Chemokines in joint disease: the key to inflammation?

scientific article published on 13 April 2004

Chemokines in joint disease: the key to inflammation? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1136/ARD.2004.020529
P932PMC publication ID1754785
P698PubMed publication ID15082471
P5875ResearchGate publication ID8621682

P2093author name stringTak PP
Haringman JJ
Ludikhuize J
P2860cites workHuman G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxisQ22010731
The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactionsQ24564834
Epithelial neutrophil activating peptide-78: a novel chemotactic cytokine for neutrophils in arthritisQ24633862
The development of clinical signs of rheumatoid synovial inflammation is associated with increased synthesis of the chemokine CXCL8 (interleukin-8)Q24792930
Synovial stromal cells from rheumatoid arthritis patients attract monocytes by producing MCP-1 and IL-8Q24793032
International union of pharmacology. XXII. Nomenclature for chemokine receptorsQ28145705
CCR3 functional responses are regulated by both CXCR3 and its ligands CXCL9, CXCL10 and CXCL11Q28190115
Chemokines and diseaseQ28200068
International Union of Pharmacology. XXX. Update on chemokine receptor nomenclatureQ28201568
IFN-gamma-inducible T cell alpha chemoattractant is a potent stimulator of normal human blood T lymphocyte transendothelial migration: differential regulation by IFN-gamma and TNF-alphaQ28203531
Anatomic localization of immature and mature dendritic cells in an ectopic lymphoid organ: correlation with selective chemokine expression in rheumatoid synoviumQ28216812
Lymphotactin: a cytokine that represents a new class of chemokineQ28241663
Regulation of the expression of IL-8 receptor A/B by IL-8: possible functions of each receptorQ28295922
A new class of membrane-bound chemokine with a CX3C motifQ28303204
Angiogenesis in cancer, vascular, rheumatoid and other diseaseQ29547165
Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigmQ29547181
Chemokines: a new classification system and their role in immunityQ29615663
Analysis of the synovial cell infiltrate in early rheumatoid synovial tissue in relation to local disease activityQ73092605
Lymphoid chemokine B cell-attracting chemokine-1 (CXCL13) is expressed in germinal center of ectopic lymphoid follicles within the synovium of chronic arthritis patientsQ73311968
CXCR3 and CCR5 ligands in rheumatoid arthritis synoviumQ73352970
Chemokines trigger immediate beta2 integrin affinity and mobility changes: differential regulation and roles in lymphocyte arrest under flowQ73406513
The role of monocyte chemoattractant protein-1 (MCP-1) in the pathogenesis of collagen-induced arthritis in ratsQ73519506
Regulation of angiogenesis by the C-X-C chemokines interleukin-8 and epithelial neutrophil activating peptide 78 in the rheumatoid jointQ73521731
The role of C-C chemokines and their receptors in osteoarthritisQ73880323
Temporal expression of inflammatory cytokines and chemokines in rat adjuvant-induced arthritisQ73904635
Inflammatory infiltrate and interleukin-8 expression in the synovium of psoriatic arthritis--an immunohistochemical and mRNA analysisQ74080716
Lymphoid neogenesis in rheumatoid synovitisQ74147962
Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependentQ74165253
Fractalkine, a novel chemokine in rheumatoid arthritis and in rat adjuvant-induced arthritisQ74242399
Rheumatoid arthritisQ74541001
A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responsesQ74715421
Chemokines regulate IL-6 and IL-8 production by fibroblast-like synoviocytes from patients with rheumatoid arthritisQ74844694
RANTES expression and contribution to monocyte chemotaxis in arthritisQ77359406
Differential production of RANTES and MCP-1 in synovial fluid from the inflamed human kneeQ77368715
Stimulation of matrix metalloprotease 3 release from human chondrocytes by the interaction of stromal cell-derived factor 1 and CXC chemokine receptor 4Q77567376
Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responsesQ77723690
Predominance of mononuclear cells expressing the chemokine receptor CCR5 in synovial effusions of patients with different forms of arthritisQ77738646
The role of an epithelial neutrophil-activating peptide-78-like protein in rat adjuvant-induced arthritisQ77841725
Association of the course of collagen-induced arthritis with distinct patterns of cytokine and chemokine messenger RNA expressionQ77872967
Cutting edge: profile of chemokine receptor expression on human plasma cells accounts for their efficient recruitment to target tissuesQ78826829
Chemokines--chemotactic cytokines that mediate inflammationQ29616433
ChemokinesQ29616435
Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversityQ29617967
Chemokines and leukocyte trafficQ29618886
