The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine

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The sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine is …
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scholarly articleQ13442814

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P356DOI10.1016/J.BRAINRESBULL.2007.06.012
P932PMC publication ID2042487
P698PubMed publication ID17720543
P5875ResearchGate publication ID6118876

P50authorTheodore A. SlotkinQ88773550
P2093author name stringGennady A Buznikov
Jean M Lauder
Ivan Milosević
Ljubisa M Rakić
Lyudmila A Nikitina
Vladimir V Bezuglov
P2860cites workCurrent issues in organophosphate toxicologyQ22337366
Comparative developmental neurotoxicity of organophosphate insecticides: effects on brain development are separable from systemic toxicityQ24547922
Developmental exposure to chlorpyrifos elicits sex-selective alterations of serotonergic synaptic function in adulthood: critical periods and regional selectivity for effects on the serotonin transporter, receptor subtypes, and cell signalingQ24810873
An invertebrate model of the developmental neurotoxicity of insecticides: effects of chlorpyrifos and dieldrin in sea urchin embryos and larvaeQ24812687
Developmental exposure of rats to chlorpyrifos leads to behavioral alterations in adulthood, involving serotonergic mechanisms and resembling animal models of depressionQ24812812
Developmental neurotoxicity of chlorpyrifos modeled in vitro: comparative effects of metabolites and other cholinesterase inhibitors on DNA synthesis in PC12 and C6 cellsQ24813250
Alterations in central nervous system serotonergic and dopaminergic synaptic activity in adulthood after prenatal or neonatal chlorpyrifos exposureQ24815257
The sea urchin embryo as a model for mammalian developmental neurotoxicity: ontogenesis of the high-affinity choline transporter and its role in cholinergic trophic activityQ24816686
Serotonergic systems targeted by developmental exposure to chlorpyrifos: effects during different critical periodsQ24816699
A case for revisiting the safety of pesticides: a closer look at neurodevelopmentQ25256593
The mysterious trace amines: protean neuromodulators of synaptic transmission in mammalian brainQ28262720
Screening for developmental neurotoxicity using PC12 cells: comparisons of organophosphates with a carbamate, an organochlorine, and divalent nickelQ28395180
Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamilyQ28395997
Organophosphorus pesticides: do they all have the same mechanism of toxicity?Q29615471
The concern for developmental neurotoxicology: is it justified and what is being done about it?Q30499452
Does the developmental neurotoxicity of chlorpyrifos involve glial targets? Macromolecule synthesis, adenylyl cyclase signaling, nuclear transcription factors, and formation of reactive oxygen in C6 glioma cellsQ31873230
Zebrafish as a neurotoxicological model.Q33207399
Developmental cholinotoxicants: nicotine and chlorpyrifosQ33608802
Functional coupling of neurotransmitters with second messengers during cleavage divisions: facts and hypotheses.Q33758945
Testing methods for developmental neurotoxicity of environmental chemicalsQ33876820
Interactions between pesticides and glia: an unexplored experimental field.Q33905458
Use of aggregating brain cell cultures to study developmental effects of organophosphorus insecticides.Q34055863
Nicotine is a developmental neurotoxicant and neuroprotectant: stage-selective inhibition of DNA synthesis coincident with shielding from effects of chlorpyrifosQ34292224
Cholinergic systems in brain development and disruption by neurotoxicants: nicotine, environmental tobacco smoke, organophosphatesQ34331472
Chlorpyrifos affects phenotypic outcomes in a model of mammalian neurodevelopment: critical stages targeting differentiation in PC12 cellsQ34603071
Cell signaling as a target and underlying mechanism for neurobehavioral teratogenesis.Q34726574
Neurotoxicity testing: a discussion of in vitro alternativesQ34942010
Environmental neurotoxic illness: research for preventionQ35031674
Organophosphate insecticides target the serotonergic system in developing rat brain regions: disparate effects of diazinon and parathion at doses spanning the threshold for cholinesterase inhibitionQ35113105
Guidelines for developmental neurotoxicity and their impact on organophosphate pesticides: a personal view from an academic perspectiveQ35795748
Organophosphate toxicology: safety aspects of nonacetylcholinesterase secondary targetsQ35862603
Environmental genomics: a key to understanding biology, pathophysiology and diseaseQ35883303
Comparative developmental neurotoxicity of organophosphates in vivo: transcriptional responses of pathways for brain cell development, cell signaling, cytotoxicity and neurotransmitter systemsQ35933418
Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of protein kinase C in chick and avian modelsQ38448550
Effect of organophosphorus insecticides and their metabolites on astroglial cell proliferationQ40384868
From oocyte to neuron: do neurotransmitters function in the same way throughout development?Q41257197
Developmental neurotoxicity of environmental agents in the neonate.Q41618755
