Chemokines as regulators of T cell differentiation.

scientific article

Chemokines as regulators of T cell differentiation. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1038/84205
P698PubMed publication ID11175801
P5875ResearchGate publication ID12154370

P50authorSanjiv A LutherQ51797070
P2093author name stringCyster JG
P2860cites workMonocyte chemotactic protein-3 (MCP3) interacts with multiple leukocyte receptors. C-C CKR1, a receptor for macrophage inflammatory protein-1 alpha/Rantes, is also a functional receptor for MCP3Q24307852
The C5a chemoattractant receptor mediates mucosal defence to infectionQ24318486
Expression of functional CXCR4 chemokine receptors on human colonic epithelial cellsQ24563114
Delayed wound healing in CXCR2 knockout miceQ24647498
The MCP/eotaxin subfamily of CC chemokinesQ28137923
A transmembrane CXC chemokine is a ligand for HIV-coreceptor BonzoQ28140312
A chemokine-driven positive feedback loop organizes lymphoid folliclesQ28142202
Monocyte chemotactic protein-2 (MCP-2) uses CCR1 and CCR2B as its functional receptorsQ28235818
Interleukin-13: central mediator of allergic asthmaQ28291712
Enhanced pulmonary allergic responses to Aspergillus in CCR2-/- miceQ28509805
The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammationQ28584806
Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout miceQ28585385
Control of inflammation, cytokine expression, and germinal center formation by BCL-6Q28585541
CC chemokine receptor 2 is critical for induction of experimental autoimmune encephalomyelitisQ28587371
CC chemokine receptor (CCR)2 is required for langerhans cell migration and localization of T helper cell type 1 (Th1)-inducing dendritic cells. Absence of CCR2 shifts the Leishmania major-resistant phenotype to a susceptible state dominated by Th2 cQ28588634
Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2.Q28590391
Impaired host defense, hematopoiesis, granulomatous inflammation and type 1-type 2 cytokine balance in mice lacking CC chemokine receptor 1Q28591681
CCR2 expression determines T1 versus T2 polarization during pulmonary Cryptococcus neoformans infectionQ28594148
Interleukin-10-deficient mice develop chronic enterocolitisQ29547881
Mast cell-T cell interactionsQ33731155
Chemokines and cell migration in secondary lymphoid organsQ33807114
Modulating chemokines: more lessons from virusesQ33826596
Human NK cells express CC chemokine receptors 4 and 8 and respond to thymus and activation-regulated chemokine, macrophage-derived chemokine, and I-309.Q33897342
Chemokines in tissue-specific and microenvironment-specific lymphocyte homingQ33898971
Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritisQ33902443
Signaling and transcription in T helper developmentQ33932729
The role of chemokine receptors in primary, effector, and memory immune responsesQ33932742
Dendritic cell regulation of TH1-TH2 developmentQ34023428
The instructive role of innate immunity in the acquired immune responseQ34375203
Polymorphism in RANTES chemokine promoter affects HIV-1 disease progressionQ35133507
Interleukin-12 is produced by macrophages in response to live or killed Bordetella pertussis and enhances the efficacy of an acellular pertussis vaccine by promoting induction of Th1 cellsQ35532427
Effect of C-C chemokine receptor 2 (CCR2) knockout on type-2 (schistosomal antigen-elicited) pulmonary granuloma formation: analysis of cellular recruitment and cytokine responsesQ35786914
Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouseQ35822641
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Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes.Q36367109
Resistance to experimental autoimmune encephalomyelitis in mice lacking the CC chemokine receptor (CCR)2.Q36368947
Defects in macrophage recruitment and host defense in mice lacking the CCR2 chemokine receptorQ36380911
Early murine cytomegalovirus (MCMV) infection induces liver natural killer (NK) cell inflammation and protection through macrophage inflammatory protein 1alpha (MIP-1alpha)-dependent pathwaysQ36381040
Abnormalities in monocyte recruitment and cytokine expression in monocyte chemoattractant protein 1-deficient miceQ36400287
Monocyte chemotactic protein 1 regulates oral tolerance induction by inhibition of T helper cell 1-related cytokinesQ36400419
HIV-specific T cell cytotoxicity mediated by RANTES via the chemokine receptor CCR3.Q36401498