Functional IL-2 receptor beta (CD122) and gamma (CD132) chains are expressed by fibroblast-like synoviocytes: activation by IL-2 stimulates monocyte chemoattractant protein-1 productionQ32133705
The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activityQ33181330
Monocyte chemoattractant protein-1.Q33768274
Chemokines and cell migration in secondary lymphoid organsQ33807114
Structure, function, and inhibition of chemokinesQ34110896
Macrophage inflammatory protein-1 alpha. A novel chemotactic cytokine for macrophages in rheumatoid arthritisQ34129985
Chemokines: immunology's high impact factorsQ34139595
Chemokines as regulators of T cell differentiation.Q34139602
Chemokines and angiogenesisQ34239074
gro-beta, a -C-X-C- chemokine, is an angiogenesis inhibitor that suppresses the growth of Lewis lung carcinoma in miceQ34290327
Interleukin-8 and the chemokine family.Q34303829
Chemokines in pathology and medicineQ34328278
Chemokines in autoimmune diseaseQ34418051
The Functional Role of the ELR Motif in CXC Chemokine-mediated AngiogenesisQ34662335
Chemokine receptor antagonism as an approach to anti-inflammatory therapy: 'just right' or plain wrong?Q34754683
Novel mechanistic concepts for the control of leukocyte transmigration: specialization of integrins, chemokines, and junctional moleculesQ35052510
Abandoned therapies and unpublished trials in rheumatoid arthritisQ35111841
Chemokine blockade and chronic inflammatory disease: proof of concept in patients with rheumatoid arthritisQ35553008
Fractalkine: a novel angiogenic chemokine in rheumatoid arthritisQ35746847
Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells: In vivo neovascularization induced by stromal-derived factor-1alpha.Q35786830
Enhanced production of monocyte chemoattractant protein-1 in rheumatoid arthritisQ35821357
An antagonist of monocyte chemoattractant protein 1 (MCP-1) inhibits arthritis in the MRL-lpr mouse modelQ36380336
Interleukin 15 is produced by endothelial cells and increases the transendothelial migration of T cells In vitro and in the SCID mouse-human rheumatoid arthritis model In vivoQ37379361
Polyclonal antibody directed against human RANTES ameliorates disease in the Lewis rat adjuvant-induced arthritis modelQ37383845
Cell cycle-dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activityQ39904117
Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potentialQ39907271
Synoviocyte-derived CXCL12 is displayed on endothelium and induces angiogenesis in rheumatoid arthritisQ40671913
Association of antigen specificity and migratory capacity of memory T cells in rheumatoid arthritisQ40739557
Mig, GRO alpha and RANTES messenger RNA expression in lining layer, infiltrates and different leucocyte populations of synovial tissue from patients with rheumatoid arthritis, psoriatic arthritis and osteoarthritisQ40758429
Immunohistological analysis of synovial tissue for differential diagnosis in early arthritisQ40790437
Persistent induction of the chemokine receptor CXCR4 by TGF-beta 1 on synovial T cells contributes to their accumulation within the rheumatoid synovium.Q40856416
Human endothelial cells express CCR2 and respond to MCP-1: direct role of MCP-1 in angiogenesis and tumor progressionQ40868885
Mouse monocyte-derived chemokine is involved in airway hyperreactivity and lung inflammationQ40945513
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytesQ41054119
In vivo properties of monocyte chemoattractant protein-1.Q41640087
Chemokine Up-regulation and activated T cell attraction by maturing dendritic cellsQ41648813
Chemoattractants induce a rapid and transient upregulation of monocyte alpha4 integrin affinity for vascular cell adhesion molecule 1 which mediates arrest: an early step in the process of emigrationQ42021031
Human chondrocytes express functional chemokine receptors and release matrix-degrading enzymes in response to C-X-C and C-C chemokinesQ42492021
CP-481,715, a potent and selective CCR1 antagonist with potential therapeutic implications for inflammatory diseasesQ42605598
Chemokines have diverse abilities to form solid phase gradientsQ43564626
Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritisQ43607170
Production of monocyte chemoattractant protein-1 by inflamed synovial tissue and cultured synoviocytesQ43757508
AMD3100, a potent and specific antagonist of the stromal cell-derived factor-1 chemokine receptor CXCR4, inhibits autoimmune joint inflammation in IFN-gamma receptor-deficient mice.Q43760150
A potent and selective nonpeptide antagonist of CXCR2 inhibits acute and chronic models of arthritis in the rabbitQ44223900
Role of Macrophage Inflammatory Protein-3α and Its Ligand CCR6 in Rheumatoid ArthritisQ47973596
Selective recruitment of CCR6-expressing cells by increased production of MIP-3 alpha in rheumatoid arthritis.Q52018468
