prone yielding hydantoin products that strongly destabilize duplex DNA. |
Q39383987 | 8-Oxo-7,8-dihydroguanine, friend and foe: Epigenetic-like regulator versus initiator of mutagenesis |
Q26795697 | A Review of Applied Aspects of Dealing with Gut Microbiota Impact on Rodent Models |
Q36063330 | A Role for the Fifth G-Track in G-Quadruplex Forming Oncogene Promoter Sequences during Oxidative Stress: Do These "Spare Tires" Have an Evolved Function? |
Q34740455 | An automated Fpg-based FADU method for the detection of oxidative DNA lesions and screening of antioxidants |
Q35086803 | An organizational approach for the assessment of DNA adduct data in risk assessment: case studies for aflatoxin B1, tamoxifen and vinyl chloride. |
Q27023485 | At the Bench: Helicobacter pylori, dysregulated host responses, DNA damage, and gastric cancer |
Q33737879 | Bacterial oncogenesis in the colon |
Q35886189 | Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA. |
Q36769367 | Biomarkers of exposure and effect in human lymphoblastoid TK6 cells following [13C2]-acetaldehyde exposure |
Q35943509 | Cervical Microbiota Associated with Higher Grade Cervical Intraepithelial Neoplasia in Women Infected with High-Risk Human Papillomaviruses |
Q36967764 | Chemical and cytokine features of innate immunity characterize serum and tissue profiles in inflammatory bowel disease |
Q35047726 | Chemistry meets biology in colitis-associated carcinogenesis |
Q36212747 | Chronic epithelial NF-κB activation accelerates APC loss and intestinal tumor initiation through iNOS up-regulation |
Q37591498 | Chronic inflammation and oxidative stress: the smoking gun for Helicobacter pylori-induced gastric cancer? |
Q35169025 | Colitis-associated neoplasia: molecular basis and clinical translation |
Q27680423 | Comparison of the Structural and Dynamic Effects of 5-Methylcytosine and 5-Chlorocytosine in a CpG Dinucleotide Sequence |
Q54163647 | Conformational stabilities of iminoallantoin and its base pairs in DNA: implications for mutagenicity. |
Q93047625 | Context Drives Diversification of Monocytes and Neutrophils in Orchestrating the Tumor Microenvironment |
Q38957763 | DNA Product Formation in Female Sprague-Dawley Rats Following Polyhalogenated Aromatic Hydrocarbon (PHAH) Exposure. |
Q34434917 | DNA glycosylase activity and cell proliferation are key factors in modulating homologous recombination in vivo |
Q37251186 | Deoxyinosine triphosphate induces MLH1/PMS2- and p53-dependent cell growth arrest and DNA instability in mammalian cells |
Q91808273 | Dietary Factors in the Control of Gut Homeostasis, Intestinal Stem Cells, and Colorectal Cancer |
Q26749361 | Dynamic Duo-The Salmonella Cytolethal Distending Toxin Combines ADP-Ribosyltransferase and Nuclease Activities in a Novel Form of the Cytolethal Distending Toxin |
Q36723229 | Effect of Base-Pairing Partner on the Thermodynamic Stability of the Diastereomeric Spiroiminodihydantoin Lesion |
Q42619529 | Electrical Current Signatures of DNA Base Modifications in Single Molecules Immobilized in the α-Hemolysin Ion Channel |
Q35058372 | Emerging roles of the microbiome in cancer |
Q37593447 | Endonuclease and Exonuclease Activities on Oligodeoxynucleotides Containing Spiroiminodihydantoin Depend on the Sequence Context and the Lesion Stereochemistry |
Q51273508 | Evolution and heterogeneity of non-hereditary colorectal cancer revealed by single-cell exome sequencing. |
Q38943129 | Excessive Reactive Oxygen Species and Exotic DNA Lesions as an Exploitable Liability |
Q39018239 | Formation and processing of DNA damage substrates for the hNEIL enzymes |
Q39037391 | Formation and repair of oxidatively generated damage in cellular DNA. |
Q41788288 | G-quadruplex folds of the human telomere sequence alter the site reactivity and reaction pathway of guanine oxidation compared to duplex DNA. |
Q41757657 | Generation of outbred Ace2 knockout mice by RNA transfection of TALENs displaying colitis reminiscent pathophysiology and inflammation |
Q59285937 | Glutathione Peroxidase 2, a Selenoprotein Exhibiting a Dual Personality in Preventing and Promoting Cancer |
