Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis

scientific article (publication date: 2011)

Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...621772L
P356DOI10.1371/JOURNAL.PONE.0021772
P932PMC publication ID3128605
P698PubMed publication ID21747955
P5875ResearchGate publication ID51484563

P50authorAna S F OliveiraQ84542194
Paul P TakQ89865007
P2093author name stringRichard Horuk
Maria C Lebre
Clarissa E Vergunst
Kris A Reedquist
Tim Wyant
Saïda Aarrass
Ivy Y K Choi
P2860cites workChemokine blockade: a new era in the treatment of rheumatoid arthritis?Q24800857
Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 miceQ57019206
Infiltrated Neutrophils Acquire Novel Chemokine Receptor Expression and Chemokine Responsiveness in Chronic Inflammatory Lung DiseasesQ62555626
The chemoattractant activity of rheumatoid synovial fluid for human lymphocytes is due to multiple cytokinesQ71778731
Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activityQ73092605
CXCR3 and CCR5 ligands in rheumatoid arthritis synoviumQ73352970
RANTES expression and contribution to monocyte chemotaxis in arthritisQ77359406
Accumulation of FoxP3-expressing CD4+CD25+ T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritisQ80229816
Is CCR2 the right chemokine receptor to target in rheumatoid arthritis?Q81514399
Absence of changes in the number of synovial sublining macrophages after ineffective treatment for rheumatoid arthritis: Implications for use of synovial sublining macrophages as a biomarkerQ81517383
MLN3897 plus methotrexate in patients with rheumatoid arthritis: safety, efficacy, pharmacokinetics, and pharmacodynamics of an oral CCR1 antagonist in a phase IIa, double-blind, placebo-controlled, randomized, proof-of-concept studyQ84966679
The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritisQ27860872
Monocyte scintigraphy in rheumatoid arthritis: the dynamics of monocyte migration in immune-mediated inflammatory diseaseQ33516229
The role of chemokine receptors in primary, effector, and memory immune responsesQ33932742
Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritisQ34129985
Chemokine blockade and chronic inflammatory disease: proof of concept in patients with rheumatoid arthritisQ35553008
Chemokines in joint disease: the key to inflammation?Q35553416
Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritisQ35636896
Chemokines and their receptors in rheumatoid arthritis: future targets?Q36063483
The complex role of the chemokine receptor CCR2 in collagen-induced arthritis: implications for therapeutic targeting of CCR2 in rheumatoid arthritisQ36096959
Cells of the synovium in rheumatoid arthritis. MacrophagesQ36465497
The dynamics of macrophage lineage populations in inflammatory and autoimmune diseasesQ37465013
Chemokine receptor antagonists: Part 1.Q37481238
Chemokine receptor antagonists: part 2.Q37481304
CCR1 antagonists: what have we learned from clinical trialsQ37763962
A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritisQ39763545
Modulation of CCR2 in rheumatoid arthritis: a double-blind, randomized, placebo-controlled clinical trialQ39850979
CCR5 blockade in rheumatoid arthritis: a randomised, double-blind, placebo-controlled clinical trial.Q42943397
Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexateQ42956746
Histone deacetylase inhibitors suppress inflammatory activation of rheumatoid arthritis patient synovial macrophages and tissueQ43184367
Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritisQ43607170
Pharmacokinetic and pharmacodynamic evaluation of the novel CCR1 antagonist CCX354 in healthy human subjects: implications for selection of clinical dose.Q45999111
Overcoming hurdles in developing successful drugs targeting chemokine receptorsQ46441158
Inhibition of the development of collagen-induced arthritis in rhesus monkeys by a small molecular weight antagonist of CCR5.Q47393101
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
P304page(s)e21772
P577publication date2011-07-01
P1433published inPLOS OneQ564954
P1476titleWhy CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis
P478volume6

Reverse relations

cites work (P2860)
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