Primary role for Gi protein signaling in the regulation of interleukin 12 production and the induction of T helper cell type 1 responsesQ36404327
Targeting of the chemokine receptor CCR1 suppresses development of acute and chronic cardiac allograft rejectionQ37303301
MCP-1 protects mice in lethal endotoxemiaQ37368530
The CC chemokine CK beta-11/MIP-3 beta/ELC/Exodus 3 mediates tumor rejection of murine breast cancer cells through NK cellsQ40831645
Monocyte chemoattractant protein-1 enhances gene expression and synthesis of matrix metalloproteinase-1 in human fibroblasts by an autocrine IL-1 alpha loopQ40875349
Inhibition by IL-12 and IFN-alpha of I-309 and macrophage-derived chemokine production upon TCR triggering of human Th1 cellsQ40887705
Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytesQ41054119
Chemokine Up-regulation and activated T cell attraction by maturing dendritic cellsQ41648813
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cellsQ41687602
Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2sQ42115088
Selective suppression of IL-12 production by chemoattractantsQ44963436
Pertussis infection and vaccination induces Th1 cellsQ45272435
T-cell subsets: chemokine receptors guide the way.Q46027701
Chemokine receptors: keys to AIDS pathogenesis?Q47964346
Requirement of MIP-1 alpha for an inflammatory response to viral infection.Q52509286
A mechanism for the impaired IFN-gamma production in C-C chemokine receptor 2 (CCR2) knockout mice: role of CCR2 in linking the innate and adaptive immune responses.Q52541798
Ulcerative colitis and adenocarcinoma of the colon in G alpha i2-deficient mice.Q53463453
Distinct patterns and kinetics of chemokine production regulate dendritic cell function.Q54093362
CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cellsQ56880736
Upon dendritic cell (DC) activation chemokines and chemokine receptor expression are rapidly regulated for recruitment and maintenance of DC at the inflammatory siteQ56943333
Control of TH2 polarization by the chemokine monocyte chemoattractant protein-1Q59089322
CCR5 is characteristic of Th1 lymphocytesQ59092711
Uncoupling of inflammatory chemokine receptors by IL-10: generation of functional decoysQ59713916
Macrophage-derived chemokine production by activated human T cellsin vitro andin vivo: preferential association with the production of type 2 cytokinesQ61638220
Elicitation of experimental allergic encephalomyelitis (EAE) in mice with the aid of pertussigenQ71000507
Expression of monocyte chemoattractant protein-1 and interleukin-8 receptors on subsets of T cells: correlation with transendothelial chemotactic potentialQ71011981
Kinetics of dendritic cell activation: impact on priming of TH1, TH2 and nonpolarized T cellsQ73035410
Macrophage-derived dendritic cells have strong Th1-polarizing potential mediated by beta-chemokines rather than IL-12Q73086212
Differentiation of phagocytic monocytes into lymph node dendritic cells in vivoQ73336913
MIP-1alpha and MCP-1 differentially regulate acute and relapsing autoimmune encephalomyelitis as well as Th1/Th2 lymphocyte differentiationQ73867325
Mice with a selective deletion of the CC chemokine receptors 5 or 2 are protected from dextran sodium sulfate-mediated colitis: lack of CC chemokine receptor 5 expression results in a NK1.1+ lymphocyte-associated Th2-type immune response in the inteQ73869118
Cutting edge: differential expression of chemokines in Th1 and Th2 cells is dependent on Stat6 but not Stat4Q73910646
Leukocyte recruitment during onset of experimental allergic encephalomyelitis is CCR1 dependentQ74165253
The chemokine macrophage-inflammatory protein-1 alpha and its receptor CCR1 control pulmonary inflammation and antiviral host defense in paramyxovirus infectionQ74183183
BCL-6 regulates chemokine gene transcription in macrophagesQ74268408
Selective recruitment of CCR4-bearing Th2 cells toward antigen-presenting cells by the CC chemokines thymus and activation-regulated chemokine and macrophage-derived chemokineQ74527777
Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturationQ77353738
IL-4 and IL-13 specifically increase adhesion molecule and inflammatory cytokine expression in human lung fibroblastsQ77492715
Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responsesQ77723690
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectcell differentiationQ210861
P304page(s)102-107
P577publication date2001-02-01
P1433published inNature ImmunologyQ1071725
P1476titleChemokines as regulators of T cell differentiation
P478volume2