Ornithine decarboxylase in developing rat heart and brain: role of sympathetic development for responses to autonomic stimulants and the effects of reserpine on maturationQ41841661
Combination antitumor effect with central nervous system depressants on rat ascites hepatomasQ42272063
Functional alterations in CNS catecholamine systems in adolescence and adulthood after neonatal chlorpyrifos exposureQ42518328
Developmental neurotoxicity of chlorpyrifos: targeting glial cellsQ42729938
Decreased synthesis of DNA in regenerating rat liver after the administration of reserpineQ43002116
Comparative presynaptic neurochemical changes in rat striatum following exposure to chlorpyrifos or parathionQ43333139
Age-related effects of chlorpyrifos on acetylcholine release in rat brainQ43578862
Alterations in serotonin transporter expression in brain regions of rats exposed neonatally to chlorpyrifosQ43737468
Cholinergic regulation of the sea urchin embryonic and larval developmentQ43873243
Biological targets of neurotoxic pesticides analysed by alteration of developmental events in the Mediterranean sea urchin, Paracentrotus lividusQ44241031
Effect of reserpine on cell proliferation in the developing rat brain: a quantivative histological studyQ44627548
Release and metabolism of dopamine in a clonal line of pheochromocytoma (PC12) cells exposed to fenthionQ45138907
Involvement of glial cells in the neurotoxicity of parathion and chlorpyrifosQ45149272
Neuropathology of organophosphate-induced delayed neuropathy (OPIDN) in young chicksQ46392680
Oxidative mechanisms contributing to the developmental neurotoxicity of nicotine and chlorpyrifosQ46553074
The alterations in CNS serotonergic mechanisms caused by neonatal chlorpyrifos exposure are permanentQ46604329
Effect of reserpine on cell proliferation and energy stores in the developing rat brainQ48112205
Neonatal chlorpyrifos exposure alters synaptic development and neuronal activity in cholinergic and catecholaminergic pathwaysQ48137279
Prenatal chlorpyrifos exposure elicits presynaptic serotonergic and dopaminergic hyperactivity at adolescence: critical periods for regional and sex-selective effectsQ48291587
Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryosQ48366776
Modulation of paraoxon toxicity by the cannabinoid receptor agonist WIN 55,212-2.Q48427863
Cholinoreceptors of early (preneural) sea urchin embryosQ48892784
[Polyenic acid 5-hydroxytryptamides and 3-hydroxytyramides as tools for studying of the pre-nervous biogenic monoamine functions].Q52162777
Neurotoxicology risk assessment guidelines: developmental neurotoxicology.Q52168613
Possibility of membrane reception of neurotransmitter in sea urchin early embryos.Q52223404
Postnatal function following prenatal reserpine exposure in rats: neurobehavioral toxicity.Q52245185
Effects of extended periods of reserpine and α-methyl-p-tyrosine treatment on the development of the putamen in fetal rabbits.Q52282982
Chlorpyrifos releases norepinephrine from adult and neonatal rat brain synaptosomes.Q52575337
Maturation-dependent effects of chlorpyrifos and parathion and their oxygen analogs on acetylcholinesterase and neuronal and glial markers in aggregating brain cell cultures.Q52580193
The role of neurohumours in early embryogenesis. 3. Pharmacological analysis of the role of neurohumours in cleavage divisions.Q53740344
The sea urchin egg as a testing object in toxicologyQ54003081
On the role of serotonin and acetylcholine in sea urchin morphogenesisQ68749124
The effect of reserpine on growth and catecholamine content of TetrahymenaQ72914549
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectneurotransmitterQ162657
chlorpyrifosQ414915
neurotoxicityQ3338704
toxic encephalopathyQ7830379
P304page(s)221-231
P577publication date2007-07-06
P1433published inBrain Research BulletinQ4955784
P1476titleThe sea urchin embryo, an invertebrate model for mammalian developmental neurotoxicity, reveals multiple neurotransmitter mechanisms for effects of chlorpyrifos: therapeutic interventions and a comparison with the monoamine depleter, reserpine
P478volume74

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cites work (P2860)
Q36965723Amyloid precursor protein 96-110 and beta-amyloid 1-42 elicit developmental anomalies in sea urchin embryos and larvae that are alleviated by neurotransmitter analogs for acetylcholine, serotonin and cannabinoids
Q60302063An ecotoxicological view on neurotoxicity assessment
Q46756391Assessment of toxic interactions between deltamethrin and copper on the fertility and developmental events in the Mediterranean sea urchin, Paracentrotus lividus.
Q42233987Early appearance and possible functions of non-neuromuscular cholinesterase activities
Q52837703Effects of chlorpyrifos on life cycle parameters, cytochrome P450S expression, and antioxidant systems in the monogonont rotifer Brachionus koreanus.
Q38510947Review: Morphofunctional and biochemical markers of stress in sea urchin life stages exposed to engineered nanoparticles
Q52730993Toxic effects of pentachlorophenol, azinphos-methyl and chlorpyrifos on the development of Paracentrotus lividus embryos.

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