Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer

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Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer is …
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scholarly articleQ13442814

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P819ADS bibcode2012PNAS..109E1820M
P356DOI10.1073/PNAS.1207829109
P932PMC publication ID3390855
P698PubMed publication ID22689960
P5875ResearchGate publication ID225293762

P50authorPeter DedonQ30069658
Erin G. PrestwichQ60042374
Aswin MangerichQ60909094
Nicola M ParryQ62747784
P2093author name stringJames G Fox
Sureshkumar Muthupalani
Steven R Tannenbaum
John S Wishnok
Gerald N Wogan
Zhongming Ge
Liang Cui
Charles G Knutson
Koli Taghizadeh
Jose L McFaline
Wenjie Ye
Melissa Mobley
P2860cites workA mouse model of ATR-Seckel shows embryonic replicative stress and accelerated agingQ22337238
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Immunity, Inflammation, and CancerQ27861048
Cellular and subcellular localization of gastrointestinal glutathione peroxidase in normal and malignant human intestinal tissueQ28216656
The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivoQ28586574
Mice with combined disruption of Gpx1 and Gpx2 genes have colitisQ28593227
Base-excision repair of oxidative DNA damageQ29615373
Inflammatory bowel diseaseQ29616286
Quantification of DNA damage products resulting from deamination, oxidation and reaction with products of lipid peroxidation by liquid chromatography isotope dilution tandem mass spectrometryQ33706263
SCID/NCr mice naturally infected with Helicobacter hepaticus develop progressive hepatitis, proliferative typhlitis, and colitis.Q33767950
Roles for inflammation and regulatory T cells in colon cancerQ33796554
Fluorogenic PCR-based quantitative detection of a murine pathogen, Helicobacter hepaticusQ33972933
The phagocytes: neutrophils and monocytesQ34013216
Four faces of cellular senescence.Q34025754
Cellular background level of 8-oxo-7,8-dihydro-2'-deoxyguanosine: an isotope based method to evaluate artefactual oxidation of DNA during its extraction and subsequent work-up.Q34158024
Nei deficient Escherichia coli are sensitive to chromate and accumulate the oxidized guanine lesion spiroiminodihydantoinQ34231955
Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1.Q34574880
Biological reactivity and biomarkers of the neutrophil oxidant, hypochlorous acidQ35035511
17β-estradiol and tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male miceQ35199750
Carcinogenic bacterial pathogen Helicobacter pylori triggers DNA double-strand breaks and a DNA damage response in its host cellsQ35202611
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CD4+ CD25+ regulatory T lymphocytes inhibit microbially induced colon cancer in Rag2-deficient miceQ35748975
Increased oxidative DNA damage and hepatocyte overexpression of specific cytochrome P450 isoforms in hepatitis of mice infected with Helicobacter hepaticus.Q35763940
Reactive species and DNA damage in chronic inflammation: reconciling chemical mechanisms and biological fatesQ35906815
Mechanisms of formation, genotoxicity, and mutation of guanine oxidation productsQ36445449
Metabolomics reveals that hepatic stearoyl-CoA desaturase 1 downregulation exacerbates inflammation and acute colitisQ36513088
RNA damage and surveillance under oxidative stressQ36627867
DNA damage induced by chronic inflammation contributes to colon carcinogenesis in miceQ36711322
Chronic active hepatitis and associated liver tumors in mice caused by a persistent bacterial infection with a novel Helicobacter speciesQ36735237
Relatively small increases in the steady-state levels of nucleobase deamination products in DNA from human TK6 cells exposed to toxic levels of nitric oxideQ36835682
Inflammation-mediated cytosine damage: a mechanistic link between inflammation and the epigenetic alterations in human cancersQ36851776
Molecular fingerprints of neutrophil-dependent oxidative stress in inflammatory bowel diseaseQ36973466
Nitric oxide and TNF-alpha trigger colonic inflammation and carcinogenesis in Helicobacter hepaticus-infected, Rag2-deficient miceQ37079014
RNA base damage and repairQ37090166
Incorporation of 5-chlorocytosine into mammalian DNA results in heritable gene silencing and altered cytosine methylation patternsQ37175511
Glutathione peroxidases in different stages of carcinogenesisQ37415671
