The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis

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The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1007/S00109-005-0637-5
P698PubMed publication ID15827759

P2093author name stringSeema S Ahuja
Sunil K Ahuja
Matthias Mack
William A Kuziel
Yogeshwar Kalkonde
Carlos A Estrada
Marlon P Quinones
P2860cites workThe chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactionsQ24564834
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Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8Q24793032
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Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout miceQ28585385
CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cQ28588634
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.Q28590391
CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infectionQ28594148
Blood monocytes consist of two principal subsets with distinct migratory propertiesQ29614286
Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2).Q30307189
CCR5 deficiency is not protective in the early stages of atherogenesis in apoE knockout miceQ30891436
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The chemokine system: redundancy for robust outputsQ33650445
Tumor necrosis factor-alpha blockade: a novel therapy for rheumatic diseaseQ34781971
Chemokines and chemokine receptors in rheumatoid arthritisQ35031896
C-C chemokine-encoding DNA vaccines enhance breakdown of tolerance to their gene products and treat ongoing adjuvant arthritisQ35126948
Pathogenesis of bone and cartilage destruction in rheumatoid arthritisQ35158472
Chemokine receptor 2 (CCR2) in atherosclerosis, infectious diseases, and regulation of T-cell polarizationQ35173616
Immunopathogenesis of collagen arthritis.Q35194784
IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic jointsQ35552036
Monocyte chemoattractant protein-1 (MCP-1) expression in human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone and retinoic acidQ35605220
Anti-TNFalpha therapy of rheumatoid arthritis: what can we learn about chronic disease?Q35694207
Experimental autoimmune encephalomyelitis (EAE) in CCR2(-/-) mice: susceptibility in multiple strainsQ35748862
Severe inflammatory arthritis and lymphadenopathy in the absence of TNF.Q36028645
An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse modelQ36380336
Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis modelQ37383845
Collagen autoimmunity and arthritis.Q39534442
Regulatory T cells can migrate to follicles upon T cell activation and suppress GC-Th cells and GC-Th cell-driven B cell responsesQ40427517
Experimental arthritis in CC chemokine receptor 2-null mice closely mimics severe human rheumatoid arthritisQ40643961
The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3.Q40674317
Collagen arthritis--what can it teach us?Q40700344
Chemokine receptor expression and function in CD4+ T lymphocytes with regulatory activity.Q40833931
Chemokine production by human chondrocytesQ42477798
Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokinesQ42492021
Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritisQ43607170
Chronic relapsing homologous collagen-induced arthritis in DBA/1 mice as a model for testing disease-modifying and remission-inducing therapiesQ43607200
Protection from pulmonary fibrosis in the absence of CCR2 signalingQ43760123
AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.Q43760150
Role of CCR2 in macrophage migration into the liver during acetaminophen-induced hepatotoxicity in the mouseQ43974826
TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infectionQ44308127
Collagen-induced arthritis in C57BL/6 (H-2b) mice: new insights into an important disease model of rheumatoid arthritisQ44928706
Expression of the chemokine receptor CCR2 on immature B cells negatively regulates their cytoskeletal rearrangement and migrationQ47652339
Dual role of CCR2 during initiation and progression of collagen-induced arthritis: evidence for regulatory activity of CCR2+ T cells.Q51830522
The chemoattraction of lymphocytes by rheumatoid arthritis - synovial fluid is not dependent on the chemokine receptor CCR5.Q53388669
Essential role of neutrophils in the initiation and progression of a murine model of rheumatoid arthritis.Q54001255
CCR5 (chemokine receptor-5) DNA-polymorphism influences the severity of rheumatoid arthritis.Q54020149
The role of CC chemokine receptor 2 in alveolar monocyte and neutrophil immigration in intact mice.Q54540668
Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 miceQ57019206
Genetic variation in CCR5 does not predict clinical outcome in inflammatory arthritisQ57306873
CC chemokine receptor 5 polymorphism in rheumatoid arthritisQ63728135
Chemokine expression in rheumatoid arthritis (RA): evidence of RANTES and macrophage inflammatory protein (MIP)-1 beta production by synovial T cellsQ71708739
CXCR3 and CCR5 ligands in rheumatoid arthritis synoviumQ73352970
Susceptibility to collagen-induced arthritis: cytokine-mediated regulationQ73352994
C-C chemokine receptor 2 and sarcoidosis: association with Lofgren's syndromeQ73711980
The colony-stimulating factors and collagen-induced arthritis: exacerbation of disease by M-CSF and G-CSF and requirement for endogenous M-CSFQ74066265
Suppression of TNF-alpha expression, inhibition of Th1 activity, and amelioration of collagen-induced arthritis by rolipramQ74460278
A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responsesQ74715421
Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritisQ74844694
Surface expression of CC- and CXC-chemokine receptors on leucocyte subsets in inflammatory joint diseasesQ77332357
Selective accumulation of CCR5+ T lymphocytes into inflamed joints of rheumatoid arthritisQ77738063
Predominance of mononuclear cells expressing the chemokine receptor CCR5 in synovial effusions of patients with different forms of arthritisQ77738646
Association of the course of collagen-induced arthritis with distinct patterns of cytokine and chemokine messenger RNA expressionQ77872967
Mice lacking mature T and B lymphocytes develop arthritic lesions after immunization with type II collagenQ77899668
Interleukin 8 and monocyte chemoattractant protein-1 in patients with juvenile rheumatoid arthritis. Relation to onset types, disease activity, and synovial fluid leukocytesQ78108584
Post-onset inhibition of murine arthritis using combined chemokine antagonist therapyQ79181133
Expression and characterization of the chemokine receptors CCR2 and CCR5 in miceQ95721029
P433issue9
P921main subjectrheumatoid arthritisQ187255
P304page(s)672-681
P577publication date2005-04-13
P1433published inJournal of Molecular MedicineQ6295593
P1476titleThe complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritis
P478volume83

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cites work (P2860)
Q47100328A time-course microarray data analysis reveals consistent dysregulated genes and upstream microRNAs in autoantibody-mediated arthritis
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Q37689783CCR5 antagonists: the answer to inflammatory disease?
Q36186892CD8α⁺ dendritic cells improve collagen-induced arthritis in CC chemokine receptor (CCR)-2 deficient mice
Q43290133CX3CR1-deficiency is associated with increased severity of disease in experimental autoimmune uveitis
Q34051768Chemokines and chemokine receptors in arthritis
Q64101722Early Peritoneal CC Chemokine Production Correlates with Divergent Inflammatory Phenotypes and Susceptibility to Experimental Arthritis in Mice
Q34896763Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells
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Q30438557Induction of CCR2-dependent macrophage accumulation by oxidized phospholipids in the air-pouch model of inflammation
Q37432097International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors
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Q36310750Monocyte chemoattractant protein-1/CCR2 axis promotes vein graft neointimal hyperplasia through its signaling in graft-extrinsic cell populations
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Q28742993Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis
Q87450517[Immunosuppressives to prevent rejection reactions after allogeneic corneal transplantation]

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