Specialized roles of the chemokine receptors CCR1 and CCR5 in the recruitment of monocytes and T(H)1-like/CD45RO(+) T cells.Q52022061
Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis synovium.Q52023146
The chemokine receptor CXCR3 mediates rapid and shear-resistant adhesion-induction of effector T lymphocytes by the chemokines IP10 and Mig.Q52039719
Elevation of interleukin-8 (IL-8) levels in joint fluids of patients with rheumatoid arthritis and the induction by IL-8 of leukocyte infiltration and synovitis in rabbit joints.Q53717677
Targeting the function of IFN-gamma-inducible protein 10 suppresses ongoing adjuvant arthritis.Q53866765
Down-modulation of chemokine receptor cartilage expression in inflammatory arthritis.Q54797188
Expression of Chemokine Receptors by Lung T Cells from Normal and Asthmatic SubjectsQ55094015
Differential expression and responsiveness of chemokine receptors (CXCR1-3) by human microvascular endothelial cells and umbilical vein endothelial cellsQ56890926
Flow cytometric analysis of intracellular chemokines in chondrocytes in vivo: constitutive expression and enhancement in osteoarthritis and rheumatoid arthritisQ57012210
Effect of a CC chemokine receptor antagonist on collagen induced arthritis in DBA/1 miceQ57019206
What can stochastic resonance do?Q59061953
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditionsQ59064735
Inflammation and angiogenesis in osteoarthritisQ59151152
T cell-mediated signaling to vascular endothelium: induction of cytokines, chemokines, and tissue factorQ60169458
Macrophage Inflammatory Protein-Iβ: A C-C Chemokine in OsteoarthritisQ62734318
Differential immobilization and hierarchical involvement of chemokines in monocyte arrest and transmigration on inflamed endothelium in shear flowQ63916914
Synovial tissue macrophage as a source of the chemotactic cytokine IL-8Q68011933
Macrophage inflammatory protein 1 modulates macrophage functionQ68107144
Production of monocyte chemotactic protein-1 in human type B synoviocytes. Synergistic effect of tumor necrosis factor alpha and interferon-gammaQ70540252
Expression of monocyte chemotactic and activating factor in rheumatoid arthritis. Regulation of its production in synovial cells by interleukin-1 and tumor necrosis factorQ70750038
Expression of the chemokine superfamily in rheumatoid arthritisQ71645876
Chemokine expression in rheumatoid arthritis (RA): evidence of RANTES and macrophage inflammatory protein (MIP)-1 beta production by synovial T cellsQ71708739
A soluble gradient of endogenous monocyte chemoattractant protein-1 promotes the transendothelial migration of monocytes in vitroQ71746761
The chemoattractant activity of rheumatoid synovial fluid for human lymphocytes is due to multiple cytokinesQ71778731
Expression of the cytokine RANTES in human rheumatoid synovial fibroblasts. Differential regulation of RANTES and interleukin-8 genes by inflammatory cytokinesQ72072827
Production of interleukin-1 receptor antagonist, inflammatory chemotactic proteins, and prostaglandin E by rheumatoid and osteoarthritic synoviocytes--regulation by IFN-gamma and IL-4Q72273786
Monocyte chemotactic proteins MCP-1, MCP-2, and MCP-3 are major attractants for human CD4+ and CD8+ T lymphocytesQ72717877
Synovial membrane inflammation and cytokine production in patients with early osteoarthritisQ73076908
Localized monocyte chemotactic protein-1 production correlates with T cell infiltration of synovium in patients with psoriatic arthritisQ73090176
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectinflammationQ101991
P304page(s)1186-1194
P577publication date2004-04-13
P1433published inAnnals of the Rheumatic DiseasesQ4767876
P1476titleChemokines in joint disease: the key to inflammation?
P478volume63

Reverse relations

cites work (P2860)
Q37707714Activation of the cholinergic anti-inflammatory system by nicotine attenuates arthritis via suppression of macrophage migration
Q38709769An initial investigation into endothelial CC chemokine expression in the human rheumatoid synovium.
Q47882479Anti-inflammatory Effect of DNA Polymeric Molecules in a Cell Model of Osteoarthritis.
Q36052572Anti-rheumatic activities of histone deacetylase (HDAC) inhibitors in vivo in collagen-induced arthritis in rodents.
Q37154852Are there promising biologic therapies for osteoarthritis?
Q42379102Association between TLR-9 gene rs187084 polymorphism and knee osteoarthritis in a Chinese population
Q89025875Association between levels of synovial anti-citrullinated peptide antibodies and neutrophil response in patients with rheumatoid arthritis
Q98735556Blockade of XCL1/Lymphotactin Ameliorates Severity of Periprosthetic Osteolysis Triggered by Polyethylene-Particles
Q34236851CCAAT/enhancer-binding protein β and NF-κB mediate high level expression of chemokine genes CCL3 and CCL4 by human chondrocytes in response to IL-1β.
