Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate

scientific article published on November 2010

Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/ART.27652
P698PubMed publication ID20662070
P5875ResearchGate publication ID45367674

P50authorJiří VencovskýQ42956790
Paul P TakQ89865007
P2093author name stringSally Hollis
Zoltán Szekanecz
Daniëlle M Gerlag
Martin Braddock
Mark Layton
ESCAPE Study Group
P2860cites workThe MOS 36-ltem Short-Form Health Survey (SF-36)Q26778425
Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritisQ34315745
Development and validation of the European League Against Rheumatism response criteria for rheumatoid arthritis. Comparison with the preliminary American College of Rheumatology and the World Health Organization/International League Against RheumatiQ34662758
Negative association between the chemokine receptor CCR5-Delta32 polymorphism and rheumatoid arthritis: a meta-analysisQ35014330
Chemokines in joint disease: the key to inflammation?Q35553416
Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritisQ35636896
Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritisQ43607170
Measuring health-related quality of life in rheumatoid arthritis: validity, responsiveness and reliability of EuroQol (EQ-5D).Q44916043
American College of Rheumatology. Preliminary definition of improvement in rheumatoid arthritisQ47643186
Once-weekly administration of 50 mg etanercept in patients with active rheumatoid arthritis: results of a multicenter, randomized, double-blind, placebo-controlled trial.Q51051064
Etanercept therapy in rheumatoid arthritis. A randomized, controlled trial.Q52221782
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectrheumatoid arthritisQ187255
P304page(s)3154-3160
P577publication date2010-11-01
P1433published inArthritis & RheumatologyQ4797636
P1476titlePreclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate
P478volume62

Reverse relations

cites work (P2860)
Q90575892A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance
Q55496778A cytokine protein-protein interaction network for identifying key molecules in rheumatoid arthritis.
Q38155907Advances in understanding the pathogenesis of autoimmune disorders: focus on chemokines and lymphocyte trafficking
Q53191263CCR5 deficiency does not reduce hypertensive end-organ damage in mice.
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Q91199065Chemokines in rheumatic diseases: pathogenic role and therapeutic implications
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Q38110963Emerging therapies for rheumatoid arthritis
Q24202751Etanercept for the treatment of rheumatoid arthritis
Q38618883Inflammatory Cell Migration in Rheumatoid Arthritis: A Comprehensive Review
Q37432097International Union of Basic and Clinical Pharmacology. [corrected]. LXXXIX. Update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors
Q38212169Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework
Q38939820Methotrexate monotherapy and methotrexate combination therapy with traditional and biologic disease modifying anti-rheumatic drugs for rheumatoid arthritis: A network meta-analysis.
Q28069360Neutrophils and Granulocytic MDSC: The Janus God of Cancer Immunotherapy
Q46441158Overcoming hurdles in developing successful drugs targeting chemokine receptors
Q45999111Pharmacokinetic and pharmacodynamic evaluation of the novel CCR1 antagonist CCX354 in healthy human subjects: implications for selection of clinical dose.
Q54967818Phase III, multicentre, double-blind, randomised, parallel-group study to evaluate the similarities between LBEC0101 and etanercept reference product in terms of efficacy and safety in patients with active rheumatoid arthritis inadequately respondin
Q47989935Protective role for CCR5 in murine lupus nephritis
Q90642824Role of Chemokines and Chemokine Receptors in Rheumatoid Arthritis
Q38647749Successes and failures of chemokine-pathway targeting in rheumatoid arthritis
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Q39158831The Multifunctional Role of the Chemokine System in Arthritogenic Processes
Q47390076The Role of Macrophages in the Response to TNF Inhibition in Experimental Arthritis
Q33746340The Utility of In Vitro Data in Making Accurate Predictions of Human P-Glycoprotein-Mediated Drug-Drug Interactions: A Case Study for AZD5672
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Q42326321What is the future of CCR5 antagonists in rheumatoid arthritis?
Q28742993Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis

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