Reverse relations

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Q35186648Regulators of G protein signalling: potential targets for treatment of allergic inflammatory diseases such as asthma
Q89959177Research Note: Correlation analysis of interleukin-6, interleukin-8, and C-C motif chemokine ligand 2 gene expression in chicken spleen and cecal tissues after Eimeria tenella infection in vivo
Q36494119Robustness trade-offs and host-microbial symbiosis in the immune system
Q34572155Role of chemokines in the pathogenesis of asthma
Q40572452Role of keratinocytes in antigen presentation and polarization of human T lymphocytes
Q24794146Science review: role of coagulation protease cascades in sepsis
Q79361616Sequential MyD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection
Q40650914Simian/Human Immunodeficiency Virus89.6Expressing the Chemokine Genes MIP-1α, RANTES, or Lymphotactin
Q40134491Single CX3CL1-Ig DNA administration enhances T cell priming in vivo
Q43494866Stromal cell derived factor 1 synthesis by spleen cells in rodent malaria, and the effects of in vivo supplementation of SDF-1alpha and CXCR4 receptor blocker
Q24292437Structural rearrangement of human lymphotactin, a C chemokine, under physiological solution conditions
Q40696990Structure, chromosomal localization and expression of the mouse regulator of G-protein signaling10 gene (mRGS10).
Q41027313Subpopulations of M-MDSCs from mice infected by an immunodeficiency-causing retrovirus and their differential suppression of T- vs B-cell responses
Q50896849Systems level analysis of osteoclastogenesis reveals intrinsic and extrinsic regulatory interactions.
Q34612549T helper cell differentiation: on again, off again
Q37214782TLR2 synergizes with both TLR4 and TLR9 for induction of the MyD88-dependent splenic cytokine and chemokine response to Streptococcus pneumoniae
Q36844950Targeting costimulatory pathways for tumor immunotherapy
Q35056023Targeting monocyte chemoattractant protein-1 signalling in disease
Q26765184Targeting the CCL2-CCR2 signaling axis in cancer metastasis
Q41267932Tea polyphenols inhibit the activation of NF-κB and the secretion of cytokines and matrix metalloproteinases by macrophages stimulated with Fusobacterium nucleatum
Q35769460Th2 cells: orchestrating barrier immunity
Q37346633The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity
Q35132169The Chemokine, CCL3, and Its Receptor, CCR1, Mediate Thoracic Radiation–Induced Pulmonary Fibrosis
Q35769489The ECM proteoglycan decorin links desmoplasia and inflammation in chronic pancreatitis
Q35568430The Role of Chemokines in Inflammatory Skin Diseases
Q36317414The abnormal expression of CCR4 and CCR6 on Tregs in rheumatoid arthritis
Q35036907The absence of CCR7 results in dysregulated monocyte migration and immunosuppression facilitating chronic cutaneous leishmaniasis
Q36097099The bacterial second messenger cdiGMP exhibits promising activity as a mucosal adjuvant
Q79450264The bacterial second messenger cyclic diGMP exhibits potent adjuvant properties
Q43910951The chemokine CCL21 modulates lymphocyte recruitment and fibrosis in chronic hepatitis C.
Q36216100The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis
Q40639914The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells.
Q34929196The chemokine system: tuning and shaping by regulation of receptor expression and coupling in polarized responses.
Q37145450The cholesterol-binding antibiotic nystatin induces expression of macrophage inflammatory protein-1 in macrophages
Q34862240The immunological synapse: integrins take the stage.
Q35686001The influence of follicular migration on T-cell differentiation
Q33769457The innate immune system is activated by stimulation of vaginal epithelial cells with Staphylococcus aureus and toxic shock syndrome toxin 1.
Q44694227The predominance of alternatively activated macrophages following challenge with cell wall peptide-polysaccharide after prior infection with Sporothrix schenckii
Q34330215The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion
Q35031901The role of MCP-1 (CCL2) and CCR2 in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).
Q38747937The role of chemokines in hypertension and consequent target organ damage
Q35583253The role of cytokines and chemokines in Histoplasma capsulatum infection
Q36389337Therapeutic T cells induce tumor-directed chemotaxis of innate immune cells through tumor-specific secretion of chemokines and stimulation of B16BL6 melanoma to secrete chemokines
Q35183162Three or more routes for leukocyte migration into the central nervous system
Q38081181Tolerance induction at the early maternal-placental interface through selective cell recruitment and targeting by immune polypeptides
Q34438782Tolerogenic dendritic cells that inhibit autoimmune arthritis can be induced by a combination of carvacrol and thermal stress
Q34489931Trafficking from the bone marrow to the thymus: a prerequisite for thymopoiesis
Q90632399Transcriptional Profiles Associated with Marek's Disease Virus in Bursa and Spleen Lymphocytes Reveal Contrasting Immune Responses during Early Cytolytic Infection
Q36607168Transgenic CCL2 expression in the central nervous system results in a dysregulated immune response and enhanced lethality after coronavirus infection
Q37728659Type 1 T-cell responses in chlamydial lung infections are associated with local MIP-1alpha response.
Q35695840Type I interferon signaling contributes to the bias that Toll-like receptor 4 exhibits for signaling mediated by the adaptor protein TRIF.
Q34491623Understanding selective trafficking of lymphocyte subsets
Q42947524Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells
Q35812229Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
Q37242997Virus-like particle vaccine activates conventional B2 cells and promotes B cell differentiation to IgG2a producing plasma cells.
Q40715506YopH prevents monocyte chemoattractant protein 1 expression in macrophages and T-cell proliferation through inactivation of the phosphatidylinositol 3-kinase pathway
Q35963596mRNA expression in different developmental stages of the chicken bursa of Fabricius
Q33964713γδ T cell subsets play opposing roles in regulating experimental autoimmune encephalomyelitis

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