Carcinogenesis in IBD: potential targets for the prevention of colorectal cancerQ37464715
Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease.Q37557637
Helicobacter hepaticus infection in mice: models for understanding lower bowel inflammation and cancerQ37612291
Human myeloperoxidase in innate and acquired immunityQ37732701
Inflammation and colon cancerQ37737408
Phagocyte partnership during the onset and resolution of inflammation.Q37760424
Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16(ink4a).Q39605512
Lipid peroxidation dominates the chemistry of DNA adduct formation in a mouse model of inflammationQ40161658
Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation studyQ40494299
Quantitation of four guanine oxidation products from reaction of DNA with varying doses of peroxynitriteQ42044944
Increased susceptibility of chronic ulcerative colitis-induced carcinoma development in DNA repair enzyme Ogg1 deficient mice.Q42569411
Aberrant repair of etheno-DNA adducts in leukocytes and colon tissue of colon cancer patientsQ42987583
Characterization of hydantoin products from one-electron oxidation of 8-oxo-7,8-dihydroguanosine in a nucleoside modelQ43674222
The hydantoin lesions formed from oxidation of 7,8-dihydro-8-oxoguanine are potent sources of replication errors in vivoQ44537507
Imbalanced secondary mucosal antioxidant response in inflammatory bowel diseaseQ44569723
Intestinal oxidative damage in inflammatory bowel disease: semi-quantification, localization, and association with mucosal antioxidantsQ44569726
Endogenous formation of novel halogenated 2'-deoxycytidine. Hypohalous acid-mediated DNA modification at the site of inflammationQ45057161
Spiroiminodihydantoin and guanidinohydantoin are the dominant products of 8-oxoguanosine oxidation at low fluxes of peroxynitrite: mechanistic studies with 18O.Q45148716
Glutathione peroxidase 2 and aquaporin 8 as new markers for colonic inflammation in experimental colitis and inflammatory bowel diseases: an important role for H2O2?Q46604024
Myeloperoxidase generates 5-chlorouracil in human atherosclerotic tissue: a potential pathway for somatic mutagenesis by macrophagesQ46834806
Hepatocellular carcinoma associated with liver-gender disruption in male mice.Q46843494
Aberrant expression of selenoproteins in the progression of colorectal cancerQ46870085
Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer.Q53260087
Evidence for upregulated repair of oxidatively induced DNA damage in human colorectal cancer.Q53281593
Bacterial cytolethal distending toxin promotes the development of dysplasia in a model of microbially induced hepatocarcinogenesis.Q53334428
Nitric oxide inhibits DNA ligase activity: potential mechanisms for NO-mediated DNA damage.Q53449877
Inhibition by nitric oxide of the repair protein, O6-methylguanine-DNA-methyltransferase.Q53473778
Decreased levels of lipid peroxidation-induced DNA damage in the onset of atherogenesis in apolipoprotein E deficient mice.Q53560580
Increased etheno-DNA adducts in affected tissues of patients suffering from Crohn's disease, ulcerative colitis, and chronic pancreatitis.Q53618244
Helicobacter pylori infection induces genetic instability of nuclear and mitochondrial DNA in gastric cells.Q54485899
Helicobacter pylori impairs DNA mismatch repair in gastric epithelial cells.Q54541008
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageingQ59086518
Selective depletion of neutrophils by a monoclonal antibody, RP-3, suppresses dextran sulphate sodium-induced colitis in rats.Q64917143
Inflammatory large bowel disease in immunodeficient mice naturally infected with Helicobacter hepaticusQ71238899
Characterization of spiroiminodihydantoin as a product of one-electron oxidation of 8-Oxo-7,8-dihydroguanosineQ73799886
Regulation of neutrophils in ulcerative colitis by colonic factors: a possible mechanism of neutrophil activation and tissue damageQ74015342
Lipid peroxidation-derived etheno-DNA adducts in human atherosclerotic lesionsQ80106845
P433issue27
P407language of work or nameEnglishQ1860
P921main subjectcolitisQ2453464
DNA damageQ5205747
P304page(s)E1820-9
P577publication date2012-06-11
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleInfection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer
P478volume109

Reverse relations

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