Q36728705 | Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair |
Q46759473 | Guanosine in a single stranded region of anticodon stem-loop tRNA models is prone to oxidatively generated damage resulting in dehydroguanidinohydantoin and spiroiminodihydantoin lesions |
Q34924272 | Gut microbiome and anticancer immune response: really hot Sh*t! |
Q26774708 | Gut microbiota imbalance and colorectal cancer |
Q38768538 | Helicobacter Infection Significantly Alters Pregnancy Success in Laboratory Mice |
Q35219281 | Helicobacter cinaedi induced typhlocolitis in Rag-2-deficient mice |
Q40362304 | Helicobacter hepaticus cytolethal distending toxin promotes intestinal carcinogenesis in 129Rag2-deficient mice. |
Q37129884 | Helicobacter saguini, a Novel Helicobacter Isolated from Cotton-Top Tamarins with Ulcerative Colitis, Has Proinflammatory Properties and Induces Typhlocolitis and Dysplasia in Gnotobiotic IL-10-/- Mice. |
Q48271035 | Human DNA Repair Genes Possess Potential G-Quadruplex Sequences in Their Promoters and 5'-Untranslated Regions. |
Q93044129 | Human NEIL3 Gene Expression Regulated by Epigenetic-Like Oxidative DNA Modification |
Q36060253 | IL-15 suppresses colitis-associated colon carcinogenesis by inducing antitumor immunity. |
Q36341399 | Identification of DNA lesions using a third base pair for amplification and nanopore sequencing |
Q36415837 | In situ analysis of 8-oxo-7,8-dihydro-2'-deoxyguanosine oxidation reveals sequence- and agent-specific damage spectra |
Q37053873 | Increased levels of inosine in a mouse model of inflammation |
Q42409870 | Infection, inflammation and colon carcinogenesis |
Q36597803 | Inflammation and colorectal cancer: colitis-associated neoplasia |
Q40332859 | Interleukin-22 drives nitric oxide-dependent DNA damage and dysplasia in a murine model of colitis-associated cancer |
Q34989590 | Interplay between DNA repair and inflammation, and the link to cancer |
Q46413562 | Interrogation of Base Pairing of the Spiroiminodihydantoin Diastereomers Using the α-Hemolysin Latch |
Q27310097 | Intestinal microbiota composition of interleukin-10 deficient C57BL/6J mice and susceptibility to Helicobacter hepaticus-induced colitis |
Q35989847 | Intrinsic mutagenic properties of 5-chlorocytosine: A mechanistic connection between chronic inflammation and cancer |
Q30989031 | Isolation and characterization of a novel Helicobacter species, Helicobacter jaachi sp. nov., from common marmosets (Callithrix jaachus). |
Q41036792 | Isolation of Helicobacter spp. from mice with rectal prolapses |
Q42144844 | Isoliquiritigenin decreases the incidence of colitis-associated colorectal cancer by modulating the intestinal microbiota |
Q36883547 | Klenow Fragment Discriminates against the Incorporation of the Hyperoxidized dGTP Lesion Spiroiminodihydantoin into DNA. |
Q35979867 | Lamellipodin-Deficient Mice: A Model of Rectal Carcinoma |
Q92647025 | Location dependence of the transcriptional response of a potential G-quadruplex in gene promoters under oxidative stress |
Q37689834 | Mechanisms of base substitution mutagenesis in cancer genomes |
Q34241115 | Microbial imbalance and intestinal pathologies: connections and contributions |
Q31156407 | Microbial pathogens trigger host DNA double-strand breaks whose abundance is reduced by plant defense responses |
Q26801329 | Microbiology and ecology are vitally important to premedical curricula |
Q27028132 | Microbiota impact on the epigenetic regulation of colorectal cancer |
Q46336458 | Mutagenic potential of hypoxanthine in live human cells |
Q64387257 | Mutagenicity of Helicobacter hepaticus infection in the lower bowel mucosa of 129/SvEv Rag2 Il10 gpt delta mice is influenced by sex |
Q26765238 | Neutrophil-Derived Proteases in the Microenvironment of Pancreatic Cancer -Active Players in Tumor Progression |
Q33854259 | No cancer predisposition or increased spontaneous mutation frequencies in NEIL DNA glycosylases-deficient mice |
Q40531526 | Novel Helicobacter species H.japonicum isolated from laboratory mice from Japan induces typhlocolitis and lower bowel carcinoma in C57BL/129 IL10-/- mice |
Q38434331 | Occurrence, Biological Consequences, and Human Health Relevance of Oxidative Stress-Induced DNA Damage |
