RNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-template

scientific article published on February 15, 1993

RNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-template is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode1993PNAS...90.1276T
P356DOI10.1073/PNAS.90.4.1276
P953full work available at URLhttp://www.pnas.org/content/90/4/1276.full.pdf
https://europepmc.org/articles/PMC45855
https://europepmc.org/articles/PMC45855?pdf=render
https://pnas.org/doi/pdf/10.1073/pnas.90.4.1276
P932PMC publication ID45855
P698PubMed publication ID7679498
P5875ResearchGate publication ID15518662

P2093author name stringS. P. Goff
A. Telesnitsky
P2860cites workA detailed model of reverse transcription and tests of crucial aspectsQ66971643
Sequence and spacing requirements of a retrovirus integration siteQ68294695
Purification and characterization of murine retroviral reverse transcriptase expressed in Escherichia coliQ68937704
Retroviral Recombination and Reverse TranscriptionQ22242273
Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl proteinQ27670506
Reverse transcriptase.RNase H from the human immunodeficiency virus. Relationship of the DNA polymerase and RNA hydrolysis activitiesQ28646746
Crystal structure at 3.5 A resolution of HIV-1 reverse transcriptase complexed with an inhibitorQ29547710
Domain structure of the Moloney murine leukemia virus reverse transcriptase: mutational analysis and separate expression of the DNA polymerase and RNase H activitiesQ33559415
Linker insertion mutagenesis of the human immunodeficiency virus reverse transcriptase expressed in bacteria: definition of the minimal polymerase domainQ33852475
Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptaseQ35237118
Retroviral reverse transcriptase: synthesis, structure, and functionQ36583854
Generation of diversity in retrovirusesQ36643346
Inhibition of RNase H activity and viral replication by single mutations in the 3' region of Moloney murine leukemia virus reverse transcriptaseQ36782119
Template switching by reverse transcriptase during DNA synthesisQ36782936
Functional organization of the murine leukemia virus reverse transcriptase: characterization of a bacterially expressed AKR DNA polymerase deficient in RNase H activityQ36882751
Computer analysis of retroviral pol genes: assignment of enzymatic functions to specific sequences and homologies with nonviral enzymesQ37402708
Origins and evolutionary relationships of retrovirusesQ38201219
DNA-induced dimerization of the Escherichia coli Rep helicaseQ38332870
Human immunodeficiency virus reverse transcriptase. Effect of primer length on template-primer bindingQ38334271
Human immunodeficiency virus 1 reverse transcriptase. Template binding, processivity, strand displacement synthesis, and template switchingQ38345021
Crosslinking of substrates occurs exclusively to the p66 subunit of heterodimeric HIV-1 reverse transcriptaseQ38515356
The reverse transcriptaseQ39426664
Defects in Moloney murine leukemia virus replication caused by a reverse transcriptase mutation modeled on the structure of Escherichia coli RNase HQ40063803
Reverse transcriptase of human immunodeficiency virus type 1: functionality of subunits of the heterodimer in DNA synthesisQ40065525
Site-directed mutagenesis of the conserved Asp-443 and Asp-498 carboxy-terminal residues of HIV-1 reverse transcriptaseQ40523947
Isolation of cloned Moloney murine leukemia virus reverse transcriptase lacking ribonuclease H activityQ40536438
Subunit-selective mutagenesis indicates minimal polymerase activity in heterodimer-associated p51 HIV-1 reverse transcriptaseQ41083490
Analysis of the RNA- and DNA-dependent DNA polymerase activities of point mutants of HIV-1 reverse transcriptase lacking ribonuclease H activityQ42616916
Polymerization and RNase H activities of the reverse transcriptases from avian myeloblastosis, human immunodeficiency, and Moloney murine leukemia viruses are functionally uncoupledQ43749171
Requirements for the catalysis of strand transfer synthesis by retroviral DNA polymerasesQ44173505
Mutational analysis of the ribonuclease H activity of human immunodeficiency virus 1 reverse transcriptaseQ45860312
Importance of the positive charge cluster in Escherichia coli ribonuclease HI for the effective binding of the substrate.Q54695492
Intrinsic properties of reverse transcriptase in reverse transcription. Associated RNase H is essentially regarded as an endonuclease.Q54722632
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectmurine leukemia virusQ673848
Moloney murine leukemia virusQ61764092
P1104number of pages5
P304page(s)1276-1280
P577publication date1993-02-01
1993-02-15
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleRNase H domain mutations affect the interaction between Moloney murine leukemia virus reverse transcriptase and its primer-template
P478volume90

Reverse relations

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