Q56998904CXCL12 (SDF-1) and CXCL13 (BCA-1) chemokines significantly induce proliferation and collagen type I expression in osteoblasts from osteoarthritis patients
Q24803773CXCR3/CXCL10 expression in the synovium of children with juvenile idiopathic arthritis
Q34086970Characterization of the KRN cell transfer model of rheumatoid arthritis (KRN-CTM), a chronic yet synchronized version of the K/BxN mouse
Q35636896Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis
Q91199065Chemokines in rheumatic diseases: pathogenic role and therapeutic implications
Q36262470Chemokines: their role in rheumatoid arthritis
Q45987541Citrullination of epithelial neutrophil-activating peptide 78/CXCL5 results in conversion from a non-monocyte-recruiting chemokine to a monocyte-recruiting chemokine.
Q52613681Cytokine-induced interleukin-1 receptor antagonist protein expression in genetically engineered equine mesenchymal stem cells for osteoarthritis treatment.
Q34365089Deficiency of CXCR2, but not other chemokine receptors, attenuates autoantibody-mediated arthritis in a murine model
Q38110963Emerging therapies for rheumatoid arthritis
Q39976859Extended interaction of beta1 integrin subunit-deficient cells (GD25) with surfaces modified with fibronectin-derived peptides: Culture optimization, adhesion and cytokine panel studies
Q37021518Exuberant expression of chemokine genes by adult human articular chondrocytes in response to IL-1beta.
Q61450662Fasitibant prevents the bradykinin and interleukin 1β synergism on prostaglandin E2 release and cyclooxygenase 2 expression in human fibroblast-like synoviocytes
Q34188481Gene expression analysis of rheumatoid arthritis synovial lining regions by cDNA microarray combined with laser microdissection: up-regulation of inflammation-associated STAT1, IRF1, CXCL9, CXCL10, and CCL5.
Q28655057Genomic analysis and differential expression of HMG and S100A family in human arthritis: upregulated expression of chemokines, IL-8 and nitric oxide by HMGB1
Q33755642IFN-gamma regulates the requirement for IL-17 in proteoglycan-induced arthritis
Q38434343Identifying key genes in rheumatoid arthritis by weighted gene co-expression network analysis
Q38872704Knee osteoarthritis: a review of management options
Q90053778Long Non-coding RNA HOTTIP Promotes CCL3 Expression and Induces Cartilage Degradation by Sponging miR-455-3p
Q33880198Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis
Q52601576Molecular basis of anti-inflammatory action of platelet-rich plasma on human chondrocytes: mechanisms of NF-κB inhibition via HGF.
Q36327429Molecular mechanisms of cell recruitment to inflammatory sites: general and tissue-specific pathways
Q36085680Osteoarthritis - an untreatable disease?
Q24803862Phenotypic and functional characterisation of CCR7+ and CCR7- CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis
Q42956746Preclinical and clinical investigation of a CCR5 antagonist, AZD5672, in patients with rheumatoid arthritis receiving methotrexate
Q28236498Proteolysis of macrophage inflammatory protein-1alpha isoforms LD78beta and LD78alpha by neutrophil-derived serine proteases
Q35555485Raised granzyme B levels are associated with erosions in patients with early rheumatoid factor positive rheumatoid arthritis.
Q37691824Resistin induces expression of proinflammatory cytokines and chemokines in human articular chondrocytes via transcription and messenger RNA stabilization
Q82300321Serum chemokines in patients with rheumatoid arthritis treated with etanercept
Q42420342Synovial effusion and synovial fluid biomarkers in psoriatic arthritis to assess intraarticular tumor necrosis factor-α blockade in the knee joint.
Q39431367Synovial tissue research: a state-of-the-art review
Q42370432TGF-β1 suppresses CCL3/4 expression through the ERK signaling pathway and inhibits intervertebral disc degeneration and inflammation-related pain in a rat model
Q36150612Targeting cellular adhesion molecules, chemokines and chemokine receptors in rheumatoid arthritis
Q38961065Targeting the chemotactic function of CD147 reduces collagen-induced arthritis
Q46457918The changes in serum chemokines following leflunomide therapy in patients with rheumatoid arthritis.
Q85623878The chemokine CCL20 induces proinflammatory and matrix degradative responses in cartilage
Q79366300The effect of infliximab on chemokines in patients with rheumatoid arthritis
Q43239473Tumor necrosis factor α- and interleukin-1β-dependent induction of CCL3 expression by nucleus pulposus cells promotes macrophage migration through CCR1.
Q28742993Why CCR2 and CCR5 blockade failed and why CCR1 blockade might still be effective in the treatment of rheumatoid arthritis

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