Q58562536 | Oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine leads to substantial DNA-histone cross-links within nucleosome core particles |
Q37696021 | Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair |
Q92884435 | PARP-1 controls NK cell recruitment to the site of viral infection |
Q33781233 | Pathogenic properties of enterohepatic Helicobacter spp. isolated from rhesus macaques with intestinal adenocarcinoma |
Q54980764 | Phosphoinositide 3-Kinase Signaling Pathway in Pancreatic Ductal Adenocarcinoma Progression, Pathogenesis, and Therapeutics. |
Q26858894 | Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation |
Q36272558 | Pulsed Azidohomoalanine Labeling in Mammals (PALM) Detects Changes in Liver-Specific LKB1 Knockout Mice. |
Q37227952 | Quantification of cellular poly(ADP-ribosyl)ation by stable isotope dilution mass spectrometry reveals tissue- and drug-dependent stress response dynamics |
Q50898122 | Quantitation of Poly(ADP-Ribose) by Isotope Dilution Mass Spectrometry. |
Q36989881 | RNase-L deficiency exacerbates experimental colitis and colitis-associated cancer |
Q39020441 | Rates of chemical cleavage of DNA and RNA oligomers containing guanine oxidation products |
Q37593573 | Reactivation of dormant anti-tumor immunity - a clinical perspective of therapeutic immune checkpoint modulation |
Q92702284 | Reactive Oxygen Species in the Tumor Microenvironment: An Overview |
Q30692305 | Reconciliation of chemical, enzymatic, spectroscopic and computational data to assign the absolute configuration of the DNA base lesion spiroiminodihydantoin |
Q34445425 | Redox regulation of apurinic/apyrimidinic endonuclease 1 activity in Long-Evans Cinnamon rats during spontaneous hepatitis |
Q39000410 | Removal of oxidatively generated DNA damage by overlapping repair pathways |
Q37532110 | Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair |
Q39080578 | Repeated H2 O2 exposure drives cell cycle progression in an in vitro model of ulcerative colitis |
Q38605994 | Reverse Transcription Past Products of Guanine Oxidation in RNA Leads to Insertion of A and C opposite 8-Oxo-7,8-dihydroguanine and A and G opposite 5-Guanidinohydantoin and Spiroiminodihydantoin Diastereomers. |
Q34965777 | Serum metabolome and lipidome changes in adult patients with primary dengue infection. |
Q39742426 | Serum metabolomics in a Helicobacter hepaticus mouse model of inflammatory bowel disease reveal important changes in the microbiome, serum peptides, and intermediary metabolism |
Q36646547 | Significance of infectious agents in colorectal cancer development |
Q41814086 | Structural context effects in the oxidation of 8-oxo-7,8-dihydro-2'-deoxyguanosine to hydantoin products: electrostatics, base stacking, and base pairing |
Q37401669 | Structural destabilization of DNA duplexes containing single-base lesions investigated by nanopore measurements |
Q35819527 | TLR2 and TLR4 polymorphisms influence mRNA and protein expression in colorectal cancer |
Q88542296 | The Fifth Domain in the G-Quadruplex-Forming Sequence of the Human NEIL3 Promoter Locks DNA Folding in Response to Oxidative Damage |
Q41354413 | The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury |
Q55601781 | The Microbiological Memory, an Epigenetic Regulator Governing the Balance Between Good Health and Metabolic Disorders. |
Q38780730 | The Nonbulky DNA Lesions Spiroiminodihydantoin and 5-Guanidinohydantoin Significantly Block Human RNA Polymerase II Elongation in Vitro |
Q40811126 | The R- and S-diastereoisomeric effects on the guanidinohydantoin-induced mutations in DNA. |
Q33898288 | The endogenous exposome |
Q30248605 | The intestinal microbiome and surgical disease. |
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Q30586686 | Thermodynamic profiles and nuclear magnetic resonance studies of oligonucleotide duplexes containing single diastereomeric spiroiminodihydantoin lesions |
Q36714153 | pH-Dependent Equilibrium between 5-Guanidinohydantoin and Iminoallantoin Affects Nucleotide Insertion Opposite the DNA Lesion |
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